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Volumn 9, Issue MAY, 2015, Pages

Leptin is required for hypothalamic regulation of miRNA stargeting POMC 3′UTR

Author keywords

Food intake; Hypothalamus; Leptin; Melanocortin; MicroRNA

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; LEPTIN; MELANOCORTIN; MICRORNA; PROOPIOMELANOCORTIN;

EID: 84929583346     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00172     Document Type: Article
Times cited : (42)

References (42)
  • 1
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga, S., Bracht, J., Hunter, S., Massirer, K., Holtz, J., Eachus, R., et al. (2005). Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553-563. doi: 10.1016/j.cell.2005.07.031
    • (2005) Cell , vol.122 , pp. 553-563
    • Bagga, S.1    Bracht, J.2    Hunter, S.3    Massirer, K.4    Holtz, J.5    Eachus, R.6
  • 2
    • 84878778711 scopus 로고    scopus 로고
    • Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs
    • Benoit, C., Ould-Hamouda, H., Crepin, D., Gertler, A., Amar, L., and Taouis, M. (2013). Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs. J. Endocrinol. 218, 35-47. doi: 10.1530/JOE-12-0561
    • (2013) J. Endocrinol , vol.218 , pp. 35-47
    • Benoit, C.1    Ould-Hamouda, H.2    Crepin, D.3    Gertler, A.4    Amar, L.5    Taouis, M.6
  • 3
    • 84863267488 scopus 로고    scopus 로고
    • Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
    • Berglund, E. D., Vianna, C. R., Donato, J. Jr., Kim, M. H., Chuang, J.-C., Lee, C. E., et al. (2012). Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J. Clin. Invest. 122, 1000-1009. doi: 10.1172/JCI59816
    • (2012) J. Clin. Invest , vol.122 , pp. 1000-1009
    • Berglund, E.D.1    Vianna, C.R.2    Donato, J.3    Kim, M.H.4    Chuang, J.-C.5    Lee, C.E.6
  • 4
    • 0032986273 scopus 로고    scopus 로고
    • Modulation of insulin secretion by leptin
    • Ceddia, R. B., William, W. N. Jr., Carpinelli, A. R., and Curi, R. (1999). Modulation of insulin secretion by leptin. Gen. Pharmacol. 32,233-237. doi: 10.1016/S0306-3623(98)00185-2
    • (1999) . Gen. Pharmacol , vol.32 , pp. 233-237
    • Ceddia, R.B.1    William, W.N.2    Carpinelli, A.R.3    Curi, R.4
  • 5
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen, A. S., Marsh, D. J., Trumbauer, M. E., Frazier, E. G., Guan, X. M., Yu, H., et al. (2000). Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26, 97-102. doi: 10.1038/79254
    • (2000) . Nat. Genet , vol.26 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 6
    • 77952368550 scopus 로고    scopus 로고
    • Mammalian microRNAs: Experimental evaluation of novel and previously annotated genes
    • Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., et al. (2010). Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 24, 992-1009. doi: 10.1101/gad.1884710
    • (2010) Genes Dev , vol.24 , pp. 992-1009
    • Chiang, H.R.1    Schoenfeld, L.W.2    Ruby, J.G.3    Auyeung, V.C.4    Spies, N.5    Baek, D.6
  • 7
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., et al. (2001). Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484. doi: 10.1038/35078085
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdán, M.G.4    Diano, S.5    Horvath, T.L.6
  • 8
    • 84892836368 scopus 로고    scopus 로고
    • The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment
    • Crépin, D., Benomar, Y., Riffault, L., Amine, H., Gertler, A., and Taouis, M. (2014). The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. Mol. Cell. Endocrinol. 384, 1-11. doi: 10.1016/j.mce.2013.12.016
    • (2014) . Mol. Cell. Endocrinol , vol.384 , pp. 1-11
    • Crépin, D.1    Benomar, Y.2    Riffault, L.3    Amine, H.4    Gertler, A.5    Taouis, M.6
  • 9
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., et al. (2004). Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. U.S.A. 101, 4661-4666. doi: 10.1073/pnas.0303992101
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 4661-4666
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3    Morino, K.4    Horvath, T.L.5    Shulman, G.I.6
  • 10
    • 80054005921 scopus 로고    scopus 로고
    • Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism
    • Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., et al. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. Toxicol. Sci. 124, 179-191. doi: 10.1093/toxsci/kfr219
    • (2011) . Toxicol. Sci , vol.124 , pp. 179-191
    • Girardet, C.1    Bonnet, M.S.2    Jdir, R.3    Sadoud, M.4    Thirion, S.5    Tardivel, C.6
  • 11
    • 84879485588 scopus 로고    scopus 로고
    • Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior
    • Greenman, Y., Kuperman, Y., Drori, Y., Asa, S. L., Navon, I., Forkosh, O., et al. (2013). Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior. Mol. Endocrinol. (Baltimore Md) 27, 1091-1102. doi: 10.1210/me.2012-1344
    • (2013) Mol. Endocrinol. (Baltimore Md) , vol.27 , pp. 1091-1102
    • Greenman, Y.1    Kuperman, Y.2    Drori, Y.3    Asa, S.L.4    Navon, I.5    Forkosh, O.6
  • 12
    • 84869760976 scopus 로고    scopus 로고
    • Locked nucleic acid-based in situ hybridisation reveals miR-7a as a hypothalamus-enriched microRNA with a distinct expression pattern
    • Herzer, S., Silahtaroglu, A., and Meister, B. (2012). Locked nucleic acid-based in situ hybridisation reveals miR-7a as a hypothalamus-enriched microRNA with a distinct expression pattern. J. Neuroendocrinol. 24, 1492-1504. doi: 10.1111/j.1365-2826.2012.02358.x
    • (2012) J. Neuroendocrinol , vol.24 , pp. 1492-1504
    • Herzer, S.1    Silahtaroglu, A.2    Meister, B.3
  • 13
    • 77950264425 scopus 로고    scopus 로고
    • Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    • Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., et al. (2010). Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 11, 286-297. doi: 10.1016/j.cmet.2010.03.002
    • (2010) Cell Metab , vol.11 , pp. 286-297
    • Hill, J.W.1    Elias, C.F.2    Fukuda, M.3    Williams, K.W.4    Berglund, E.D.5    Holland, W.L.6
  • 14
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., et al. (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141. doi: 10.1016/S0092-8674(00)81865-6
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3    Dunmore, J.H.4    Fang, Q.5    Berkemeier, L.R.6
  • 15
    • 0037387207 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels
    • Ibrahim, N., Bosch, M. A., Smart, J. L., Qiu, J., Rubinstein, M., Ronnekleiv, O. K., et al. (2003). Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 144, 1331-1340. doi: 10.1210/en.2002-221033
    • (2003) Endocrinology , vol.144 , pp. 1331-1340
    • Ibrahim, N.1    Bosch, M.A.2    Smart, J.L.3    Qiu, J.4    Rubinstein, M.5    Ronnekleiv, O.K.6
  • 16
    • 60049085382 scopus 로고    scopus 로고
    • The role of leptin-melanocortin system and human weight regulation: Lessons from experiments ofnature
    • Lee, Y. S. (2009). The role of leptin-melanocortin system and human weight regulation: lessons from experiments ofnature. Ann. Acad. Med. Singapore 38, 34-11.
    • (2009) Ann. Acad. Med. Singapore , vol.38 , pp. 11-34
    • Lee, Y.S.1
  • 17
    • 70349393847 scopus 로고    scopus 로고
    • Differential expression of microRNAs in mouse liver under aberrant energy metabolic status
    • Li, S., Chen, X., Zhang, H., Liang, X., Xiang, Y., Yu, C., et al. (2009). Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J. Lipid Res. 50, 1756-1765. doi: 10.1194/jlr.M800509-JLR200
    • (2009) J. Lipid Res , vol.50 , pp. 1756-1765
    • Li, S.1    Chen, X.2    Zhang, H.3    Liang, X.4    Xiang, Y.5    Yu, C.6
  • 18
    • 58149350340 scopus 로고    scopus 로고
    • Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction
    • Lovis, P., Roggli, E., Laybutt, D. R., Gattesco, S., Yang, J.-Y., Widmann, C., et al. (2008). Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 57, 2728-2736. doi: 10.2337/db07-1252
    • (2008) Diabetes , vol.57 , pp. 2728-2736
    • Lovis, P.1    Roggli, E.2    Laybutt, D.R.3    Gattesco, S.4    Yang, J.-Y.5    Widmann, C.6
  • 19
    • 0036866913 scopus 로고    scopus 로고
    • Leptin: A review of its peripheral actions and interactions
    • Margetic, S., Gazzola, C., Pegg, G. G., and Hill, R. A. (2002). Leptin: a review of its peripheral actions and interactions. Int. J. Obes. Relat. Metab. Disord. 26, 1407-1433. doi: 10.1038/sj.ijo.0802142
    • (2002) Int. J. Obes. Relat. Metab. Disord , vol.26 , pp. 1407-1433
    • Margetic, S.1    Gazzola, C.2    Pegg, G.G.3    Hill, R.A.4
  • 20
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic Pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by Leptin
