The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 11, 2011, Pages 1411-1427

  Moss, Gary P ^a   Sun, Yi ^b   Wilkinson, Simon C ^c   Davey, Neil ^b   Adams, Rod ^b   Martin, Gary P ^d   Prapopopolou, M ^d   Brown, Marc B ^e  

^a KEELE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e MEDPHARM LTD   (United Kingdom)

Author keywords

Gaussian processes; in vitro methods; percutaneous absorption; quantitative structure permeability relationships

Indexed keywords

DIMETICONE;

ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; ARTIFICIAL NEURAL NETWORK; CONTROLLED STUDY; CORRELATION COEFFICIENT; COVARIANCE; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; INTERMETHOD COMPARISON; KERNEL METHOD; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; REGRESSION ANALYSIS; SKIN ABSORPTION; SKIN PERMEABILITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL MEMBRANE PERMEABILITY; DIMETHYLPOLYSILOXANES; HUMANS; MEMBRANES, ARTIFICIAL; MICE; MODELS, ANIMAL; MODELS, THEORETICAL; NORMAL DISTRIBUTION; RATS; SKIN; SKIN ABSORPTION; SWINE;

EID: 80054115151     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01345.x     Document Type: Article

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