Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-Ethenoadenine-induced mutations

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 4966-4980

  Adhikari, Sanjay ^a,b   Chetram, Mahandranauth A ^a   Woodrick, Jordan ^a   Mitra, Partha S ^a   Manthena, Praveen V ^a   Khatkar, Pooja ^a   Dakshanamurthy, Sivanesan ^a   Dixon, Monica ^a   Karmahapatra, Soumendra K ^a   Nuthalapati, Nikhil K ^a   Gupta, Suhani ^a   Narasimhan, Ganga ^a   Mazumder, Raja ^c   Loffredo, Christopher A ^a   Üren, Aykut ^a   Roy, Rabindra ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

DNA GLYCOSYLASE; DNA REPAIR; GERM LINE; INDUCED MUTATIONS; PURINE BASIS;

REPAIR;

1,N6 ETHENOADENINE; ALKYLATING AGENT; DNA A; DNA BASE; DNA GLYCOSYLTRANSFERASE; EPSILON A DNA; MESYLIC ACID METHYL ESTER; N METHYLPURINE DNA GLYCOSYLASE; PROTEIN VARIANT; UNCLASSIFIED DRUG; 1,N(6)-ETHENOADENINE; ADENINE; MUTAGENIC AGENT;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA REPAIR; EMBRYO; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE; GENE MUTATION; GENETIC VARIABILITY; GENOMIC INSTABILITY; GERM LINE; HETEROZYGOTE; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MOUSE; MPG GENE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STEADY STATE; SURFACE PLASMON RESONANCE; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; KINETICS; KNOCKOUT MOUSE; METABOLISM; MISSENSE MUTATION;

ADENINE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; DNA GLYCOSYLASES; DNA REPAIR; GENE EXPRESSION; GENOMIC INSTABILITY; HEK293 CELLS; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; MUTAGENS; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; SURFACE PLASMON RESONANCE;

EID: 84929494445     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.627000     Document Type: Article

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