Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer

Oral Oncology

Volumn 51, Issue 6, 2015, Pages 565-569

  Mali, Shrikant Balasaheb ^a  

^a MGV's KBH Dental College   (India)

Author keywords

Head and neck cancer; Molecular strategies for head and neck cancer; Signal Transducers and Activators of Transcription STAT; STAT3; STAT3 inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERYTHROPOIETIN RECEPTOR; INTERLEUKIN RECEPTOR; NICOTINIC RECEPTOR; PROTEIN INHIBITOR; STAT3 PROTEIN;

ARTICLE; CANCER CELL; CELL CONTACT; CELL INVASION; CELL MIGRATION; DNA BINDING; DOWN REGULATION; ENZYME ACTIVITY; GENE CONTROL; HEAD AND NECK CANCER; HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; ANTAGONISTS AND INHIBITORS; HEAD AND NECK TUMOR; METABOLISM; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; HEAD AND NECK NEOPLASMS; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, INTERLEUKIN; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84929133297     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2015.03.004     Document Type: Review

References (57)

1. K.S. Siveen, S. Sikka, R. Surana, X. Dai, J. Zhang, and A.P. Kumar et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors Biochim Biophys Acta 1845 2 2014 136 154 10.1016/j.bbcan.2013.12.005 Epub 2014 January 2
2. A.l. Lavecchia, C. Di Giovanni, and E. Novellino STAT-3 inhibitors: state of the art and new horizons for cancer treatment Curr Med Chem 18 16 2011 2359 2375
3. S.Y.l. Lai, and F.M. Johnson Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches Drug Resist Updat 13 3 2010 67 78 10.1016/j.drup.2010.04.001 Epub 2010 May 14
4. B. Debnath, S. Xu, and N. Neamati Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein J Med Chem 55 2012 6645 6668
5. C.M. Silva Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis Oncogene 23 2004 8017 8023
6. Z.l. You, D. Xu, J. Ji, W. Guo, W. Zhu, and J. He JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma Clin Transl Oncol 14 2 2012 143 149 10.1007/s12094-012-0774-6
7. B.l. Burtness, J.E. Bauman, and T. Galloway Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibition Lancet Oncol 14 8 2013 e302 e309 10.1016/S1470-2045 13)70085-8
8. A.l. Subramaniam, M.K. Shanmugam, E. Perumal, F. Li, A. Nachiyappan, and X. Dai et al. proliferation and invasion of hepatocellular carcinoma Biochim Biophys Acta 1835 1 2013 46 60 10.1016/j.bbcan.2012.10.002 Epub 2012 October 26
9. D.l. Masciocchi, A. Gelain, S. Villa, F. Meneghetti, and D. Barlocco Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy Future Med Chem 3 5 2011 567 597 10.4155/fmc.11.22
10. A.l. Jarnicki, T. Putoczki, and M. Ernst Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling? Cell Div 17 5 2010 14 10.1186/1747-1028-5-14
11. M.l. Masuda, M. Suzui, R. Yasumatu, T. Nakashima, Y. Kuratomi, and K. Azuma et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma Cancer Res 62 12 2002 3351 3355
12. H.l. Yu, and R. Jove The STATs of cancer - new molecular targets come of age Nat Rev Cancer 4 2 2004 97 105
13. R.A.l. Steinman, A. Wentzel, Y. Lu, C. Stehle, and J.R. Grandis Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2 Oncogene 22 23 2003 3608 3615
14. A.l. Vultur, J. Cao, R. Arulanandam, J. Turkson, R. Jove, and P. Greer et al. Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells Oncogene 23 15 2004 2600 2616
15. C.l. Suiqing, Z. Min, and C. Lirong Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma J Dermatol 32 5 2005 354 360
16. I.C.l. Gaemers, H.L. Vos, H.H. Volders, S.W. van der Valk, and J. Hilkens A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells J Biol Chem 276 9 2001 6191 6199 2 Epub 2000 November 17
