Ex-vivo lung perfusion

Transplant International

Volumn 28, Issue 6, 2015, Pages 643-656

  Van Raemdonck, Dirk ^a,b   Neyrinck, Arne ^a,b   Cypel, Marcelo ^c,d   Keshavjee, Shaf ^c,d  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c TORONTO GENERAL HOSPITAL   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

ex vivo lung perfusion; lung assessment; lung conditioning; lung preservation; lung repair; lung transplantation

Indexed keywords

CENTRIFUGAL PUMP; EX VIVO LUNG PERFUSION; EX VIVO STUDY; FILTER; GAS ANALYSIS EQUIPMENT; HUMAN; IMMUNOMODULATION; LEUKOCYTE FILTER; LUNG ASSIST DEVICE; LUNG COMPLIANCE; LUNG GRAFT REJECTION; LUNG PERFUSION; LUNG TRANSPLANTATION; NONHUMAN; ORGAN DONOR; OXYGENATION; OXYGENATOR; POSITIVE END EXPIRATORY PRESSURE; PRIMARY GRAFT DYSFUNCTION; PRIORITY JOURNAL; REVIEW; TIDAL VOLUME; ALLOGRAFT; ANIMAL; CLINICAL TRIAL (TOPIC); DEVICES; DONOR; EQUIPMENT DESIGN; EXTRACORPOREAL CIRCULATION; INFLAMMATION; LUNG; ORGAN PRESERVATION; PERFUSION; PHYSIOLOGY; PROCEDURES; TEMPERATURE; TIME FACTOR; TREATMENT OUTCOME;

ALLOGRAFTS; ANIMALS; CLINICAL TRIALS AS TOPIC; EQUIPMENT DESIGN; EXTRACORPOREAL CIRCULATION; HUMANS; INFLAMMATION; LUNG; LUNG TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION; TEMPERATURE; TIME FACTORS; TISSUE DONORS; TREATMENT OUTCOME;

EID: 84929502063     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12317     Document Type: Review

References (94)

