Thoracic organs: Current preservation technology and future prospects; part 1: Lung

Current Opinion in Organ Transplantation

Volumn 15, Issue 2, 2010, Pages 150-155

  Van Raemdonck, Dirk ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Ex vivo lung perfusion; Lung preservation; Lung transplantation

Indexed keywords

EX VIVO STUDY; EXTRACORPOREAL CIRCULATION; GRAFT RECIPIENT; HUMAN; INCIDENCE; ISCHEMIA; LUNG GRAFT REJECTION; LUNG PERFUSION; LUNG TRANSPLANTATION; NONHUMAN; ORGAN DONOR; ORGAN PRESERVATION; REPERFUSION INJURY; RESUSCITATION; REVIEW; RISK REDUCTION; STORAGE TEMPERATURE; TREATMENT OUTCOME;

ANIMALS; COLD ISCHEMIA; GRAFT SURVIVAL; HUMANS; LUNG TRANSPLANTATION; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; PERFUSION; PRIMARY GRAFT DYSFUNCTION; RESPIRATION, ARTIFICIAL; TISSUE DONORS; WARM ISCHEMIA;

EID: 77952256598     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283373b7e     Document Type: Review

References (58)

1. Christie JD, Edwards LB, Aurora P, et al. The Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Lung and Heart-Lung Transplantation Report-2009. J Heart Lung Transplant 2009; 28:1031-1049. This study describes the 2009 lung and heart-lung annual report on the Registry by the International Society for Heart and Lung Transplantation.
2. International Society for Heart and Lung Transplantation registry data. http://www.ishlt.org/downloadables/slides/2009/lung-adult. pp953, 135, ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death (Deaths: January 1992-June 2008). Date accessed 21 December 2009. These 2009 slides depict the outcome and risk factors after LTx according to the data available from the Registry by the International Society for Heart and Lung Transplantation.
3. Van Raemdonck D, Neyrinck A, Verleden GM, et al. Lung donor selection and management. Proc Am Thorac Soc 2009; 6:28-38. This study provides a state of the art on current lung donor selection and management.
4. Shigemura N, Bhama J, Nguyen D, et al. Pitfalls in donor lung procurements: how should the procedure be taught to transplant trainees? J Thorac Car-diovasc Surg 2009; 138:486-490. This study outlines the importance of supervision of the transplant trainee by a senior surgeon during organ procurement to prevent technical errors with regard to adequate graft preservation that may ultimately affect the successful use of the organ or lead to serious complications in the recipient.
5. Hardesty RL, Griffith BP. Autoperfusion of the heart and lungs for preservation during distant procurement. J Thorac Cardiovasc Surg 1987; 9:11-18. (Pubitemid 17231213)
6. Toronto Lung Transplant Group. Unilateral lung transplantation for pulmonary fibrosis. N Eng J Med 1986; 314:1140-1145. (Pubitemid 16138660)
7. Fraser CD, Tamura F, Adachi H, et al. Donor core-cooling provides improved static preservation for heart-lung transplantation. Ann Thorac Surg 1988; 45:253-257. (Pubitemid 18075446)
8. Haverich A, Aziz S, Scott WC, et al. Improved lung preservation using Euro-Collins solution forflush-perfusion. Thorac Cardiovasc Surg 1986; 34:368-376. (Pubitemid 17200704)
9. Colquhoun IW, Kirk AJB, Au J, et al. Single-flush perfusion with modified Euro-Collins solution: experience in clinical lung preservation. J Heart Lung Transplant 1992; 11: S209-S214.
10. Hirt SW, Wahlers T, Jurmann M, et al. Improvement of currently used methods for lung preservation with prostacyclin and University of Wisconsin solution. J Heart Lung Transplant 1992; 11:656-664.
11. Hardesty RL, Aeba R, Armitage JM, et al. A clinical trial of University of Wisconsin solution for pulmonary preservation. J Thorac Cardiovasc Surg 1993; 105:660-666. (Pubitemid 23127723)
12. Keshavjee SH, Yamazaki F, Yokomise H, et al. The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation. J Thorac Cardiovasc Surg 1992; 103:314-325.
13. Steen S, Sjöberg T, Massa G, et al. Safe pulmonary preservation for 12 h with low-potassium-dextran solution. Ann Thorac Surg 1993; 55:434-440. (Pubitemid 23060818)
14. Steen S, Kimblad PO, Sjöberg T, et al. Safe lung preservation for twenty-four hours with Perfadex. Ann Thorac Surg 1994; 57:450-457. (Pubitemid 24101147)
15. Xiong L, Legagneux J, Wassef M, et al. Protective effects of Celsior in lung transplantation. J Heart Lung Transplant 1999; 18:320-327. (Pubitemid 29205267)
16. Hopkinson DN, Bhabra MS, Hooper TL. Pulmonary graft preservation: a worldwide survey of current clinical practice. J Heart Lung Transplant 1998; 17:525-531. (Pubitemid 28247039)
