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Volumn 15, Issue 7, 2015, Pages 524-528

The therapeutic potential of rutin for diabetes: An update

Author keywords

Anti inflammatory; Antioxidant; Diabetes; Multifunctional compound; Organ protection; Rutin

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CHOLESTEROL; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 2; LAMININ; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; REACTIVE OXYGEN METABOLITE; RUTOSIDE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; ANTIDIABETIC AGENT;

EID: 84929306925     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955751507150424103721     Document Type: Article
Times cited : (64)

References (63)
  • 1
    • 67649351473 scopus 로고    scopus 로고
    • (Accessed October 31, 2014)
    • Diabetes: Fact sheet No.312. http://www.who.int/mediacentre/ factsheets/fs312/en/index.html (Accessed October 31, 2014).
    • Diabetes: Fact sheet No.312
  • 2
    • 82955247909 scopus 로고    scopus 로고
    • IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • Whitingc, D.R.; Guariguata, L.; Weil, C.; Shaw, J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diab. Res. Clin. Pract., 2011, 94, 311-321.
    • (2011) Diab. Res. Clin. Pract , vol.94 , pp. 311-321
    • Whitingc, D.R.1    Guariguata, L.2    Weil, C.3    Shaw, J.4
  • 3
    • 84907302919 scopus 로고    scopus 로고
    • The Antidiabetic Therapeutic Potential of Dietary Polyphenols
    • Habtemariam, S.; Varghese, G.K. The Antidiabetic Therapeutic Potential of Dietary Polyphenols. Cur. Pharm. Biotechnol., 2014, 15, 391-400.
    • (2014) Cur. Pharm. Biotechnol , vol.15 , pp. 391-400
    • Habtemariam, S.1    Varghese, G.K.2
  • 4
    • 84861803291 scopus 로고    scopus 로고
    • Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia
    • Roselli, M.; Lentini, G.; Habtemariam, S. Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia. Phytothe. Res., 2012, 26, 908-914.
    • (2012) Phytothe. Res , vol.26 , pp. 908-914
    • Roselli, M.1    Lentini, G.2    Habtemariam, S.3
  • 5
    • 79960843843 scopus 로고    scopus 로고
    • Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats
    • Arjumand, W.; Seth, A.; Sultana, S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats. Food Chem. Toxicol., 2011, 49(9), 2013-2021.
    • (2011) Food Chem. Toxicol , vol.49 , Issue.9 , pp. 2013-2021
    • Arjumand, W.1    Seth, A.2    Sultana, S.3
  • 6
    • 58249128687 scopus 로고    scopus 로고
    • Rutin has therapeutic effect on septic arthritis caused by Candida albicans
    • Han, Y. Rutin has therapeutic effect on septic arthritis caused by Candida albicans. Int. Immunopharmacol., 2009, 9(2), 207-211.
    • (2009) Int. Immunopharmacol , vol.9 , Issue.2 , pp. 207-211
    • Han, Y.1
  • 7
    • 84864076531 scopus 로고    scopus 로고
    • Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo
    • Lee, W.; Ku, S.K.; Bae, J.S. Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo. Food Chem. Toxicol., 2012, 50(9), 3048-3055.
    • (2012) Food Chem. Toxicol , vol.50 , Issue.9 , pp. 3048-3055
    • Lee, W.1    Ku, S.K.2    Bae, J.S.3
  • 8
    • 84861200675 scopus 로고    scopus 로고
    • Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type
    • Javed, H.; Khan, M.M.; Ahmad, A.; Vaibhav, K.; Ahmad, M.E.; Khan, A.; Ashafaq, M.; Islam, F.; Siddiqui, MS.; Safhi, MM.; Islam, F. Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience, 2012, 210, 340-352.
