Enhanced GRK2 expression and desensitization of βAr vasodilatation in hypertensive patients

Clinical and Translational Science

Volumn 1, Issue 3, 2008, Pages 215-220

  Izzo, Raffaele ^a   Cipolletta, Ersilia ^a   Ciccarelli, Michele ^a   Campanile, Alfonso ^a   Santulli, Gaetano ^a   Palumbo, Gianluigi ^a   Vasta, Antonio ^a   Formisano, Salvatore ^b   Trimarco, Bruno ^a   Iaccarino, Guido ^a  

^a Dipartimento di Medicina Clinica Scienze Cardiovascolari ed Immunologiche   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

AR signaling; Desensitization; Hypertension; Peripheral blood lymphocytes; Vasodilatation

Indexed keywords

BETA ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; HEPARIN; ISOPRENALINE;

ADULT; ARTICLE; BLOOD VESSEL TONE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; HUMAN; HYPERTENSION; IN VIVO STUDY; LYMPHOCYTE; MALE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; VASODILATATION;

ADULT; FEMALE; FOREARM; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEPARIN; HUMANS; HYPERTENSION; ISOPROTERENOL; MALE; MIDDLE AGED; RECEPTORS, ADRENERGIC, BETA; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; VASODILATION;

EID: 70450275806     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/j.1752-8062.2008.00050.x     Document Type: Article

References (35)

1. Head GA. The sympathetic nervous system in hypertension: Assessment by blood pressure variability and ganglionic blockade. J Hypertens. 2003;21(9):1619-1621.
2. Feldman RD. Defective venous beta-adrenergic response in borderline hypertensive subjects is corrected by a low sodium diet. J Gin Invest. 1990;85(3):647-652.
3. Stein CM, Nelson R, Deegan R, He H, Wood M, Wood AJ. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Gin invest 1995;96(1):579-585.
4. Stein CM, Nelson R, Deegan R, He H, Inagami T, Frazer M, Badr KF, Wood M, Wood AJ. Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension. 1995;25(6):1294-1300.
5. Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Leukocyte beta-receptor alterations in hypertensive subjects. J Gin Invest. 1984;73(3):648-653.
6. Iaccarino G, Campanile A, Santulli G, Zuppieri F, Koch W. G protein-coupled receptor kinases and hypertension: A review of disease mechanisms. High Blood Press Cardiovasc Prev 2006;13(4):151-158.
7. Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitization of beta-adrenergic receptor function. Faseb J. 1990;4(11):2881-2889.
8. Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-p rote in-coupled receptor kinase 2. Cell. 2007;129(3):511-522.
9. Zeiders JL, Seidler FJ, Iaccarino G, Koch WJ, Slotkin TA. Ontogeny of cardiac beta-ad re noceptor desensitization mechanisms: Agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling. J Mol Cell Cardiol 1999;31(2):413-423.
10. Penela P, Ribas C, Mayor F, Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 2003;15(11):973-981.
11. Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol. 2002;61(4):749-758.
12. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science N.Y. 1995;268(5215):1350-1353.
13. Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure, Eur Heart J. 2005;26(17):1752-1758.
14. Iaccarino G, Keys JR, Rapacciuolo A, Shotwell KF, Lefkowitz RJ, Rockman HA, Koch WJ. Regulation of myocardial betaARKl expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha lB-adrenergic receptors. J Am Coll Cardiol. 2001;38(2):534-540.
15. Choi DJ, Koch WJ, Hunter JJ, Rockman HA. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. J Biol Chem. 1997;272(27):17223-17229.
16. Vincent J, Blaschke TF, Hoffman BB. Desensitization of beta-adrenoceptor- and prostaglandin El receptor-mediated human vascular smooth muscle relaxation. J Cardiovasc Pharmacol. 1992;19(3):447-452.
17. Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL. Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Proc Natl Acad Sci USA. 1989;86(9):3011-3015.
18. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A. ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007;25(9):1751-1762.
19. Lembo G, Iaccarino G, Vecchione C, Barbato E, Izzo R, Fontana D, Trimarco B. Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm. J Gin invest. 1997;100(8):2007-2014.
20. Miller MR, Megson IL. Recent developments in nitric oxide donor drugs. Br J Pharmacol. 2007;151(3):305-321.
21. Lembo G, Iaccarino G, Vecchione C, Rendina V, Parrella L, Trimarco B. Insulin modulation of beta-adrenergic vasodilator pathway in human forearm. Circulation. 1996;93(7):1403-1410.
22. Gros R, Chorazyczewski J, Meek MD, Benovic JL, Ferguson SS, Feldman RD. G-P rote in-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension. 2000;35(1Pt 1): 38-42.
23. Stein M, Deegan R, Wood AJ. Long-term exposure to beta 2-receptor agonist specifically desensitizes beta-receptor-mediated venodilation. Gin Pharmacol Ther. 1993;54(2):187-193.
24. Model MA, Omann GM. Experimental approaches for observing homologous desensitisation and their pitfalls. Pharmacol Res 1998;38(1):41-44.
25. Kazanietz MG, Enero MA. Desensitization of the beta-2 adrenoceptor-mediated vasodilation in rat aorta after prolonged treatment with the beta-2 adrenoceptor agonist clenbuterol. J Pharmacol Exp Ther. 1990;252(2):758-764.
26. Hiebert LM, McDuffie NM. The internalization and release of heparins by cultured endothelial cells: The process is cell source, heparin source, time and concentration dependent. Artery. 1990;17(2):107-118.
27. Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA, Cannon RO, 3rd. Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation. 1995;91(6):1732-1738.
28. Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B. Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries. Am J Physiol. 2003;285(1):H369-H374.
29. Iaccarino G, Cipolletta E, Fiorillo A, Annecchiarico M, Ciccarelli M, Cimini V, Koch WJ, Trimarco B. Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension. Circulation. 2002;106(3):349-355.
30. Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervero P, Pastore L, Astone D, Trimarco B, Iaccarino G. Endothelial beta(2) adrenergic signaling to AKT: Role of G(i) and SRC. Cell Signal. 2007;19(9):1949-1955.
31. Bruck H, Leineweber K, Park J, Weber M, Heusch G, Philipp T, Brodde OE. Human beta2-adrenergic receptor gene haplotypes and venodilation in vivo. Gin Pharmacol Ther. 2005;78(3):232-238.
32. Khalaila JM, Elami A, Caraco Y. Interaction between beta2 adrenergic receptor polymorphisms determines the extent of isoproterenol-induced vasodilatation ex vivo. Pharmacogen Genomics 2007;17(10):803-811.
33. Barbato E, Berger A, Delrue L, Van Durme F, Manoharan G, Boussy T, Heyndrickx GR, De Bruyne B, Ciampi Q, Vanderheyden M, Wijns W, Bartunek J. GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease. Atherosclerosis 2007;194(2):e80-e86.
34. Feldman RD, Gros R. Impaired vasodilator function in hypertension: The role of alterations in receptor-G protein coupling. Trends Cardiovasc Med. 1998;8(7):297-305.
35. Gros R, Benovic JL, Tan CM, Feldman RD. G-protein-coupled receptor kinase activity is increased in hypertension. J Gin Invest. 1997;99(9):2087-2093.