메뉴 건너뛰기




Volumn 13, Issue 5, 2012, Pages 5729-5739

Ginsenoside RG3 reduces lipid accumulation with AMP-activated protein kinase (AMPK) activation in HepG2 cells

Author keywords

AMPK; Cardiovascular disease (CVD); Cholesterol; Ginsenoside Rg3; HMGCR; SREBP 2; Triglyceride

Indexed keywords

CHOLESTEROL; GINSENOSIDE RG 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; GINSENOSIDE;

EID: 84861548814     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13055729     Document Type: Article
Times cited : (73)

References (27)
  • 2
    • 27644573085 scopus 로고    scopus 로고
    • World Health Organization (WHO), Available online, accessed on 1 February 2012
    • World Health Organization (WHO). Cardiovascular Diseases, 2011. Available online: http://www.who.int/mediacentre/factsheets/fs317/en/index.html (accessed on 1 February 2012).
    • (2011) Cardiovascular Diseases
  • 3
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: An update on their molecular mechanisms and medical applications
    • Lü, J.-M.; Yao, Q.; Chen, C. Ginseng compounds: An update on their molecular mechanisms and medical applications. Curr. Vasc. Parmacol. 2009, 7, 293-302.
    • (2009) Curr. Vasc. Parmacol , vol.7 , pp. 293-302
    • Lü, J.-M.1    Yao, Q.2    Chen, C.3
  • 5
    • 79953272785 scopus 로고    scopus 로고
    • Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells
    • 2011
    • Yeo, C.; Lee, S.; Popovich, D.G. Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells. Evid.-Based Complement. Alternat. Med. 2011, 2011, 610625-610633.
    • (2011) Evid.-Based Complement. Alternat. Med , pp. 610625-610633
    • Yeo, C.1    Lee, S.2    Popovich, D.G.3
  • 6
    • 41849121572 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK
    • Park, M.W.; Ha, J.; Chung, S.H. 20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK. Biol. Pharm. Bull. 2008, 31, 748-751.
    • (2008) Biol. Pharm. Bull , vol.31 , pp. 748-751
    • Park, M.W.1    Ha, J.2    Chung, S.H.3
  • 8
    • 57049157743 scopus 로고    scopus 로고
    • Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model
    • Lim, S.; Yoon, J.W.; Choi, S.H.; Cho, B.J.; Kim, J.T.; Chang, H.S.; Park, H.S.; Park, K.S.; Lee, H.K.; Kim Y.-B.; et al. Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model. Metabolism 2009, 58, 8-15.
    • (2009) Metabolism , vol.58 , pp. 8-15
    • Lim, S.1    Yoon, J.W.2    Choi, S.H.3    Cho, B.J.4    Kim, J.T.5    Chang, H.S.6    Park, H.S.7    Park, K.S.8    Lee, H.K.9    Kim, Y.-B.10
  • 9
    • 68949102484 scopus 로고    scopus 로고
    • Effects of in vitro-digested ginsenosides on lipid accumulation in 3T3-L1 adipocytes
    • Kim, S.N.; Lee, J.H.; Shin, H.; Son, S.H.; Kim, Y.S. Effects of in vitro-digested ginsenosides on lipid accumulation in 3T3-L1 adipocytes. Planta Med. 2009, 75, 596-601.
    • (2009) Planta Med , vol.75 , pp. 596-601
    • Kim, S.N.1    Lee, J.H.2    Shin, H.3    Son, S.H.4    Kim, Y.S.5
  • 10
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown, M.S.; Goldstein, J.L. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89, 331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 11
    • 70350341460 scopus 로고    scopus 로고
    • Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells
    • Kang, Q.; Chen, A. Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br. J. Pharmacol. 2009, 157, 1354-1367.
    • (2009) Br. J. Pharmacol , vol.157 , pp. 1354-1367
    • Kang, Q.1    Chen, A.2
  • 13
    • 9144271181 scopus 로고    scopus 로고
    • AMP-activated protein kinase is required for the lipid-lowering effect of Metformin in insulin-resistant human HepG2 cells
    • Zang, M.; Zuccollo, A.; Hou, X.; Nagate, D.; Walsh, K.; Herscovitz, H.; Brecher, P.; Ruderman, N.B.; Cohen, R.A. AMP-activated protein kinase is required for the lipid-lowering effect of Metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 2004, 279, 47898-47905.
    • (2004) J. Biol. Chem , vol.279 , pp. 47898-47905
    • Zang, M.1    Zuccollo, A.2    Hou, X.3    Nagate, D.4    Walsh, K.5    Herscovitz, H.6    Brecher, P.7    Ruderman, N.B.8    Cohen, R.A.9
  • 14
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg, G.R.; Kemp, B.E. AMPK in health and disease. Physiol. Rev. 2009, 89, 1025-1078.
