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Volumn 10, Issue 3, 2015, Pages

HP1 β is a biomarker for breast cancer prognosis and PARP inhibitor therapy

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1ALPHA; HETEROCHROMATIN PROTEIN 1BETA; HETEROCHROMATIN PROTEIN 1GAMMA; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VELIPARIB; BIOLOGICAL MARKER; ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROTEIN P53; HETEROCHROMATIN-SPECIFIC NONHISTONE CHROMOSOMAL PROTEIN HP-1; NONHISTONE PROTEIN; TUMOR MARKER;

EID: 84929492504     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/joumal.pone.0121207     Document Type: Article
Times cited : (34)

References (45)
  • 1
    • 84871702334 scopus 로고    scopus 로고
    • Gene signatures in breast cancer: Current and future uses
    • 23323153
    • Arranz EE, Vara JA, Gamez-Pozo A, Zamora P. Gene signatures in breast cancer: current and future uses. Translational oncology. 2012;5(6):398-403. PMID: 23323153
    • (2012) Translational Oncology , vol.5 , Issue.6 , pp. 398-403
    • Arranz, E.E.1    Vara, J.A.2    Gamez-Pozo, A.3    Zamora, P.4
  • 3
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • 11823860
    • van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871):530-6. PMID: 11823860
    • (2002) Nature , vol.415 , Issue.6871 , pp. 530-536
    • Van't Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3    He, Y.D.4    Hart, A.A.5    Mao, M.6
  • 5
    • 73949136029 scopus 로고    scopus 로고
    • The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: A retrospective of the last decade
    • 19927298
    • Weigelt B, Baehner FL, Reis-Filho JS. The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. The Journal of pathology. 2010;220(2):263-80. doi: 10.1002/path.2648 PMID: 19927298
    • (2010) The Journal of Pathology , vol.220 , Issue.2 , pp. 263-280
    • Weigelt, B.1    Baehner, F.L.2    Reis-Filho, J.S.3
  • 6
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • 23000897
    • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70. doi: 10.1038/nature11412 PMID: 23000897
    • (2012) Nature , vol.490 , Issue.7418 , pp. 61-70
    • Cancer Genome Atlas, N.1
  • 7
    • 84860389802 scopus 로고    scopus 로고
    • Stratifying triple-negative breast cancer: Which definition (s) to use?
    • 21457488
    • Adamo B, Anders CK. Stratifying triple-negative breast cancer: which definition (s) to use? Breast cancer research: BCR. 2011;13(2):105. doi: 10.1186/bcr2852 PMID: 21457488
    • (2011) Breast Cancer Research: BCR , vol.13 , Issue.2 , pp. 105
    • Adamo, B.1    Anders, C.K.2
  • 8
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: Breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
    • 20400477
    • O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-7. doi: 10.1093/carcin/bqq069 PMID: 20400477
    • (2010) Carcinogenesis , vol.31 , Issue.6 , pp. 961-967
    • O'Donovan, P.J.1    Livingston, D.M.2
  • 9
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • 15510162
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nature reviews Cancer. 2004;4(10):814-9. PMID: 15510162
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 10
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
    • 16912188
    • McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, etal. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition. Cancer research. 2006;66(16):8109-15. PMID: 16912188
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3    Kluzek, K.4    Bialkowska, A.5    Swift, S.6
  • 11
    • 79954560252 scopus 로고    scopus 로고
    • Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations
    • 21487248
    • Dedes KJ, Wilkerson PM, Wetterskog D, Weigelt B, Ashworth A, Reis-Filho JS. Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations. Cell cycle. 2011;10(8):1192-9. PMID: 21487248
    • (2011) Cell Cycle , vol.10 , Issue.8 , pp. 1192-1199
    • Dedes, K.J.1    Wilkerson, P.M.2    Wetterskog, D.3    Weigelt, B.4    Ashworth, A.5    Reis-Filho, J.S.6
  • 12
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
    • 15829966
    • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature. 2005;434(7035):913-7. PMID: 15829966
    • (2005) Nature , vol.434 , Issue.7035 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 13
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • 15829967
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434(7035):917-21. PMID: 15829967
    • (2005) Nature , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 14
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • 19553641
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. The New England journal of medicine. 2009;361-(2):123-34. doi: 10.1056/NEJMoa0900212 PMID: 19553641
    • (2009) The New England Journal of Medicine , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 15
    • 84883245810 scopus 로고    scopus 로고
    • Differential chemotherapeutic sensitivity for breast tumors with "BRCA-ness": A review
    • Chalasani P, Livingston R. Differential Chemotherapeutic Sensitivity for Breast Tumors With "BRCA-ness": A Review. The oncologist. 2013.