1. Yusen RD, Christie JD, Edwards LB, et al,. The Registry of the International Society for Heart and Lung Transplantation: thirtieth adult lung and heart-lung transplant report-2013; focus theme: age. J Heart Lung Transplant 2013; 32: 965.
2. Van Raemdonck D, Neyrinck A, Verleden GM, et al,. Lung donor selection and management. Proc Am Thorac Soc 2009; 6: 28.
3. Yeung JC, Cypel M, Waddell TK, Van Raemdonck D, Keshavjee S,. Update on donor assessment, resuscitation, and acceptance criteria, including novel techniques-non-heart-beating donor lung retrieval and ex vivo donor lung perfusion. Thorac Surg Clin 2009; 19: 261.
4. Cypel M, Keshavjee S,. Strategies for safe donor expansion: donor management, donations after cardiac death, ex vivo-lung perfusion. Curr Opin Organ Transplant 2013 [Epub ahead of print].
5. Van Raemdonck DEM, Verleden GM, Coosemans W, et al,. Increasing the donor pool. Eur Respir Mon 2009; 45: 104.
6. Van Raemdonck DEM, Rega FR, Neyrinck AP, Jannis N, Verleden GM, Lerut TE,. Non-heart-beating donors. Semin Thorac Cardiovasc Surg 2004; 16: 309.
7. Carrel A, Lindbergh CA,. The culture of whole organs. Science 1935; 81: 621.
8. Jirsch DW, Fisk RL, Couves CM,. Ex vivo evaluation of stored lungs. Ann Thorac Surg 1970; 10: 163.
9. Hardesty RL, Griffith BP,. Autoperfusion of the heart and lungs for preservation during distant procurement. J Thorac Cardiovasc Surg 1987; 93: 11.
10. Steen S, Sjoberg T, Pierre L, Liao Q, Eriksson L, Algotsson L,. Transplantation of lungs from a non-heart-beating donor. Lancet 2001; 357: 825.
11. Steen S, Liao Q, Wierup PN, Bolys R, Pierre L, Sjöberg T,. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg 2003; 76: 244.
12. Van Raemdonck DEM, Jannis NCP, De Leyn PRJ, Flameng WJ, Lerut TE,. Warm ischemic tolerance in collapsed pulmonary grafts is limited to 1 hour. Ann Surg 1998; 228: 788.
13. Rega FR, Vandezande EJ, Jannis NC, Verleden GM, Lerut TE, Van Raemdonck DE,. The role of leucocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors. Perfusion 2003; 18 (suppl 1): 13.
14. Rega FR, Jannis NC, Verleden GM, Lerut TE, Van Raemdonck DE,. Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes. Ann Surg 2003; 238: 782.
15. Neyrinck AP, Van De Wauwer C, Geudens N, et al,. Comparative study of donor lung injury in heart-beating versus non-heart-beating donors. Eur J Cardiothorac Surg 2006; 30: 628.
16. Van De Wauwer C, Neyrinck AP, Geudens N, et al,. The mode of death in the non-heart-beating donor has an impact on lung graft quality. Eur J Cardiothorac Surg 2009; 36: 919.
17. Meers CM, Tsagkaropoulos S, Wauters S, et al,. A model of ex vivo perfusion of porcine donor lungs injured by gastric aspiration: a step towards pretransplant reconditioning. J Surg Res 2011; 170: e159.
18. Meers C, Wauters S, Verbeken E, et al,. Preemptive therapy with steroids but not macrolides improves gas exchange in caustic-injured donor lungs. J Surg Res 2011; 170: e141.
19. Cypel M, Yeung JC, Hirayama S, et al,. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27: 1319.
20. Cypel M, Rubacha M, Yeung JC, et al,. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009; 9: 2262.
21. Cypel M, Liu M, Rubacha M, et al,. Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009; 1: 4ra9.
22. Koike T, Yeung JC, Cypel M, et al,. Kinetics of lactate metabolism during acellular normothermic ex vivo lung perfusion. J Heart Lung Transplant 2011; 30: 1312.
23. Yeung JC, Cypel M, Machuca TN, et al,. Physiologic assessment of the ex vivo donor lung for transplantation. J Heart Lung Transplant 2012; 31: 1120.
24. Bhabra MS, Hopkinson DN, Shaw TE, Onwu N, Hooper TL,. Controlled reperfusion protects lung grafts during a transient early increase in permeability. Ann Thorac Surg 1998; 65: 187.
25. Halldorsson A, Kronon M, Allen BS, et al,. Controlled reperfusion prevents pulmonary injury after 24 hours of lung preservation. Ann Thorac Surg 1998; 66: 877.
26. de Perrot M, Imai Y, Volgyesi GA, et al,. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg 2002; 124: 1137.
27. Petak F, Habre W, Hantos Z, Sly PD, Morel DR,. Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs. J Appl Physiol 2002; 92: 169.
28. Broccard AF, Vannay C, Feihl F, Schaller MD,. Impact of low vascular pressure on ventilator-induced lung injury. Crit Care Med 2002; 30: 2183.
29. Mulloy DP, Stone ML, Crosby IK, et al,. Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function. J Thorac Cardiovasc Surg 2012; 144: 1208.
30. Neyrinck A, Rega F, Jannis N, et al,. Ex vivo reperfusion of human lungs declined for transplantation: a novel approach to alleviate donor organ shortage? J Heart Lung Transplant 2004; 23: S172 (abstract 387).
31. Wigfield CH, Cypel M, Yeung J, et al,. Successful emergent lung transplantation after remote ex vivo perfusion optimization and transportation of donor lungs. Am J Transplant 2012; 12: 2838.
