GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 5141-5155

  Tutunea Fatan, Elena ^a,b   Caetano, Fabiana A ^a   Gros, Robert ^a,b   Ferguson, Stephen S G ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

CARDIO-VASCULAR DISEASE; KNOCK DOWNS; THERAPEUTIC STRATEGY;

BIOLOGY;

G ALPHA Q11 PROTEIN; G ALPHA S PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, MOUSE; ANGIOTENSIN II; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GENE SILENCING; HYPERTENSION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE CELL; VASOCONSTRICTION; ANIMAL; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MUS;

ANGIOTENSIN II; ANIMALS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE KNOCKDOWN TECHNIQUES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HYPERTENSION; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84929105228     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.615658     Document Type: Article

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