    • Mizuno, T. M., Kleopoulos, S. P., Bergen, H. T., Roberts, J. L., Priest, C. A., and Mobbs, C. V. (1998). Hypothalamic Pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by Leptin. Diabetes 47, 294-297. doi: 10.2337/diab.47.2.294
    • (1998) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 21
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control offood intake and bodyweight
    • Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., and Schwartz, M. W. (2006). Central nervous system control offood intake and bodyweight. Nature 443, 289-295. doi: 10.1038/nature05026
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 22
    • 33746404163 scopus 로고    scopus 로고
    • Expression of PACAP receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus
    • Mounien, L., Bizet, P., Boutelet, I., Gourcerol, G., Basille, M., Gonzalez, B., et al. (2006a). Expression of PACAP receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Ann. N.Y. Acad. Sci. 1070, 457-461. doi: 10.1196/annals.1317.061
    • (2006) Ann. N.Y. Acad. Sci , vol.1070 , pp. 457-461
    • Mounien, L.1    Bizet, P.2    Boutelet, I.3    Gourcerol, G.4    Basille, M.5    Gonzalez, B.6
  • 23
    • 33751042201 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide directly modulates the activity of proopiomelanocortin neurons in the rat arcuate nucleus
    • Mounien, L., Bizet, P., Boutelet, I., Gourcerol, G., Fournier, A., Vaudry, H., et al. (2006b). Pituitary adenylate cyclase-activating polypeptide directly modulates the activity of proopiomelanocortin neurons in the rat arcuate nucleus. Neuroscience 143, 155-163. doi: 10.1016/j.neuroscience.2006.07.022
    • (2006) Neuroscience , vol.143 , pp. 155-163
    • Mounien, L.1    Bizet, P.2    Boutelet, I.3    Gourcerol, G.4    Fournier, A.5    Vaudry, H.6
  • 24
    • 33646500989 scopus 로고    scopus 로고
    • Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus
    • Mounien, L., Bizet, P., Boutelet, I., Vaudry, H., and Jégou, S. (2005). Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology 82, 164-170. doi: 10.1159/000091737
    • (2005) Neuroendocrinology , vol.82 , pp. 164-170
    • Mounien, L.1    Bizet, P.2    Boutelet, I.3    Vaudry, H.4    Jégou, S.5
  • 25
    • 57849118731 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system
    • Mounien, L., Do Rego, J.-C., Bizet, P., Boutelet, I., Gourcerol, G., Fournier, A., et al. (2009). Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system. Neuropsychopharmacology 34, 424-435. doi: 10.1038/npp.2008.73
    • (2009) Neuropsychopharmacology , vol.34 , pp. 424-435
    • Mounien, L.1    Do Rego, J.-C.2    Bizet, P.3    Boutelet, I.4    Gourcerol, G.5    Fournier, A.6
  • 26
    • 77953502759 scopus 로고    scopus 로고
    • Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons
    • Mounien, L., Marty, N., Tarussio, D., Metref, S., Genoux, D., Preitner, F., et al. (2010). Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J. 24, 1747-1758. doi: 10.1096/fj.09-144923
    • (2010) FASEB J , vol.24 , pp. 1747-1758
    • Mounien, L.1    Marty, N.2    Tarussio, D.3    Metref, S.4    Genoux, D.5    Preitner, F.6
  • 27
    • 67349179168 scopus 로고    scopus 로고
    • The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue ofgeneticallyobese mice. Biochem. Biophys. Res
    • Nakanishi, N., Nakagawa, Y., Tokushige, N., Aoki, N., Matsuzaka, T., Ishii, K., et al. (2009). The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue ofgeneticallyobese mice. Biochem. Biophys. Res. Commun. 385, 492-496. doi: 10.1016/j.bbrc.2009.05.058
    • (2009) Commun , vol.385 , pp. 492-496
    • Nakanishi, N.1    Nakagawa, Y.2    Tokushige, N.3    Aoki, N.4    Matsuzaka, T.5    Ishii, K.6
  • 28
    • 0037507152 scopus 로고    scopus 로고
    • Precursor-protein convertase 1 gene expression in the mouse hypothalamus: Differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin
    • Nilaweera, K. N., Barrett, P., Mercer, J. G., and Morgan, P. J. (2003). Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin. Neuroscience 119, 713-720. doi: 10.1016/S0306-4522(02)00869-2
    • (2003) Neuroscience , vol.119 , pp. 713-720
    • Nilaweera, K.N.1    Barrett, P.2    Mercer, J.G.3    Morgan, P.J.4
  • 29
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I., et al. (1997). Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138. doi: 10.1126/science.278.5335.135