17. G.l. Niu, K.L. Wright, M. Huang, L. Song, E. Haura, and J. Turkson et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis Oncogene 21 13 2002 2000 2008
18. A.D.l. Laird, G. Li, K.G. Moss, R.A. Blake, M.A. Broome, and J.M. Cherrington et al. Src family kinase activity is required for signal transducer and activator of transcription 3 and focal adhesionkinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells Mol Cancer Ther 2 5 2003 461 469
19. S.l. Yan, Z. Li, and C.J. Thiele Inhibition of STAT3 with orally active JAK inhibitor AZD1480 decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo Oncotarget 4 3 2013 433 445
20. B. Barre, and S. Avril Coqueret O opposite regulation of Myc and p21waf1 transcription by STAT3 proteins J Biol Chem 278 5 2003 Jan 31 2990 2996
21. K. Al Zaid Siddiquee, and J. Turkson STAT3 as a target for inducing apoptosis in solid and hematological tumors Cell Res 18 2 2008 254 267
22. V. Gurbuz, E. Konac, N. Varol, A. Yilmaz, and S. Gurocak et al. Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro Oncol Lett 7 2014 755 763
23. S.M. Denley, N.B. Jamieson, P. McCall, K.A. Oien, and J.P. Morton et al. Activation of the IL-6R/JAK/STAT pathway is associated with a poor outcome in resected pancreatic ductal adenocarcinoma J Gastrointest Surg 17 2013 887 898
24. S.l. Fletcher, J.A. Drewry, V.M. Shahani, B.D. Page, and P.T. Gunning Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein Iochem Cell Biol 87 6 2009 825 833 10.1139/o09-044
25. B.D.l. Page, D.P. Ball, and P.T. Gunning Signal transducer and activator of transcription 3 inhibitors: a patent review Expert Opin Ther Pat 21 1 2011 65 83 10.1517/13543776.2011.539205 Epub 2010 November 29
26. A. Samsonov, N. Zenser, F. Zhang, H. Zhang, and J. Fetter et al. Tagging of genomic STAT3 and STAT1 with fluorescent proteins and insertion of a luciferase reporter in the cyclin D1 gene provides a modified A549 cell line to screen for selective STAT3 inhibitors PLoS One 8 2013 e68391
27. J.A.l. Bonner, E.S. Yang, H.Q. Trummell, S. Nowsheen, C.D. Willey, and K.P. Raisch Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma Radiother Oncol 99 3 2011 339 343 10.1016/j.radonc.2011.05.070 Epub 2011 June 23
28. E. Pectasides, A.M. Egloff, and C. Sasaki et al. Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better prognosis Clin Cancer Res 16 2010 2427 2434
29. R.J. Leeman-Neill, S.E. Wheeler, and S.V. Singh et al. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3 Carcinogenesis 30 11 2009 1848 1856 [PubMed:19762335]
30. M.E. Kupferman, A. Jayakumar, and G. Zhou et al. Therapeutic suppression of constitutive and inducible JAK\STAT activation in head and neck squamous cell carcinoma J Exp Ther Oncol 8 2 2009 117 127
31. I. Arany, S.H. Chen, and J.K. Megyesi et al. Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck Cancer Lett 199 2003 83 89
32. R.J. Leeman, V.W. Lui, and J.R. Grandis STAT3 as a therapeutic target in head and neck cancer Expert Opin Biol Ther 6 2006 231 241
33. R.R. Seethala, W.E. Gooding, and P.N. Handler et al. Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes Clin Cancer Res 14 2008 1303 1309
34. J. Arredondo, A.I. Chernyavsky, D.L. Jolkovsky, K.E. Pinkerton, and S.A. Grando Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes FASEB J 20 2006 2093 2101
35. J.K. Nagpal, R. Mishra, and B.R. Das Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis Cancer 94 2002 2393 2400
36. Y. Tu, Y. Zhong, J. Fu, Y. Cao, and G. Fu et al. Activation of JAK/STAT signal pathway predicts poor prognosis of patients with gliomas Med Oncol 28 2011 15 23
37. A.K.l. Mankan, and F.R. Greten Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors Expert Opin Investig Drugs 20 9 2011 1263 1275 10.1517/13543784.2011.601739 Epub 2011 July 14
