Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

Toxicology and Applied Pharmacology

Volumn 284, Issue 2, 2015, Pages 273-280

  Alves, Vinicius M ^a,b   Muratov, Eugene ^b,c   Fourches, Denis ^b   Strickland, Judy ^d   Kleinstreuer, Nicole ^d   Andrade, Carolina H ^a   Tropsha, Alexander ^b  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c A V BOGATSKY PHYSICO CHEMICAL INSTITUTE   (Ukraine)

^d ILS NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)   (United States)

Author keywords

QSAR; Skin permeability; Skin sensitization; Skin toxicants; Virtual screening

Indexed keywords

DANGEROUS GOODS;

COMPUTER SIMULATION; DANGEROUS GOODS; DERMATITIS, ALLERGIC CONTACT; DRUG EFFECTS; FACTUAL DATABASE; HUMAN; IMMUNOLOGY; INTOXICATION; METABOLISM; PERMEABILITY; PHYSIOLOGY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SKIN; SKIN ABSORPTION; SOFTWARE; THEORETICAL MODEL;

COMPUTER SIMULATION; DATABASES, FACTUAL; DERMATITIS, ALLERGIC CONTACT; HAZARDOUS SUBSTANCES; HUMANS; MODELS, THEORETICAL; PERMEABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; SKIN ABSORPTION; SOFTWARE;

EID: 84929366157     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.12.013     Document Type: Article

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