-
1
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106:661-673.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
2
-
-
24944460598
-
de L.T. Shelterin The protein complex that shapes and safeguards human telomeres
-
de L.T., Shelterin the protein complex that shapes and safeguards human telomeres. Genes Dev 2005, 19:2100-2110.
-
(2005)
Genes Dev
, vol.19
, pp. 2100-2110
-
-
-
4
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
5
-
-
0015844590
-
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
-
Olovnikov A.M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973, 41:181-190.
-
(1973)
J Theor Biol
, vol.41
, pp. 181-190
-
-
Olovnikov, A.M.1
-
6
-
-
0015515155
-
Origin of concatemeric T7 DNA
-
Watson J.D. Origin of concatemeric T7 DNA. Nat New Biol 1972, 239:197-201.
-
(1972)
Nat New Biol
, vol.239
, pp. 197-201
-
-
Watson, J.D.1
-
7
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
8
-
-
0037178761
-
Connecting chromosomes, crisis, and cancer
-
Maser R.S., DePinho R.A. Connecting chromosomes, crisis, and cancer. Science 2002, 297:565-569.
-
(2002)
Science
, vol.297
, pp. 565-569
-
-
Maser, R.S.1
DePinho, R.A.2
-
9
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406:641-645.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
-
10
-
-
0032536049
-
Telomeres and senescence: ending the debate
-
de Lange T. Telomeres and senescence: ending the debate. Science 1998, 279:334-335.
-
(1998)
Science
, vol.279
, pp. 334-335
-
-
de Lange, T.1
-
11
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985, 43:405-413.
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
12
-
-
0029162563
-
Telomere elongation in immortal human cells without detectable telomerase activity
-
Bryan T.M., Englezou A., Gupta J., Bacchetti S., Reddel R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995, 14:4240-4248.
-
(1995)
EMBO J
, vol.14
, pp. 4240-4248
-
-
Bryan, T.M.1
Englezou, A.2
Gupta, J.3
Bacchetti, S.4
Reddel, R.R.5
-
13
-
-
0030697342
-
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
-
Bryan T.M., Englezou A., la-Pozza L., Dunham M.A., Reddel R.R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997, 3:1271-1274.
-
(1997)
Nat Med
, vol.3
, pp. 1271-1274
-
-
Bryan, T.M.1
Englezou, A.2
la-Pozza, L.3
Dunham, M.A.4
Reddel, R.R.5
-
14
-
-
0042140590
-
Telomere dysfunction: a potential cancer predisposition factor
-
Wu X., Amos C.I., Zhu Y., Zhao H., Grossman B.H., Shay J.W., et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 2003, 95:1211-1218.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1211-1218
-
-
Wu, X.1
Amos, C.I.2
Zhu, Y.3
Zhao, H.4
Grossman, B.H.5
Shay, J.W.6
-
15
-
-
44449150460
-
Telomere length and the risk of lung cancer
-
Jang J.S., Choi Y.Y., Lee W.K., Choi J.E., Cha S.I., Kim Y.J., et al. Telomere length and the risk of lung cancer. Cancer Sci 2008, 99:1385-1389.
-
(2008)
Cancer Sci
, vol.99
, pp. 1385-1389
-
-
Jang, J.S.1
Choi, Y.Y.2
Lee, W.K.3
Choi, J.E.4
Cha, S.I.5
Kim, Y.J.6
-
16
-
-
84905493151
-
Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts
-
Seow W.J., Cawthon R.M., Purdue M.P., Hu W., Gao Y.T., Huang W.Y., et al. Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts. Cancer Res 2014, 74:4090-4098.
-
(2014)
Cancer Res
, vol.74
, pp. 4090-4098
-
-
Seow, W.J.1
Cawthon, R.M.2
Purdue, M.P.3
Hu, W.4
Gao, Y.T.5
Huang, W.Y.6
-
17
-
-
79960034290
-
A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer
-
Shen M., Cawthon R., Rothman N., Weinstein S.J., Virtamo J., Hosgood H.D., et al. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer 2011, 73:133-137.