17. Muller C, Fürst H, Reichenspurner H, et al. Lung procurement by low-potassium dextran and the effect on preservation injury. Transplantation 1999; 68:1139-1143. (Pubitemid 29517704)
18. Strüber M, Wilhelmi M, Harringer W, et al. Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation. Eur J Cardiothorac Surg 2001; 19:190-194. (Pubitemid 32141037)
19. Fischer S, Matte-Martyn A, de Perrot M, et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg 2001; 121:594-596. (Pubitemid 32230234)
20. Rega F, Dupont L, Verleden G, et al. Switch from Euro-Collins to Perfadex for pulmonary graft preservation resulted in superior outcome in transplant recipients. J Heart Lung Transplant 2003; 22: S111. (abstract).
21. Rabanal JM, Ibanez AM, Mons R, et al. Influence of preservation solution on early lung function (Euro-Collins vs Perfadex). Transplant Proc 2003; 35:1938-1939. (Pubitemid 37093771)
22. Aziz TM, Pillay TM, Corris PA, et al. Perfadex for clinical lung procurement: is it an advance? Ann Thorac Surg 2003; 75:990-995.
23. Nath DS, Walter AR, Johnson AC, et al. Does Perfadex affect outcomes in clinical lung transplantation? J Heart Lung Transplant 2005; 24:2243-2248.
24. Oto T, Griffiths AP, Rosenfeldt F, et al. Early outcomes comparing Perfadex, Eurocollins, and Papworth solutions in lung transplantation. Ann Thorac Surg 2006; 82:1842-1848. (Pubitemid 44584905)
25. Ganesh JS, Rogers CA, Banner NR, et al. Does the method of lung preservation influence outcome after transplantation? An analysis of 681 consecutive procedures. J Thorac Cardiovasc Surg 2007; 134:1313-1321.
26. Ferraro P, Martin J, Dery J, et al. Late retrograde perfusion of donor lungs does not decrease the severity of primary graft dysfunction. Ann Thorac Surg 2008; 86:1123-1129. This clinical study failed to show an advantage of an additional preimplan-tation retrograde flush with LPDG compared with an antegrade flush with LPDG only.
27. D'Armini AM, Grande AM, Rinaldi M, et al. Prospective randomized clinical study of Celsior versus University of Wisconsin in double lung transplant. J Heart Lung Transplant 2001; 20:183. (abstract).
28. Thabut G, Vinatier I, Brugiere O, et al. Influence of preservation solution on early graft failure in clinical lung transplantation. Am J Respir Crit Care Med 2001; 164:1204-1208. (Pubitemid 33052251)
29. Baron O, Fabre S, Haloun A, et al. Retrospective clinical comparison of Celsior solution to modified blood Wallwork solution in lung transplantation for cystic fibrosis. Prog Transplant 2002; 12:176-180. (Pubitemid 35025769)
30. Van De Wauwer C, Neyrinck AP, Geudens N, et al. Retrograde flush following warm ischemia in the nonheart-beating donor results in superior graft performance at reperfusion. J Surg Res 2009; 154:118-125 This study provides experimental evidence for the practice of a retrograde flush in lungs recovered from donors after circulatory arrest.
31. Varela A, Cordoba M, Serrano-Fiz S, et al. Early lung allograft function after retrograde and anterograde preservation. J Thorac Cardiovasc Surg 1997; 114:1119-1120. (Pubitemid 28023895)
32. Venuta F, Rendina EA, Bufi M, et al. Preimplantation retrograde pneumoplegia in clinical lung transplantation. J Thorac Cardiovasc Surg 1999; 118:107-114. (Pubitemid 29321005)
33. Venuta F, Anile M. Invited commentary: late retrograde perfusion of donor lungs does not decrease the severity of primary graft dysfunction. Ann Thorac Surg 2008; 86:1129-1130.
34. Okamoto T, Nakamura T, Zhang J, et al. Successful sub-zero non-freezing preservation of rat lungs at -2°C utilizing a new supercooling technology. J Heart Lung Transplant 2008; 27:1150-1157. This experimental study in rat lungs showed superior graft function with storage temperature of -2°C in a nonfrozen state as compared with the standard 4°C. It is unknown so far whether these findings can be repeated in human lungs.
35. Clark SC, Sudarshan CD, Dark JH. Controlled perfusion of the transplanted lung. Ann Thorac Surg 2001; 71:1755-1756.
36. Ardehali A, Laks H, Russell H, et al. Modified reperfusion and ischemia-reperfusion injury in human lung transplantation. J Thorac Cardiovasc Surg 2003; 126:1929-1934. (Pubitemid 38020754)
37. Pereszlenyi A, Lang G, Steltzer H, et al. Bilateral lung transplantation with intra-and postoperatively prolonged ECMO support in patients with pulmonary hypertension. Eur J Cardiothorac Surg 2002; 21:858-863. (Pubitemid 34326390)
38. de Perrot M, Imai Y, Volgyesi GA, et al. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg 2002; 124:1137-1144. (Pubitemid 35417000)
