Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages

Nature Communications

Volumn 6, Issue , 2015, Pages

  Wen, Mingyue ^a   Ma, Xianwei ^a   Cheng, Hong ^b   Jiang, Wei ^a   Xu, Xiongfei ^a   Zhang, Yi ^a   Zhang, Yan ^a   Guo, Zhenhong ^a   Yu, Yizhi ^a   Xu, Hongmei ^a   Qian, Cheng ^a   Cao, Xuetao ^a   An, Huazhang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; PROTEIN KINASE; SMURF1 PROTEIN; STK38 PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYTOKINE; MAP3K2 PROTEIN, HUMAN; MAP3K2 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; N-MYC DOWNSTREAM-REGULATED GENE 1 PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SMURF1 PROTEIN, MOUSE; STK38 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN; TLR9 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ENZYME ACTIVITY; IMMUNE RESPONSE; INHIBITION; RODENT; SIGNAL; YEAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; EXPERIMENTAL PERITONITIS; FEMALE; GENE EXPRESSION; HEK293 CELL LINE; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; LETHALITY; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; SURVIVAL RATE; UBIQUITINATION; ANIMAL; C57BL MOUSE; CHEMISTRY; CPG ISLAND; DRUG EFFECTS; GENETICS; HELA CELL LINE; HETEROZYGOTE; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; RNA INTERFERENCE; TIME FACTOR;

MUS;

ANIMALS; CELL CYCLE PROTEINS; CPG ISLANDS; CYTOKINES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; HEK293 CELLS; HELA CELLS; HETEROZYGOTE; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MAP KINASE KINASE KINASE 2; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84929379233     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8167     Document Type: Article

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