The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons

Neurobiology of Aging

Volumn 36, Issue 6, 2015, Pages 2213-2223

  Salganik, Maxim ^a,b   Sergeyev, Valeriy G ^c,d   Shinde, Vishal ^c   Meyers, Craig A ^a   Gorbatyuk, Marina S ^c   Lin, Jonathan H ^e   Zolotukhin, Sergey ^a   Gorbatyuk, Oleg S ^c,f  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UDMURT STATE UNIVERSITY   (Russian Federation)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f The University of Alabama at Birmingham   (United States)

Author keywords

Dopamine; Glucose regulated protein 78; Parkinson Disease; Recombinant Adeno associated virus; Substantia nigra pars compacta; Tyrosine hydroxylase

Indexed keywords

ALPHA SYNUCLEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; PARVOVIRUS VECTOR; SMALL INTERFERING RNA; HEAT SHOCK PROTEIN; HSPA5 PROTEIN, RAT;

ADENO ASSOCIATED VIRUS; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; FEMALE; MALE; NERVE DEGENERATION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; FISCHER 344 RAT; GENE SILENCING; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN FOLDING; SUBSTANTIA NIGRA;

AGING; ALPHA-SYNUCLEIN; ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEAT-SHOCK PROTEINS; HOMEOSTASIS; HUMANS; MALE; MOLECULAR CHAPERONES; PARKINSON DISEASE; PROTEIN FOLDING; RATS, INBRED F344; RNA, SMALL INTERFERING; SUBSTANTIA NIGRA;

EID: 84929270787     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.02.018     Document Type: Article

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