    • (2013) The Oncologist
    • Chalasani, P.1    Livingston, R.2
  • 16
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concepttrial
    • 20609467
    • Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concepttrial. Lancet. 2010;376(9737):235-44. doi: 10.1016/S0140-6736 (10) 60892-6 PMID: 20609467
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3    Domchek, S.M.4    Audeh, M.W.5    Weitzel, J.N.6
  • 17
    • 84878831995 scopus 로고    scopus 로고
    • HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response
    • 23589625
    • Lee YH, Kuo CY, Stark JM, Shih HM, Ann DK. HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response. Nucleic acids research. 2013;41(11):5784-98. doi: 10.1093/nar/qkt231 PMID: 23589625
    • (2013) Nucleic Acids Research , vol.41 , Issue.11 , pp. 5784-5798
    • Lee, Y.H.1    Kuo, C.Y.2    Stark, J.M.3    Shih, H.M.4    Ann, D.K.5
  • 19
    • 28844495048 scopus 로고    scopus 로고
    • Heterochromatin protein 1: A pervasive controlling influence
    • 16261261
    • Hiragami K, Festenstein R. Heterochromatin protein 1: a pervasive controlling influence. Cellular and molecular life sciences: CMLS. 2005;62(23):2711-26. PMID: 16261261
    • (2005) Cellular and Molecular Life Sciences: CMLS , vol.62 , Issue.23 , pp. 2711-2726
    • Hiragami, K.1    Festenstein, R.2
  • 20
    • 71949105212 scopus 로고    scopus 로고
    • The emerging role of HP1 in the DNA damage response
    • 19805510
    • Dinant C, Luijsterburg MS. The emerging role of HP1 in the DNA damage response. Molecular and cellular biology. 2009;29(24):6335-40. doi: 10.1128/MCB.01048-09 PMID: 19805510
    • (2009) Molecular and Cellular Biology , vol.29 , Issue.24 , pp. 6335-6340
    • Dinant, C.1    Luijsterburg, M.S.2
  • 21
    • 66149111681 scopus 로고    scopus 로고
    • Revisiting the role of heterochromatin protein 1 in DNA repair
    • 19451270
    • Ball AR Jr., Yokomori K. Revisiting the role of heterochromatin protein 1 in DNA repair. The Journal of cell biology. 2009;185(4):573-5. doi: 10.1083/icb.200904033 PMID: 19451270
    • (2009) The Journal of Cell Biology , vol.185 , Issue.4 , pp. 573-575
    • Ball, A.R.1    Yokomori, K.2
  • 22
    • 0038244058 scopus 로고    scopus 로고
    • Gene expression predictors of breast cancer outcomes
    • Epub 2003/05/16. 12747878
    • Huang E, Cheng SH, Dressman H, Pittman J, Tsou MH, Horng CF, et al. Gene expression predictors of breast cancer outcomes. Lancet. 2003;361(9369):1590-6. Epub 2003/05/16. PMID: 12747878
    • (2003) Lancet , vol.361 , Issue.9369 , pp. 1590-1596
    • Huang, E.1    Cheng, S.H.2    Dressman, H.3    Pittman, J.4    Tsou, M.H.5    Horng, C.F.6
  • 23
  • 25
    • 60549117554 scopus 로고    scopus 로고
    • Discovery of the Poly (ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1 H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer
    • 19143569
    • Penning TD, Zhu GD, Gandhi VB, Gong J, Liu X, Shi Y, et al. Discovery of the Poly (ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1 H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. Journal of medicinal chemistry. 2009;52(2):514-23. doi: 10.1021/jm801171j PMID: 19143569
    • (2009) Journal of Medicinal Chemistry , vol.52 , Issue.2 , pp. 514-523
    • Penning, T.D.1    Zhu, G.D.2    Gandhi, V.B.3    Gong, J.4    Liu, X.5    Shi, Y.6
  • 26
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Epub 2006/12/13. 17157791
    • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006;10(6):515-27. Epub 2006/12/13. PMID: 17157791
    • (2006) Cancer Cell , vol.10 , Issue.6 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3    Yeh, J.4    Baehner, F.L.5    Fevr, T.6
  • 27
    • 84866071912 scopus 로고    scopus 로고
    • Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models