39. DeCampos KN, Keshavjee S, Slutsky AS, Liu M. Alveolar recruitment prevents rapid-reperfusion-induced injury of lung transplants. J Heart Lung Transplant 1999; 18:1096-1102.
40. Lang G, Aigner C, Winkler G, et al. Prolonged venoarterial extracorporeal membrane oxygenation after transplantation restores functional integrity of severely injured lung allografts and prevents the development of pulmonary graft failure in a pig model. J Thoracic Cardiovasc Surg 2009; 137:1493-1498. This experimental study demonstrates the beneficial effect of ECMO support during and after implantation on restoration of lung function. The benefit is attributed to the reduced pulmonary artery flow (pressure) and protective ventilation of predamaged lungs.
41. Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a nonheart-beating donor. Lancet 2001; 357:825-829.
42. Steen S, Liao Q, Wierup PN, et al. Transplantation of lungs from nonheart-beating donors after functional assessment ex vivo. Ann Thorac Surg 2003; 76:244-252. (Pubitemid 36819750)
43. Rega FR, Jannis NC, Verleden GM, et al. Long-term preservation with interim evaluation of lungs from a nonheart-beating donor after a warm ischemic interval of 90min. Ann Surg 2003; 238:782-792.
44. Erasmus ME, Fernhout MH, Elstrodt JM, et al. Normothermic ex vivo lung perfusion of nonheart-beating donor lungs in pigs: from pretransplant function analysis towards a 6-h machine preservation. Transpl Int 2006; 19:589-593.
45. Snell GI, Oto T, Levvey B, et al. Evaluation of techniques for lung transplantation following donation after cardiac death. Ann Thorac Surg 2006; 81:2014-2019. (Pubitemid 43775541)
46. Neyrinck A, Rega F, Jannis N, et al. Ex vivo reperfusion of human lungs declined for transplantation: a novel approach to alleviate donor organ shortage? J Heart Lung Transplant 2004; 23 (S2) : S173. (abstract).
47. Wierup P, Haraldsson A, Nilsson F, et al. Ex vivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006; 81:460-466. (Pubitemid 43120535)
48. Egan TM, Haithcock JA, Nicotra WA, et al. Ex vivo evaluation of human lungs for transplant suitability. Ann Thorac Surg 2006; 81:1205-1213.
49. Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Eng J Med 2009; 360:7-19. This paper describes the first randomized clinical trial demonstrating superior preservation of machine perfusion versus cold storage associated with a reduced risk of delayed graft function and improved graft survival in the first year after kidney transplantation
50. Imber CJ, St Peter SD, Lopez de Cenarruzabeitia I, et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation 2002; 73:701-709.
51. Ozeki T, Kwon MH, Gu J, et al. Heart preservation using continuous ex vivo perfusion improves viability and functional recovery. Circ J 2007; 71:153-159. (Pubitemid 46045565)
52. Rosenbaum DH, Peltz M, DiMaio JM, et al. Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism. J Heart Lung Transplant 2008; 27:93-99.
53. Cypel M, Yeung JC, Hirayama S, et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27:1319-1325. This study describes the technique for successful 12-h EVLP without edema formation. This study forms the basis for continued research on prolonged lung preservation and pretransplant conditioning prior to transplantation.
54. Cypel M, Rubacha M, Yeung J, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation. J Heart Lung Transplant 2009; 9:2262-2269. This study demonstrated for the first time that EVLP is superior to cold storage if lungs are to be preserved for longer than 12 h.
55. Ingemansson R, Eyjolfsson A, Mared L, et al. Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo. Ann Thorac Surg 2009; 87:255-260. This study demonstrated for the first time that lungs of inferior quality could be improved with ex-vivo perfusion before successful transplantation.
56. Cypel M, Yeung J, Liu M, et al. Normothermic human ex vivo lung perfusion for improved assessment of extended criteria donor lungs for transplantation. J Heart Lung Transplant 2009; 28 (S2) : S126. (abstract).
57. Tenderich G, El-Banayosy A, Rosengard B, et al. Prospective multicenter European trial to evaluate the safety and performance of the organ care system for heart transplants (PROTECT). J Heart Lung Transplant 2007; 26 (S2) : S64. (abstract).
58. McCurry K, Jeevanandam V, Mihaljevic T, et al. Prospective multicenter safety and effectiveness evaluation of the organ care system device for cardiac use (PROCEED). J Heart Lung Transplant 2008; 27: S166. (abstract).