    • (2012) Neuroscience , vol.210 , pp. 340-352
    • Javed, H.1    Khan, M.M.2    Ahmad, A.3    Vaibhav, K.4    Ahmad, M.E.5    Khan, A.6    Ashafaq, M.7    Islam, F.8    Siddiqui, M.S.9    Safhi, M.M.10    Islam, F.11
  • 9
    • 84867663872 scopus 로고    scopus 로고
    • Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats
    • Pyrzanowska, J.; Piechal, A.; Blecharz-Klin, K.; Joniec-Maciejak, I.; Zobel, A.; Widy-Tyszkiewicz, E. Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats. Pharmacol. Rep., 2012, 64(4), 808-816.
    • (2012) Pharmacol. Rep , vol.64 , Issue.4 , pp. 808-816
    • Pyrzanowska, J.1    Piechal, A.2    Blecharz-Klin, K.3    Joniec-Maciejak, I.4    Zobel, A.5    Widy-Tyszkiewicz, E.6
  • 10
    • 84886092169 scopus 로고    scopus 로고
    • Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice
    • Gao, M.; Ma, Y.; Liu, D. Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. Pharm. Res., 2013, 30(11), 2940- 2950.
    • (2013) Pharm. Res , vol.30 , Issue.11 , pp. 2940-2950
    • Gao, M.1    Ma, Y.2    Liu, D.3
  • 11
    • 84896346155 scopus 로고    scopus 로고
    • Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis
    • Chen, H.; Miao, Q.; Geng, M.; Liu, J.; Hu, Y.; Tian, L.; Pan, J.; Yang, Y. Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Sci. World J., 2013, 2013, 269165.
    • (2013) Sci. World J , vol.2013
    • Chen, H.1    Miao, Q.2    Geng, M.3    Liu, J.4    Hu, Y.5    Tian, L.6    Pan, J.7    Yang, Y.8
  • 13
    • 84899631802 scopus 로고    scopus 로고
    • Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice
    • Machawal, L.; Kumar, A. Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice. Pharmacol. Rep., 2014, 66(1), 15-21.
    • (2014) Pharmacol. Rep , vol.66 , Issue.1 , pp. 15-21
    • Machawal, L.1    Kumar, A.2
  • 14
    • 84878240917 scopus 로고    scopus 로고
    • Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity
    • Magalingam, K.B.; Radhakrishnan, A.; Haleagrahara, N. Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Int. J. Mol. Med., 2013, 32, 235-240.
    • (2013) Int. J. Mol. Med , vol.32 , pp. 235-240
    • Magalingam, K.B.1    Radhakrishnan, A.2    Haleagrahara, N.3
  • 15
    • 80052947979 scopus 로고    scopus 로고
    • Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice
    • Tongjaroenbuangam, W.; Ruksee, N.; Chantiratikul, P.; Pakdeenarong, N.; Kongbuntad, W.; Govitrapong, P. Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice. Neurochem. Int., 2011, 59(5), 677-685.
    • (2011) Neurochem. Int , vol.59 , Issue.5 , pp. 677-685
    • Tongjaroenbuangam, W.1    Ruksee, N.2    Chantiratikul, P.3    Pakdeenarong, N.4    Kongbuntad, W.5    Govitrapong, P.6
  • 16
    • 84865255311 scopus 로고    scopus 로고
    • Hypoglycaemic effect of Melothria heterophylla in streptozotocin-induced diabetic rats
    • Mondal, A.; Maity, T.K.; Pal, D. Hypoglycaemic effect of Melothria heterophylla in streptozotocin-induced diabetic rats. Pharm. Biol., 2012, 50(9), 1151-1156.
    • (2012) Pharm. Biol , vol.50 , Issue.9 , pp. 1151-1156
    • Mondal, A.1    Maity, T.K.2    Pal, D.3
  • 17
    • 77953902140 scopus 로고    scopus 로고
    • Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats
    • Rauter, A.P.; Martins, A.; Borges, C.; Mota-Filipe, H.; Pinto, R.; Sepodes, B.; Justino, J. Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res., 2010, S2, S133-S138.