-
(2011)
Lung Cancer
, vol.73
, pp. 133-137
-
-
Shen, M.1
Cawthon, R.2
Rothman, N.3
Weinstein, S.J.4
Virtamo, J.5
Hosgood, H.D.6
-
18
-
-
84875436593
-
Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China
-
Lan Q., Cawthon R., Gao Y., Hu W., Hosgood H.D., Barone-Adesi F., et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS ONE 2013, 8:e59230.
-
(2013)
PLoS ONE
, vol.8
, pp. e59230
-
-
Lan, Q.1
Cawthon, R.2
Gao, Y.3
Hu, W.4
Hosgood, H.D.5
Barone-Adesi, F.6
-
19
-
-
1442327515
-
The shortest telomeres drive karyotype evolution in transformed cells
-
Der-Sarkissian H., Bacchetti S., Cazes L., Londono-Vallejo J.A. The shortest telomeres drive karyotype evolution in transformed cells. Oncogene 2004, 23:1221-1228.
-
(2004)
Oncogene
, vol.23
, pp. 1221-1228
-
-
Der-Sarkissian, H.1
Bacchetti, S.2
Cazes, L.3
Londono-Vallejo, J.A.4
-
20
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann M.T., Strong M.A., Hao L.Y., Greider C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107:67-77.
-
(2001)
Cell
, vol.107
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
21
-
-
26944472376
-
Telomere dysfunction drives chromosomal instability in human mammary epithelial cells
-
Soler D., Genesca A., Arnedo G., Egozcue J., Tusell L. Telomere dysfunction drives chromosomal instability in human mammary epithelial cells. Genes Chromosomes Cancer 2005, 44:339-350.
-
(2005)
Genes Chromosomes Cancer
, vol.44
, pp. 339-350
-
-
Soler, D.1
Genesca, A.2
Arnedo, G.3
Egozcue, J.4
Tusell, L.5
-
22
-
-
84901787515
-
Telomerase enzymatic component hTERT shortens long telomeres in human cells
-
Zheng Y.L., Zhang F., Sun B., Du J., Sun C., Yuan J., et al. Telomerase enzymatic component hTERT shortens long telomeres in human cells. Cell Cycle 2014, 13:1765-1776.
-
(2014)
Cell Cycle
, vol.13
, pp. 1765-1776
-
-
Zheng, Y.L.1
Zhang, F.2
Sun, B.3
Du, J.4
Sun, C.5
Yuan, J.6
-
23
-
-
80053229934
-
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes
-
Heaphy C.M., Subhawong A.P., Hong S.M., Goggins M.G., Montgomery E.A., Gabrielson E., et al. Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol 2011, 179:1608-1615.
-
(2011)
Am J Pathol
, vol.179
, pp. 1608-1615
-
-
Heaphy, C.M.1
Subhawong, A.P.2
Hong, S.M.3
Goggins, M.G.4
Montgomery, E.A.5
Gabrielson, E.6
-
24
-
-
84888411928
-
Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction
-
Sakellariou D., Chiourea M., Raftopoulou C., Gagos S. Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction. Neoplasia 2013, 15:1301-1313.
-
(2013)
Neoplasia
, vol.15
, pp. 1301-1313
-
-
Sakellariou, D.1
Chiourea, M.2
Raftopoulou, C.3
Gagos, S.4
-
25
-
-
19944428332
-
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas
-
Henson J.D., Hannay J.A., McCarthy S.W., Royds J.A., Yeager T.R., Robinson R.A., et al. A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res 2005, 11:217-225.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 217-225
-
-
Henson, J.D.1
Hannay, J.A.2
McCarthy, S.W.3
Royds, J.A.4
Yeager, T.R.5
Robinson, R.A.6
-
26
-
-
84887123502
-
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas
-
Abedalthagafi M., Phillips J.J., Kim G.E., Mueller S., Haas-Kogen D.A., Marshall R.E., et al. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Mod Pathol 2013, 26:1425-1432.
