Proteasome-mediated Proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis

Journal of Biological Chemistry

Volumn 290, Issue 20, 2015, Pages 12572-12584

  Heine, Erin M ^a   Berger, Tamar R ^a   Pluciennik, Anna ^a   Orr, Christopher R ^a   Zboray, Lori ^a   Merry, Diane E ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEURODEGENERATIVE DISEASES; PROTEOLYSIS; TOXICITY;

ANDROGEN RECEPTORS; BIOCHEMICAL ANALYSIS; FULL-LENGTH PROTEINS; MUTANT PROTEINS; NEURONAL DYSFUNCTION; NUCLEAR INCLUSIONS; POLYGLUTAMINE DISEASE; POLYGLUTAMINE PROTEINS;

PROTEINS;

ANDROGEN RECEPTOR; ANTIBODY; ANTIBODY 3B5H10; POLYGLUTAMINE; PROTEASOME; UNCLASSIFIED DRUG; PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS INCLUSION BODY; EMBRYO; IMMUNOCYTOCHEMISTRY; KENNEDY DISEASE; MALE; MOUSE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN STRUCTURE; RECEPTOR BINDING; ANIMAL; GENETICS; METABOLISM; MUSCLE ATROPHY; PATHOLOGY; PC12 CELL LINE; PROTEINOSIS; RAT;

ANIMALS; MICE; MUSCULAR DISORDERS, ATROPHIC; PC12 CELLS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEOLYSIS; RATS; RECEPTORS, ANDROGEN;

EID: 84929340862     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.617894     Document Type: Article

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