Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Kandahari, Adrese M ^a   Yang, Xinlin ^a   Dighe, Abhijit S ^a   Pan, Dongfeng ^b   Cui, Quanjun ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ADAPTIVE IMMUNITY; CLINICAL TRIAL (TOPIC); DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; MOLECULAR DIAGNOSIS; MOLECULAR RECOGNITION; NONHUMAN; OSTEOARTHRITIS; REVIEW; SYSTEMATIC REVIEW (TOPIC); IMMUNOLOGY; PATHOLOGY; QUALITY OF LIFE;

EARLY DIAGNOSIS; HUMANS; IMMUNITY, INNATE; OSTEOARTHRITIS; QUALITY OF LIFE;

EID: 84929645851     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/192415     Document Type: Review

References (105)

1. L. Murphy and C. G. Helmick, "The impact of osteoarthritis in the United States: a population-health perspective: a population-based review of the fourth most common cause of hospitalization in U.S. adults," American Journal of Nursing, vol. 112, no. 3, pp. S13-S19, 2012.
2. R. C. Lawrence, D. T. Felson, C. G. Helmick et al., "Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II," Arthritis and Rheumatism, vol. 58, no. 1, pp. 26-35, 2008.
3. C. J. Malemud, "Anticytokine therapy for osteoarthritis: evidence to date," Drugs and Aging, vol. 27, no. 2, pp. 95-115, 2010.
4. A. L. G. Calich, D. S. Domiciano, and R. Fuller, "Osteoarthritis: can anti-cytokine therapy play a role in treatment?" Clinical Rheumatology, vol. 29, no. 5, pp. 451-455, 2010.
5. B. J. E. de Lange-Brokaar, A. Ioan-Facsinay, G. J. V. M.van Osch et al., "Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review," Osteoarthritis and Cartilage, vol. 20, no.12, pp. 1484-1499, 2012.
6. F. Berenbaum, "Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)," Osteoarthritis and Cartilage, vol. 21, no. 1, pp. 16-21, 2013.
7. F. Berenbaum, F. Eymard, and X. Houard, "Osteoarthritis, inflammation and obesity," Current Opinion in Rheumatology, vol. 25, no. 1, pp. 114-118, 2013.
8. K. O. Yaykasli, O. F. Hatipoglu, E. Yaykasli et al., "Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-êB signaling pathways in human chondrocytes," Cell Biology International, 2014.
9. W. Hui, G. J. Litherland, M. S. Elias et al., "Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases," Annals of the Rheumatic Diseases, vol. 71, no. 3, pp. 455-462, 2012.
10. M. Otero, R. Lago, R. Gómez, F. Lago, J. J. Gomez-Reino, and O. Gualillo, "Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes," Life Sciences, vol.81, no. 19-20, pp. 1452-1460, 2007.
11. P.-J. Francin, A. Abot, C. Guillaume et al., "Association between adiponectin and cartilage degradation in human osteoarthritis," Osteoarthritis and Cartilage, vol. 22, no. 3, pp. 519-526, 2014.
12. S. Clockaerts, Y. M. Bastiaansen-Jenniskens, J. Runhaar et al., "The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review," Osteoarthritis and Cartilage, vol. 18, no. 7, pp. 876-882, 2010.
13. M. Bohnsack, F. Meier, G. F. Walter et al., "Distribution of substance-P nerves inside the infrapatellar fat pad and the adjacent synovial tissue: a neurohistological approach to anterior knee pain syndrome," Archives of Orthopaedic and Trauma Surgery, vol. 125, no. 9, pp. 592-597, 2005.
14. D. H. Sohn, J. Sokolove, O. Sharpe et al., "Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4," Arthritis Research and Therapy, vol. 14, article R7, 2012.
15. S.-L. Su, C.-D. Tsai, C.-H. Lee, D. M. Salter, and H.-S. Lee, "Expression and regulation of Toll-like receptor 2 by IL-1β and fibronectin fragments in human articular chondrocytes," Osteoarthritis and Cartilage, vol. 13, no. 10, pp. 879-886, 2005.