-
(2013)
Mod Pathol
, vol.26
, pp. 1425-1432
-
-
Abedalthagafi, M.1
Phillips, J.J.2
Kim, G.E.3
Mueller, S.4
Haas-Kogen, D.A.5
Marshall, R.E.6
-
27
-
-
0037328880
-
Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls
-
Zheng Y.L., Loffredo C.A., Yu Z., Jones R.T., Krasna M.J., Alberg A.J., et al. Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls. Carcinogenesis 2003, 24:269-274.
-
(2003)
Carcinogenesis
, vol.24
, pp. 269-274
-
-
Zheng, Y.L.1
Loffredo, C.A.2
Yu, Z.3
Jones, R.T.4
Krasna, M.J.5
Alberg, A.J.6
-
28
-
-
27144526977
-
Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans
-
Zheng Y.L., Loffredo C.A., Alberg A.J., Yu Z., Jones R.T., Perlmutter D., et al. Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans. Cancer Res 2005, 65:9566-9573.
-
(2005)
Cancer Res
, vol.65
, pp. 9566-9573
-
-
Zheng, Y.L.1
Loffredo, C.A.2
Alberg, A.J.3
Yu, Z.4
Jones, R.T.5
Perlmutter, D.6
-
29
-
-
78650527417
-
Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer risk
-
Zheng Y.L., Zhou X., Loffredo C.A., Shields P.G., Sun B. Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer risk. Hum Mol Genet 2011, 20:378-386.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 378-386
-
-
Zheng, Y.L.1
Zhou, X.2
Loffredo, C.A.3
Shields, P.G.4
Sun, B.5
-
30
-
-
69749092744
-
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
-
Martinez P., Thanasoula M., Munoz P., Liao C., Tejera A., McNees C., et al. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 2009, 23:2060-2075.
-
(2009)
Genes Dev
, vol.23
, pp. 2060-2075
-
-
Martinez, P.1
Thanasoula, M.2
Munoz, P.3
Liao, C.4
Tejera, A.5
McNees, C.6
-
31
-
-
84899017741
-
Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin
-
Episkopou H., Draskovic I., Van B.A., Tilman G., Mattiussi M., Gobin M., et al. Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin. Nucleic Acids Res 2014, 42:4391-4405.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 4391-4405
-
-
Episkopou, H.1
Draskovic, I.2
Van, B.A.3
Tilman, G.4
Mattiussi, M.5
Gobin, M.6
-
32
-
-
7644237444
-
Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops
-
Cesare A.J., Griffith J.D. Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol Cell Biol 2004, 24:9948-9957.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9948-9957
-
-
Cesare, A.J.1
Griffith, J.D.2
-
33
-
-
70350540794
-
Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility
-
Hosgood H.D., Cawthon R., He X., Chanock S., Lan Q. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer 2009, 66:157-161.
-
(2009)
Lung Cancer
, vol.66
, pp. 157-161
-
-
Hosgood, H.D.1
Cawthon, R.2
He, X.3
Chanock, S.4
Lan, Q.5
-
35
-
-
4444292721
-
Telomere dysfunction in genome instability syndromes
-
Callen E., Surralles J. Telomere dysfunction in genome instability syndromes. Mutat Res 2004, 567:85-104.
-
(2004)
Mutat Res
, vol.567
, pp. 85-104
-
-
Callen, E.1
Surralles, J.2
-
36
-
-
0034661010
-
Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
-
Ho H.Y., Cheng M.L., Lu F.J., Chou Y.H., Stern A., Liang C.M., et al. Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 2000, 29:156-169.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 156-169
-
-
Ho, H.Y.1
Cheng, M.L.2
Lu, F.J.3
Chou, Y.H.4
Stern, A.5
Liang, C.M.6
-
37
-
-
3042591085
-
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
-
Kurz D.J., Decary S., Hong Y., Trivier E., Akhmedov A., Erusalimsky J.D. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004, 117:2417-2426.
-
(2004)
J Cell Sci
, vol.117
, pp. 2417-2426
-
-
Kurz, D.J.1
Decary, S.2
Hong, Y.3
Trivier, E.4
Akhmedov, A.5
Erusalimsky, J.D.6
-
38
-
-
0036629255
-
Oxidative stress shortens telomeres
-
Von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002, 27:339-344.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 339-344
-
-
Von Zglinicki, T.1
-
39
-
-
0036236630
-
Replicative aging, telomeres, and oxidative stress
-
Saretzki G., Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann NY Acad Sci 2002, 959:24-29.
