Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Khan, Mohammad Ahmed ^a   Singh, Mhaveer ^a   Khan, Masood Shah ^a   Najmi, Abul Kalam ^a   Ahmad, Sayeed ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BOSWELLIA SERRATA EXTRACT; BOSWELLIC ACID; CASPASE 3; DOXORUBICIN; INTERLEUKIN 6; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; IL6 PROTEIN, HUMAN; PLANT EXTRACT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; LIVER CELL CARCINOMA; LIVER TOXICITY; MONOTHERAPY; MTT ASSAY; NONHUMAN; RAT; BOSWELLIA; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; TREATMENT OUTCOME; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BOSWELLIA; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; DRUG SYNERGISM; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; INTERLEUKIN-6; LIVER NEOPLASMS; PLANT EXTRACTS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929503242     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/294143     Document Type: Article

References (46)

1. P. A. Farazi and R. A. DePinho, "Hepatocellular carcinoma pathogenesis: from genes to environment, " Nature Reviews Cancer, vol. 6, no. 9, pp. 674-687, 2006.
2. M. A. Hossain, D. H. Kim, J. Y. Jang et al., "Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo, " International Journal of Oncology, vol. 40, no. 5, pp. 1636-1642, 2012.
3. A. K. Nowak, P. K. H. Chow, and M. Findlay, "Systemic therapy for advanced hepatocellular carcinoma: a review, " European Journal of Cancer, vol. 40, no. 10, pp. 1474-1484, 2004.
4. O. Dudeck and J. Ricke, "Advances in regional chemotherapy of the liver, " Expert Opinion on Drug Delivery, vol. 8, no. 8, pp. 1057-1069, 2011.
5. J. H. Silber, G. Barber, L. Paz-Ares, N. Dobbs, and C. Twelves, "Doxorubicin-induced cardiotoxicity, " The New England Journal of Medicine, vol. 333, no. 20, pp. 1359-1360, 1995.
6. P. D. King and M. C. Perry, "Hepatotoxicity of chemotherapy, " Oncologist, vol. 6, no. 2, pp. 162-176, 2001.
7. R. S. Benjamin, P. H. Wiernik, and N. R. Bachur, "Adriamycin chemotherapy: efficacy, safety, and pharmacologic basis of an intermittent single high dosage schedule, " Cancer, vol. 33, no. 1, pp. 19-27, 1974.
8. S. Wang, E. A. Konorev, S. Kotamraju, J. Joseph, S. Kalivendi, and B. Kalyanaraman, "Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: intermediacy of H2O2-and p53-dependent pathways, " Journal of Biological Chemistry, vol. 279, no. 24, pp. 25535-25543, 2004.
9. O. Hovorka, V. Subr, D. Vetvicka et al., "Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation, " European Journal of Pharmaceutics and Biopharmaceutics, vol. 76, pp. 514-524, 2010.
10. P. Mukhopadhyay, M. Rajesh, S. Batkai et al., "Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro, "TheAmerican Journal of Physiology-Heart and Circulatory Physiology, vol. 296, pp. 1466-1483, 2009.
11. Y. Shen, M. Takahashi, H. Byun et al., "Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells, " Cancer Biology and Therapy, vol. 13, no. 7, pp. 542-552, 2012.
12. S. P. Yong, J. H. Lee, J. Bondar, J. A. Harwalkar, H. Safayhi, and M. Golubic, "Cytotoxic action of acetyl-11-keto-β-boswellic acid (AKBA) onmeningioma cells, " PlantaMedica, vol. 68, no. 5, pp. 397-401, 2002.
13. Y. Shao, C. Ho, C. Chin, V. Badmaev, W. Ma, and M. Huang, "Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture, " PlantaMedica, vol. 64, no. 4, pp. 328-331, 1998.
14. L. Zhao, M. G. Wientjes, and J. L.-. Au, "Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses, " Clinical Cancer Research, vol. 10, no. 23, pp. 7994-8004, 2004.
15. J. J. Liu, A. Nilsson, S. Oredsson, V. Badmaev, W. Z. Zhao, and R. D. Duan, "Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells, " Carcinogenesis, vol. 23, no. 12, pp. 2087-2093, 2002.
16. X. Pang, Z. Yi, X. Zhang et al., "Acetyl-11-keto-β-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis, " Cancer Research, vol. 69, no. 14, pp. 5893-5900, 2009.
17. S. Bhushan, A. Kumar, F. Malik et al., "A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells, " Apoptosis, vol. 12, no. 10, pp. 1911-1926, 2007.
18. R. Kirk, "Targeted therapies: the maths behind combination therapy, " Nature Reviews Clinical Oncology, vol. 10, no. 9, p. 488, 2013.
19. W. Yeo, T. S. Mok, B. Zee et al., "A randomized phase III study of doxorubicin versus cisplatin/interferon α-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma, " Journal of theNational Cancer Institute, vol. 97, no. 20, pp. 1532-1538, 2005.
20. A. Forner, J. M. Llovet, and J. Bruix, "Hepatocellular carcinoma, " The Lancet, vol. 379, no. 9822, pp. 1245-1255, 2012.
21. M. Iqbal, K. Dubey, T. Anwer, A. Ashish, and K. K. Pillai, "Protective effects of telmisartan against acute doxorubicin-induced cardiotoxicity in rats, " Pharmacological Reports, vol. 60, no. 3, pp. 382-390, 2008.
22. M. Khan, T. Li, M. K. AhmadKhan et al., "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction, " BioMed Research International, vol. 2013, Article ID 719858, 11 pages, 2013.
