Advances in lung preservation

Surgical Clinics of North America

Volumn 93, Issue 6, 2013, Pages 1373-1394

  Machuca, Tiago N ^a   Cypel, Marcelo ^a   Keshavjee, Shaf ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Exvivo lung perfusion; Lung transplantation; Non heart beating donor; Organ preservation; Organ procurement

Indexed keywords

ADENOVIRUS VECTOR; ANTIBIOTIC AGENT; BUCLADESINE; CILASTATIN PLUS IMIPENEM; DEXTRAN 40; GLYCERYL TRINITRATE; HEPARIN; HUMAN ALBUMIN; INTERLEUKIN 10; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; POLYPROPYLENE; POTASSIUM; PRESERVATION SOLUTION; SALBUTAMOL;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; ATELECTASIS; CANNULATION; COLD ISCHEMIA; COLLOID; CONTAINER; DNA MODIFICATION; DRUG MEGADOSE; ESCHERICHIA COLI PNEUMONIA; EX VIVO LUNG PERFUSION; EXTRACORPOREAL OXYGENATION; HEART DEATH; HUMAN; ISOLATED LUNG; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG CANCER; LUNG CIRCULATION; LUNG CLEARANCE; LUNG COMPLIANCE; LUNG EDEMA; LUNG EMBOLISM; LUNG INFLATION; LUNG PERFUSION; LUNG PRESSURE; LUNG STORAGE; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NONVIRAL GENE THERAPY; ONCOTIC PRESSURE; ORGAN DONOR; ORGAN PRESERVATION; OXYGENATION; POSITIVE END EXPIRATORY PRESSURE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; STEADY STATE; TIDAL VOLUME; VIRAL GENE DELIVERY SYSTEM; WARMING;

EX VIVO LUNG PERFUSION; LUNG TRANSPLANTATION; NON-HEART BEATING DONOR; ORGAN PRESERVATION; ORGAN PROCUREMENT;

ANIMALS; BRAIN DEATH; COLD ISCHEMIA; DEATH; HUMANS; LUNG; LUNG TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS;

EID: 84887229795     PISSN: 00396109     EISSN: 15583171     Source Type: Journal    
DOI: 10.1016/j.suc.2013.08.001     Document Type: Review

References (100)