32. Brandes H, Albes JM, Conzelmann A, Wehrmann M, Ziemer G,. Comparison of pulsatile and nonpulsatile perfusion of the lung in an extracorporeal large animal model. Eur Surg Res 2002; 34: 321.
33. Van De Wauwer C, Munneke AJ, Engels GE, et al,. In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category I-II. Transplant Int 2013; 26: 485.
34. Van Raemdonck D,. Thoracic organs: current preservation technology and future prospects; part 1: lung. Curr Opin Organ Transplant 2010; 15: 150.
35. Machuca TN, Cypel M, Keshavjee S,. Advances in lung preservation. Surg Clin North Am 2013; 93: 1373.
36. Munshi L, Keshavjee S, Cypel M,. Donor management and lung preservation. Lancet Respir Med 2013; 1: 318.
37. Hosgood SA, Nicholson ML,. Normothermic kidney preservation. Curr Opin Organ Transplant 2011; 16: 169.
38. Hessheimer AJ, Fondevilla C, Garcia-Valdecasas JC,. Extracorporeal machine liver perfusion: are we warming up? Curr Opin Organ Transplant 2012; 17: 143.
39. Hassanein WH, Zellos L, Tyrrell TA, et al,. Continuous perfusion of donor hearts in the beating state extends preservation time and improves recovery of function. J Thorac Cardiovasc Surg 1998; 116: 821.
40. Esmailian F, Kobashigawa JA, Naka Y, et al,. The PROCEED II International Heart Transplant Trial with the Organ Care System Technology (OCS). J Heart Lung Transplant 2013; 32: S95 (abstract 238).
41. International Randomized Study of the TransMedics Organ Care System (OCS Lung) for Lung Preservation and Transplantation (Inspire). http://clinicaltrials.gov/ct2/show/NCT01630434?term=Inspire&rank=7. Accessed 9 April 2014.
42. Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D, ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2005; 24: 1454.
43. ™). J Heart Lung Transplant 2013; 32: S16 (abstract 19).
44. Fisher AJ, Dark JH, Corris PA,. Improving donor lung evaluation: a new approach to increase organ supply for lung transplantation. Thorax 1998; 53: 818.
45. Kaneda H, Waddell TK, de Perrot M, et al,. Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am J Transplant 2006; 6: 544.
46. Erasmus ME, Fernhout MH, Elstrodt JM, et al,. Normothermic ex vivo lung perfusion of non-heart-beating donor lungs in pigs: from pretransplant function analysis towards a 6-h machine preservation. Transpl Int 2006; 19: 589.
47. Snell GI, Oto T, Levvey B, et al,. Evaluation of techniques for lung transplantation following donation after cardiac death. Ann Thorac Surg 2006; 81: 2014.
48. Gomez-de Antonio D, Campo-Canaveral JL, Crowley S, et al,. Clinical lung transplantation from uncontrolled non-heart-beating donors revisited. J Heart Lung Transplant 2012; 31: 349.
49. Moradiellos FJ, Naranjo JM, Cordoba M, et al,. Clinical lung transplantation after ex vivo evaluation of uncontrolled non heart-beating donor lungs: initial experience. J Heart Lung Transplant 2011; 30: S38 (abstract 90).
50. Novel Lung Trial: Normothermic Ex Vivo Lung Perfusion (Evlp) As An Assessment Of Extended/Marginal Donor Lungs. http://clinicaltrials.gov/ct2/show/NCT01365429?term=NOVEL&rank=406 Accessed 9 April 2014.
51. Sanchez PG, Davis RD, D'Ovidio F, et al,. Normothermic ex vivo lung perfusion as an assessment of marginal donor lungs-the NOVEL lung trial. J Heart Lung Transplant 2013; 32: S16 (abstract 21).
52. A study of Donor Ex-Vivo Lung Perfusion in United Kingdom lung transplantation (DEVELOP-UK) http://www.controlled-trials.com/ISRCTN44922411 Accessed 9 April 2014.
53. International EXPAND Lung Pivotal Trial (EXPANDLung). http://clinicaltrials.gov/ct2/show/NCT01963780?term=Expand&rank=42 Accessed 9 April 2014.
54. Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA,. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol 2002; 93: 1869.
55. Rega FR, Wuyts WA, Vanaudenaerde BM, et al,. Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor. J Heart Lung Transplant 2005; 24: 1369.
56. Geudens N, Wuyts WA, Rega FR, et al,. N-acetyl cysteine attenuates the inflammatory response in warm ischemic pig lungs. J Surg Res 2008; 146: 177.
57. Inci I, Ampollini L, Arni S, et al,. Ex vivo reconditioning of marginal donor lung injured by acid aspiration. J Heart Lung Transplant 2008; 27: 1229.
58. Wipper S, Janna L, Dupree A, et al,. Ex-vivo repair of donor pig lungs damaged by aspiration. J Heart Lung Transplant 2009; 28 (S2): S237 (abstract 493).
59. Inci I, Zhai W, Arni S, et al,. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 2007; 26: 1054.
60. Machuca TN, Hsin MK, Ott HC, et al,. Injury-specific ex vivo treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation. Am J Respir Crit Care Med 2013; 188: 878.
61. Yeung JC, Wagnetz D, Cypel M, et al,. Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig. Mol Ther 2012; 20: 1204.
62. Karamanou DM, Perry J, Walden HR, et al,. The effect of ex-vivo perfusion on the microbiological profile of the donor lung. J Heart Lung Transplant 2010; 29: S94 (abstract 279).
63. Bonato R, Machuca TN, Cypel C, et al,. Ex vivo treatment of infection in human donor lungs. J Heart Lung Transplant 2012; 31: S97 (abstract 270).
