Epigenetic determinants of erythropoiesis: Role of the histone methyltransferase SetD8 in promoting erythroid cell maturation and survival

Molecular and Cellular Biology

Volumn 35, Issue 12, 2015, Pages 2073-2087

  deVilbiss, Andrew W ^a   Sanalkumar, Rajendran ^a   Hall, Bryan D R ^a   Katsumura, Koichi R ^a   de Andrade, Isabela Fraga ^a   Bresnick, Emery H ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; HISTONE H4; HISTONE H4 LYSINE 20; HISTONE METHYLTRANSFERASE; PROTEIN BCL XL; PROTEIN SETD8; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; GATA2 PROTEIN, MOUSE; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; SETD8 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENHANCER REGION; EPIGENETICS; ERYTHROBLAST; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FETUS; GENE REPRESSION; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; TRANSCRIPTION INITIATION;

MURINAE;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; EPIGENESIS, GENETIC; ERYTHROID CELLS; ERYTHROPOIESIS; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; MICE; TRANSCRIPTIONAL ACTIVATION;

EID: 84929409244     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01422-14     Document Type: Article

References (86)

1. Bresnick EH, Katsumura KR, Lee HY, Johnson KD, Perkins AS. 2012. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res 40:5819-5831. http://dx.doi.org/10.1093/nar/gks281.
2. Merika M, Orkin SH. 1993. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13:3999-4010.
3. Ko LJ, Engel JD. 1993. DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol 13:4011-4022.
4. Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. 1991. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem 266:22948-22953.
5. Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. 1991. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A 88:10642-10646. http://dx.doi.org/10.1073/pnas.88.23.10642.
6. Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD. 1990. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev 4:1650-1662. http://dx.doi.org/10.1101/gad.4.10.1650.
7. Wilson DB, Dorfman DM, Orkin SH. 1990. A nonerythroid GATAbinding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol 10:4854-4862.
8. Nardelli J, Thiesson D, Fujiwara Y, Tsai F.-Y, Orkin SH. 1999. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol 210: 305-321. http://dx.doi.org/10.1006/dbio.1999.9278.
9. Gao X, Johnson KD, Chang YI, Boyer ME, Dewey CN, Zhang J, Bresnick EH. 2013. Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J Exp Med 210:2833-2842. http://dx.doi.org/10.1084/jem.20130733.
10. de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R, Kartalaei PS, Camper SA, Speck N, Dzierzak E. 2013. Gata2 is required for HSC generation and survival. J Exp Med 210:2843-2850. http://dx.doi.org/10.1084/jem.20130751.
11. Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221-226. http://dx.doi.org/10.1038/371221a0.
12. Tsai F-Y, Orkin SH. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89: 3636-3643.
13. Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E. 2004. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med 200:871-882. http://dx.doi.org/10.1084/jem.20031556.
14. Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, Raffeld M, Kuhns DB, Ding L, Paulson ML, Marciano BE, Gea-Banacloche JC, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM. 2011. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood 118:2653-2655. http://dx.doi.org/10.1182/blood-2011-05-356352.
15. Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. 2011. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 118:2656-2658. http://dx.doi.org/10.1182/blood-2011-06-360313.
16. Hahn CN, Chong CE, Carmichael CL, Wilkins EJ, Brautigan PJ, Li XC, Babic M, Lin M, Carmagnac A, Lee YK, Kok CH, Gagliardi L, Friend KL, Ekert PG, Butcher CM, Brown AL, Lewis ID, To LB, Timms AE, Storek J, Moore S, Altree M, Escher R, Bardy PG, Suthers GK, D'Andrea RJ, Horwitz MS, Scott HS. 2011. Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet 43:1012-1017. http://dx.doi.org/10.1038/ng.913.
17. Johnson KD, Hsu AP, Ryu MJ, Wang J, Gao X, Boyer ME, Liu Y, Lee Y, Calvo KR, Keles S, Zhang J, Holland SM, Bresnick EH. 2012. Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest 122:3692-3704. http://dx.doi.org/10.1172/JCI61623.