1. Christie J.D., Edwards L.B., Kucheryavaya A.Y., et al. The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. JHeart Lung Transplant 2012, 31:1073-1086.
2. Valapour M., Paulson K., Smith J.M., et al. OPTN/SRTR 2011 annual data report: lung. Am J Transplant 2013, 13(Suppl 1):149-177.
3. Titman A., Rogers C.A., Bonser R.S., et al. Disease-specific survival benefit of lung transplantation in adults: a national cohort study. Am J Transplant 2009, 9:1640-1649.
4. Klein A.S., Messersmith E.E., Ratner L.E., et al. Organ donation and utilization in the United States, 1999-2008. Am J Transplant 2010, 10:973-986.
5. Botha P., Trivedi D., Weir C.J., et al. Extended donor criteria in lung transplantation: impact on organ allocation. JThorac Cardiovasc Surg 2006, 131:1154-1160.
6. Pierre A.F., Sekine Y., Hutcheon M., et al. Evaluation of extended donor and recipient criteria for lung transplantation. JHeart Lung Transplant 2001, 20:256.
7. D'Alessandro A.M., Hoffmann R.M., Knechtle S.J., et al. Successful extrarenal transplantation from non-heart-beating donors. Transplantation 1995, 59:977-982.
8. Cypel M., Sato M., Yildirim E., et al. Initial experience with lung donation after cardiocirculatory death in Canada. JHeart Lung Transplant 2009, 28:753-758.
9. Erasmus M.E., Verschuuren E.A., Nijkamp D.M., et al. Lung transplantation from nonheparinized category III non-heart-beating donors. A single-centre report. Transplantation 2010, 89:452-457.
10. Love R.B. Perspectives on lung transplantation and donation-after-determination-of-cardiac-death donors. Am J Transplant 2012, 12:2271-2272.
11. Mason D.P., Brown C.R., Murthy S.C., et al. Growing single-center experience with lung transplantation using donation after cardiac death. Ann Thorac Surg 2012, 94:406-411. [discussion: 11-2].
12. De Oliveira N.C., Osaki S., Maloney J.D., et al. Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center. JThorac Cardiovasc Surg 2010, 139:1306-1315.
13. Levvey B.J., Harkess M., Hopkins P., et al. Excellent clinical outcomes from a national donation-after-determination-of-cardiac-death lung transplant collaborative. Am J Transplant 2012, 12:2406-2413.
14. Puri V., Scavuzzo M., Guthrie T., et al. Lung transplantation and donation after cardiac death: a single center experience. Ann Thorac Surg 2009, 88:1609-1614. [discussion: 14-5].
15. de Antonio D.G., Marcos R., Laporta R., et al. Results of clinical lung transplant from uncontrolled non-heart-beating donors. JHeart Lung Transplant 2007, 26:529-534.
16. Bonser R.S., Taylor R., Collett D., et al. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry. Lancet 2012, 380:747-755.
17. Cypel M., Yeung J.C., Liu M., et al. Normothermic exvivo lung perfusion in clinical lung transplantation. NEngl J Med 2011, 364:1431-1440.
18. Boutilier R.G. Mechanisms of cell survival in hypoxia and hypothermia. JExp Biol 2001, 204:3171-3181.
19. Zhao G., al-Mehdi A.B., Fisher A.B. Anoxia-reoxygenation versus ischemia in isolated rat lungs. Am J Physiol 1997, 273:L1112-L1117.
20. Hochachka P.W. Defense strategies against hypoxia and hypothermia. Science 1986, 231:234-241.
21. Keshavjee S.H., Yamazaki F., Cardoso P.F., et al. Amethod for safe twelve-hour pulmonary preservation. JThorac Cardiovasc Surg 1989, 98:529-534.
22. Maccherini M., Keshavjee S.H., Slutsky A.S., et al. The effect of low-potassium-dextran versus Euro-Collins solution for preservation of isolated type II pneumocytes. Transplantation 1991, 52:621-626.
23. Keshavjee S.H., Yamazaki F., Yokomise H., et al. The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation. JThorac Cardiovasc Surg 1992, 103:314-325.
24. Haverich A., Aziz S., Scott W.C., et al. Improved lung preservation using Euro-Collins solution for flush-perfusion. Thorac Cardiovasc Surg 1986, 34:368-376.
25. Wang L.S., Nakamoto K., Hsieh C.M., et al. Influence of temperature of flushing solution on lung preservation. Ann Thorac Surg 1993, 55:711-715.
26. Albes J.M., Fischer F., Bando T., et al. Influence of the perfusate temperature on lung preservation: is there an optimum?. Eur Surg Res 1997, 29:5-11.
