Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

DNA Repair

Volumn 11, Issue 6, 2012, Pages 570-578

  Dey, Sanjib ^a   Maiti, Amit K ^a   Hegde, Muralidhar L ^a   Hegde, Pavana M ^a   Boldogh, Istvan ^a   Sarkar, Partha S ^b   Abdel Rahman, Sherif Z ^a   Sarker, Altaf H ^c   Hang, Bo ^c   Xie, Jingwu ^d   Tomkinson, Alan E ^e   Zhou, Mian ^f   Shen, Binghui ^f   Wang, Guanghai ^g   Wu, Chen ^g   Yu, Dianke ^g   Lin, Dongxin ^g   Cardenas, Victor ^a   Hazra, Tapas K ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITY OF NEW MEXICO   (United States)

^f Chinese Academy of Medical Sciences ^*  (United States)

^g CANCER HOSPITAL   (China)

Author keywords

BER; Lung cancer; NEIL2; SNP

Indexed keywords

DNA BASE; DNA GLYCOSYLTRANSFERASE; GENOMIC DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIGASE; LIGASE 3ALPHA; NEI LIKE 2 PROTEIN; PHOSPHATASE; POLYMERASE BETA; POLYNUCLEOTIDE KINASE 3' PHOSPHATASE; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ADULT; AGED; ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CANCER GENETICS; CANCER RISK; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LUNG CANCER; LUNG CARCINOGENESIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE FREQUENCY; GENOTYPE; HEK293 CELLS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION RATE; OLIGONUCLEOTIDES, ANTISENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS;

CRICETULUS GRISEUS;

EID: 84861479075     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2012.03.005     Document Type: Article

References (51)

