Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts

Cardiovascular Research

Volumn 53, Issue 4, 2002, Pages 841-851

  Lydell, Carmen P ^a   Chan, Andy ^b   Wambolt, Richard B ^a   Sambandam, Nandakumar ^a   Parsons, Hannah ^a   Bondy, Gregory P ^a   Rodrigues, Brian ^b   Popov, Kirill M ^c   Harris, Robert A ^d   Brownsey, Roger W ^b   Allard, Michael F ^a  

^a ST PAUL S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Energy metabolism; Gene expression; Glycolysis; Hypertrophy; Protein phosphorylation

Indexed keywords

DICHLOROACETIC ACID; GLUCOSE; ISOENZYME; OXIDOREDUCTASE INHIBITOR; PALMITIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE PHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE OXIDATION; GLYCOLYSIS; HEART VENTRICLE HYPERTROPHY; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ANIMALS; GENE EXPRESSION; GLUCOSE; GLYCOLYSIS; HYPERTROPHY, LEFT VENTRICULAR; MALE; OXIDATION-REDUCTION; PROTEIN KINASES; PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0036199643     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00560-0     Document Type: Article

References (56)

1. Effects of moderate hypertension on cardiac function and metabolism in the rabbit
2. Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats
3. Increased glycolytic metabolism in cardiac hypertrophy and congestive failure
4. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts
5. Control of oxidative metabolism in volume-overloaded rat hearts: Effect of propionyl-L-carnitine
6. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
7. Glucose for the heart
8. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
9. Dichloroacetate improves post-ischemic function of hypertrophied rat hearts
10. Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia
11. Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts
12. Ischemia and reperfusion injury in the hypertrophied heart
13. Hypertrophied rat hearts are less responsive to the metabolic and functional effects of insulin
14. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts
15. Molecular biology and biochemistry of pyruvate dehydrogenase complexes
16. Fuel selection in animals
17. Mechanisms modifying glucose oxidation in diabetes mellitus
18. Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
19. Pyruvate inhibition of pyruvate dehydrogenase kinase. Effects of progressive starvation and hyperthyroidism in vivo, and of dibutyryl cyclic AMP and fatty acids in cultured cardiac myocytes
20. Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system
21. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
22. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
23. Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: Role of thyroid hormone status and lipid supply
24. Different mechanisms underlie the long-term regulation of pyruvate dehydrogenase kinase (PDHK) by tri-iodothyronine in heart and liver
25. Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats
26. Rat models of hypertension, cardiac hypertrophy and failure
27. Pressure overload induced in newborn rats: Effects on left ventricular growth, morphology, and function
28. Semiquantitative analysis of collagen types in the hypertrophied left ventricle
29. Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart
30. Contribution of glycogen to aerobic myocardial glucose utilization
31. Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle
32. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism
33. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue
34. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation
35. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
36. Glutamic dehydrogenase from rat heart mitochondria. I. Purification and physical properties including molecular weight determination
37. Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase
38. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases
39. Serum from patients with chronic renal insufficiency alters growth characteristics and ANP mRNA expression of adult rat cardiac myocytes
40. Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: Role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide
41. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
42. Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex
43. Regulation of heart muscle pyruvate dehydrogenase kinase
44. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat
45. Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts
46. Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy
47. Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts
48. Energy metabolism in normal and hypertrophied right ventricle of the ferret heart
49. The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity
50. Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy
51. Evidence for increased glycolytic metabolism in cardiac hypertrophy and congestive heart failure
52. Dichloroacetate-induced changes in liver of normal and diabetic rats
53. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo
54. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
55. Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization
56. Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy