IκB Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation

Cell Reports

Volumn 8, Issue 5, 2014, Pages 1300-1307

  Peschke, Katrin ^a   Weitzmann, Anke ^a   Heger, Klaus ^b   Behrendt, Rayk ^a   Schubert, Nadja ^a   Scholten, Julia ^e   Voehringer, David ^c   Hartmann, Karin ^d   Dudeck, Anne ^a   Schmidt Supprian, Marc ^b   Roers, Axel ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e IQVIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CALCIUM IONOPHORE; CYTOKINE; I KAPPA B KINASE; I KAPPA B KINASE 2; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; IKBKB PROTEIN, MOUSE; NEMO PROTEIN, MOUSE; QB SNARE PROTEIN; QC SNARE PROTEIN; SIGNAL PEPTIDE; SNAP23 PROTEIN, MOUSE;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUSION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; IN VITRO STUDY; MALE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; DEGRANULATION; GENETICS; IMMUNOLOGY; MAST CELL; METABOLISM; PHYSIOLOGY;

ANIMALIA; MUS;

ALLERGENS; ANAPHYLAXIS; ANIMALS; CELL DEGRANULATION; CYTOKINES; I-KAPPA B KINASE; IMMUNOGLOBULIN E; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; MICE; MICE, INBRED C57BL; NF-KAPPA B; QB-SNARE PROTEINS; QC-SNARE PROTEINS;

EID: 84922525719     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.07.046     Document Type: Article

References (18)

1. Dudeck A., Dudeck J., Scholten J., Petzold A., Surianarayanan S., Köhler A., Peschke K., Vöhringer D., Waskow C., Krieg T., et al. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity 2011, 34:973-984.
2. Eshhar Z., Ofarim M., Waks T. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J.Immunol. 1980, 124:775-780.
3. Galli S.J., Tsai M. IgE and mast cells in allergic disease. Nat. Med. 2012, 18:693-704.
4. Hepp R., Puri N., Hohenstein A.C., Crawford G.L., Whiteheart S.W., Roche P.A. Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J.Biol. Chem. 2005, 280:6610-6620.
5. Jeong H.J., Koo H.N., Na H.J., Kim M.S., Hong S.H., Eom J.W., Kim K.S., Shin T.Y., Kim H.M. Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine 2002, 18:252-259.
6. Kambayashi T., Koretzky G.A. Proximal signaling events in Fc epsilon RI-mediated mast cell activation. J.Allergy Clin. Immunol. 2007, 119:544-552. quiz 553-554.
7. Klemm S., Gutermuth J., Hültner L., Sparwasser T., Behrendt H., Peschel C., Mak T.W., Jakob T., Ruland J. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J.Exp. Med. 2006, 203:337-347.
8. Kühn R., Schwenk F., Aguet M., Rajewsky K. Inducible gene targeting in mice. Science 1995, 269:1427-1429.
9. Lorentz A., Klopp I., Gebhardt T., Manns M.P., Bischoff S.C. Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated Tcells in IgE receptor-mediated cytokine expression in mature human mast cells. J.Allergy Clin. Immunol. 2003, 111:1062-1068.
10. Lorentz A., Baumann A., Vitte J., Blank U. The SNARE Machinery in Mast Cell Secretion. Front. Immunol. 2012, 3:143.
11. Marquardt D.L., Walker L.L. Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity. J.Allergy Clin. Immunol. 2000, 105:500-505.
12. Pasparakis M., Courtois G., Hafner M., Schmidt-Supprian M., Nenci A., Toksoy A., Krampert M., Goebeler M., Gillitzer R., Israel A., et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 2002, 417:861-866.
13. Peng Y., Power M.R., Li B., Lin T.J. Inhibition of IKK down-regulates antigen+ IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. J.Leukoc. Biol. 2005, 77:975-983.
14. Sasaki Y., Derudder E., Hobeika E., Pelanda R., Reth M., Rajewsky K., Schmidt-Supprian M. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 2006, 24:729-739.
15. Schmidt-Supprian M., Bloch W., Courtois G., Addicks K., Israël A., Rajewsky K., Pasparakis M. NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol. Cell 2000, 5:981-992.
16. Scholten J., Hartmann K., Gerbaulet A., Krieg T., Müller W., Testa G., Roers A. Mast cell-specific Cre/loxP-mediated recombination invivo. Transgenic Res. 2008, 17:307-315.
17. Suzuki K., Verma I.M. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 2008, 134:485-495.
18. Voehringer D., Liang H.E., Locksley R.M. Homeostasis and effector function of lymphopenia-induced "memory-like" Tcells in constitutively Tcell-depleted mice. J.Immunol. 2008, 180:4742-4753.