16. R. F. P. Schelbergen, A. B. Blom, M. H. J. van den Bosch et al., "Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on toll-like receptor 4," Arthritis & Rheumatism, vol. 64, no. 5, pp. 1477-1487, 2012.
17. Q. Wang, A. L. Rozelle, C. M. Lepus et al., "Identification of a central role for complement in osteoarthritis," Nature Medicine, vol.17, no. 12, pp. 1674-1679, 2011.
18. W. H. Busby Jr., S. A. Yocum, M. Rowland et al., "Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid," Osteoarthritis and Cartilage, vol. 17, no. 4, pp. 547-555, 2009.
19. J. A. Kummer, P. P. Tak, B. M. N. Brinkman et al., "Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis," Clinical Immunology and Immunopathology, vol. 73, no. 1, pp. 88-95, 1994.
20. R. S. Huss, J. I. Huddleston, S. B. Goodman, E. C. Butcher, and B. A. Zabel, "Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation," Arthritis & Rheumatism, vol. 62, no. 12, pp. 3799-3805, 2010.
21. P. P. Tak, L. Spaeny-Dekking, M. C. Kraan, F. C. Breedveld, C. J. Froelich, and C. E. Hack, "The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)," Clinical and Experimental Immunology, vol. 116, no. 2, pp. 366-370,1999.
22. T. E. Damsgaard, F. B. Sørensen, T. Herlin, and P. O. Schiøtz, "Stereological quantification of mast cells in human synovium," APMIS, vol. 107, no. 3, pp. 311-317,1999.
23. G. Dean, J. A. Hoyland, J. Denton, R. P. Donn, and A. J. Freemont, "Mast cells in the synovium and synovial fluid in osteoarthritis," British Journal of Rheumatology, vol. 32, no. 8, pp. 671-675, 1993.
24. M. G. Buckley, P. J. Gallagher, and A. F. Walls, "Mast cell subpopulations in the synovial tissue of patients with osteoarthritis: selective increase in numbers of tryptase-positive, chymasenegative mast cells," The Journal of Pathology, vol. 186, no. 1, pp. 67-74, 1998.
25. B. Riepl, S. Grässel, R. Wiest, M. Fleck, and R. H. Straub, "Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis," Arthritis Research and Therapy, vol. 12, article R110, 2010.
26. O. Soehnlein, Y. Kai-Larsen, R. Frithiof et al., "Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages," The Journal of Clinical Investigation, vol. 118, no. 10, pp. 3491-3502, 2008.
27. K. Gupta, M. Shukla, J. B. Cowland, C. J. Malemud, and T. M. Haqqi, "Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9," Arthritis & Rheumatism, vol. 56, no. 10, pp. 3326-3335, 2007.
28. J. M. Milner, A. D. Rowan, T. E. Cawston, and D. A. Young, "Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis," Arthritis Research & Therapy, vol. 8, no. 5, article R142, 2006.
29. J. Bondeson, A. B. Blom, S. Wainwright, C. Hughes, B. Caterson, and W. B. van den Berg, "The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis," Arthritis and Rheumatism, vol. 62, no. 3, pp. 647-657, 2010.
30. J. Saklatvala, "Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage," Nature, vol. 322, no. 6079, pp. 547-549, 1986.
31. A. Haseeb and T. M. Haqqi, "Immunopathogenesis of osteoarthritis," Clinical Immunology, vol. 146, no. 3, pp. 185-196, 2013.
32. V. Lefebvre, C. Peeters-Joris, and G. Vaes, "Modulation by interleukin 1 and tumor necrosis factor α of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes," Biochimica et Biophysica Acta, vol. 1052, no. 3, pp. 366-378,1990.
33. M. J. Benito, D. J. Veale, O. Fitz Gerald, W. B. van den Berg, and B. Bresnihan, "Synovial tissue inflammation in early and late osteoarthritis," Annals of the Rheumatic Diseases, vol. 64, no. 9, pp. 1263-1267, 2005.