18. Hsu AP, Johnson KD, Falcone EL, Sanalkumar R, Sanchez L, Hickstein DD, Cuellar-Rodriguez J, Lemieux JE, Zerbe CS, Bresnick EH, Holland SM. 2013. GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome. Blood 121:3830-3837, S1-S7. http://dx.doi.org/10.1182/blood-2012-08-452763.
19. Sanalkumar R, Johnson KD, Gao X, Boyer ME, Chang YI, Hewitt KJ, Zhang J, Bresnick EH. 2014. Mechanism governing a stem cellgenerating cis-regulatory element. Proc Natl Acad Sci U S A 111:E1091-E1100. http://dx.doi.org/10.1073/pnas.1400065111.
20. Kang YA, Sanalkumar R, O'Geen H, Linnemann AK, Chang CJ, Bouhassira EE, Farnham PJ, Keles S, Bresnick EH. 2012. Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol 32:226-239. http://dx.doi.org/10.1128/MCB.06166-11.
21. Fujiwara T, O'Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA, Choi K, Farnham PJ, Bresnick EH. 2009. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 36:667-681. http://dx.doi.org/10.1016/j.molcel.2009.11.001.
22. Grass JA, Jing H, Kim S-I, Martowicz ML, Pal S, Blobel GA, Bresnick EH. 2006. Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol 26:7056-7067. http://dx.doi.org/10.1128/MCB.01033-06.
23. Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339:446-451. http://dx.doi.org/10.1038/339446a0.
24. Evans T, Felsenfeld G. 1989. The erythroid-specific transcription factor Eryf1: a new finger protein. Cell 58:877-885. http://dx.doi.org/10.1016/0092-8674(89)90940-9.
25. Evans T, Reitman M, Felsenfeld G. 1988. An erythrocyte-specific DNAbinding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A 85:5976-5980. http://dx.doi.org/10.1073/pnas.85.16.5976.
26. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257-260. http://dx.doi.org/10.1038/349257a0.
27. Simon MC, Pevny L, Wiles MV, Keller G, Costantini F, Orkin SH. 1992. Rescue of erythroid development in gene targeted GATA-1-mouse embryonic stem cells. Nat Genet 1:92-98. http://dx.doi.org/10.1038/ng0592-92.
28. Pevny L, Lin CS, D'Agati V, Simon MC, Orkin SH, Costantini F. 1995. Development of hematopoietic cells lacking transcription factor GATA-1. Development 121:163-172.
29. Grass JA, Boyer ME, Pal S, Wu J, Weiss MJ, Bresnick EH. 2003. GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci USA 100:8811-8816. http://dx.doi.org/10.1073/pnas.1432147100.
30. Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. 1997. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90:109-119. http://dx.doi.org/10.1016/S0092-8674(00)80318-9.
31. Crispino JD, Lodish MB, MacKay JP, Orkin SH. 1999. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell 3:219-228. http://dx.doi.org/10.1016/S1097-2765(00)80312-3.
32. Johnson KD, Boyer ME, Kang JA, Wickrema A, Cantor AB, Bresnick EH. 2007. Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood 109:5230-5233. http://dx.doi.org/10.1182/blood-2007-02-072983.
33. Bresnick EH, Lee HY, Fujiwara T, Johnson KD, Keles S. 2010. GATA switches as developmental drivers. J Biol Chem 285:31087-31093. http://dx.doi.org/10.1074/jbc.R110.159079.
34. Dore LC, Chlon TM, Brown CD, White KP, Crispino JD. 2012. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood 119:3724-3733. http://dx.doi.org/10.1182/blood-2011-09-380634.
35. May G, Soneji S, Tipping AJ, Teles J, McGowan SJ, Wu M, Guo Y, Fugazza C, Brown J, Karlsson G, Pina C, Olariu V, Taylor S, Tenen DG, Peterson C, Enver T. 2013. Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors. Cell Stem Cell 13:754-768. http://dx.doi.org/10.1016/j.stem.2013.09.003.
36. Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. 2013. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes Cells 18:921-933. http://dx.doi.org/10.1111/gtc.12086.
37. Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. 1998. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A 95: 2061-2066. http://dx.doi.org/10.1073/pnas.95.5.2061.
38. Hong W, Nakazawa M, Chen YY, Kori R, Vakoc CR, Rakowski C, Blobel GA. 2005. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J 24:2367-2378. http://dx.doi.org/10.1038/sj.emboj.7600703.
39. Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. 2010. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocyticerythroid compartment. Blood 115:2156-2166. http://dx.doi.org/10.1182/blood-2009-10-251280.
40. Gao Z, Huang Z, Olivey HE, Gurbuxani S, Crispino JD, Svensson EC. 2010. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 29:457-468. http://dx.doi.org/10.1038/emboj.2009.368.
41. DeVilbiss AW, Boyer ME, Bresnick EH. 2013. Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators. Proc Natl Acad Sci U S A 110:E3398-E3407. http://dx.doi.org/10.1073/pnas.1302771110.
42. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D. 2002. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 9:1201-1213. http://dx.doi.org/10.1016/S1097-2765(02)00548-8.
43. Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM, Torres-Padilla ME, Heard E, Reinberg D. 2009. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol 29:2278-2295. http://dx.doi.org/10.1128/MCB.01768-08.
44. Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD. 2002. Mitotic-specific methylation of histone H4 Lys 20 follows increased PRSet7 expression and its localization to mitotic chromosomes. Genes Dev 16:2225-2230. http://dx.doi.org/10.1101/gad.1014902.
45. Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC. 2010. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev 24:2531-2542. http://dx.doi.org/10.1101/gad.1984210.
46. Trojer P, Li G, Sims RJ, III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D. 2007. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 129:915-928. http://dx.doi.org/10.1016/j.cell.2007.03.048.
47. Congdon LM, Houston SI, Veerappan CS, Spektor TM, Rice JC. 2010. PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression. J Cell Biochem 110: 609-619. http://dx.doi.org/10.1002/jcb.22570.
48. Cui K, Zang C, Roh TY, Schones DE, Childs RW, Peng W, Zhao K. 2009. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4:80-93. http://dx.doi.org/10.1016/j.stem.2008.11.011.
49. Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I, Zhao K. 2007. High-resolution profiling of histone methylations in the human genome. Cell 129:823-837. http://dx.doi.org/10.1016/j.cell.2007.05.009.
50. Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh TY, Peng W, Zhang MQ, Zhao K. 2008. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 40:897-903. http://dx.doi.org/10.1038/ng.154.
51. Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA, Weiss MJ. 2004. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104:3136-3147. http://dx.doi.org/10.1182/blood-2004-04-1603.
52. Weiss MJ, Yu C, Orkin SH. 1997. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a genetargeted cell line. Mol Cell Biol 17:1642-1651.
53. Im H, Grass JA, Johnson KD, Boyer ME, Wu J, Bresnick EH. 2004. Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol Biol 284:129-146. http://dx.doi.org/10.1385/1-59259-816-1:129.
54. Im H, Grass JA, Johnson KD, Kim S-I, Boyer ME, Imbalzano AN, Bieker JJ, Bresnick EH. 2005. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A 102:17065-17070. http://dx.doi.org/10.1073/pnas.0506164102.
55. Wozniak RJ, Keles S, Lugus JJ, Young K, Boyer ME, Tran TT, Choi K, Bresnick EH. 2008. Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol 28: 6681-6694. http://dx.doi.org/10.1128/MCB.01061-08.
56. Katsumura KR, Yang C, Boyer ME, Li L, Bresnick EH. 2014. Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2. EMBORep 15:938-947. http://dx.doi.org/10.15252/embr.201438808.
57. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. 1999. GATA-1 and erythropoietin cooperate to promoter erythroid cell survival by regulating bcl-xl expression. Blood 94:87-96.
58. Persons DA, Allay JA, Allay ER, Ashmun RA, Orlic D, Jane SM, Cunningham JM, Nienhuis AW. 1999. Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood 93: 488-499.
59. Bresnick EH, Martowicz ML, Pal S, Johnson KD. 2005. Developmental control via GATA factor interplay at chromatin domains. J Cell Physiol 205:1-9. http://dx.doi.org/10.1002/jcp.20393.
60. Sangiorgi F, Woods CM, Lazarides E. 1990. Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage. Development 110:85-96.
61. Ngai J, Capetanaki YG, Lazarides E. 1984. Differentiation of murine erythroleukemia cells results in the rapid repression of vimentin gene expression. J Cell Biol 99:306-314. http://dx.doi.org/10.1083/jcb.99.1.306.
62. Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA. 2008. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell 29: 232-242. http://dx.doi.org/10.1016/j.molcel.2007.11.020.
63. DeVilbiss AW, Sanalkumar R, Johnson KD, Keles S, Bresnick EH. 2014. Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. Exp Hematol 42:618-629. http://dx.doi.org/10.1016/j.exphem.2014.05.004.
64. Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, Engel JD. 2012. Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest 122:3705-3717. http://dx.doi.org/10.1172/JCI61619.
65. Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. 2010. A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet 6:e1001103. http://dx.doi.org/10.1371/journal.pgen.1001103.
66. Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. 2011. Context-dependent function of "GATA switch" sites in vivo. Blood 117:4769-4772. http://dx.doi.org/10.1182/blood-2010-10-313031.
67. Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M. 2014. A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell 25:415-427. http://dx.doi.org/10.1016/j.ccr.2014.02.008.
68. Groschel S, Sanders MA, Hoogenboezem R, de Wit E, Bouwman BA, Erpelinck C, van der Velden VH, Havermans M, Avellino R, van Lom K, Rombouts EJ, van Duin M, Dohner K, Beverloo HB, Bradner JE, Dohner H, Lowenberg B, Valk PJ, Bindels EM, de Laat W, Delwel R. 2014. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell 157:369-381. http://dx.doi.org/10.1016/j.cell.2014.02.019.
69. Wong P, Hattangadi SM, Cheng AW, Frampton GM, Young RA, Lodish HF. 2011. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 118:e128-e138. http://dx.doi.org/10.1182/blood-2011-03-341404.
70. Tripic T, Deng W, Cheng Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA. 2009. SCL and associated protein distinguish active from repressive GATA transcription factor complexes. Blood 113:2191-2201. http://dx.doi.org/10.1182/blood-2008-07-169417.
71. Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. 2009. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 36:682-695. http://dx.doi.org/10.1016/j.molcel.2009.11.002.
72. Wu W, Morrissey CS, Keller CA, Mishra T, Pimkin M, Blobel GA, Weiss MJ, Hardison RC. 2014. Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis. Genome Res 24:1945-1962. http://dx.doi.org/10.1101/gr.164830.113.
73. Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Gottgens B. 2010. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7:532-544. http://dx.doi.org/10.1016/j.stem.2010.07.016.
74. Swygert SG, Peterson CL. 2014. Chromatin dynamics: interplay between remodeling enzymes and histone modifications. Biochim Biophys Acta 1839:728-736. http://dx.doi.org/10.1016/j.bbagrm.2014.02.013.
75. Bartholomew B. 2014. Regulating the chromatin landscape: structural and mechanistic perspectives. Annu Rev Biochem 83:671-696. http://dx.doi.org/10.1146/annurev-biochem-051810-093157.
76. Beck DB, Oda H, Shen SS, Reinberg D. 2012. PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev 26:325-337. http://dx.doi.org/10.1101/gad.177444.111.
77. Hattangadi SM, Wong P, Zhang L, Flygare J, Lodish HF. 2011. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood 118:6258-6268. http://dx.doi.org/10.1182/blood-2011-07-356006.
78. Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. 2011. Global DNA demethylation during mouse erythropoiesis in vivo. Science 334:799-802. http://dx.doi.org/10.1126/science.1207306.
79. Malik J, Getman M, Steiner LA. 2015. Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation. Mol Cell Biol 35:2059-2072. doi:http://dx.doi.org/10.1128/MCB.01413-14.
80. Pop R, Shearstone JR, Shen Q, Liu Y, Hallstrom K, Koulnis M, Gribnau J, Socolovsky M. 2010. A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol 8(9):pii:e1000484. http://dx.doi.org/10.1371/journal.pbio.1000484.
81. Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem cell homeostasis. Blood 106:477-484. http://dx.doi.org/10.1182/blood-2004-08-2989.
82. Luesink M, Hollink IH, van der Velden VH, Knops RH, Boezeman JB, de Haas V, Trka J, Baruchel A, Reinhardt D, van der Reijden BA, van den Heuvel-Eibrink MM, Zwaan CM, Jansen JH. 2012. High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia. Blood 120: 2064-2075. http://dx.doi.org/10.1182/blood-2011-12-397083.
83. Vicente C, Vazquez I, Conchillo A, Garcia-Sanchez MA, Marcotegui N, Fuster O, Gonzalez M, Calasanz MJ, Lahortiga I, Odero MD. 2012. Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities. Leukemia 26:550-554. http://dx.doi.org/10.1038/leu.2011.235.
84. Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH. 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBOJ 16:3145-3157. http://dx.doi.org/10.1093/emboj/16.11.3145.
85. Wozniak RJ, Boyer ME, Grass JA, Lee Y, Bresnick EH. 2007. Contextdependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells. J Biol Chem 282:14665-14674. http://dx.doi.org/10.1074/jbc.M700792200.
86. Lee HY, Johnson KD, Boyer ME, Bresnick EH. 2011. Relocalizing genetic loci into specific subnuclear neighborhoods. J Biol Chem 286: 18834-18844. http://dx.doi.org/10.1074/jbc.M111.221481.