Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

Journal of Hepatology

Volumn 62, Issue 6, 2015, Pages 1375-1381

  Zhong, Wei ^a   Zhang, Wenliang ^a   Li, Qiong ^a   Xie, Guoxiang ^b   Sun, Qian ^a   Sun, Xiuhua ^a   Tan, Xiaobing ^a   Sun, Xinguo ^a   Jia, Wei ^b   Zhou, Zhanxiang ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Alcohol; Alda 1; Aldehyde dehydrogenase 2; Apoptosis; Steatosis

Indexed keywords

4 HYDROXYNONENAL; ACETALDEHYDE; ALANINE AMINOTRANSFERASE; ALCOHOL; ALDA 1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ASPARTATE AMINOTRANSFERASE; CHAPERONE; CYTOCHROME P450 4A; ENZYME ACTIVATOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIVER PROTECTIVE AGENT; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; 1,3 BENZODIOXOLE DERIVATIVE; ALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; BENZAMIDE DERIVATIVE; N-(1,3-BENZODIOXOL-5-YLMETHYL)-2,6-DICHLOROBENZAMIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL INTOXICATION; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; LIPID METABOLISM; LIPID STORAGE; LIVER INJURY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; SINGLE DRUG DOSE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; FATTY LIVER, ALCOHOLIC; LIVER; METABOLIC CLEARANCE RATE; METABOLISM; PATHOLOGY;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; APOPTOSIS; BENZAMIDES; BENZODIOXOLES; CELL DEATH; CELL LINE; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FATTY LIVER, ALCOHOLIC; LIPID METABOLISM; LIVER; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; RATS;

EID: 84929605783     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.12.022     Document Type: Article

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