    • (2010) Phytother Res , vol.S2 , pp. S133-S138
    • Rauter, A.P.1    Martins, A.2    Borges, C.3    Mota-Filipe, H.4    Pinto, R.5    Sepodes, B.6    Justino, J.7
  • 18
    • 33747074105 scopus 로고    scopus 로고
    • The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney
    • Kamalakkannan, N.; Stanely, M.P.P. The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. J. Pharm. Pharmacol., 2006, 58(8), 1091-1098.
    • (2006) J. Pharm. Pharmacol , vol.58 , Issue.8 , pp. 1091-1098
    • Kamalakkannan, N.1    Stanely, M.P.P.2
  • 19
    • 33750072937 scopus 로고    scopus 로고
    • Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats
    • Stanely, M.P.P.; Kannan, N.K. Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. J. Pharm. Pharmacol., 2006, 58(10), 1373-1383.
    • (2006) J. Pharm. Pharmacol , vol.58 , Issue.10 , pp. 1373-1383
    • Stanely, M.P.P.1    Kannan, N.K.2
  • 20
    • 33750042821 scopus 로고    scopus 로고
    • Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues
    • Kamalakkannan, N.; Stanely M.P.P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol. Cell. Biochem., 2006, 293(1-2), 211-219.
    • (2006) Mol. Cell. Biochem , vol.293 , Issue.1-2 , pp. 211-219
    • Kamalakkannan, N.1    Stanely, M.P.P.2
  • 21
    • 33645103657 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats
    • Kamalakkannan, N.; Prince, P.S. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic. Clin. Pharmacol. Toxicol., 2006, 98(1), 97-03.
    • (2006) Basic. Clin. Pharmacol. Toxicol , vol.98 , Issue.1 , pp. 97-103
    • Kamalakkannan, N.1    Prince, P.S.2
  • 24
    • 84867849002 scopus 로고    scopus 로고
    • Preventive effects of rutin on the development of experimental diabetic nephropathy in rats
    • Hao, H.H.; Shao, Z.M.; Tang, D.Q.; Lu, Q.; Chen, X.; Yin, X.X.; Wu, J.; Chen, H. Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci., 2012, 91(19- 20), 959-967.
    • (2012) Life Sci , vol.91 , Issue.19-20 , pp. 959-967
    • Hao, H.H.1    Shao, Z.M.2    Tang, D.Q.3    Lu, Q.4    Chen, X.5    Yin, X.X.6    Wu, J.7    Chen, H.8
  • 25
    • 84901919044 scopus 로고    scopus 로고
    • Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation
    • Hsu, C.Y.; Shih, H.Y.; Chia, Y.C.; Lee, C.H.; Ashida, H.; Lai, Y.K.; Weng, C.F. Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation. Mol. Nutr. Food Res., 2014, 58(6), 1168-1176.
    • (2014) Mol. Nutr. Food Res , vol.58 , Issue.6 , pp. 1168-1176
    • Hsu, C.Y.1    Shih, H.Y.2    Chia, Y.C.3    Lee, C.H.4    Ashida, H.5    Lai, Y.K.6    Weng, C.F.7
  • 26
    • 84869809410 scopus 로고    scopus 로고
    • Chlorogenic acid and rutin play a major role in the in vivo antidiabetic activity of Morus alba leaf extract on type II diabetic rats
    • Hunyadi, A.; Martins, A.; Hsieh, T.J.; Seres, A.; Zupko, I. Chlorogenic acid and rutin play a major role in the in vivo antidiabetic activity of Morus alba leaf extract on type II diabetic rats. PLoS One, 2012, 7(11), e50619.
    • (2012) PLoS One , vol.7 , Issue.11
    • Hunyadi, A.1    Martins, A.2    Hsieh, T.J.3    Seres, A.4    Zupko, I.5
  • 27
    • 79954484907 scopus 로고    scopus 로고
    • α-Glucosidase inhibitory activity of kaempferol- 3-O-rutinoside
    • Habtemariam, S. α-Glucosidase inhibitory activity of kaempferol- 3-O-rutinoside. Nat. Prod. Commun., 2011, 6(2), 201-203.
