Ex Vivo Management of Lungs

Lung Transplantation

Volumn , Issue , 2016, Pages 160-167

  Van Raemdonck, Dirk ^a   Rega, Filip ^b   Neyrinck, Arne ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80051545216     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3109/9781439802571-20     Document Type: Chapter

References (43)

1. Van Raemdonck D, Neyrinck A, Verleden GM, et al. Lung donor selection and management. Proc Am Thorac Soc 2009; 6(1):28-38.
2. Van Raemdonck DEM, Rega FR, Neyrinck AP, et al. Non-heart-beating donors. Semin Thorac Cardiovasc Surg 2004; 16(4):309-321.
3. Jirsch DW, Fisk RL, Couves CM. Ex vivo evaluation of stored lungs. Ann Thorac Surg 1970; 10(2):163-168.
4. Hardesty RL, Griffith BP. Autoperfusion of the heart and lungs for preservation during distant procurement. J Thorac Cardiovasc Surg 1987; 93(1):11-18.
5. Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a non-heart-beating donor. Lancet 2001; 357(9259):825-829.
6. Steen S, Liao Q, Wierup PN, et al. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg 2003; 76(1):244-252.
7. Rega FR, Jannis NC, Verleden GM, et al. Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes. Ann Surg 2003; 238(6):782-792.
8. Rega FR, Vandezande EJ, Jannis NC, et al. The role of leucocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors. Perfusion 2003; 18(suppl 1):13-21.
9. Erasmus ME, Fernhout MH, Elstrodt JM, et al. Normothermic ex vivo lung perfusion of nonheart- beating donor lungs in pigs: from pretransplant function analysis towards a 6-h machine preservation. Transpl Int 2006; 19(7):589-593.
10. Snell GI, Oto T, Levvey B, et al. Evaluation of techniques for lung transplantation following donation after cardiac death. Ann Thorac Surg 2006; 81(6):2014-2019.
11. Cypel M, Yeung JC, Hirayama S, et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27(12):1319-1325.
12. Neyrinck A, Rega F, Jannis N, et al. Ex vivo reperfusion of human lungs declined for transplantation: a novel approach to alleviate donor organ shortage? J Heart Lung Transplant 2004; 23(S2):S173 (abstr).
13. Wierup P, Haraldsson A, Nilsson F, et al. Ex vivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006; 81(2):460-466.
14. Egan TM, Haithcock JA, Nicotra WA, et al. Ex vivo evaluation of human lungs for transplant suitability. Ann Thorac Surg 2006; 81(4):1205-1213.
15. Welbourn CR, Goldman G, Paterson IS, et al. Pathophysiology of ischaemia reperfusion injury: central role of neutrophil. Br J Surg 1991; 78(6):651-655.
16. Bhabra MS, Hopkinson DN, Shaw TE, et al. Controlled reperfusion protects lung grafts during a transient early increase in permeability. Ann Thorac Surg 1998; 65(1):187-192.
17. Halldorsson A, Kronon M, Allen BS, et al. Controlled reperfusion prevents pulmonary injury after 24 hours of lung preservation. Ann Thorac Surg 1998; 66(3):877-885.
18. de Perrot M, Imai Y, Volgyesi GA, et al. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg 2002; 124(6):1137-1144.
19. Tenderich G, El-Banayosy A, Rosengard B, et al. Prospective multi-center European trial to evaluate the safety and performance of the organ care system for heart transplants (PROTECT). J Heart Lung Transplant 2007; 26(S2):S64 (abstr).
20. Ware LB, Wang Y, Fang X, et al. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet 2002; 360(9333):619-620.
21. Stewart S, Ciulli F, Wells FC, et al. Pathology of unused donor lungs. Transplant Proc 1993; 25(1 pt 2):1167-1168.
22. Husain AN, Hinkamp TJ. Donor lung pathology: correlation with outcome of transplanted contralateral lung. J Heart Lung Transplant 1993; 12(6 pt 1):932-939.
23. Ware LB, Fang X, Wang Y, et al. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant 2005; 24(10):1650-1656.
24. Fisher AJ, Dark JH, Corris PA. Improving donor lung evaluation: a new approach to increase organ supply for lung transplantation. Thorax 1998; 53(10):818-820.
25. Kaneda H, Waddell TK, de Perrot M, et al. Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am J Transplant 2006; 6(3):544-551.
26. Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceaseddonor kidney transplantation. N Engl J Med 2009; 360(1):7-19.
27. Imber CJ, St Peter SD, Lopez de Cenarruzabeitia I, et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation 2002; 73(5):701-709.
28. Ozeki T, Kwon MH, Gu J, et al. Heart preservation using continuous ex vivo perfusion improves viability and functional recovery. Circ J 2007; 71(1):153-159.
29. Brandes H, Albes JM, Conzelmann A, et al. Comparison of pulsatile and nonpulsatile perfusion of the lung in an extracorporeal large animal model. Eur Surg Res 2002; 34(4):321-329.
30. Cypel M, Hirayama S, Rubacha M, et al. Ex-vivo normothermic lung perfusion interrupts ischemic injury and restores cellular metabolism. J Heart Lung Transplant 2008; 27(S2):S199-S200 (abstr).
31. Cypel M, Rubacha M, Yeung J, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009; 9(10):2262-2269.
32. Ware LB, Fang X, Wang Y, et al. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol 2002; 93(5):1869-1874.
33. Rega FR, Wuyts WA, Vanaudenaerde BM, et al. Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor. J Heart Lung Transplant 2005; 24(9):1369-1377.
34. Geudens N, Wuyts WA, Rega FR, et al. N-acetyl cysteine attenuates the inflammatory reponse in warm ischemic pig lungs. J Surg Res 2008; 146(2):177-183.
35. Inci I, Ampollini L, Arni S, et al. Ex vivo reconditioning of marginal donor lung injured by acid aspiration. J Heart Lung Transplant 2008; 27(11):1229-1236.
36. Inci I, Zhai W, Arni S, et al. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 2007; 26(10):1054-1060.
37. Wipper S, Janna L, Dupree A, et al. Ex-vivo repair of donor pig lungs damaged by aspiration. J Heart Lung Transplant 2009; 28(S2):S237 (abstr).
38. Wipper S, Dupree A, Lindner J, et al. Reconditioning of donor lungs after brain death induced dysfunction. J Heart Lung Transplant 2008; 27(S2):S179-S180 (abstr).
39. Cypel M, Rubacha M, Sato M, et al. Adenoviral mediated interleukin 10 gene therapy in normothermic ex-vivo lung perfusion. J Heart Lung Transplant 2007; 26(S2):S212-S213 (abstr).
40. Cypel M, Rubacha M, Hirayama S, et al. Ex-vivo repair and regeneration of damaged human donor lungs. J Heart Lung Transplant 2008; 27(S2):S180 (abstr).
41. Steen S, Ingemansson R, Riksson L, et al. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 2007; 83(6):2191-2195.
42. Ingemansson R, Eyjolfsson A, Mared L, et al. Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo. Ann Thorac Surg 2009; 87(1):255-260.
43. Cypel M, Yeung J, Liu M, et al. Normothermic human ex vivo lung perfusion for improved assessment of extended criteria donor lungs for transplantation. J Heart Lung Transplant 2009; 28(S2):S126 (abstr).