1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics. CA Cancer J. Clin. 2010, 60:277-300.
2. Marchetti A., Martella C., Felicioni L., Barassi F., Salvatore S., Chella A., Camplese P.P., Iarussi T., Mucilli F., Mezzetti A., Cuccurullo F., Sacco R., Buttitta F. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J. Clin. Oncol. 2005, 23:857-865.
3. Zochbauer-Muller S., Gazdar A.F., Minna J.D. Molecular pathogenesis of lung cancer. Annu. Rev. Physiol. 2002, 64:681-708.
4. Samet J.M. Radiation and cancer risk: a continuing challenge for epidemiologists. Environ. Health 2011, 10(Suppl. 1):S4.
5. Wagoner J.K., Archer V.E., Lundin F.E., Holaday D.A., Lloyd J.W. Radiation as the cause of lung cancer among uranium miners. N. Engl. J. Med. 1965, 273:181-188.
6. Breen A.P., Murphy J.A. Reactions of oxyl radicals with DNA. Free Radic. Biol. Med. 1995, 18:1033-1077.
7. Ames B.N., Gold L.S., Willett W.C. The causes and prevention of cancer. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:5258-5265.
8. Cadet J., Berger M., Douki T., Ravanat J.L. Oxidative damage to DNA: formation, measurement, and biological significance. Rev. Physiol. Biochem. Pharmacol. 1997, 131:1-87.
9. Wallace S.S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res. 1998, 150:S60-S79.
10. Ward J.F. The complexity of DNA damage: relevance to biological consequences. Int. J. Radiat. Biol. 1994, 66:427-432.
11. Krokan H.E., Standal R., Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochem. J. 1997, 325:1-16.
12. Krokan H.E., Nilsen H., Skorpen F., Otterlei M., Slupphaug G. Base excision repair of DNA in mammalian cells. FEBS Lett. 2000, 476:73-77.
13. Friedberg E.C., Walker G.C., Siede W., Wood R.D., Schultz R.A., Ellenberger T. DNA Repair and Mutagenesis 2006, ASM, Press, Washington, DC.
14. Ikeda S., Biswas T., Roy R., Izumi T., Boldogh I., Kurosky A., Sarker A.H., Seki S., Mitra S. Purification and charcterization of human hNTH1, a homolog of Escherichia coli endonuclease III: direct identification of Lys-212 as the active nucleophilic residue. J. Biol. Chem. 1998, 273:21585-21593.
15. Lu R., Nash H.M., Verdine G.L. A DNA repair enzyme that excises oxidatively damaged guanines from the mammalian genome is frequently lost in lung cancer. Curr. Biol. 1997, 7:397-407.
16. Hazra T.K., Izumi T., Boldogh I., Imhoff B., Kow Y.W., Jaruga P., Dizdaroglu M., Mitra S. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:3523-3528.
17. Hazra T.K., Kow Y.W., Hatahet Z., Imhoff B., Boldogh I., Mokkapati S.K., Mitra S., Izumi T. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J. Biol. Chem. 2002, 277:30417-30420.
18. Bandaru V., Sunkara S., Wallace S.S., Bond J.P. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair 2002, 517-529.
19. Takao M., Kanno S., Kobayashi K., Zhang Q.M., Yonei S., Van der Horst G.T., Yasui A. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J. Biol. Chem. 2002, 277:42205-42213.
20. Liu M., Bandaru V., Bond J.P., Jaruga P., Zhao X., Christov P.P., Burrows C.J., Rizzo C.J., Dizdaroglu M., Wallace S.S. The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:4925-4930.
21. Dodson M.L., Michaels M.L., Lloyd R.S. Unified catalytic mechanisms for DNA glycosylases. J. Biol. Chem. 1994, 269:32709-32712.
22. Hazra T.K., Izumi T., Maidt L., Floyd R.A., Mitra S. The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. Nucl. Acids Res. 1998, 26:5116-5122.
23. Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 1994, 63:915-948.
24. Caldecott K.W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 2008, 9:619-631.
25. Wiederhold L., Leppard J.B., Kedar P., Karimi-Busheri F., Rasouli-Nia A., Weinfeld M., Tomkinson A.E., Izumi T., Prasad R., Wilson S.H., Mitra S., Hazra T.K. AP endonuclease-independent DNA base excision repair in human cells. Mol. Cell 2004, 15:209-220.
26. Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T.K. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: evidence for a repair complex in human cells. DNA Repair (Amst.) 2006, 5:1439-1448.
27. Tomkinson A.E., Mackey Z.B. Structure and function of mammalian DNA ligases. Mutat. Res. 1998, 407:1-9.
28. Dou H., Mitra S., Hazra T.K. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J. Biol. Chem. 2003, 278:49679-49684.
29. Dou H., Theriot C.A., Das A., Hegde M.L., Matsumoto Y., Boldogh I., Hazra T.K., Bhakat K.K., Mitra S. Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. J. Biol. Chem. 2008, 283:3130-3140.
30. Hegde M.L., Theriot C.A., Das A., Hegde P.M., Guo Z., Gary R.K., Hazra T.K., Shen B., Mitra S. Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J. Biol. Chem. 2008, 283:27028-27037.
31. Banerjee D., Mandal S.M., Das A., Hegde M.L., Das S., Bhakat K.K., Boldogh I., Sarkar P.S., Mitra S., Hazra T.K. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J. Biol. Chem. 2011, 286:6006-6016.
32. Bregeon D., Doddridge Z.A., You H.J., Weiss B., Doetsch P.W. Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli. Mol. Cell 2003, 12:959-970.
33. Saxowsky T.T., Doetsch P.W. RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?. Chem. Rev. 2006, 106:474-488.
34. Das S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. J. Biol. Chem. 2007, 282:28474-28484.
35. Santos J.H., Meyer J.N., Mandavilli B.S., Van Houten B. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol. Biol. 2006, 314:183-199.
36. Jung D., Cho Y., Meyer J.N., Di Giulio R.T. The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus). Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2009, 149:182-186.
37. Bradley M.O., Bhuyan B., Francis M.C., Langenbach R., Peterson A., Huberman E. Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program. Mutat. Res. 1981, 87:81-142.
38. Maiti A.K., Boldogh I., Spratt H., Mitra S., Hazra T.K. Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme. DNA Repair (Amst.) 2008, 7:1213-1220.
39. Thacker J. The chromosomes of a V79 Chinese hamster line and a mutant subline lacking HPRT activity. Cytogenet. Cell Genet. 1981, 29:16-25.
40. Fredriksson S., Gullberg M., Jarvius J., Olsson C., Pietras K., Gustafsdottir S.M., Ostman A., Landegren U. Protein detection using proximity-dependent DNA ligation assays. Nat. Biotechnol. 2002, 20:473-477.
41. Soderberg O., Gullberg M., Jarvius M., Ridderstrale K., Leuchowius K.J., Jarvius J., Wester K., Hydbring P., Bahram F., Larsson L.G., Landegren U. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat. Methods 2006, 3:995-1000.
42. U.S. Department of Health and Human Services The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General 2006, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Rockville, MD. http://m.cancer.gov/topics/factsheets/ETS.
43. Thun M.J., Hannan L.M., Adams-Campbell L.L., Boffetta P., Buring J.E., Feskanich D., Flanders W.D., Jee S.H., Katanoda K., Kolonel L.N., Lee I.M., Marugame T., Palmer J.R., Riboli E., Sobue T., Avila-Tang E., Wilkens L.R., Samet J.M. Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 2008, 5:e185.
44. Tanaka Y., Maniwa Y., Bermudez V.P., Doi T., Nishio W., Ohbayashi C., Okita Y., Hurwitz J., Hayashi Y., Yoshimura M. Nonsynonymous single nucleotide polymorphisms in DNA damage repair pathways and lung cancer risk. Cancer 2010, 116:896-902.
45. Kiyohara C., Takayama K., Nakanishi Y. Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis. J. Nucl. Acids 2010, 2010:701760.
46. Broderick P., Bagratuni T., Vijayakrishnan J., Lubbe S., Chandler I., Houlston R.S. Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition. BMC Cancer 2006, 6:243.
47. Zhai X., Zhao H., Liu Z., Wang L.E., El-Naggar A.K., Sturgis E.M., Wei Q. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. Clin. Cancer Res. 2008, 14:4345-4352.
48. Gimelbrant A., Hutchinson J.N., Thompson B.R., Chess A. Widespread monoallelic expression on human autosomes. Science 2007, 318:1136-1140.
49. Khatib H. Is it genomic imprinting or preferential expression?. Bioessays 2007, 29:1022-1028.
50. Bell C.G., Beck S. Advances in the identification and analysis of allele-specific expression. Genome Med. 2009, 1:56.
51. Knight J.C. Allele-specific gene expression uncovered. Trends Genet. 2004, 20:113-116.