64. Boffini M, Bonato R, Rinaldi M,. The potential role of ex vivo lung perfusion for the diagnosis of infection before lung transplantation. Transplant Int 2014; 27: e5.
65. Wallinder A, Hansson C, Dellgren G,. Hemoconcentration in ex vivo lung perfusion: a case report of a novel technique used in clinical lung transplantation. J Thorac Cardiovasc Surg 2013; 145: e76.
66. Kakishita T, Oto T, Hori S, et al,. Suppression of inflammatory cytokines during ex vivo lung perfusion with an adsorbent membrane. Ann Thorac Surg 2010; 89: 1773.
67. Fildes JE, Regan SC, Al-Aloul M, et al,. Improved clinical outcome of patients transplanted with reconditioned donor lungs via evlp compared to standard lung transplantation. Transplant Int 2011; 2: 77 (abstract O-274).
68. Van Raemdonck D, Neyrinck A, Rega F, Devos T, Pirenne J,. Machine perfusion in organ transplantation: a tool for ex-vivo graft conditioning with mesenchymal stem cells? Curr Opin Organ Transpl 2013; 18: 24.
69. Fang X, Neyrinck AP, Matthay MA, Lee JW,. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem 2010; 20: 26211.
70. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA,. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 2009; 106: 16357.
71. Gotts JE, Matthay MA,. Mesenchymal stem cells and acute lung injury. Crit Care Med 2011; 27: 719.
72. Ott HC, Clippinger B, Conrad C, et al,. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010; 16: 927.
73. Song J, Kim S, Liu Z, et al,. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg 2011; 92: 998.
74. Egan TM, Haithcock JA, Nicotra WA, et al,. Ex vivo evaluation of human lungs for transplant suitability. Ann Thorac Surg 2006; 81: 1205.
75. Wierup P, Haraldsson A, Nilsson F, et al,. Ex vivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006; 81: 460.
76. Pêgo-Fernandes PM, de Medeiros IL, Mariani AW, et al,. Ex Vivo Lung Perfusion: early Report of Brazilian Experience. Transplant Proc 2010; 42: 440.
77. Medeiros IL, Pêgo-Fernandes PM, Mariani AW, et al,. Histologic and functional evaluation of lungs reconditioned by ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: 305.
78. Steen S, Ingemansson R, Riksson L, et al,. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 2007; 83: 2191.
79. Ingemansson R, Eyjolfsson A, Mared L, et al,. Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo. Ann Thorac Surg 2009; 87: 255.
80. Lindstedt S, Hlebowicz J, Koul B, et al,. Comparative outcome of double lung transplantation using conventional donor lungs and non-acceptable donor lungs reconditioned ex vivo. Interact Cardiovasc Thorac Surg 2011; 12: 162.
81. Lindstedt S, Eyjolfsson A, Koul B, et al,. How to recondition ex vivo initially rejected donor lungs for clinical transplantation: clinical experience from Lund university hospital. J Transplant 2011; 2011: 754383.
82. Zych B, Marczin N, Carby M, et al,. Ex vivo lung perfusion-a way to salvage lungs for transplantation? Initial experience at a single institution. Br J Transplant 2009; 4: 10.
83. Zych B, Popov AF, Stavri G, et al,. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant 2012; 31: 274.
84. Cypel M, Yeung J, Liu M, et al,. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Eng J Med 2011; 364: 1431.
85. Cypel M, Yeung JC, Machuca T, et al,. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg 2012; 144: 1200.
86. Aigner C, Slama A, Hötzenecker K, et al,. Clinical ex vivo lung perfusion-pushing the limits. Am J Transplant 2012; 12: 1839.
87. Wallinder A, Ricksten SE, Hansson C, et al,. Transplantation of initially rejected donor lungs after ex vivo lung perfusion. J Thorac Cardiovasc Surg 2012; 144: 1222.
88. Wallinder A, Ricksten S-E, Silverborn M, et al,. Early results in transplantation of initially rejected donor lungs after ex vivo lung perfusion: a case-control study. Eur J Cardiothorac Surg 2014; 45: 40.
89. Dark JH, Karamanou D, Clark S, et al,. Successful transplantation of unusable donor lungs using ex-vivo lung perfusion: the Newcastle experience. J Heart Lung Transplant 2012; 31: S115 (abstract 323).
90. Valenza F, Rosso L, Gatti S, et al,. Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. Transplant Proc 2012; 44: 1826.
91. Boffini M, Ricci D, Barbero C, et al,. Ex-vivo lung perfusion (EVLP) increases the pool of lung grafts: analysis of its potential and real impact on a lung transplant program. Transplant Proc 2013; 45: 2624.
92. Cypel M, Aigner C, Sage E, et al,. Three center experience with clinical normothermic ex vivo lung perfusion. J Heart Lung Transplant 2013; 32: S16 (abstract 20).
93. Warnecke G, Moradiellos J, Tudorache I, et al,. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients. Lancet 2012; 380: 1851.
94. Van Raemdonck D, Rega F, Neyrinck A,. Ex-vivo management of lungs. In:, Vigneswaran WT, Garrity ER, eds. Lung Transplantation. New York: Informa Health Care, 2010: 160.