    • 22778154
    • Clark CC, Weitzel JN, O'Connor TR. Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Molecular cancer therapeutics. 2012;11(9):1948-58. doi: 10.1158/1535-7163. MCT-11-0597 PMID: 22778154
    • (2012) Molecular Cancer Therapeutics , vol.11 , Issue.9 , pp. 1948-1958
    • Clark, C.C.1    Weitzel, J.N.2    O'Connor, T.R.3
  • 29
    • 56149098200 scopus 로고    scopus 로고
    • Linking heterochromatin protein 1 (HP1) to cancer progression
    • 18983859
    • Dialynas GK, Vitalini MW, Wallrath LL. Linking Heterochromatin Protein 1 (HP1) to cancer progression. Mutation research. 2008;647(1-2):13-20. doi: 10.1016/i.mrfmmm.2008.10.008 PMID: 18983859
    • (2008) Mutation Research , vol.647 , Issue.1-2 , pp. 13-20
    • Dialynas, G.K.1    Vitalini, M.W.2    Wallrath, L.L.3
  • 30
    • 0034214846 scopus 로고    scopus 로고
    • Down-regulation of HP1 Hsalpha expression is associated with the metastatic phenotype in breast cancer
    • 10910038
    • Kirschmann DA, Lininger RA, Gardner LM, Seftor EA, Odero VA, Ainsztein AM, et al. Down-regulation of HP1 Hsalpha expression is associated with the metastatic phenotype in breast cancer. Cancer research. 2000;60(13):3359-63. PMID: 10910038
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3359-3363
    • Kirschmann, D.A.1    Lininger, R.A.2    Gardner, L.M.3    Seftor, E.A.4    Odero, V.A.5    Ainsztein, A.M.6
  • 31
    • 77449146508 scopus 로고    scopus 로고
    • Heterochromatin protein 1 alpha: A hallmark of cell proliferation relevant to clinical oncology
    • 20049717
    • De Koning L, Savignoni A, Boumendil C, Rehman H, Asselain B, Sastre-Garau X, et al. Heterochromatin protein 1 alpha: a hallmark of cell proliferation relevant to clinical oncology. EMBO molecular medicine. 2009;1(3):178-91. doi: 10.1002/emmm.200900022 PMID: 20049717
    • (2009) EMBO Molecular Medicine , vol.1 , Issue.3 , pp. 178-191
    • De Koning, L.1    Savignoni, A.2    Boumendil, C.3    Rehman, H.4    Asselain, B.5    Sastre-Garau, X.6
  • 32
    • 84860390436 scopus 로고    scopus 로고
    • Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis
    • 21366896
    • Keam B, Im SA, Lee KH, Han SW, Oh DY, Kim JH, et al. Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis. Breast cancer research: BCR. 2011;13(2):R22. doi: 10.1186/bcr2834 PMID: 21366896
    • (2011) Breast Cancer Research: BCR , vol.13 , Issue.2 , pp. R22
    • Keam, B.1    Im, S.A.2    Lee, K.H.3    Han, S.W.4    Oh, D.Y.5    Kim, J.H.6
  • 33
    • 84875158075 scopus 로고    scopus 로고
    • HP1 gamma expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy
    • 23522301
    • Slezak J, Truong M, Huang W, Jarrard D. HP1 gamma expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy. BMC cancer. 2013;13:148. doi: 10.1186/1471-2407-13-148 PMID: 23522301
    • (2013) BMC Cancer , vol.13 , pp. 148
    • Slezak, J.1    Truong, M.2    Huang, W.3    Jarrard, D.4
  • 34
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
    • 22522925
    • Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature. 2012;486(7403):346-52. doi: 10.1038/nature10983 PMID: 22522925
    • (2012) Nature , vol.486 , Issue.7403 , pp. 346-352
    • Curtis, C.1    Shah, S.P.2    Chin, S.F.3    Turashvili, G.4    Rueda, O.M.5    Dunning, M.J.6
  • 35
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: From the known and the unknown
    • 10653597
    • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. Journal of cellular physiology. 2000;182(3):311-22. PMID: 10653597
    • (2000) Journal of Cellular Physiology , vol.182 , Issue.3 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 37
    • 20244374922 scopus 로고    scopus 로고
    • Ki-67 expression in breast carcinoma: Its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker?