27. Date H., Lima O., Matsumura A., et al. In a canine model, lung preservation at 10 degrees C is superior to that at 4 degrees C. A comparison of two preservation temperatures on lung function and on adenosine triphosphate level measured by phosphorus 31-nuclear magnetic resonance. JThorac Cardiovasc Surg 1992, 103:773-780.
28. Date H., Matsumura A., Manchester J.K., et al. Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation. JThorac Cardiovasc Surg 1993, 105:492-501.
29. Fukuse T., Hirata T., Nakamura T., et al. Influence of deflated and anaerobic conditions during cold storage on rat lungs. Am J Respir Crit Care Med 1999, 160:621-627.
30. Struber M., Hohlfeld J.M., Kofidis T., et al. Surfactant function in lung transplantation after 24 hours of ischemia: advantage of retrograde flush perfusion for preservation. JThorac Cardiovasc Surg 2002, 123:98-103.
31. de Perrot M., Keshavjee S. Lung preservation. Semin Thorac Cardiovasc Surg 2004, 16:300-308.
32. de Perrot M., Keshavjee S. Lung transplantation. Lung preservation. Chest Surg Clin N Am 2003, 13:443-462.
33. Carrel A., Lindbergh C.A. The culture of whole organs. Science 1935, 81:621-623.
34. Cypel M., Rubacha M., Yeung J., et al. Normothermic exvivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009, 9:2262-2269.
35. Cypel M., Yeung J.C., Hirayama S., et al. Technique for prolonged normothermic exvivo lung perfusion. JHeart Lung Transplant 2008, 27:1319-1325.
36. Frank J.A., Briot R., Lee J.W., et al. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol 2007, 293:L52-L59.
37. Sakuma T., Okaniwa G., Nakada T., et al. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med 1994, 150:305-310.
38. Broccard A.F., Hotchkiss J.R., Kuwayama N., et al. Consequences of vascular flow on lung injury induced by mechanical ventilation. Am J Respir Crit Care Med 1998, 157:1935-1942.
39. Piacentini E., Lopez-Aguilar J., Garcia-Martin C., et al. Effects of vascular flow and PEEP in a multiple hit model of lung injury in isolated perfused rabbit lungs. JTrauma 2008, 65:147-153.
40. Fisher A.B., Dodia C., Linask J. Perfusate composition and edema formation in isolated rat lungs. Exp Lung Res 1980, 1:13-21.
41. Rubini A. Effect of perfusate temperature on pulmonary vascular resistance and compliance by arterial and venous occlusion in the rat. Eur J Appl Physiol 2005, 93:435-439.
42. Suzuki S., Sugita M., Ono S., et al. Difference in the effects of low temperatures on the tension of human pulmonary artery and vein ring segments. Respiration 2000, 67:189-193.
43. Pierre A.F., DeCampos K.N., Liu M., et al. Rapid reperfusion causes stress failure in ischemic rat lungs. JThorac Cardiovasc Surg 1998, 116:932-942.
44. Broccard A.F., Vannay C., Feihl F., et al. Impact of low pulmonary vascular pressure on ventilator-induced lung injury. Crit Care Med 2002, 30:2183-2190.
45. Petak F., Habre W., Hantos Z., et al. Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs. JAppl Physiol 2002, 92:169-178.
46. Chang R.S., Wright K., Effros R.M. Role of albumin in prevention of edema in perfused rabbit lungs. JAppl Physiol 1981, 50:1065-1070.
47. Kraft S.A., Fujishima S., McGuire G.P., et al. Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs. JAppl Physiol 1995, 78:499-504.
48. Laumonier T., Walpen A.J., Maurus C.F., et al. Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells. Transplantation 2003, 76:838-843.
49. Zeerleder S., Mauron T., Lammle B., et al. Effect of low-molecular weight dextran sulfate on coagulation and platelet function tests. Thromb Res 2002, 105:441-446.
50. Fischer S., Matte-Martyn A., De Perrot M., et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. JThorac Cardiovasc Surg 2001, 121:594-596.
51. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. NEngl J Med 2000, 342:1301-1308.
52. Amato M.B., Barbas C.S., Medeiros D.M., et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. NEngl J Med 1998, 338:347-354.
53. de Perrot M., Imai Y., Volgyesi G.A., et al. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. JThorac Cardiovasc Surg 2002, 124:1137-1144.
