Absorption and metabolism characteristics of rutin in caco-2 cells

The Scientific World Journal

Volumn 2013, Issue , 2013, Pages

  Zhang, Xiaofang ^a   Song, Jinhui ^b   Shi, Xiaopeng ^a   Miao, Shan ^c   Li, Yan ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Shenyang 463 Hospital   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; RUTOSIDE;

APICAL MEMBRANE; ARTICLE; CELL STRAIN CACO 2; CELL TRANSPORT; DRUG ABSORPTION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; INTESTINE ABSORPTION; TANDEM MASS SPECTROMETRY; CACO 2 CELL LINE; CELL MEMBRANE; HUMAN; METABOLIC CLEARANCE RATE; METABOLISM; PHYSIOLOGY;

CACO-2 CELLS; CELL MEMBRANE; HUMANS; INTESTINAL ABSORPTION; METABOLIC CLEARANCE RATE; RUTIN;

EID: 84886644513     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2013/382350     Document Type: Article

References (38)

1. Visioli F., de la Lastra C. A., Andres-Lacueva C., Aviram M., Calhau C., Cassano A., D'Archivio M., Faria A., Favé G., Fogliano V., Llorach R., Vitaglione P., Zoratti M., Edeas M., Polyphenols and human health: a prospectus. Critical Reviews in Food Science and Nutrition 2011 51 6 524 546 2-s2.0-79959299039 10.1080/10408391003698677
2. Magrone T., Jirillo E., Potential application of dietary polyphenols from red wine to attaining healthy ageing. Current Topics in Medicinal Chemistry 2011 11 14 1780 1796 2-s2.0-79959954393 10.2174/156802611796235116
3. Asensi M., Ortega A., Mena S., Feddi F., Estrela J. M., Natural polyphenols in cancer therapy. Critical Reviews in Clinical Laboratory Sciences 2011 48 5-6 197 216 2-s2.0-84055197777 10.3109/10408363.2011.631268
4. Visioli F., Davalos A., Polyphenols and Cardiovascular disease: a critical summary of the evidence. Mini-Reviews in Medicinal Chemistry 2011 11 14 1186 1190 2-s2.0-82955214628
5. Kamalakkannan N., Prince P. S. M., Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic and Clinical Pharmacology and Toxicology 2006 98 1 97 103 2-s2.0-33645103657 10.1111/j.1742-7843.2006.pto-241.x
6. Wu C. D., Grape products and oral health. Journal of Nutrition 2009 139 1818S 1823S
7. Sumbul S., Ahmad M. A., Asif M., Akhtar M., Role of phenolic compounds in peptic ulcer: an overview. Journal of Pharmacy and Bioallied Sciences 2011 3 3 361 367 2-s2.0-80052704798 10.4103/0975-7406.84437
8. Wu B., Kulkarni K., Basu S., Zhang S., Hu M., First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. Journal of Pharmaceutical Sciences 2011 100 9 3655 3681 2-s2.0-79960147010 10.1002/jps.22568
9. Yang C. S., Sang S., Lambert J. D., Lee M.-J., Bioavailability issues in studying the health effects of plant polyphenolic compounds. Molecular Nutrition and Food Research 2008 52 1 S139 S151 2-s2.0-53449089371 10.1002/mnfr.200700234
10. Darby R. A. J., Callaghan R., McMahon R. M., P-glycoprotein inhibition: the past, the present and the future. Current Drug Metabolism 2011 12 8 722 731 2-s2.0-80053471265
11. Sakaeda T., MDR1 genotype-related pharmacokinetics: fact or fiction? Drug Metabolism and Pharmacokinetics 2005 20 6 391 414 2-s2.0-32044455207 10.2133/dmpk.20.391
12. Wright E. M., Loo D. D., Hirayama B. A., Biology of human sodium glucose transporters. Physiological Reviews 2011 91 2 733 794 2-s2.0-78651349221 10.1152/physrev.00055.2009
13. Ieiri I., Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). Drug Metabolism and Pharmacokinetics 2012 27 1 85 105 2-s2.0-84857768340 10.2133/dmpk.DMPK-11-RV-098
14. Alvarez A. I., Real R., Pérez M., Mendoza G., Prieto J. G., Merino G., Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response. Journal of Pharmaceutical Sciences 2010 99 2 598 617 2-s2.0-74049143120 10.1002/jps.21851
15. Marquez B., van Bambeke F., ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions. Current Drug Targets 2011 12 5 600 620 2-s2.0-79953317272 10.2174/138945011795378504
16. Melaine N., Liénard M.-O., Dorval I., Le Goascogne C., Lejeune H., Jégou B., Multidrug resistance genes and P-glycoprotein in the testis of the rat, mouse, guinea pig, and human. Biology of Reproduction 2002 67 6 1699 1707 2-s2.0-0036892223 10.1095/biolreprod.102.003558 (Pubitemid 35387998)
17. Volpe D. A., Drug-permeability and transporter assays in Caco-2 and MDCK cell lines. Future Medicinal Chemistry 2011 3 16 2063 2077 2-s2.0-81855206518 10.4155/fmc.11.149
18. Calhau C., Martel F., Hipólito-Reis C., Azevedo I., Modulation of uptake of organic cationic drugs in cultured human colon adenocarcinoma Caco-2 cells by an ecto-alkaline phosphatase activity. Journal of Cellular Biochemistry 2002 87 4 408 416 2-s2.0-0036031925 10.1002/jcb.10306 (Pubitemid 35231704)