23. N. L. Komarova and C. R. Boland, "Cancer: calculated treatment, " Nature, vol. 499, no. 7458, pp. 291-292, 2013.
24. Y. Yang, X. Yan, W. Duan et al., "Pterostilbene exerts antitumor activity via the Notch1 signaling pathway in human lung adenocarcinoma cells, " PLoS ONE, vol. 8, no. 5, Article ID e62652, 2013.
25. Y. Liu, L. Wang, Y. Wu et al., "Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway, " Toxicology, vol. 304, pp. 120-131, 2013.
26. P. Sharma, S. D. Saini, L. B. Kuhn et al., "Knowledge of hepatocellular carcinoma screening guidelines and clinical practices among gastroenterologists, " Digestive Diseases and Sciences, vol. 56, no. 2, pp. 569-577, 2011.
27. R. F. Hoernlein, T. Orlikowsky, C. Zehrer et al., "Acetyl-11-keto-β-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I, " Journal of Pharmacology and Experimental Therapeutics, vol. 288, no. 2, pp. 613-619, 1999.
28. M. Lu, L. Xia, H. Hua, and Y. Jing, "Acetyl-keto-β-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells, " Cancer Research, vol. 68, no. 4, pp. 1180-1186, 2008.
29. L. Zhao, M. G. Wientjes, and J. L. Au, "Evaluation of combination chemotherapy: Integration of nonlinear regression, curve shift, isobologram, and combination index analyses, " Clinical Cancer Research, vol. 10, no. 23, pp. 7994-8004, 2004.
30. P. D. Ottewell, H. Monkkonen, M. Jones, D. V. Lefley, R. E. Coleman, and I. Holen, "Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer, " Journal of theNational Cancer Institute, vol. 100, no. 16, pp. 1167-1178, 2008.
31. L. Xia, D. Chen, R. Han, Q. Fang, S. Waxman, and Y. Jing, "Boswellic acid acetate induces apoptosis through caspasemediated pathways in myeloid leukemia cells, " Molecular CancerTherapeutics, vol. 4, no. 3, pp. 381-388, 2005.
32. T. Syrovets, B. Buchele, C. Krauss, Y. Laumonnier, and T. Simmet, "Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-α induction in monocytes by direct interaction with IκBkinases, " Journal of Immunology, vol. 174, no. 1, pp. 498-506, 2005.
33. P. Utaisincharoen, N. Tangthawornchaikul, S. Ubol, P. Chaisuriya, and S. Sirisinha, "Tnf-α induces caspase 3 (CPP 32) dependent apoptosis in human cholangiocarcinoma cell line, " Southeast Asian Journal of Tropical Medicine and PublicHealth, vol. 31, no. 1, pp. 167-170, 2000.
34. R. M. Locksley, N. Killeen, and M. J. Lenardo, "The TNF and TNF receptor superfamilies: Integrating mammalian biology, " Cell, vol. 104, no. 4, pp. 487-501, 2001.
35. B. B. Aggarwal, "Signalling pathways of the TNF superfamily: a double-edged sword, " Nature Reviews Immunology, vol. 3, no. 9, pp. 745-756, 2003.
36. U. Gaur and B. B. Aggarwal, "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily, " Biochemical Pharmacology, vol. 66, no. 8, pp. 1403-1408, 2003.
37. J. Zamorano, A. L. Mora, M. Boothby, and A. D. Keegan, "NFkappaB activation plays an important role in the IL-4-induced protection from apoptosis, " International Immunology, vol. 13, no. 12, pp. 1479-1487, 2001.
38. Y. Takada, H. Ichikawa, V. Badmaev, and B. B. Aggarwal, "Acetyl-11-keto-β-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-κB and NF-κB-regulated gene expression, " The Journal of Immunology, vol. 176, no. 5, pp. 3127-3140, 2006.
39. R. Sferra, A. Vetuschi, V. Catitti et al., "Boswellia serrata and Salvia miltiorrhiza extracts reduceDMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation, " European Review for Medical and Pharmacological Sciences, vol. 16, no. 11, pp. 1484-1498, 2012.
40. F. Tulubas, A. Gurel, M. Oran, B. Topcu, V. Caglar, and E. Uygur, "The protective effects of ω-3 fatty acids on doxorubicininduced hepatotoxicity and nephrotoxicity in rats, " Toxicology and Industrial Health. In press.
41. C. Carvalho, R. X. Santos, S. Cardoso et al., "Doxorubicin: the good, the bad and the ugly effect, " CurrentMedicinal Chemistry, vol. 16, no. 25, pp. 3267-3285, 2009.
42. Y. Kalender, M. Yel, and S. Kalender, "Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin, " Toxicology, vol. 209, no. 1, pp. 39-45, 2005.
43. M. Kaplan, E. A. Mutlu, M. Benson, J. Z. Fields, A. Banan, and A. Keshavarzian, "Use of herbal preparations in the treatment of oxidant-mediated inflammatory disorders, " Complementary Therapies in Medicine, vol. 15, no. 3, pp. 207-216, 2007.
44. E. N. Ali and S. Z. Mansour, "Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats, " ChineseMedicine, vol. 6, article 36, 2011.
45. R. M. Hartmann, M. I. M. Martins, J. Tieppo, H. S. Fillmann, and N. P. Marroni, "Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid, " Digestive Diseases and Sciences, vol. 57, no. 8, pp. 2038-2044, 2012.
46. S. R. Dalton, S. M. L. Lee, R. N. King et al., "Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice, " Biochemical Pharmacology, vol. 77, no. 7, pp. 1283-1290, 2009.