54. Yeung J.C., Cypel M., Machuca T.N., et al. Physiologic assessment of the exvivo donor lung for transplantation. JHeart Lung Transplant 2012, 31:1120-1126.
55. Cypel M., Yeung J.C., Machuca T., et al. Experience with the first 50 exvivo lung perfusions in clinical transplantation. JThorac Cardiovasc Surg 2012, 144:1200-1206.
56. Aigner C., Slama A., Hotzenecker K., et al. Clinical exvivo lung perfusion-pushing the limits. Am J Transplant 2012, 12:1839-1847.
57. Cypel M., Aigner C., Sage E., et al. Three center experience with clinical normothermic exvivo lung perfusion. JHeart Lung Transplant 2013, 32:S16.
58. Zych B., Popov A.F., Stavri G., et al. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. JHeart Lung Transplant 2012, 31:274-281.
59. Valenza F., Rosso L., Gatti S., et al. Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. Transplant Proc 2012, 44:1826-1829.
60. Moradiellos F.J., Naranjo J.M., Cordoba M., et al. Clinical lung transplantation after exvivo evaluation of uncontrolled non heart-beating donor lungs: initial experience. JHeart Lung Transplant 2011, 30:S38.
61. Sanchez P.G., Davis R.D., D'Ovidio F., et al. Normothermic exvivo lung perfusion as an assessment of marginal donor lungs-the NOVEL lung trial. JHeart Lung Transplant 2013, 32:S16-S17.
62. Steen S., Sjoberg T., Pierre L., et al. Transplantation of lungs from a non-heart-beating donor. Lancet 2001, 357:825-829.
63. Ingemansson R., Eyjolfsson A., Mared L., et al. Clinical transplantation of initially rejected donor lungs after reconditioning exvivo. Ann Thorac Surg 2009, 87:255-260.
64. Lindstedt S., Eyjolfsson A., Koul B., et al. How to recondition exvivo initially rejected donor lungs for clinical transplantation: clinical experience from Lund University Hospital. Am J Transplant 2011, 2011:754383.
65. Wallinder A., Ricksten S.E., Hansson C., et al. Transplantation of initially rejected donor lungs after exvivo lung perfusion. JThorac Cardiovasc Surg 2012, 144:1222-1228.
66. Warnecke G., Moradiellos J., Tudorache I., et al. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients. Lancet 2012, 380:1851-1858.
67. Valenza F., Rosso L., Coppola S., et al. Beta-adrenergic agonist infusion during extracorporeal lung perfusion: effects on glucose concentration in the perfusion fluid and on lung function. JHeart Lung Transplant 2012, 31:524-530.
68. Bonato R., Machuca T., Cypel M., et al. Exvivo treatment of infection in human donor lungs. JHeart Lung Transplant 2012, 31:S97-S98.
69. Lee J.W., Krasnodembskaya A., McKenna D.H., et al. Therapeutic effects of human mesenchymal stem cells in exvivo human lungs injured with live bacteria. Am J Respir Crit Care Med 2013, 187(7):751-760.
70. Fischer S., Liu M., MacLean A.A., et al. Invivo transtracheal adenovirus-mediatedtransfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion injury and improves early posttransplant graft function in the rat. Hum Gene Ther 2001, 12:1513-1526.
71. Martins S., de Perrot M., Imai Y., et al. Transbronchial administration of adenoviral-mediated interleukin-10 gene to the donor improves function in a pig lung transplant model. Gene Ther 2004, 11:1786-1796.
72. Fischer S., De Perrot M., Liu M., et al. Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis. JThorac Cardiovasc Surg 2003, 126:1174-1180.
73. Cassivi S.D., Cardella J.A., Fischer S., et al. Transtracheal gene transfection of donor lungs prior to organ procurement increases transgene levels at reperfusion and following transplantation. JHeart Lung Transplant 1999, 18:1181-1188.
74. Cypel M., Liu M., Rubacha M., et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009, 1:4ra9.
75. Yeung J.C., Wagnetz D., Cypel M., et al. Exvivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig. Mol Ther 2012, 20:1204-1211.
76. Machuca T., Bonato R., Cypel M., et al. Exvivo adenoviral IL-10 gene therapy in a pig lung transplantation survival model. JHeart Lung Transplant 2012, 31:S141.
77. Lee J.W., Fang X., Gupta N., et al. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the exvivo perfused human lung. Proc Natl Acad Sci USA 2009, 106:16357-16362.