19. Smetanová L., Sttinová V., Svoboda Z., Caco-2 cells, biopharmaceutics classification system (BCS) and biowaiver. Acta Medica 2011 54 3 8
20. Crowe A., Wright C., The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers. Xenobiotica 2012 42 6 538 549 2-s2.0-84860564934 10.3109/00498254.2011.643256
21. Ikeda K., Myotoku M., Hirotani Y., Characterization of multidrug resistance-associated protein mRNAs expression profiles in Caco-2 and HT-1080 cell lines induced by methotrexate. Pharmazie 2008 63 12 883 889 2-s2.0-61449200375 10.1691/ph.2008.8166
22. Lampen A., Ebert B., Stumkat L., Jacob J., Seidel A., Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochimica et Biophysica Acta 2004 1681 1 38 46 2-s2.0-9244220651 10.1016/j.bbaexp.2004.09.010 (Pubitemid 39550369)
23. Alhamoruni A., Lee A. C., Wright K. L., Larvin M., O'Sullivan S. E., Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability. Journal of Pharmacology and Experimental Therapeutics 2010 335 1 92 102 2-s2.0-77957230984 10.1124/jpet.110.168237
24. Vaidyanathan J. B., Walle T., Cellular uptake and efflux of the tea flavonoid (-)-epicatechin-3-gallate in the human intestinal cell line Caco-2. Journal of Pharmacology and Experimental Therapeutics 2003 307 2 745 752 2-s2.0-0142241274 10.1124/jpet.103.054296 (Pubitemid 37310692)
25. Young J. M., Morris M. E., Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Molecular Pharmaceutics 2007 4 6 865 872 2-s2.0-37549031270 10.1021/mp7000928
26. Ma Q., Kim E.-Y., Han O., Bioactive dietary polyphenols decrease heme iron absorption by decreasing basolateral iron release in human intestinal Caco-2 cells. Journal of Nutrition 2010 140 6 1117 1121 2-s2.0-77952611768 10.3945/jn.109.117499
27. Bielawski J., Szulc Z. M., Hannun Y. A., Bielawska A., Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 2006 39 2 82 91 2-s2.0-33746271951 10.1016/j.ymeth.2006.05.004 (Pubitemid 44107706)
28. Teng Z., Yuan C., Zhang F., Huan M., Cao W., Li K., Yang J., Cao D., Zhou S., Mei Q., Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in caco-2 cells. PLoS ONE 2012 7 1 2-s2.0-84855828232 10.1371/journal.pone.0029647 e29647
29. de van Wetering K., Burkon A., Feddema W., Bot A., De Jonge H., Somoza V., Borst P., Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Molecular Pharmacology 2009 75 4 876 885 2-s2.0-63849152475 10.1124/mol.108.052019
30. Ming X., Knight B. M., Thakker D. R., Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Molecular Pharmaceutics 2011 8 5 1677 1686 2-s2.0-80053530180 10.1021/mp200026v
31. Stagos D., Amougias G., Matakos A., Spyrou A., Tsatsakis A. M., Kouretas D., Chemoprevention of liver cancer by plant polyphenols. Food and Chemical Toxicology 2012 50 6 2155 2170 2-s2.0-84860332038 10.1016/j.fct.2012.04.002
32. Varoni E. M., Lodi G., Sardella A., Carrassi A., Iriti M., Plant polyphenols and oral health: old phytochemicals for new fields. Current Medicinal Chemistry 2012 19 11 1706 1720 2-s2.0-84860524449 10.2174/ 092986712799945012
33. Sun H., Chow E. C. Y., Liu S., Du Y., Pang K. S., The Caco-2 cell monolayer: usefulness and limitations. Expert Opinion on Drug Metabolism and Toxicology 2008 4 4 395 411 2-s2.0-44349116738 10.1517/17425255.4.4.395 (Pubitemid 351728514)
34. Brandon E. F. A., Bosch T. M., Deenen M. J., Levink R., Van Der Wal E., Van Meerveld J. B. M., Bijl M., Beijnen J. H., Schellens J. H. M., Meijerman I., Validation of in vitro cell models used in drug metabolism and transport studies; Genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines. Toxicology and Applied Pharmacology 2006 211 1 1 10 2-s2.0-31444453937 10.1016/j.taap.2005.05.004 (Pubitemid 43152092)
35. Borlak J., Zwadlo C., Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells. Xenobiotica 2003 33 9 927 943 2-s2.0-0141884785 10.1080/00498250310001614286 (Pubitemid 37255403)
36. Naruhashi K., Kurahashi Y., Fujita Y., Kawakita E., Yamasaki Y., Hattori K., Nishimura A., Shibata N., Comparison of the expression and function of ATP binding cassette transporters in Caco-2 and T84 cells on stimulation by selected endogenous compounds and xenobiotics. Drug Metabolism and Pharmacokinetics 2011 26 2 145 153 2-s2.0-79955709672 10.2133/dmpk.DMPK-10-RG-075
37. Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A.-L., Karlsson J., Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metabolism and Disposition 2007 35 8 1333 1340 2-s2.0-34547169521 10.1124/dmd.107.014902 (Pubitemid 47121774)
38. Berggren S., Gall C., Wollnitz N., Ekelund M., Karibom U., Hoogstraate J., Schrenk D., Lennernäs H., Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine. Molecular Pharmaceutics 2007 4 2 252 257 2-s2.0-34247352929 10.1021/mp0600687 (Pubitemid 46640601)