    • (2011) Nat. Prod. Commun , vol.6 , Issue.2 , pp. 201-203
    • Habtemariam, S.1
  • 28
    • 34548477225 scopus 로고    scopus 로고
    • α - Glucosidase inhibitory effect by the flower buds of Tussilago farfara L
    • Gao, H.; Huang, Y-N.; Xu, P-Y.; Inagaki, C.; Kawabata, J. α - Glucosidase inhibitory effect by the flower buds of Tussilago farfara L. Food Chem., 2008, 106(3), 1195-1201.
    • (2008) Food Chem , vol.106 , Issue.3 , pp. 1195-1201
    • Gao, H.1    Huang, Y.-N.2    Xu, P.-Y.3    Inagaki, C.4    Kawabata, J.5
  • 29
    • 73349100639 scopus 로고    scopus 로고
    • Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase
    • Li, Y.Q.; Zhou, F.C.; Gao, F.; Bian, J.S.; Shan, F. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. J. Agric. Food Chem., 2009, 57(24), 11463- 11468.
    • (2009) J. Agric. Food Chem , vol.57 , Issue.24 , pp. 11463-11468
    • Li, Y.Q.1    Zhou, F.C.2    Gao, F.3    Bian, J.S.4    Shan, F.5
  • 30
    • 84906066628 scopus 로고    scopus 로고
    • α -Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves
    • Pham, A.T.; Malterud, K.E.; Paulsen, B.S.; Diallo, D.; Wangensteen, H. α -Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves. Pharm. Biol., 2014, 52(9), 1166-1169.
    • (2014) Pharm. Biol , vol.52 , Issue.9 , pp. 1166-1169
    • Pham, A.T.1    Malterud, K.E.2    Paulsen, B.S.3    Diallo, D.4    Wangensteen, H.5
  • 31
    • 77956629122 scopus 로고    scopus 로고
    • Natural products as alphaamylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: An update
    • Tundis, R.; Loizzo, M.R.; Menichini, F. Natural products as alphaamylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: An update. Mini. Rev. Med. Chem., 2010, 10(4), 315-331.
    • (2010) Mini. Rev. Med. Chem , vol.10 , Issue.4 , pp. 315-331
    • Tundis, R.1    Loizzo, M.R.2    Menichini, F.3
  • 32
    • 84874934910 scopus 로고    scopus 로고
    • Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle
    • Kappel, V.D.; Zanatta, L.; Postal, BG.; Silva, F.R. Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle. Arch Biochem Biophys., 2013, 532(2), 55-60.
    • (2013) Arch Biochem Biophys , vol.532 , Issue.2 , pp. 55-60
    • Kappel, V.D.1    Zanatta, L.2    Postal, B.G.3    Silva, F.R.4
  • 34
    • 84871755225 scopus 로고    scopus 로고
    • Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activatedprotein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells
    • Lee, J.O.; Lee, S.K.; Kim, J.H.; Kim, N.; You, G.Y.; Moon, J.W.; Kim, S.J.; Park, S.H.; Kim, H.S. Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activatedprotein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells. J. Biol. Chem., 2012, 287(53), 44121-44129.
    • (2012) J. Biol. Chem , vol.287 , Issue.53 , pp. 44121-44129
    • Lee, J.O.1    Lee, S.K.2    Kim, J.H.3    Kim, N.4    You, G.Y.5    Moon, J.W.6    Kim, S.J.7    Park, S.H.8    Kim, H.S.9
  • 35
    • 84897094099 scopus 로고    scopus 로고
    • Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide
    • Dhanya, R.; Arun, K.B.; Syama, H.P.; Nisha, P.; Sundaresan, A.; Santhosh, K.T.R.; Jayamurthy, P. Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide. Food Chem., 2014, 158, 546-554.