78. Gupta N., Su X., Popov B., et al. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. JImmunol 2007, 179:1855-1863.
79. Inci I., Ampollini L., Arni S., et al. Exvivo reconditioning of marginal donor lungs injured by acid aspiration. JHeart Lung Transplant 2008, 27:1229-1236.
80. Meers C.M., Tsagkaropoulos S., Wauters S., et al. Amodel of exvivo perfusion of porcine donor lungs injured by gastric aspiration: a step towards pretransplant reconditioning. JSurg Res 2011, 170:e159-e167.
81. Meers C.M., Wauters S., Verbeken E., et al. Preemptive therapy with steroids but not macrolides improves gas exchange in caustic-injured donor lungs. JSurg Res 2011, 170:e141-e148.
82. Ware L.B., Fang X., Wang Y., et al. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. JHeart Lung Transplant 2005, 24:1650-1656.
83. Oto T., Rabinov M., Griffiths A.P., et al. Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: a major mechanism of primary graft failure?. JThorac Cardiovasc Surg 2005, 130:1446.
84. Inci I., Zhai W., Arni S., et al. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. JHeart Lung Transplant 2007, 26:1054-1060.
85. Chandler W.L., Alessi M.C., Aillaud M.F., et al. Clearance of tissue plasminogen activator (TPA) and TPA/plasminogen activator inhibitor type 1 (PAI-1) complex: relationship to elevated TPA antigen in patients with high PAI-1 activity levels. Circulation 1997, 96:761-768.
86. Dalla-Volta S., Palla A., Santolicandro A., et al. PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activator Italian multicenter study 2. JAm Coll Cardiol 1992, 20:520-526.
87. Meneveau N., Schiele F., Metz D., et al. Comparative efficacy of a two-hour regimen of streptokinase versus alteplase in acute massive pulmonary embolism: immediate clinical and hemodynamic outcome and one-year follow-up. JAm Coll Cardiol 1998, 31:1057-1063.
88. Machuca TN, Hsin MK, Ott HC, etal. Injury specific treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation. Am J Respir Crit Care Med, in press.
89. Tremblay L.N., Yamashiro T., DeCampos K.N., et al. Effect of hypotension preceding death on the function of lungs from donors with nonbeating hearts. JHeart Lung Transplant 1996, 15:260-268.
90. Nakajima D., Chen F., Yamada T., et al. Reconditioning of lungs donated after circulatory death with normothermic exvivo lung perfusion. JHeart Lung Transplant 2012, 31:187-193.
91. Sanchez P.G., Bittle G.J., Williams K., et al. Exvivo lung evaluation of prearrest heparinization in donation after cardiac death. Ann Surg 2013, 257:534-541.
92. Dong B., Stewart P.W., Egan T.M. Postmortem and exvivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non-heart-beating donors. JThorac Cardiovasc Surg 2013, 146(2):429-436.e1.
93. Dong B.M., Abano J.B., Egan T.M. Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function. Am J Transplant 2009, 9:2707-2715.
94. Mulloy D.P., Stone M.L., Crosby I.K., et al. Exvivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function. JThorac Cardiovasc Surg 2012, 144:1208-1215.
95. Wigfield C.H., Cypel M., Yeung J., et al. Successful emergent lung transplantation after remote exvivo perfusion optimization and transportation of donor lungs. Am J Transplant 2012, 12:2838-2844.
96. De Perrot M., Sekine Y., Fischer S., et al. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am J Respir Crit Care Med 2002, 165:211-215.
97. Hoffman S.A., Wang L., Shah C.V., et al. Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. Am J Transplant 2009, 9:389-396.
98. Sarwal M.M., Benjamin J., Butte A.J., et al. Transplantomics and biomarkers in organ transplantation: a report from the first international conference. Transplantation 2011, 91:379-382.
99. Soleymani L., Fang Z., Sargent E.H., et al. Programming the detection limits of biosensors through controlled nanostructuring. Nat Nanotechnol 2009, 4:844-848.
100. Yang H., Hui A., Pampalakis G., et al. Direct, electronic microRNA detection for the rapid determination of differential expression profiles. Angew Chem Int Ed Engl 2009, 48:8461-8464.