-
(2002)
Ann NY Acad Sci
, vol.959
, pp. 24-29
-
-
Saretzki, G.1
Von Zglinicki, T.2
-
40
-
-
0028077099
-
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age
-
Vaziri H., Dragowska W., Allsopp R.C., Thomas T.E., Harley C.B., Lansdorp P.M. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994, 91:9857-9860.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9857-9860
-
-
Vaziri, H.1
Dragowska, W.2
Allsopp, R.C.3
Thomas, T.E.4
Harley, C.B.5
Lansdorp, P.M.6
-
41
-
-
84855486059
-
Dyskeratosis congenita as a disorder of telomere maintenance
-
Nelson N.D., Bertuch A.A. Dyskeratosis congenita as a disorder of telomere maintenance. Mutat Res 2012, 730:43-51.
-
(2012)
Mutat Res
, vol.730
, pp. 43-51
-
-
Nelson, N.D.1
Bertuch, A.A.2
-
42
-
-
84876335525
-
Telomere dysfunction and tumor suppression responses in dyskeratosis congenita: balancing cancer and tissue renewal impairment
-
Hartwig F.P., Collares T. Telomere dysfunction and tumor suppression responses in dyskeratosis congenita: balancing cancer and tissue renewal impairment. Ageing Res Rev 2013, 12:642-652.
-
(2013)
Ageing Res Rev
, vol.12
, pp. 642-652
-
-
Hartwig, F.P.1
Collares, T.2
-
43
-
-
84888004712
-
Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy
-
Gramatges M.M., Bertuch A.A. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy. Transl Res 2013, 162:353-363.
-
(2013)
Transl Res
, vol.162
, pp. 353-363
-
-
Gramatges, M.M.1
Bertuch, A.A.2
-
44
-
-
79952017845
-
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
-
Martinez P., Blasco M.A. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 2011, 11:161-176.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 161-176
-
-
Martinez, P.1
Blasco, M.A.2
-
45
-
-
38949156672
-
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
-
Choi J., Southworth L.K., Sarin K.Y., Venteicher A.S., Ma W., Chang W., et al. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet 2008, 4:e10.
-
(2008)
PLoS Genet
, vol.4
, pp. e10
-
-
Choi, J.1
Southworth, L.K.2
Sarin, K.Y.3
Venteicher, A.S.4
Ma, W.5
Chang, W.6
-
46
-
-
67650065306
-
Telomerase modulates Wnt signalling by association with target gene chromatin
-
Park J.I., Venteicher A.S., Hong J.Y., Choi J., Jun S., Shkreli M., et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 2009, 460:66-72.
-
(2009)
Nature
, vol.460
, pp. 66-72
-
-
Park, J.I.1
Venteicher, A.S.2
Hong, J.Y.3
Choi, J.4
Jun, S.5
Shkreli, M.6
-
47
-
-
0033948285
-
Mechanisms and implications of the age-associated decrease in DNA repair capacity
-
Goukassian D., Gad F., Yaar M., Eller M.S., Nehal U.S., Gilchrest B.A. Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J 2000, 14:1325-1334.
-
(2000)
FASEB J
, vol.14
, pp. 1325-1334
-
-
Goukassian, D.1
Gad, F.2
Yaar, M.3
Eller, M.S.4
Nehal, U.S.5
Gilchrest, B.A.6
-
48
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007, 447:725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
50
-
-
0037062454
-
Constitutive telomerase expression promotes mammary carcinomas in aging mice
-
Artandi S.E., Alson S., Tietze M.K., Sharpless N.E., Ye S., Greenberg R.A., et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA 2002, 99:8191-8196.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8191-8196
-
-
Artandi, S.E.1
Alson, S.2
Tietze, M.K.3
Sharpless, N.E.4
Ye, S.5
Greenberg, R.A.6
|