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6
  • 30
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., et al. (2007). Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449, 228-232. doi: 10.1038/nature06098
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3    Enriori, P.J.4    Choi, B.5    Zhang, C.-Y.6
  • 31
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by Leptin
    • Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., et al. (2004). Rapid rewiring of arcuate nucleus feeding circuits by Leptin. Science 304, 110-115. doi: 10.1126/science.1089459
    • (2004) Science , vol.304 , pp. 110-115
    • Pinto, S.1    Roseberry, A.G.2    Liu, H.3    Diano, S.4    Shanabrough, M.5    Cai, X.6
  • 32
    • 33745838578 scopus 로고    scopus 로고
    • Central insulin action in energy and glucose homeostasis
    • Plum, L., Belgardt, B. F., and Bruning, J. C. (2006). Central insulin action in energy and glucose homeostasis. J. Clin. Invest. 116, 1761-1766. doi: 10.1172/JCI29063
    • (2006) J. Clin. Invest , vol.116 , pp. 1761-1766
    • Plum, L.1    Belgardt, B.F.2    Bruning, J.C.3
  • 33
    • 0036791462 scopus 로고    scopus 로고
    • Leptin and insulin action in the central nervous system
    • discussion: S68-S84, 85-87
    • Porte, D. Jr., Baskin, D. G., and Schwartz, M. W. (2002). Leptin and insulin action in the central nervous system. Nutr. Rev. 60, S20-S29. discussion: S68-S84, 85-87. doi: 10.1301/002966402320634797
    • (2002) Nutr. Rev , vol.60
    • Porte, D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 35
    • 84899459495 scopus 로고    scopus 로고
    • Perturbation of hypothalamic microRNA expression patterns in male rats after metabolic distress: Impact of obesity and conditions of negative energy balance
    • Sangiao-Alvarellos, S., Pena-Bello, L., Manfredi-Lozano, M., Tena-Sempere, M., and Cordido, F. (2014). Perturbation of hypothalamic microRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance. Endocrinology 155, 1838-1850. doi: 10.1210/en.2013-1770
    • (2014) Endocrinology , vol.155 , pp. 1838-1850
    • Sangiao-Alvarellos, S.1    Pena-Bello, L.2    Manfredi-Lozano, M.3    Tena-Sempere, M.4    Cordido, F.5
  • 36
    • 84877659963 scopus 로고    scopus 로고
    • Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity
    • Schneeberger, M., Altirriba, J., Garcia, A., Esteban, Y., Castaňo, C., García-Lavandeira, M., et al. (2012). Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Mol. Metab. 2, 74-85. doi: 10.1016/j.molmet.2012.10.001
    • (2012) . Mol. Metab , vol.2 , pp. 74-85
    • Schneeberger, M.1    Altirriba, J.2    Garcia, A.3    Esteban, Y.4    Castaňo, C.5    García-Lavandeira, M.6
  • 37
    • 0023959725 scopus 로고
    • Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
    • Smith, A. I., and Funder, J. W. (1988). Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr. Rev. 9, 159-179. doi: 10.1210/edrv-9-1-159
    • (1988) . Endocr. Rev , vol.9 , pp. 159-179
    • Smith, A.I.1    Funder, J.W.2
  • 39
    • 34548682763 scopus 로고    scopus 로고
    • Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes
    • Thompson, R. C., Deo, M., and Turner, D. L. (2007). Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes. Methods (San Diego Calif.) 43, 153-161. doi: 10.1016/j.ymeth.2007.04.008
    • (2007) Methods (San Diego Calif.) , vol.43 , pp. 153-161
    • Thompson, R.C.1    Deo, M.2    Turner, D.L.3
  • 40
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., et al. (2010). Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479. doi: 10.1523/JNEUROSCI.3118-09.2010
    • (2010) J. Neurosci , vol.30 , pp. 2472-2479
    • Williams, K.W.1    Margatho, L.O.2    Lee, C.E.3    Choi, M.4    Lee, S.5    Scott, M.M.6
  • 41
    • 65549144017 scopus 로고    scopus 로고
    • MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    • Xie, H., Lim, B., and Lodish, H. F. (2009). MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58, 1050-1057. doi: 10.2337/db08-1299
    • (2009) Diabetes , vol.58 , pp. 1050-1057
    • Xie, H.1    Lim, B.2    Lodish, H.F.3
  • 42
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen, L., Diehl, N., Brennan, M. B., and Hochgeschwender, U. (1999). Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066-1070. doi: 10.1038/12506
    • (1999) . Nat. Med , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.