Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2

Hypertension

Volumn 63, Issue 1, 2014, Pages 80-87

  Katsumata, Yoshinori ^a   Shinmura, Ken ^a   Sugiura, Yuki ^a,b   Tohyama, Shugo ^a   Matsuhashi, Tomohiro ^a   Ito, Hideyuki ^a   Yan, Xiaoxiang ^a   Ito, Kentaro ^a   Yuasa, Shinsuke ^a   Ieda, Masaki ^a   Urade, Yoshihiro ^c   Suematsu, Makoto ^a   Fukuda, Keiichi ^a   Sano, Motoaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

15 deoxyprostaglandin J2; Nrf2; Oxidative stress; PPAR gamma; Prostaglandin D2; Prostaglandin F2a receptor

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; AMINO ACID TRANSPORTER; CARRIER PROTEINS AND BINDING PROTEINS; CYCLOOXYGENASE 2; DEXAMETHASONE; FLUPROSTENOL; GLUCOCORTICOID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE A2; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; LIPOCALIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN D2; PROSTAGLANDIN F2 ALPHA; SLC7A11 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR DP2; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 15-DEOXYPROSTAGLANDIN J2; ISOMERASE; NFE2L2 PROTEIN, MOUSE; PROSTAGLANDIN F2ALPHA RECEPTOR; PROSTAGLANDIN R2 D-ISOMERASE; PROSTAGLANDIN RECEPTOR; 15 DEOXYPROSTAGLANDIN J2; DRUG DERIVATIVE; PROSTAGLANDIN R2 D ISOMERASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART PROTECTION; HEART RATE; IMMUNOBLOTTING; ISOLATED HEART; MALE; MOUSE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENETICS; HEART; HEART MUSCLE; KNOCKOUT MOUSE; METABOLISM; DRUG EFFECT; NRF2; OXIDATIVE STRESS; PROSTAGLANDIN F2Α RECEPTOR;

ANIMALS; DEXAMETHASONE; GLUCOCORTICOIDS; HEART; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; PPAR GAMMA; PROSTAGLANDIN D2; RECEPTORS, PROSTAGLANDIN;

15-DEOXYPROSTAGLANDIN J2; NRF2; OXIDATIVE STRESS; PPAR GAMMA; PROSTAGLANDIN D2; PROSTAGLANDIN F2Α RECEPTOR;

EID: 84891633265     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.01639     Document Type: Article

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