Preemptive therapy with steroids but not macrolides improves gas exchange in caustic-injured donor lungs

Journal of Surgical Research

Volumn 170, Issue 1, 2011, Pages

  Meers, Caroline M ^a   Wauters, Shana ^a   Verbeken, Eric ^b   Scheers, Hans ^a   Vanaudenaerde, Bart ^a   Verleden, Geert M ^a   Van Raemdonck, Dirk ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

ex vivo lung perfusion; gastric aspiration; lung transplantation; therapy strategies

Indexed keywords

8 ISOPROSTANE; C REACTIVE PROTEIN; CLARITHROMYCIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; METHYLPREDNISOLONE; PLACEBO;

ACUTE LUNG INJURY; AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; LEAF GAS EXCHANGE; LUNG COMPLIANCE; LUNG EDEMA; LUNG GRAFT REJECTION; LUNG HEMODYNAMICS; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; STOMACH JUICE;

ACUTE LUNG INJURY; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; CLARITHROMYCIN; HEMODYNAMICS; LUNG; LUNG TRANSPLANTATION; MALE; METHYLPREDNISOLONE; PERFUSION; PNEUMONIA, ASPIRATION; PULMONARY GAS EXCHANGE; SWINE; TISSUE DONORS;

EID: 80051549917     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.05.062     Document Type: Article

References (31)

1. J.D. Christie, L.B. Edwards, and A.Y. Kucheryavaya The Registry of the International Society for Heart and Lung Transplantation: Twenty-seventh official adult lung and heart-lung transplant report-2010 J Heart Lung Transplant 29 2010 1104
2. C. Meers, D. Van Raemdonck, and G. Verleden The number of lung transplants can be safely doubled using extended criteria donors; A single-center review Transpl Int 23 2010 628
3. A. Neyrinck, F. Rega, and N. Jannis Ex vivo reperfusion of human lungs declined for transplantation; A novel approach to alleviate donor organ shortage? [abstract] J Heart Lung Transplant 23 2004 S172
4. T.M. Egan, J.A. Haithcock, and W.A. Nicotra Ex vivo evaluation of human lungs for transplant suitability Ann Thorac Surg 81 2006 1205
5. P. Wierup, A. Haraldsson, and F. Nilsson Ex vivo evaluation of nonacceptable donor lungs Ann Thorac Surg 81 2006 460
6. A. Neyrinck, C. Van De Wauwer, and N. Geudens Comparative study of donor lung injury in heart-beating versus non-heart-beating donors Eur J Cardiothorac Surg 30 2006 628
7. F. Rega, N.C. Jannis, and G.M. Verleden Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes Ann Surg 238 2003 782
8. C. Van De Wauwer, A.P. Neyrinck, and N. Geudens Retrograde flush following topical cooling is superior to preserve the non-heart-beating donor lung Eur J Cardiothorac Surg 31 2007 1125
9. C.M. Meers, W. De Wever, and E. Verbeken A porcine model of acute lung injury by instillation of gastric fluid J Surg Res 166 2011 e195
10. A.J. Fisher, S.C. Donnelly, and N. Hirani Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation Am J Respir Crit Care Med 163 2001 259
11. H.G. Folkesson, A. Norlin, and Y. Wang Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats J Appl Physiol 88 2000 416
12. D. Mokra, I. Tonhajzerova, and M. Petraskova Effects of dexamethasone on cardiovascular functions in acute phase in meconium-injured rabbits Pediatr Int 51 2009 132
13. E.J. Giamarellos-Bourboulis Macrolides beyond the conventional antimicrobials: A class of potent immunomodulators Int J Antimicrob Agents 31 2008 12
14. G.M. Verleden, B.M. Vanaudenaerde, and L.J. Dupont Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome Am J Respir Crit Care Med 174 2006 566
15. C.M. Meers, W. De Wever, and E. Verbeken A porcine model to study ex vivo reconditioning of injured donor lungs J Surg Res 166 2011 e175
16. R.V. Venkateswaran, V.B. Patchell, and I.C. Wilson Early donor management increases the retrieval rate of lungs for transplantation Ann Thorac Surg 85 2008 278
17. D.M. Follette, S.M. Rudich, and W.D. Babcock Improved oxygenation and increased lung donor recovery with high-dose steroid administration after brain death J Heart Lung Transplant 17 1998 423
18. P. von Bismarck, K. Klemm, and C.F. Garcia Wistadt Selective NF-kappaB inhibition, but not dexamethasone, decreases acute lung injury in a newborn piglet airway inflammation model Pulm Pharmacol Ther 22 2009 297
19. S.G. Gerhardt, J.F. McDyer, and R.E. Girgis Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: Results of a pilot study Am J Respir Crit Care Med 168 2003 121
20. B.M. Vanaudenaerde, W.A. Wuyts, and N. Geudens Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells Am J Transplant 7 2007 76
21. R. Vos, B.M. Vanaudenaerde, and S.E. Verleden A randomized placebo-controlled trial of azithromycin to prevent bronchiolitis obliterans syndrome after lung transplantation Eur Respir J 37 2010 164
22. N. Geudens, L. Timmermans, and H. Vanhooren Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury Transpl Int 21 2008 688
23. C. Benden, and A. Boehler Long-term clarithromycin therapy in the management of lung transplant recipients Transplantation 87 2009 1538
24. K. Remund, T. Rechsteiner, and Z. Guo The macrolide clarithromycin inhibits experimental post-transplant bronchiolitis obliterans Exp Lung Res 35 2009 830
25. D. Van Raemdonck, F. Rega, and A. Neyrinck Ex vivo management of lungs W.T. Vigneswaran, E.R. Garrity, Lung transplantation 2010 Informa Health Care New York 160 167
26. S. Steen, Q. Liao, and P.N. Wierup Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo Ann Thorac Surg 76 2003 244
27. R. Ingemansson, A. Eyjolfsson, and L. Mared Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo Ann Thorac Surg 87 2009 255
28. B. Zych, A. Popov, and M. Carby Early outcomes of bilateral sequential single lung transplantation after ex vivo lung evaluation and reconditioning J Heart Lung Transplant 30 4S 2011 89
29. J. Moradiellos, J. Naranjo, and M. Córdoba Clinical lung transplantation after ex vivo evaluation of uncontrolled non-heart-beating donor lungs: Initial experience J Heart Lung Transplant 30 4S 2011 90
30. C. Aigner, A. Slama, and K. Hötzenecker Clinical ex vivo lung perfusion-Pushing the limits J Heart Lung Transplant 30 4S 2011 88
31. K. De Bosscher, and G. Haegeman Minireview: Latest perspectives on antiinflammatory actions of glucocorticoids Mol Endocrinol 23 2009 281