34. L. I. Sakkas, C. Scanzello, N. Johanson et al., "T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis," Clinical and Diagnostic Laboratory Immunology, vol. 5, no. 4, pp. 430-437, 1998.
35. I. Saito, T. Koshino, K. Nakashima, M. Uesugi, and T. Saito, "Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees," Osteoarthritis and Cartilage, vol. 10, no. 2, pp. 156-162, 2002.
36. F. Pessler, L. X. Chen, L. Dai et al., "A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans' Illness and joint pain compared to normal and osteoarthritis synovium," Clinical Rheumatology, vol. 27, no. 9, pp. 1127-1134, 2008.
37. F. Eckstein, W. Wirth, and M. C. Nevitt, "Recent advances in osteoarthritis imaging-the Osteoarthritis Initiative," Nature Reviews Rheumatology, vol. 8, no. 10, pp. 622-630, 2012.
38. C. Ding, Y. Zhang, and D. Hunter, "Use of imaging techniques to predict progression in osteoarthritis," Current Opinion in Rheumatology, vol. 25, no. 1, pp. 127-135, 2013.
39. A. Guermazi, F. W. Roemer, D. Burstein, and D. Hayashi, "Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis," Arthritis Research and Therapy, vol. 13, article 247, 2011.
40. V. B. Kraus, "Waiting for action on the osteoarthritis front," Current Drug Targets, vol. 11, no. 5, pp. 518-520, 2010.
41. F. W. Roemer, C. K. Kwoh, M. J. Hannon et al., "Risk factors for magnetic resonance imaging-detected patellofemoral and tibiofemoral cartilage loss during a six-month period: the Joints on Glucosamine study," Arthritis and Rheumatism, vol. 64, no. 6, pp. 1888-1898, 2012.
42. S. K. Tanamas, A. E. Wluka, J.-P. Pelletier et al., "Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study," Rheumatology, vol. 49, no. 12, pp. 2413-2419, 2010.
43. C. K. Kwoh, "Osteoarthritis: clinical relevance of bone marrow lesions in OA," Nature Reviews Rheumatology, vol. 9, no. 1, pp. 7-8, 2013.
44. L. Sharma, J. S. Chmiel, O. Almagor et al., "Significance of preradiographic magnetic resonance imaging lesions in persons at increased risk of knee osteoarthritis," Arthritis & Rheumatology, vol. 66, no. 7, pp. 1811-1819, 2014.
45. F. W. Roemer, A. Guermazi, D. T. Felson et al., "Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study," Annals of the Rheumatic Diseases, vol.70, no. 10, pp. 1804-1809, 2011.
46. J. Sokolove and C. M. Lepus, "Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations," Therapeutic Advances in Musculoskeletal Disease, vol. 5, no. 2, pp. 77-94, 2013.
47. H.-J. Park, S. S. Kim, S.-Y. Lee et al., "A practical MRI grading system for osteoarthritis of the knee: association with Kellgren-Lawrence radiographic scores," European Journal of Radiology, vol.82, no. 1, pp. 112-117, 2013.
48. H. J. Braun and G. E. Gold, "Diagnosis of osteoarthritis: imaging," Bone, vol. 51, no. 2, pp. 278-288, 2012.
49. H. Nakamura, K. Masuko, K. Yudoh et al., "Positron emission tomography with 18F-FDG in osteoarthritic knee," Osteoarthritis and Cartilage, vol. 15, no. 6, pp. 673-681, 2007.
50. C. Y. J. Wenham and P. G. Conaghan, "New horizons in osteoarthritis," Age and Ageing, vol. 42, no. 3, pp. 272-278, 2013.
51. Y. Zhang, B. Kundu, K. D. Fairchild et al., "Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging," Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 24, pp. 6876-6878, 2007.
