GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia

American Journal of Hypertension

Volumn 25, Issue 3, 2012, Pages 366-371

  Napolitano, Raffaele ^a   Campanile, Alfonso ^a   Sarno, Laura ^a   Anastasio, Antonio ^a   Maruotti, Giuseppe M ^a   Morlando, Maddalena ^a   Trimarco, Bruno ^a   Martinelli, Pasquale ^a   Iaccarino, Guido ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

blood pressure; G proteins; hypertension; hypertension in pregnancy; preeclampsia; pregnancy; protein kinases; vasculature

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 2;

ADULT; ARTICLE; BIRTH WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DELIVERY; DENSITOMETRY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENZYME BLOOD LEVEL; FEMALE; FETUS; FETUS CIRCULATION; GESTATIONAL AGE; HUMAN; LINEAR REGRESSION ANALYSIS; MATERNAL HYPERTENSION; MEAN ARTERIAL PRESSURE; PLACENTA CIRCULATION; PREECLAMPSIA; PREGNANCY COMPLICATION; PREMATURE LABOR; PRIORITY JOURNAL; PROTEINURIA; SYSTOLIC BLOOD PRESSURE; UMBILICAL ARTERY;

ADULT; CASE-CONTROL STUDIES; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, ADRENERGIC, BETA; UMBILICAL ARTERIES;

EID: 84857058141     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1038/ajh.2011.211     Document Type: Article

References (33)

1. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol. 2000;183:S1-S22.
2. WHO. Make every mother and child count. World Health Report 2005. WHO: Geneva, 2005.
3. Why Mothers Die 2000-2002. The confidential enqueries into maternal deaths in the United Kingdom. RCOG: London, 2004.
4. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672-683. (Pubitemid 38364626)
5. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365:785-799. (Pubitemid 40311367)
6. Bolte AC, van Geijn HP, Dekker GA. Pathophysiology of preeclampsia and the role of serotonin. Eur J Obstet Gynecol Reprod Biol 2001; 95:12-21. (Pubitemid 32208665)
7. Carty DM, Delles C, Dominiczak AF. Novel biomarkers for predicting preeclampsia. Trends Cardiovasc Med 2008; 18:186-194.
8. George EM, Granger JP. Endothelin: key mediator of hypertension in preeclampsia. Am J Hypertens 2011; 24:964-969.
9. Bolin M, Wiberg-Itzel E, Wikström AK, Goop M, Larsson A, Olovsson M, Akerud H. Angiopoietin-1/angiopoietin-2 ratio for prediction of preeclampsia. Am J Hypertens 2009; 22:891-895.
10. Campanile A, Iaccarino G. G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine. Biomark Med 2009; 3:525-540.
11. Gros R, Benovic JL, Tan CM, Feldman RD. G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest 1997; 99:2087-2093. (Pubitemid 27203764)
12. Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol 2002; 61:749-758. (Pubitemid 34273154)
13. Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 2005; 11:952-958. (Pubitemid 41294440)
14. Melchiorre K, Leslie K, Prefumo F, Bhide A, Thilaganathan B. First-trimester uterine artery Doppler indices in the prediction of small-for-gestational age pregnancy and intrauterine growth restriction. Ultrasound Obstet Gynecol 2009; 33:524-529.
15. Napolitano R, Santo S, D'Souza R, Bhide A, Thilaganathan B. Sensitivity of higher, lower and mean second-trimester uterine artery Doppler resistance indices in screening for pre-eclampsia. Ultrasound Obstet Gynecol 2010; 36:573-576.
16. Napolitano R, Rajakulasingam R, Memmo A, Bhide A, Thilaganathan B. Uterine artery Doppler screening for pre-eclampsia: comparison of the lower, mean and higher first-trimester pulsatility indices. Ultrasound Obstet Gynecol 2011; 37: 534-537.
17. Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B. AKT participates in endothelial dysfunction in hypertension. Circulation 2004; 109:2587-2593. (Pubitemid 38720561)
18. Iaccarino G, Barbato E, Cipolleta E, Esposito A, Fiorillo A, Koch WJ, Trimarco B. Cardiac betaARK1 upregulation induced by chronic salt deprivation in rats. Hypertension 2001; 38:255-260. (Pubitemid 34224754)
19. Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S. Expression of G-proteincoupled receptor kinases in pregnant term and non-pregnant human myometrium. J Endocrinol 1999; 162:401-408. (Pubitemid 29447433)
20. Simon V, Mhaouty-Kodja S, Legrand C, Cohen-Tannoudji J. Concomitant increase of G protein-coupled receptor kinase activity and uncoupling of beta-adrenergic receptors in rat myometrium at parturition. Endocrinology 2001; 142: 1899-1905. (Pubitemid 32405947)
21. Willets JM, Taylor AH, Shaw H, Konje JC, Challiss RA. Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells. Mol Endocrinol 2008; 22:1893-1907.
22. Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B, Eckhart AD. G proteincoupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. Hypertension 2009; 54:71-76.
23. Izzo R, Cipolletta E, Ciccarelli M, Campanile A, Santulli G, Palumbo G, Vasta A, Formisano S, Trimarco B, Iaccarino G. Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients. Clin Transl Sci 2008; 1:215-220. (Pubitemid 352831524)
24. Vasapollo B, Novelli GP, Valensise H. Total vascular resistance and left ventricular morphology as screening tools for complications in pregnancy. Hypertension 2008; 51:1020-1026. (Pubitemid 351398969)
25. Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P, Trimarco B, Iaccarino G. The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance. Cardiovasc Res 2009; 84:407-415.
26. Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cell Signal 2011 epub ahead of print 2011 Oct 1.
27. Aune B, Vårtun A, Oian P, Sager G. Evidence of dysfunctional beta2-adrenoceptor signal system in pre-eclampsia. BJOG 2000; 107:116-121. (Pubitemid 30042734)
28. Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouché M, Rakotoniaina Z, Guérard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M. Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod 2006; 74:209-216. (Pubitemid 43068810)
29. Hynes PG, Friel AM, Smith TJ, Morrison JJ. Beta-adrenoceptor subtype expression in human placenta and umbilical arteries in normal and preeclamptic pregnancies. Hypertens Pregnancy 2008; 27:169-181. (Pubitemid 351892687)
30. Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf ) 2007; 190:9-19. (Pubitemid 46570176)
31. Villar J, Carroli G, Wojdyla D, Abalos E, Giordano D, Ba'aqeel H, Farnot U, Bergsjø P, Bakketeig L, Lumbiganon P, Campodónico L, Al-Mazrou Y, Lindheimer M, Kramer M; World Health Organization Antenatal Care Trial Research Group. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditionS̈ Am J Obstet Gynecol 2006; 194:921-931.
32. Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 2005; 26:1752-1758. (Pubitemid 41219848)
33. Staff AC, Dechend R, Pijnenborg R. Learning from the placenta: acute atherosis and vascular remodeling in preeclampsia-novel aspects for atherosclerosis and future cardiovascular health. Hypertension 2010; 56:1026-1034.