Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

Cell Communication and Signaling

Volumn 13, Issue 1, 2015, Pages

  Cursons, Joseph ^a   Leuchowius, Karl Johan ^b,c   Waltham, Mark ^d   Tomaskovic Crook, Eva ^d   Foroutan, Momeneh ^a   Bracken, Cameron P ^e,f   Redfern, Andrew ^g   Crampin, Edmund J ^a,h,i   Street, Ian ^b,c   Davis, Melissa J ^a   Thompson, Erik W ^c,d,j  

^a The University of Melbourne   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^f UNIVERSITY OF ADELAIDE   (Australia)

^g ROYAL PERTH HOSPITAL   (Australia)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

^j QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

more..

Author keywords

AKT; Breast cancer; EGF; EMT; Epithelial mesenchymal plasticity; Hypoxia; MDA MB 468; MEK; Metastasis

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 4 AMINO N [1 (4 CHLOROPHENYL) 3 HYDROXYPROPYL] 1 (7H PYRROLO[2,3 D]PYRIMIDIN 4 YL) 4 PIPERIDINECARBOXAMIDE; 6 (2,6 DICHLOROPHENYL) 8 METHYL 2 (3 METHYLTHIOANILINO) 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; AFATINIB; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; AV 412; BOSUTINIB; DACTOLISIB; DASATINIB; EPIDERMAL GROWTH FACTOR; ERLOTINIB; EVEROLIMUS; GEFITINIB; GNE 493; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LAPATINIB; N (2,3 DIHYDRO 7,8 DIMETHOXYIMIDAZO[1,2 C]QUINAZOLIN 5 YL)NICOTINAMIDE; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PD 173952; PD 198306; PHOSPHOTRANSFERASE INHIBITOR; PICTILISIB; SARACATINIB; SELUMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN A; 4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, HUMAN; PROTEIN KINASE B; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BREAST CANCER CELL LINE; CANCER GROWTH; CELL HYPOXIA; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIAL MESENCHYMAL PLASTICITY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MDA MB 468 CANCER CELL LINE; PHENOTYPE; PMC42 ET CANCER CELL LINE; PMC42 LA CANCER CELL LINE; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA SEQUENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; DRUG EFFECTS; METABOLISM; METASTASIS; PATHOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; EVEROLIMUS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; PYRROLES; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84929321877     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/s12964-015-0106-x     Document Type: Article

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