    • (2009) Physiol. Rev , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 16
    • 46249091398 scopus 로고    scopus 로고
    • A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line
    • Huang, J.; Tang, X.-H.; Ikejima, T.; Sun, X.-J.; Wang, X.-B.; Xi, R.-G.; Wu, L.-J. A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. Arch. Pharm. Res. 2008, 31, 323-329.
    • (2008) Arch. Pharm. Res , vol.31 , pp. 323-329
    • Huang, J.1    Tang, X.-H.2    Ikejima, T.3    Sun, X.-J.4    Wang, X.-B.5    Xi, R.-G.6    Wu, L.-J.7
  • 17
    • 80053064682 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway
    • Jiang, J.-W.; Chen, X.-M.; Chen, X.-H.; Zhang, S.-S. Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway. World J. Gastroenterol. 2011, 17, 3605-3613.
    • (2011) World J. Gastroenterol , vol.17 , pp. 3605-3613
    • Jiang, J.-W.1    Chen, X.-M.2    Chen, X.-H.3    Zhang, S.-S.4
  • 18
    • 77953397753 scopus 로고    scopus 로고
    • Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats
    • Kang, K.S.; Yamabe, N.; Kim, H.Y.; Park, J.H.; Yokozawa, T. Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats. Biol. Pharm. Bull. 2010, 33, 1077-1081.
    • (2010) Biol. Pharm. Bull , vol.33 , pp. 1077-1081
    • Kang, K.S.1    Yamabe, N.2    Kim, H.Y.3    Park, J.H.4    Yokozawa, T.5
  • 20
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J.D.; Goldstein, J.L.; Brown, M.S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109, 1125-1131.
    • (2002) J. Clin. Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 21
    • 0032104180 scopus 로고    scopus 로고
    • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
    • Horton, J.D.; Shimomura, I.; Brown, M.S.; Hammer, R.E.; Goldstein, J.L.; Shimano, H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 1998, 101, 2331-2339.
    • (1998) J. Clin. Invest , vol.101 , pp. 2331-2339
    • Horton, J.D.1    Shimomura, I.2    Brown, M.S.3    Hammer, R.E.4    Goldstein, J.L.5    Shimano, H.6
  • 22
    • 0035873619 scopus 로고    scopus 로고
    • SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
    • Matsda, M.; Korn, B.S.; Hammer, R.E.; Moon, Y.-A.; Komuro, R.; Horton, J.D.; Goldstein, J.L.; Brown, M.S.; Shimomura, I. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001, 15, 1206-1216.
    • (2001) Genes Dev , vol.15 , pp. 1206-1216
    • Matsda, M.1    Korn, B.S.2    Hammer, R.E.3    Moon, Y.-A.4    Komuro, R.5    Horton, J.D.6    Goldstein, J.L.7    Brown, M.S.8    Shimomura, I.9
  • 23
    • 60149100105 scopus 로고    scopus 로고
    • Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro
    • Chen, Q.; Reimer, R.A. Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition 2009, 25, 340-349.
    • (2009) Nutrition , vol.25 , pp. 340-349
    • Chen, Q.1    Reimer, R.A.2
  • 24
    • 63849206613 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
    • Viollet, B.; Guigas, B.; Leclerc, J.; Hébrard, S.; Lantier, L.; Mounier, R.; Andreelli, F.; Foretz, M. AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives. Acta Physiol. 2009, 196, 81-98.
    • (2009) Acta Physiol , vol.196 , pp. 81-98
    • Viollet, B.1    Guigas, B.2    Leclerc, J.3    Hébrard, S.4    Lantier, L.5    Mounier, R.6    Andreelli, F.7    Foretz, M.8
  • 25
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li, Y.; Xu, S.; Mihaylova, M.M.; Zheng, B.; Hou, X.; Jiang, B.; Park, O.; Luo, Z.; Lefai, E.; Shyy, J.Y.-J.; et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011, 13, 376-388.
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6    Park, O.7    Luo, Z.8    Lefai, E.9    Shyy, J.Y.-J.10
  • 26
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the www for General Users and for Biologist Programmers
    • Krawetz, S., Misener, S., Eds.; Humana Press: Totowa, NJ, USA
    • Rozen, S.; Skaletsky, H.J. Primer3 on the www for General Users and for Biologist Programmers. In Bioinformatics Methods and Protocols: Methods in Molecular Biology; Krawetz, S., Misener, S., Eds.; Humana Press: Totowa, NJ, USA, 1999; Volume 132, pp. 365-386.
    • (1999) Bioinformatics Methods and Protocols: Methods in Molecular Biology , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.