Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Journal of Molecular and Cellular Cardiology

Volumn 82, Issue , 2015, Pages 116-124

  Matsuhashi, Tomohiro ^a   Hishiki, Takako ^a,b   Zhou, Heping ^c   Ono, Tomohiko ^a   Kaneda, Ruri ^a,b   Iso, Tatsuya ^d   Yamaguchi, Aiko ^d   Endo, Jin ^a   Katsumata, Yoshinori ^a   Atsushi, Anzai ^a   Yamamoto, Tsunehisa ^a   Shirakawa, Kohsuke ^a   Yan, Xiaoxiang ^a   Shinmura, Ken ^a   Suematsu, Makoto ^a,b   Fukuda, Keiichi ^a   Sano, Motoaki ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d GUNMA UNIVERSITY   (Japan)

Author keywords

Acetylation; Ketone; Metabolic modulation therapy; Metabolomics

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; DICHLOROACETIC ACID; HISTONE H3; HISTONE H4; MESSENGER RNA; PYRUVATE DEHYDROGENASE; 3 HYDROXYBUTYRIC ACID; HISTONE; PYRUVATE DEHYDROGENASE ACTIVATOR; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; EPIGENETICS; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE UTILIZATION; HEART MUSCLE CELL; HEART PROTECTION; HEART REMODELING; HEART VENTRICLE OVERLOAD; HISTONE ACETYLATION; IN VIVO STUDY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RAT; TISSUE REGENERATION; TRANSCRIPTION REGULATION; UPREGULATION; ACETYLATION; ANIMAL; ANTIBODY SPECIFICITY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEART; HEART MUSCLE; HEART VENTRICLE REMODELING; METABOLISM; METABOLOME; METABOLOMICS; MITOCHONDRION; PHOSPHORYLATION; PROCEDURES;

3-HYDROXYBUTYRIC ACID; ACETYL COENZYME A; ACETYLATION; ANIMALS; DICHLOROACETIC ACID; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HEART; HISTONES; MALE; METABOLOME; METABOLOMICS; MICE; MITOCHONDRIA; MYOCARDIUM; ORGAN SPECIFICITY; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; RATS; TRANSCRIPTION, GENETIC; VENTRICULAR REMODELING;

EID: 84929455277     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.02.021     Document Type: Article

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