    • (2014) Food Chem , vol.158 , pp. 546-554
    • Dhanya, R.1    Arun, K.B.2    Syama, H.P.3    Nisha, P.4    Sundaresan, A.5    Santhosh, K.T.R.6    Jayamurthy, P.7
  • 36
    • 77951931613 scopus 로고    scopus 로고
    • Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells
    • Cai, E.P.; Lin, J.K. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells. J. Agric. Food Chem., 2009, 57(20), 9817-9827.
    • (2009) J. Agric. Food Chem , vol.57 , Issue.20 , pp. 9817-9827
    • Cai, E.P.1    Lin, J.K.2
  • 37
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler, A.E.; Janson, J.; Bonner-Weir, S.; Ritzel, R.; Rizza, R.A.; Butler, P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes, 2003, 52(1), 102-110.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 38
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • (2005)
    • Cnop, M.; Welsh, N.; Jonas, J.C.; Jorns, A.; Lenzen, S.; Eizirik, D.L. (2005). Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes, 2005, 54S, S97-S107.
    • (2005) Diabetes , vol.54 S , pp. S97-S107
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 39
    • 84863593197 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end-product formation on eye lens protein by rutin
    • Muthenna, P.; Akileshwari, C.; Saraswat, M.; Bhanuprakash, R.G. Inhibition of advanced glycation end-product formation on eye lens protein by rutin. Br. J. Nutr., 2012, 107(7), 941-949.
    • (2012) Br. J. Nutr , vol.107 , Issue.7 , pp. 941-949
    • Muthenna, P.1    Akileshwari, C.2    Saraswat, M.3    Bhanuprakash, R.G.4
  • 40
    • 34447547880 scopus 로고    scopus 로고
    • Influence of flavonols as in vitro on low density lipoprotein glycation
    • Ghaffari, M.A.; Mojab, S. Influence of flavonols as in vitro on low density lipoprotein glycation. Iran Biomed. J., 2007, 11(3), 185- 191.
    • (2007) Iran Biomed. J , vol.11 , Issue.3 , pp. 185-191
    • Ghaffari, M.A.1    Mojab, S.2
  • 41
    • 33947679408 scopus 로고    scopus 로고
    • Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure
    • Urios, P.; Grigorova-Borsos, A.M.; Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur. J. Nutr. 2007, 46(3), 139-146.
    • (2007) Eur. J. Nutr , vol.46 , Issue.3 , pp. 139-146
    • Urios, P.1    Grigorova-Borsos, A.M.2    Sternberg, M.3
  • 42
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry, R.J.; Samuel, V.T.; Petersen, K.F.; Shulman, G.I. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature, 2014, 510(7503), 84-91.
    • (2014) Nature , vol.510 , Issue.7503 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 43
    • 35548964229 scopus 로고    scopus 로고
    • Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes
    • Hsu, C.L.; Yen, G.C. Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. J. Agric. Food. Chem., 2007, 55(21), 8404-8410.
    • (2007) J. Agric. Food. Chem , vol.55 , Issue.21 , pp. 8404-8410
    • Hsu, C.L.1    Yen, G.C.2
  • 44
    • 0034951366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
    • Guan, Y-F.; Breyer, M.D. Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease. Kidney Int., 2001, 60(1), 14-30.
    • (2001) Kidney Int , vol.60 , Issue.1 , pp. 14-30
    • Guan, Y.-F.1    Breyer, M.D.2
  • 45
    • 79952082354 scopus 로고    scopus 로고
    • Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells
    • Wu, C.H.; Lin M.C.; Wang, H.C.; Yang, M.Y.; Jou, M.J.; Wang, C.J. Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. J. Food Sci., 2011, 76(2), T65-72.
    • (2011) J. Food Sci , vol.76 , Issue.2 , pp. T65-T72
    • Wu, C.H.1    Lin, M.C.2    Wang, H.C.3    Yang, M.Y.4    Jou, M.J.5    Wang, C.J.6
  • 46
    • 84886644513 scopus 로고    scopus 로고
    • Absorption and metabolism characteristics of rutin in Caco-2 cells
    • Zhang, X.; Song, J.; Shi, X.; Miao, S.; Li, Y.; Wen, A. Absorption and metabolism characteristics of rutin in Caco-2 cells. Sci. World J., 2013, 2013, 382350.