52. L. W. Locke, M. D. Chordia, Y. Zhang et al., "A novel neutrophilspecific PET imaging agent: cFLFLFK-PEG-64 Cu," The Journal of Nuclear Medicine, vol. 50, no. 5, pp. 790-797, 2009.
53. L. Xiao, Y. Zhang, Z. Liu, M. Yang, L. Pu, and D. Pan, "Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging," Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 12, pp. 3515-3517, 2010.
54. Y. Zhang, L. Xiao, M. D. Chordia et al., "Neutrophil targeting heterobivalent SPECT imaging probe: CFLFLF-PEG-TKPPR-99mTc," Bioconjugate Chemistry, vol. 21, no. 10, pp. 1788-1793, 2010.
55. L. Xiao, Y. Zhang, S. S. Berr et al., "A novel near-infrared fluorescence imaging probe for in vivo neutrophil tracking," Molecular Imaging, vol. 11, no. 5, pp. 372-382, 2012.
56. S. Massey, K. Johnston, T. M. Mott et al., "In vivo bio luminescence imaging of Burkholderia mallei respiratory infection and treatment in the mouse model," Frontiers in Microbiology, vol. 2, article 174, 2011.
57. G. J. Stasiuk, H. Smith, M. Wylezinska-Arridge et al., "Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation," Chemical Communications, vol. 49, no. 6, pp. 564-566, 2013.
58. J. Zhou, Y.-T. Tsai, H. Weng et al., "Real-time detection of implant-associated neutrophil responses using a formyl peptide receptor-targeting NIR nanoprobe," International Journal of Nanomedicine, vol. 7, pp. 2057-2068, 2012.
59. D. A. Dorward, C. D. Lucas, A. G. Rossi, C. Haslett, and K. Dhaliwal, "Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution," Pharmacology and Therapeutics, vol. 135, no. 2, pp. 182-199, 2012.
60. S. E. VanCompernolle, K. L. Clark, K. A. Rummel, and S. C. Todd, "Expression and function of formyl peptide receptors on human fibroblast cells," The Journal of Immunology, vol.171, no. 4, pp. 2050-2056, 2003.
61. A. Viswanathan, R. G. Painter, N. A. Lanson Jr., and G. Wang, "Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells," Stem Cells, vol. 25, no. 5, pp. 1263-1269, 2007.
62. W. Kao, R. Gu, Y. Jia et al., "A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis," British Journal of Pharmacology, vol. 171, no. 17, pp. 4087-4096, 2014.
63. F. P. J. G. Lafeber and W. E. van Spil, "Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time," Osteoarthritis and Cartilage, vol.21, no. 10, pp. 1452-1464, 2013.
64. M. Attur, S. Krasnokutsky-Samuels, J. Samuels, and S. B. Abramson, "Prognostic biomarkers in osteoarthritis," Current Opinion in Rheumatology, vol. 25, no. 1, pp. 136-144, 2013.
65. L. I. Sakkas, G. Koussidis, E. Avgerinos, J. Gaughan, and C. D. Platsoucas, "Decreased expression of the CD3ζ chain in T cells infiltrating the synovial membrane of patients with osteoarthritis," Clinical and Diagnostic Laboratory Immunology, vol.11, no. 1, pp. 195-202, 2004.
66. C. R. Scanzello, E. Umoh, F. Pessler et al., "Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease," Osteoarthritis and Cartilage, vol. 17, no. 8, pp. 1040-1048, 2009.
67. S. Khalifé and M. Zafarullah, "Molecular targets of natural health products in arthritis," Arthritis Research & Therapy, vol. 13, article 102, 2011.
68. S. Kyrkanides, R. H. Tallents, J.-N. H. Miller et al., "Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice," Journal of Neuroinflammation, vol.8,article 112, 2011.
69. C. L. Hill, D. J. Hunter, J. Niuetal., "Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis," Annals of the Rheumatic Diseases, vol.66, no. 12, pp. 1599-1603, 2007.