38. B.W. Dymock, and C.S. See Inhibitors of JAK2 and JAK3: An update on the patent literature 2010-2012 Expert Opin Ther Pat 23 4 2013 449 501
39. S.C. Nallar et al. Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis J Biol Chem 288 11 2013 7930 7941
40. M. Hedvat, D. Huszar, A. Herrmann, J.M. Gozgit, and A. Schroeder et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors Cancer Cell 16 2009 487 497
41. J.D. Klein, D. Sano, M. Sen, J.N. Myers, J.R. Grandis, and S. Kim STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma PLoS One 9 1 2014 e81819 10.1371/journal.pone.0081819 eCollection
42. N. Jing, and D.J. Tweardy Targeting Stat3 in cancer therapy Anticancer Drugs 16 6 2005 601 607 [PubMed: 15930886]
43. T.l. Kijima, H. Niwa, R.A. Steinman, S.D. Drenning, W.E. Gooding, and A.L. Wentzel et al. STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo Cell Growth Differ 13 8 2002 355 362
44. K.S.l. Ahn, G. Sethi, B. Sung, A. Goel, R. Ralhan, and B.B. Aggarwal et al. Inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 Cancer Res 68 11 2008 4406 4415 10.1158/0008-5472.CAN-07-6696
45. R.J. Leeman-Neill, S.E. Wheeler, S.V. Singh, S.M. Thomas, R.R. Seethala, and D.B. Neill et al. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3 Carcinogenesis 30 11 2009 1848 1856 10.1093/carcin/bgp211 Epub 2009 September 16
46. J. Kowshik, A.B. Baba, H. Giri, G. Deepak Reddy, M. Dixit, and S. Nagini Astaxanthin inhibits JAK/STAT-signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer PLoS One 9 10 2014 e109114 10.1371/journal.pone.0109114 eCollection
47. R.J.l. Leeman-Neill, R.R. Seethala, S.V. Singh, M.L. Freilino, J.S. Bednash, and S.M. Thomas et al. Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma Cancer Prev Res (Phila) 4 2 2011 230 237 10.1158/1940-6207.CAPR-10-0249 Epub 2010 December 16
48. M.A. Macha et al. Rognostic significance of nuclear pSTAT3 in oral cancer Head Neck 22 2010 [Epub ahead of print]
49. Y. Safdari, M. Khalili, S. Farajnia, M. Asgharzadeh, Y. Yazdani, and M. Sadeghi Recent advances in head and neck squamous cell carcinoma-a review Clin Biochem 47 13-14 2014 1195 1202 10.1016/j.clinbiochem.2014.05.066 Epub 2014 June 6
50. P. Matar, F. Rojo, and R. Cassia et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD 1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting Clin Cancer Res 2004 1839 6487 6501
51. S. Schmitz, K.K. Ang, J. Vermorken, R. Haddad, C. Suarez, and G.T. Wolf et al. Targeted therapies for squamous cell carcinoma of the head and neck: current knowledge and future directions Cancer Treat Rev. 40 3 2014 390 404 10.1016/j.ctrv.2013.09.007 Epub 2013 September 14
52. H.l. Stegeman, J.H. Kaanders, M.M. Verheijen, W.J. Peeters, D.L. Wheeler, and M. Iida et al. Combining radiotherapy with MEK1/2 STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines Mol Cancer 12 1 2013 133 10.1186/1476-4598-12-133
53. L.Y. Bourguignon, K. Peyrollier, W. Xia, and E. Gilad Hyaluronan- CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells J Biol Chem 283 2008 17635 17651
54. L.Y.l. Bourguignon, C. Earle, G. Wong, C.C. Spevak, and K. Krueger Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells Oncogene 31 2 2012 149 160 10.1038/onc.2011.222 Epub 2011 June 20
55. Q.l. Zhang, C. Zhang, J. He, Q. Guo, D. Hu, and X. Yang et al. STAT3 inhibitor stattic enhances radiosensitivity in esophageal squamous cell carcinoma Tumour Biol 10 2014 Epub ahead of print
56. Y. Pan, F. Zhou, R. Zhang, and F.X. Claret Stat3 inhibitor static exhibits potent antitumor activity and induces chemo and radiosensitivity in nasopharyngeal carcinoma PLoS One 8 1 2013 e54565
57. M. Adachi, C. Cui, C.T. Dodge, M.K. Bhayani, and S.Y. Lai Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma Oral Oncol 48 2012 1220 1226