    • (2013) Sci. World J , vol.2013
    • Zhang, X.1    Song, J.2    Shi, X.3    Miao, S.4    Li, Y.5    Wen, A.6
  • 47
    • 23844481074 scopus 로고    scopus 로고
    • Absorption of quercetin and rutin in rat small intestine
    • Carbonaro, M.; Grant, G. Absorption of quercetin and rutin in rat small intestine. Ann. Nutr. Metab., 2005, 49(3), 178-182.
    • (2005) Ann. Nutr. Metab , vol.49 , Issue.3 , pp. 178-182
    • Carbonaro, M.1    Grant, G.2
  • 48
    • 0035427615 scopus 로고    scopus 로고
    • Intestinal absorption of rutin in free and conjugated forms
    • Andlauer, W.; Stumpf, C.; Furst, P. Intestinal absorption of rutin in free and conjugated forms. Biochem. Pharmacol., 2001, 62(3), 369- 374.
    • (2001) Biochem. Pharmacol , vol.62 , Issue.3 , pp. 369-374
    • Andlauer, W.1    Stumpf, C.2    Furst, P.3
  • 49
    • 0037462073 scopus 로고    scopus 로고
    • Absorption and urinary excretion of quercetin, rutin, and αG-rutin, a water soluble flavonoid, in rats
    • Shimoi, K.; Yoshizumi, K.; Kido, T.; Usui, Y.; Yumoto, T. Absorption and urinary excretion of quercetin, rutin, and αG-rutin, a water soluble flavonoid, in rats. J. Agric. Food. Chem., 2003, 51(9), 2785- 2789.
    • (2003) J. Agric. Food. Chem , vol.51 , Issue.9 , pp. 2785-2789
    • Shimoi, K.1    Yoshizumi, K.2    Kido, T.3    Usui, Y.4    Yumoto, T.5
  • 50
    • 2942620341 scopus 로고    scopus 로고
    • Antidiabetic influence of quercetin in streptozotocininduced diabetic rats
    • Shetty, A.K.; Rashmi, R.; Rajan, M.G.R.; Sambaiah, K.; Salimath, P.V. Antidiabetic influence of quercetin in streptozotocininduced diabetic rats. Nut. Res., 2004, 24(5), 373-381.
    • (2004) Nut. Res , vol.24 , Issue.5 , pp. 373-381
    • Shetty, A.K.1    Rashmi, R.2    Rajan, M.G.R.3    Sambaiah, K.4    Salimath, P.V.5
  • 51
    • 0041589462 scopus 로고    scopus 로고
    • Antidiabetic effects of quercetin in streptozocin-induced diabetic rats
    • Vessal, M.; Hemmati, M.; Vasei, M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C: Pharmacol. Toxicol., 2003, 135C(3), 357-364.
    • (2003) Comp. Biochem. Physiol. C: Pharmacol. Toxicol , vol.135 C , Issue.3 , pp. 357-364
    • Vessal, M.1    Hemmati, M.2    Vasei, M.3
  • 52
    • 39649087113 scopus 로고    scopus 로고
    • Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity
    • Fang, X-K.; Gao, J.; Zhu, D-N. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci., 2008, 82(11-12), 615-622.
    • (2008) Life Sci , vol.82 , Issue.11-12 , pp. 615-622
    • Fang, X.-K.1    Gao, J.2    Zhu, D.-N.3
  • 53
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • Heilbronn, L.K.; Campbell, L.V. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des., 2008, 14(12), 1225-1230.
    • (2008) Curr. Pharm. Des , vol.14 , Issue.12 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 54
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn, J.J.; Klover, P.J.; Nowak, I.A.; Mooney, R.A. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes, 2002, 51(12), 3391-3399.
