Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure

Journal of Molecular Biology

Volumn 421, Issue 4-5, 2012, Pages 587-600

  Peters Libeu, Clare ^a,b   Miller, Jason ^a,c   Rutenber, Earl ^a,b   Newhouse, Yvonne ^a,b   Krishnan, Preethi ^a,c   Cheung, Kenneth ^a,c   Hatters, Danny ^a,b   Brooks, Elizabeth ^a,c   Widjaja, Kartika ^a,c   Tran, Tina ^a,c   Mitra, Siddhartha ^a,c   Arrasate, Montserrat ^a,c   Mosquera, Luis A ^d   Taylor, Dean ^c   Weisgraber, Karl H ^a,b,c   Finkbeiner, Steven ^a,c,e  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Sunol Molecular Corporation   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amyloid; antibody; huntingtin structure; Huntington's disease; polyglutamine expansion

Indexed keywords

EPITOPE; HUNTINGTIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; POLYGLUTAMINE;

ARTICLE; HUNTINGTON CHOREA; IMMUNOGLOBULIN STRUCTURE; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

EID: 84862700907     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.01.034     Document Type: Article

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