The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through interactions with lipopolysaccharide and macrophages/monocytes

Journal of Immunology

Volumn 194, Issue 11, 2015, Pages 5397-5406

  Hansen, Finja C ^a   Kalle Brune, Martina ^a   Van Der Plas, Mariena J A ^a   Strömdahl, Ann Charlotte ^a   Malmsten, Martin ^b   Mörgelin, Matthias ^a   Schmidtchen, Artur ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; GKY25 PEPTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; CYTOKINE; LIPOPOLYSACCHARIDE; LY96 PROTEIN, MOUSE; PEPTIDE FRAGMENT; PROTEIN MD 2; STRESS ACTIVATED PROTEIN KINASE; THROMBIN; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; DRUG BINDING; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; DRUG EFFECTS; ENZYME ACTIVATION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE; CYTOKINES; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR SEQUENCE DATA; MONOCYTES; NF-KAPPA B; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; THROMBIN; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84929629727     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403009     Document Type: Article

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