An evaluation of the potential of linear and nonlinear skin permeation models for the prediction of experimentally measured percutaneous drug absorption

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 4, 2012, Pages 566-577

  Brown, Marc B ^a,b   Lau, Chi Hian ^a   Lim, Sian T ^a   Sun, Yi ^b   Davey, Neail ^b   Moss, Gary P ^c   Yoo, Seon Hie ^d   De Muynck, Christian ^d  

^a MEDPHARM LTD   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

^d Nycomed   (Germany)

Author keywords

in silico; in vitro; mathematical models; prediction; skin permeation

Indexed keywords

DRUG;

5F MODEL; ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG SOLUBILITY; GAUSSIAN PROCESS REGRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MACHINE LEARNING; MATHEMATICAL MODEL; POTTS AND GUY MODEL; QUANTITATIVE STRUCTURE PERMEABILITY RELATIONSHIP; QUANTITATIVE STRUCTURE PROPERTY RELATION; SKIN ABSORPTION; TRANSPORT KINETICS; WILSCHUT ROBINSON MODEL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; FEMALE; HUMANS; LINEAR MODELS; MIDDLE AGED; MODELS, THEORETICAL; NONLINEAR DYNAMICS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN ABSORPTION;

EID: 84862819920     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01436.x     Document Type: Article

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