    • 12599241
    • Trihia H, Murray S, Price K, Gelber RD, Golouh R, Goldhirsch A, et al. Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker? Cancer. 2003;97(5):1321-31. PMID: 12599241
    • (2003) Cancer , vol.97 , Issue.5 , pp. 1321-1331
    • Trihia, H.1    Murray, S.2    Price, K.3    Gelber, R.D.4    Golouh, R.5    Goldhirsch, A.6
  • 39
    • 84878755125 scopus 로고    scopus 로고
    • Ki-67 is a prognostic parameter in breast cancer patients: Results of a large population-based cohort of a cancer registry
    • 23674192
    • Inwald EC, Klinkhammer-Schalke M, Hofstadter F, Zeman F, Koller M, Gerstenhauer M, et al. Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry. Breast cancer research and treatment. 2013;139(2):539-52. doi: 10.1007/s10549-013-2560-8 PMID: 23674192
    • (2013) Breast Cancer Research and Treatment , vol.139 , Issue.2 , pp. 539-552
    • Inwald, E.C.1    Klinkhammer-Schalke, M.2    Hofstadter, F.3    Zeman, F.4    Koller, M.5    Gerstenhauer, M.6
  • 40
    • 34248595234 scopus 로고    scopus 로고
    • Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12, 155 patients
    • 17453008
    • de Azambuja E, Cardoso F, de Castro G Jr., Colozza M, Mano MS, Durbecq V, et al. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12, 155 patients. British journal of cancer. 2007;96(10):1504-13. PMID: 17453008
    • (2007) British Journal of Cancer , vol.96 , Issue.10 , pp. 1504-1513
    • De Azambuja, E.1    Cardoso, F.2    De Castro, G.3    Colozza, M.4    Mano, M.S.5    Durbecq, V.6
  • 41
    • 0036919266 scopus 로고    scopus 로고
    • Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins
    • 12485163
    • Kametaka A, Takagi M, Hayakawa T, Haraguchi T, Hiraoka Y, Yoneda Y. Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins. Genes Cells. 2002;7-(12):1231-42. PMID: 12485163
    • (2002) Genes Cells , vol.7 , Issue.12 , pp. 1231-1242
    • Kametaka, A.1    Takagi, M.2    Hayakawa, T.3    Haraguchi, T.4    Hiraoka, Y.5    Yoneda, Y.6
  • 42
    • 0036153717 scopus 로고    scopus 로고
    • The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: A potential role in the regulation of higher-order chromatin structure
    • 11793364
    • Scholzen T, Endl E, Wohlenberg C, vander Sar S, Cowell IG, Gerdes J, et al. The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. The Journal of pathology. 2002;196(2):135-44. PMID: 11793364
    • (2002) The Journal of Pathology , vol.196 , Issue.2 , pp. 135-144
    • Scholzen, T.1    Endl, E.2    Wohlenberg, C.3    Sar, S.V.4    Cowell, I.G.5    Gerdes, J.6
  • 43
    • 84855698070 scopus 로고    scopus 로고
    • BRCAness profile of sporadic ovarian cancer predicts disease recurrence
    • 22253870
    • Wysham WZ, Mhawech-Fauceglia P, Li H, Hays L, Syriac S, Skrepnik T, et al. BRCAness profile of sporadic ovarian cancer predicts disease recurrence. PloSone. 2012;7(1):e30042. doi: 10.1371/journal.pone.0030042 PMID: 22253870
    • (2012) PloSone , vol.7 , Issue.1 , pp. e30042
    • Wysham, W.Z.1    Mhawech-Fauceglia, P.2    Li, H.3    Hays, L.4    Syriac, S.5    Skrepnik, T.6
  • 44
    • 84864053120 scopus 로고    scopus 로고
    • BRCAness: Finding the Achilles heel in ovarian cancer
    • 22673632
    • Rigakos G, Razis E. BRCAness: finding the Achilles heel in ovarian cancer. The oncologist. 2012;17-(7):956-62. doi: 10.1634/theoncoloqist.2012-0028 PMID: 22673632
    • (2012) The Oncologist , vol.17 , Issue.7 , pp. 956-962
    • Rigakos, G.1    Razis, E.2


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