Desperately looking for the right target in osteoarthritis: The anti-IL-1 strategy

Arthritis Research and Therapy

Volumn 13, Issue 4, 2011, Pages

  Chevalier, Xavier ^a   Conrozier, Thierry ^b   Richette, Pascal ^c  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMG 108; C REACTIVE PROTEIN; COLLAGEN TYPE 2; FREE RADICAL; INTERLEUKIN 1; INTERLEUKIN 1BETA; MONOCLONAL ANTIBODY; NITRIC OXIDE; PROSTANOID; PROTEOGLYCAN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ANTIRHEUMATIC AGENT;

ARTHRALGIA; CARTILAGE CELL; CHONDROPROTECTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG SAFETY; ENZYME SYNTHESIS; FOLLOW UP; HUMAN; IMMUNOTHERAPY; NEUTROPHIL COUNT; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; PROSTAGLANDIN RELEASE; PROTEIN SYNTHESIS INHIBITION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHEUMATOID ARTHRITIS; SINGLE DRUG DOSE; ANIMAL; ARTICLE; DRUG ANTAGONISM; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; HUMANS; INTERLEUKIN-1; OSTEOARTHRITIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 80052209352     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3436     Document Type: Review

References (10)

1. Cohen SB, Proudman S, Kivitz AJ, Burch FX, Donohue JP, Burstein D, Sun Y-N, Banfield C, Vincent MS, Ni L, Zack DJ. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL 1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther 2011, 13:R125. 10.1186/ar3430, 21801403.
2. Pelletier JP, Martel-Pelletier J, Abramson SE. Review: osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001, 44:1237-1247. 10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F, 11407681.
3. Chevalier X. Up-regulation of enzymatic activity by interleukin-1 in osteoarthritis. Biomed Pharmacother 1997, 51:58-62. 10.1016/S0753-3322(97)87727-X, 9161468.
4. Sachs D, Cunha FQ, Poole S, Ferreira SH. Tumour necrosis factor-α, interleukin-1β and interleukin-8 induce persistent mechanical nociceptor hypersensitivity. Pain 2002, 96:89-97. 10.1016/S0304-3959(01)00433-X, 11932065.
5. Caron JP, Fernandes JC, Martel-Pelletier J, Tardif G, Mineau F, Geng C, Pelletier JP. Chondroprotective effect of intra-articular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 1996, 39:1535-1544. 10.1002/art.1780390914, 8814066.
6. Bresnihan B. Anakinra as a new therapeutic option in rheumatoid arthritis: clinical results and perspectives. Clin Exp Rheumatol 2002, 20(5 Suppl 27):S32-S34.
7. Chevalier X, Giraudeau B, Conrozier T, Marliere J, Kiefer P, Goupille P. Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J Rheumatol 2005, 32:1317-1323.
8. Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, Loeuille D, Kivitz AJ, Silver D, Appleton BE. Intra-articular injection of anakinra (r-met-huIL-1ra) in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 2009, 61:344-352. 10.1002/art.24096, 19248129.
9. Hanna FS, Bell RJ, Cicuttini FM, Davison SL, Wluka AE, Davis SR. High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life. Arthritis Res Ther 2008, 10:R27. 10.1186/ar2380, 2374464, 18312679.
10. Sharif M, Shepstone L, Elson CJ, Dieppe PA, Kirwan JR. Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis 2000, 59:71-74. 10.1136/ard.59.1.71, 1752992, 10627432.