Successful emergent lung transplantation after remote ex vivo perfusion optimization and transportation of donor lungs

American Journal of Transplantation

Volumn 12, Issue 10, 2012, Pages 2838-2844

  Wigfield, C H ^a   Cypel, M ^b   Yeung, J ^b   Waddell, T ^b   Alex, C ^a   Johnson, C ^c   Keshavjee, S ^b   Love, R B ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Ex vivo lung perfusion (EVLP); extended criteria donor; lung transplantation

Indexed keywords

LINEZOLID; MOXIFLOXACIN; NITRIC OXIDE; OSELTAMIVIR; PIPERACILLIN PLUS TAZOBACTAM; PRESERVATION SOLUTION;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CRYOPRESERVATION; DYSPNEA; EMERGENCY SURGERY; ENDOTRACHEAL INTUBATION; EX VIVO LUNG PERFUSION; EXTRACORPOREAL MEMBRANE OXYGENATION DEVICE; FEVER; FLU LIKE SYNDROME; GRAFT RECIPIENT; HOSPITAL; HUMAN; INFLUENZA A; LUNG INJURY; LUNG PERFUSION; LUNG TRANSPLANTATION; MALAISE; MALE; MEDICAL DEVICE; ORGAN DONOR; PHYSICAL EXAMINATION; PNEUMONIA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RESPIRATORY FAILURE; TRAFFIC AND TRANSPORT; TREATMENT OUTCOME;

ADULT; HUMANS; LUNG TRANSPLANTATION; MALE; PERFUSION; TISSUE DONORS;

EID: 84867059018     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04175.x     Document Type: Article

References (18)

1. Christie JD, Edwards LB, Kucheryavaya AY, et al,. The Registry of the International Society for Heart and Lung Transplantation: Twenty-eight Adult Lung and Heart-Lung Transplant Report-2011. J Heart Lung Transplant 2011; 30: 1104-1120.
2. United Network for Organ Sharing Scientific Registry Data. Available at: http://www.unos.org. 2011. Accessed February 15, 2012.
3. Institute of Medicine. Organ donation: Opportunities for action, committee on increasing rates of organ donation. In:, Childress JF, Liverman CT, eds. Board on health sciences policy. Washington, DC: The National Academies Press, 2006.
4. Egan TM, Murray S, Bustami RT, et al,. Development of the new lung allocation system in the United States. Am J Transplant 2006; 6: 1212-1227.
5. Aigner C, Winkler G, Jaksch P, et al,. Extended donor criteria for lung transplantation-A clinical reality. Eur J Cardiothorac Surg 2005; 27: 757-761.
6. Botha P, Trivedi D, Weir CJ, et al,. Extended donor criteria in lung transplantation: impact on organ allocation. J Thorac Cardiovasc Surg 2006; 131: 1154-1160.
7. de Perrot M, Bonser RS, Dark J, et al,. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: Donor-related risk factors and markers. J Heart Lung Transplant 2005; 24: 1460-1467.
8. Christie JD, Kotloff RM, Ahya VN, et al,. The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med 2005; 171: 1312-1316.
9. Lee JC, Christie JD, Keshavjee S,. Primary graft dysfunction: definition, risk factors, short- and long-term outcomes. Semin Respir Crit Care Med 2010; 31: 161-171.
10. Angel LF, Levine DJ, Restrepo MI, et al,. Impact of a lung transplantation donor- management protocol on lung donation and recipient outcomes. Am J Respir Crit Care Med 2006; 174: 710-716.
11. Van Raemdonck D, Neyrinck A, Verleden GM, et al,. Lung donor selection and management. Proc Am Thorac Soc 2009; 6: 28-38.
12. Cypel M, Yeung JC, Hirayama S, et al,. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27: 1319-1325.
13. Cypel M, Rubacha M, Yeung J, et al,. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009; 9: 2262-2269.
14. Cypel M, Yeung JC, Keshavjee S, et al,. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011; 364: 1431-1440.
15. Jones DA, Bailey M, Beca J, et al,. Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators. JAMA 2009; 302: 1888-1895.
16. Avlonitis VS, Wigfield CH, Kirby JA, Dark JH,. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant 2005; 5: 684-693.
17. Cypel M, Yeung JC, Keshavjee S, et al,. Update on donor assessment, resuscitation, and acceptance criteria, including novel techniques-non-heart- beating donor lung retrieval and ex vivo donor lung perfusion. Thorac Surg Clin 2009; 19: 261-274.
18. Cypel M, Liu M, Rubacha M, et al,. Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009; 1: 4ra9.