Distinct mPTP activation mechanisms in ischaemia-reperfusion: Contributions of Ca2+, ROS, pH, and inorganic polyphosphate

Cardiovascular Research

Volumn 106, Issue 2, 2015, Pages 237-248

  Seidlmayer, Lea K ^a   Juettner, Vanessa V ^a   Kettlewell, Sarah ^b   Pavlov, Evgeny V ^c,d   Blatter, Lothar A ^a   Dedkova, Elena N ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c DALHOUSIE UNIVERSITY   (Canada)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

Inorganic polyphosphate; Ischaemia reperfusion injury; Mitochondrial permeability transition pore; Mitochondrial ryanodine receptor; Oxidative stress

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTIOXIDANT; CALCIUM ION; CHLORIDE; DANTROLENE; HYDROGEN PEROXIDE; MANGANESE TETRAKIS (4 BENZOIC ACID)PORPHYRIN CHLORIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATE; POLYPHOSPHATE; PORPHYRIN DERIVATIVE; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 1; SUPEROXIDE; TROLOX C; UNCLASSIFIED DRUG; CALCIUM; CARRIER PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOSOL; DEPOLARIZATION; EXPERIMENTAL RABBIT; HEART MUSCLE CELL; NONHUMAN; PH; PRIORITY JOURNAL; REPERFUSION; REPERFUSION INJURY; TISSUE INJURY; ANIMAL; DRUG EFFECTS; HEART MITOCHONDRION; ISCHEMIA; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; PHYSIOLOGY; RABBIT;

ANIMALS; CALCIUM; CELL DEATH; HYDROGEN PEROXIDE; ISCHEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; PHOSPHATES; POLYPHOSPHATES; RABBITS; REACTIVE OXYGEN SPECIES;

EID: 84929069328     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv097     Document Type: Article

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