AICAR-induced activation of AMPK inhibits TSH/SREBP-2/HMGCR pathway in liver

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Liu, Shudong ^a,c   Jing, Fei ^a   Yu, Chunxiao ^a   Gao, Ling ^a,b   Qin, Yejun ^a   Zhao, Jiajun ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Academy of Clinical Medicine   (China)

^c Shandong Rongjun General Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THYROTROPIN; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE (NADPH); PHOSPHOTHREONINE; RIBONUCLEOTIDE; THYROTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HMGCR GENE; HMGCS GENE; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THYROTROPIN BLOOD LEVEL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HEP-G2 CELL LINE; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; HYDROXYMETHYLGLUTARYL-COA-REDUCTASES, NADP-DEPENDENT; LIVER; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOTHREONINE; RECEPTORS, THYROTROPIN; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THYROTROPIN; UP-REGULATION;

EID: 84929119241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124951     Document Type: Article

References (36)

1. Tian L, Song Y, Xing M, Zhang W, Ning G, Li X, et al. A novel role for thyroid-stimulating hormone: upregulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology. 2010; 52: 1401-1409. doi: 10.1002/hep.23800 PMID: 20648556
2. Wang T, Xu J, Bo T, Zhou X, Jiang X, Gao L, et al. Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice. Endocr J. 2013; 60: 941-950. PMID: 23665701
3. Karthick N, Dillara K, Poornima KN, Subhasini AS. Dyslipidaemic changes in women with subclinical hypothyroidism. J Clin Diagn Res. 2013; 7: 2122-2125. doi: 10.7860/JCDR/2013/5777.3448 PMID: 24298454
4. Asvold BO, Vatten LJ, Nilsen TI, Bjoro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol. 2007; 156: 181-186. PMID: 17287407
5. Garduno-Garcia Jde J, Alvirde-Garcia U, Lopez-Carrasco G, Padilla Mendoza ME, Mehta R, Arellano-Campos O, et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol. 2010; 163: 273-278. doi: 10.1530/EJE-10-0312 PMID: 20516204
6. Santos-Palacios S, Brugos-Larumbe A, Guillen-Grima F, Galofre JC. A cross-sectional study of the association between circulating TSH level and lipid profile in a large Spanish population. Clin Endocrinol (Oxf). 2013; 79: 874-881. doi: 10.1111/cen.12216 PMID: 23550997
7. Peppa M, Betsi G, Dimitriadis G. Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease. J Lipids. 2011: 575840.
8. Goldstein JL, DeBose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell. 2006; 124: 35-46. PMID: 16413480
9. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997; 89: 331-340. PMID: 9150132
10. Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest. 1998; 101: 2331-2339. PMID: 9616204
11. Min HK, Kapoor A, Fuchs M, Mirshahi F, Zhou H, Maher J, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012; 15: 665-674. doi: 10.1016/j.cmet.2012.04.004 PMID: 22560219
12. Chung GE, Kim D, Kim W, Yim JY, Park MJ, Kim YJ, et al. Non-alcoholic fatty liver disease across the spectrum of hypothyroidism. J Hepatol. 2012; 57: 150-156. doi: 10.1016/j.jhep.2012.02.027 PMID: 22425701
13. Xu L, Ma H, Miao M, Li Y. Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: a prospective case-control study. J Hepatol. 2012; 57: 1153-1154. doi: 10.1016/j. jhep.2012.05.025 PMID: 22940010
14. Sert A, Pirgon O, Aypar E, Yilmaz H, Odabas D. Subclinical hypothyroidism as a risk factor for the development of cardiovascular disease in obese adolescents with nonalcoholic fatty liver disease. Pediatr Cardiol. 2013; 34: 1166-1174. doi: 10.1007/s00246-013-0638-z PMID: 23344895
15. Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012; 13: 251-262. doi: 10.1038/nrm3311 PMID: 22436748
16. Bijland S, Mancini SJ, Salt IP. Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clin Sci (Lond). 2013; 124: 491-507. doi: 10.1042/CS20120536 PMID: 23298225
17. Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012; 336: 918-922. doi: 10.1126/ science.1215327 PMID: 22517326
18. Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009; 9: 407-416. doi: 10.1016/j.cmet.2009.03.012 PMID: 19416711
19. Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY. AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science. 2011; 332: 247-251. doi: 10.1126/science.1201678 PMID: 21436401
20. Yang J, Maika S, Craddock L, King JA, Liu ZM. Chronic activation of AMP-activated protein kinasealpha1 in liver leads to decreased adiposity in mice. Biochem Biophys Res Commun. 2008; 370: 248-253. doi: 10.1016/j.bbrc.2008.03.094 PMID: 18381066
21. Knowles C, Liu ZM, Yang J. Compensatory increase in lipogenic gene expression in adipose tissue of transgenic mice expressing constitutively active AMP-activated protein kinase-alpha1 in liver. Biochem Biophys Res Commun. 2011; 412: 249-252. doi: 10.1016/j.bbrc.2011.07.078 PMID: 21820413
22. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011; 13: 376-388. doi: 10.1016/j.cmet.2011.03.009 PMID: 21459323
23. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, et al. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006; 55: 2180-2191. PMID: 16873680
24. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25: 402-408. PMID: 11846609
25. Rice LM, Donigan M, Yang M, Liu W, Pandya D, Joseph BK, et al. Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding. J Biol Chem. 2014; 289: 17268-17279. doi: 10.1074/jbc.M114.570390 PMID: 24770487
26. Toth JI, Datta S, Athanikar JN, Freedman LP, Osborne TF. Selective coactivator interactions in gene activation by SREBP-1a and -1c. Mol Cell Biol. 2004; 24: 8288-8300. PMID: 15340088
27. Kim SJ, Kim JS, Kim SW, Brantley E, Yun SJ, He J, et al. Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer. Neoplasia. 2011; 13: 167-179. PMID: 21403842
28. Andrade BM, Araujo RL, Perry RL, Souza EC, Cazarin JM, Carvalho DP, et al. A novel role for AMP-kinase in the regulation of the Na+/I-symporter and iodide uptake in the rat thyroid gland. Am J Physiol Cell Physiol. 2011; 300: C1291-1297. doi: 10.1152/ajpcell.00136.2010 PMID: 21389275
29. Luboshitzky R, Aviv A, Herer P, Lavie L. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. 2002; 12: 421-425. PMID: 12097204
30. Erem C. Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activity. Clin Endocrinol (Oxf). 2006; 64: 323-329. PMID: 16487444
31. Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes. 2005; 54: 1331-1339. PMID: 15855317
32. Lee S, Lee MS, Kim CT, Kim IH, Kim Y. Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells. Int J Mol Sci. 2012; 13: 5729-5739. doi: 10.3390/ijms13055729 PMID: 22754327
33. Kotzka J, Lehr S, Roth G, Avci H, Knebel B, Muller-Wieland D. Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo. J Biol Chem. 2004; 279: 22404-22411. PMID: 14988395
34. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010; 24: 1403-1417. doi: 10.1101/gad.1901210 PMID: 20595232
35. Arito M, Horiba T, Hachimura S, Inoue J, Sato R. Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem. 2008; 283: 15224-15231. doi: 10.1074/jbc.M800910200 PMID: 18403372
36. Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, et al. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab. 2005; 1: 379-391. PMID: 16054087