Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 35, 2013, Pages 14314-14319

  Galick, Heather A ^a   Kathe, Scott ^a   Liu, Minmin ^a   Robey Bond, Susan ^a   Kidane, Dawit ^b   Wallace, Susan S ^a   Sweasy, Joann B ^a,b  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; MCF10A breast epithelial cells; Mutagenesis

Indexed keywords

D239Y PROTEIN; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; HYDROGEN PEROXIDE; NTH1 PROTEIN; PROTEIN VARIANT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL INVASION; CELL TRANSFORMATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENOMIC INSTABILITY; GERM LINE; HUMAN; HUMAN CELL; INDEL MUTATION; MUTATION RATE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

DNA REPAIR; MCF10A BREAST EPITHELIAL CELLS; MUTAGENESIS;

HYDROGEN-ION CONCENTRATION;

EID: 84883340246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306752110     Document Type: Article

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