70. M. L. Schenker, R. L. Mauck, and S. Mehta, "Pathogenesis and prevention of posttraumatic osteoarthritis after intra-articular fracture," Journal of the American Academy of Orthopaedic Surgeons, vol. 22, no. 1, pp. 20-28, 2014.
71. R. F. Loeser, "Osteoarthritis year in review 2013: biology," Osteoarthritis and Cartilage, vol. 21, no. 10, pp. 1436-1442, 2013.
72. E. F. Goljan, Rapid Review Pathology, Elsevier/Saunders, Philadelphia, Pa, USA, 4th edition, 2014.
73. X. Chevalier, T. Conrozier, and P. Richette, "Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy," Arthritis Research and Therapy, vol. 13, article 124, 2011.
74. M. Z. C. Ruan, A. Erez, K. Guse et al., "Proteoglycan 4 expression protects against the development of osteoarthritis," Science Translational Medicine, vol. 5, no. 176, Article ID 176ra34, 2013.
75. J. A. Martin, D. McCabe, M. Walter, J. A. Buckwalter, and T. O. McKinley, "N-acetylcysteine inhibits post-impact chondrocyte death in osteochondral explants," The Journal of Bone and Joint Surgery A, vol. 91, no. 8, pp. 1890-1897, 2009.
76. P. L. E. M. Van Lent, A. B. Blom, P. Van Der Kraan et al., "Crucial role of synovial lining macrophages in the promotion of transforming growth factor β-mediated osteophyte formation," Arthritis and Rheumatism, vol. 50, no. 1, pp. 103-111, 2004.
77. H. Nakamura, S. Yoshino, T. Kato, J. Tsuruha, and K. Nishioka "T-cell mediated inflammatory pathway in osteoarthritis," Osteoarthritis and Cartilage, vol. 7, no. 4, pp. 401-402,1999.
78. A. Guerassimov, Y. Zhang, A. Cartman et al., "Immune responses to cartilage link protein and the G1 domain of proteoglycan aggrecan in patients with osteoarthritis," Arthritis &Rheumatism, vol. 42, no. 3, pp. 527-533,1999.
79. H. de Jong, S. E. Berlo, P. Hombrink et al., "Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis," Annals of the Rheumatic Diseases, vol. 69, no. 1, pp. 255-262, 2010.
80. R.-R. Da, Y. Qin, D. Baeten, and Y. Zhang, "B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis," The Journal of Immunology, vol. 178, no. 1, pp. 557-565, 2007.
81. S. Shiokawa, N. Matsumoto, and J. Nishimura, "Clonal analysis of B cells in the osteoarthritis synovium," Annals of the Rheumatic Diseases, vol. 60, no. 8, pp. 802-805, 2001.
82. J. Mollenhauer, K. von der Mark, G. Burmester, K. Gluckert, E. Lutjen-Drecoll, and K. Brune, "Serum antibodies against chondrocyte cell surface proteins in osteoarthritis and rheumatoid arthritis," The Journal of Rheumatology, vol. 15, no. 12, pp. 1811-1817, 1988.
83. F. Doss, J. Menard, M. Hauschild et al., "Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells," Scandinavian Journal of Rheumatology, vol. 36, no. 2, pp. 136-139, 2007.
84. M. D. Smith, S. Triantafillou, A. Parker, P. P. Youssef, and M. Coleman, "Synovial membrane inflammation and cytokine production in patients with early osteoarthritis," The Journal of Rheumatology, vol. 24, no. 2, pp. 365-371,1997.
85. M. Kobayashi, G. R. Squires, A. Mousa et al., "Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage," Arthritis and Rheumatism, vol.52, no. 1, pp. 128-135, 2005.
86. Z. Fan, B. Bau, H. Yang, S. Soeder, and T. Aigner, "Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1β," Arthritis & Rheumatism, vol. 52, no. 1, pp. 136-143, 2005.
87. N. Akhtar and T. M. Haqqi, "Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes," Arthritis Research and Therapy, vol. 13, no. 3, article R93, 2011.