    • (2002) Diabetes , vol.51 , Issue.12 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 55
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson, S.E.; Lee, J.; Goldfine, A.B. Inflammation and insulin resistance. J. Clin. Invest., 2006, 116(7),1793-1801.
    • (2006) J. Clin. Invest , vol.116 , Issue.7 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 56
    • 0037347906 scopus 로고    scopus 로고
    • Antiinflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation
    • Selloum, L.; Bouriche, H.; Tigrine, C.; Boudoukha, C. Antiinflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. Exp. Toxicol. Pathol., 2003, 54(4), 313-318.
    • (2003) Exp. Toxicol. Pathol , vol.54 , Issue.4 , pp. 313-318
    • Selloum, L.1    Bouriche, H.2    Tigrine, C.3    Boudoukha, C.4
  • 57
    • 84884272654 scopus 로고    scopus 로고
    • Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice
    • Chen, Y.S.; Hu, Q.H.; Zhang, X.; Zhu, Q.; Kong, L.D. Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. Pharmacol., 2013, 92(1-2), 75-83.
    • (2013) Pharmacol , vol.92 , Issue.1-2 , pp. 75-83
    • Chen, Y.S.1    Hu, Q.H.2    Zhang, X.3    Zhu, Q.4    Kong, L.D.5
  • 58
    • 80054937038 scopus 로고    scopus 로고
    • Protective effects of rutin on rat glomerular mesangial cells cultured in high glucose conditions
    • Tang, D.Q.; Wei, Y.Q.; Gao, Y.Y.; Yin, X.X.; Yang, D.Z.; Mou, J.; Jiang X.L. Protective effects of rutin on rat glomerular mesangial cells cultured in high glucose conditions. Phytother. Res., 2011, 25(11), 1640-1647.
    • (2011) Phytother. Res , vol.25 , Issue.11 , pp. 1640-1647
    • Tang, D.Q.1    Wei, Y.Q.2    Gao, Y.Y.3    Yin, X.X.4    Yang, D.Z.5    Mou, J.6    Jiang, X.L.7
  • 60
    • 78449307046 scopus 로고    scopus 로고
    • Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney
    • Korkmaz, A.; Kolankaya, D. Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney. J. Surg. Res., 2010, 164(2), 309-315.
    • (2010) J. Surg. Res , vol.164 , Issue.2 , pp. 309-315
    • Korkmaz, A.1    Kolankaya, D.2
  • 61
    • 84868251099 scopus 로고    scopus 로고
    • Protective effects of rutin against potassium bromate induced nephrotoxicity in rats
    • Khan R.A.; Khan, M.R.; Sahreen, S. Protective effects of rutin against potassium bromate induced nephrotoxicity in rats. BMC Comp. Alt. Med., 2012, 12, 204.
    • (2012) BMC Comp. Alt. Med , vol.12 , pp. 204
    • Khan, R.A.1    Khan, M.R.2    Sahreen, S.3
  • 62
    • 84875328317 scopus 로고    scopus 로고
    • Mechanisms that underlie the induction of vasodilation in pulmonary artery by rutin
    • Li, Q.; Niu, S.; Wang, R.; Li, Y.; Zhang, R.; Zhu, D. Mechanisms that underlie the induction of vasodilation in pulmonary artery by rutin. Int. Angiol., 2012, 31(6), 557-564.
    • (2012) Int. Angiol , vol.31 , Issue.6 , pp. 557-564
    • Li, Q.1    Niu, S.2    Wang, R.3    Li, Y.4    Zhang, R.5    Zhu, D.6
  • 63
    • 79958211266 scopus 로고    scopus 로고
    • Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
    • Panchal, S.K.; Poudyal, H.; Arumugam, T.V.; Brown, L. Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. J. Nutr., 2011, 141(6), 1062-1069.
    • (2011) J. Nutr , vol.141 , Issue.6 , pp. 1062-1069
    • Panchal, S.K.1    Poudyal, H.2    Arumugam, T.V.3    Brown, L.4


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