Injury-specific ex vivo treatment of the donor lung: Pulmonary thrombolysis followed by successful lung transplantation

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 7, 2013, Pages 878-880

  Machuca, Tiago N ^a   Hsin, Michael K ^a   Ott, Harald C ^a   Chen, Manyin ^a   Hwang, David M ^a   Cypel, Marcelo ^a   Waddell, Thomas K ^a   Keshavjee, Shaf ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; BLOOD CLOT LYSIS; BRAIN DEATH; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; ECHOCARDIOGRAPHY; FEMALE; HEART VENTRICLE FUNCTION; HUMAN; HUMAN TISSUE; LETTER; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

BRAIN DEATH; ECHOCARDIOGRAPHY; FEMALE; HUMANS; LUNG TRANSPLANTATION; MIDDLE AGED; PULMONARY EMBOLISM; STROKE; TISSUE DONORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84886257627     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201302-0368LE     Document Type: Letter

References (17)

1. Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011;364: 1431-1440.
2. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant 2005;24:1650-1656. (Pubitemid 41396466)
3. Oto T, Rabinov M, Griffiths AP, Whitford H, Levvey BJ, Esmore DS, Williams TJ, SnellGI. Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: a major mechanism of primary graft failure? J Thorac Cardiovasc Surg 2005;130:1446-1452.
4. Fischer S, Gohrbandt B, Meyer A, Simon AR, Haverich A, Strüber M. Should lungs from donors with severe acute pulmonary embolism be accepted for transplantation? The Hannover experience. J Thorac Cardiovasc Surg 2003;126:1641-1643. (Pubitemid 37449202)
5. Frenia D, Nathan SD, Ahmad S, Guerrero M, Distefano D, Massamiano P, Lefrak E, Burton N. Successful lung transplantation from a donor with a saddle pulmonary embolus. J HeartLungTransplant 2005;24:1137-1139. (Pubitemid 41127206)
6. Sareyyupoglu B, Shigemura N, Toyoda Y. Utilizing donor lungs after thrombolytic therapy and thrombectomy for acute massive pulmonary embolus. J Heart Lung Transplant 2011;30:358.
7. Shihata M, Ghorpade N, Lien D, Modry D. Ex vivo bilateral pulmonary embolectomy for donor lungs prior to transplantation. Ann Thorac Surg 2008;85:2110-2112. (Pubitemid 351685557)
8. Cypel M, Yeung JC, Hirayama S, Rubacha M, Fischer S, Anraku M, Sato M, Harwood S, Pierre A, Waddell TK, et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008;27:1319-1325.
9. Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W; Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med 2002;347:1143-1150.
10. Chandler WL, Alessi MC, Aillaud MF, Henderson P, Vague P, Juhan- Vague I. Clearance of tissue plasminogen activator (TPA) and TPA/ plasminogen activator inhibitor type 1 (PAI-1) complex: relationship to elevated TPA antigen in patients with high PAI-1 activity levels. Circulation 1997;96:761-768. (Pubitemid 27329607)
11. Dalla-Volta S, Palla A, Santolicandro A, Giuntini C, Pengo V, Visioli O, Zonzin P, Zanuttini D, Barbaresi F, Agnelli G, et al. PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activator Italian multicenter study 2. J Am Coll Cardiol 1992;20:520-526.
12. Meneveau N, Schiele F, Metz D, Valette B, Attali P, Vuillemenot A, Grollier G, Elaerts J, Mossard JM, Viel JF, et al. Comparative efficacy of a two-hour regimen of streptokinase versus alteplase in acute massive pulmonary embolism: immediate clinical and hemodynamic outcome and one-year follow-up. J Am Coll Cardiol 1998; 31:1057-1063. (Pubitemid 28212506)
13. Knecht MF, Heinrich F, Spanuth E. Evaluation of plasma D-dimer in the diagnosis and in the course of fibrinolytic therapy of deep vein thrombosis and pulmonary embolism. Thromb Res 1992;67:213-220.
14. Goldhaber SZ, Haire WD, Feldstein ML, Miller M, Toltzis R, Smith JL, Taveira da Silva AM, Come PC, Lee RT, Parker JA, et al. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet 1993;341: 507-511. (Pubitemid 23066083)
15. Inci I, Zhai W, Arni S, Inci D, Hillinger S, Lardinois D, Vogt P,Weder W. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 2007;26: 1054-1060. (Pubitemid 47494662)
16. Cypel M, Rubacha M, Yeung J, Hirayama S, Torbicki K, Madonik M, Fischer S, Hwang D, Pierre A, Waddell TK, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009;9:2262-2269.
17. Cypel M, Liu M, Rubacha M, et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci Trans Med 2009;1:4ra9.