88. J. N. Gouze, K. Bordji, S. Gulberti et al., "Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes," Arthritis & Rheumatism, vol. 44, no. 2, pp. 351-360, 2001.
89. F. Heraud, A. Heraud, and M.-F. Harmand, "Apoptosis in normal and osteoarthritic human articular cartilage," Annals of the Rheumatic Diseases, vol. 59, no. 12, pp. 959-965, 2000.
90. M. Mathy-Hartert, L. Hogge, C. Sanchez, G. Deby-Dupont, J. M. Crielaard, and Y. Henrotin, "Interleukin-1β and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation," Osteoarthritis and Cartilage, vol. 16, no. 7, pp. 756-763, 2008.
91. J.-P. Pelletier, F. Mineau, P. Ranger, G. Tardif, and J. Martel-Pelletier, "The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation," Osteoarthritis and Cartilage, vol. 4, no. 1, pp. 77-84,1996.
92. X. Li, M. Ellman, P. Muddasani et al., "Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis," Arthritis & Rheumatism, vol.60, no. 2, pp. 513-523, 2009.
93. P.-A. Guerne, B. L. Zuraw, J. H. Vaughan, D. A. Carson, and M. Lotz, "Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis," The Journal of Clinical Investigation, vol. 83, no. 2, pp. 585-592, 1989.
94. F. Legendre, J. Dudhia, J.-P. Pujol, and P. Bogdanowicz, "JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of Sox9 expression," The Journal of Biological Chemistry, vol. 278, no. 5, pp. 2903-2912, 2003.
95. B. Porée, M. Kypriotou, C. Chadjichristos et al., "Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter," The Journal of Biological Chemistry, vol. 283, no. 8, pp. 4850-4865, 2008.
96. T. E. Cawston, V. A. Curry, C. A. Summers et al., "The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint," Arthritis & Rheumatology, vol. 41, pp. 1760-1771, 1998.
97. J. Suurmond, A. L. Dorjee, M. R. Boon et al., "Mast cells are the main interleukin-17-positive cells in anti-citrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium," Arthritis Research & Therapy, vol. 13, no. 5, article R150, 2011.
98. T. L. Y. Brown, H. J. Spencer, K. E. Beenken et al., "Evaluation of dynamic [18 F]-FDG-PET imaging for the detection of acute post-surgical bone infection," PLoS ONE, vol. 7, no. 7, Article ID e41863, 2012.
99. C. Wu, F. Li, G. Niu, and X. Chen, "PET imaging of inflammation biomarkers," Theranostics, vol. 3, no. 7, pp. 448-466, 2013.
100. C. M. Griessinger, R. Kehlbach, D. Bukala et al., "In vivo tracking of th1 cells by PET reveals quantitative and temporal distribution and specific homing in lymphatic tissue," The Journal of Nuclear Medicine, vol. 55, no. 2, pp. 301-307, 2014.
101. L. Tran, A. D. R. Huitema, M. H. Van Rijswijk et al., "CD20 antigen imaging with 124I-rituximab PET/CT in patients with rheumatoid arthritis," Human Antibodies, vol. 20, no. 1-2, pp. 29-35, 2011.
102. Q. Wang, X. Shi, X. Zhu, M. Ehlers, J. Wu, and C. Schmuck, "A fluorescent light-up probe as an inhibitor of intracellular β-tryptase," Chemical Communications, vol. 50, no. 46, pp. 6120-6122, 2014.
103. Q. Cao, W. Cai, Z.-B. Li et al., "PET imaging of acute and chronic inflammation in living mice," European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 11, pp. 1832-1842, 2007.
104. G. Girardi, J. Fraser, R. Lennen, R. Vontell, M. Jansen, and G. Hutchison, "Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development," Molecular Psychiatry, 2014.
105. D. Hartung, M. Schäfers, S. Fujimoto et al., "Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions," European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, supplement 1, pp. S1-S8, 2007.