Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition

European Respiratory Journal

Volumn 45, Issue 5, 2015, Pages 1258-1272

  Gohy, Sophie T ^a,b   Hupin, Cloé ^a   Fregimilicka, Chantal ^a   Detry, Bruno R ^a   Bouzin, Caroline ^a   Chevronay, Héloïse Gaide ^c   Lecocq, Marylène ^a   Weynand, Birgit ^d   Ladjemi, Maha Z ^a,e   Pierreux, Christophe E ^c   Birembaut, Philippe ^f   Polette, Myriam ^f   Pilette, Charles ^a,b,e  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^c DE DUVE INSTITUTE   (Belgium)

^d UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^e Welbio (Walloon Excellence in Lifesciences and Biotechnology)   (Belgium)

^f UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; PROTEIN ZO1; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN; CADHERIN; CDH1 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN; TJP1 PROTEIN, HUMAN;

ADULT; AGED; AIR LIQUID INTERFACE; ARTICLE; BASEMENT MEMBRANE; BRONCHUS MUCOSA; CELL CULTURE; CELL DEDIFFERENTIATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TARGETING; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT PARAMETERS; AIRWAY OBSTRUCTION; BRONCHUS; CYTOLOGY; EPITHELIUM CELL; FIBROSIS; GENE EXPRESSION REGULATION; IN VITRO STUDY; LUNG; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

AGED; AIRWAY OBSTRUCTION; BRONCHI; CADHERINS; CELL DEDIFFERENTIATION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBRONECTINS; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; IN VITRO TECHNIQUES; LUNG; MALE; MIDDLE AGED; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84928995539     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00135814     Document Type: Article

References (42)

1. WHO. Global burden disease. www.who.int/healthinfo/global-burden-disease/projections/en/. Date last updated July 2013. Date last accessed: January 2015.
2. Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011; 378: 1015-1026.
3. Barnes PJ. New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov 2013; 12: 543-559.
4. Valenta T, Hausmann G, Basler K. The many faces and functions of beta-catenin. EMBO J 2012; 31: 2714-2736.
5. Puchelle E, Zahm JM, Tournier JM, et al. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3: 726-733.
6. Rennard SI. Inflammation and repair processes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: S12-S16.
7. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
8. Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004; 1: 176-183.
9. Kim V, Criner GJ. Chronic bronchitis and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 228-237.
10. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784.
11. Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006; 103: 13180-13185.
12. Sohal SS, Reid D, Soltani A, et al. Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 2010; 15: 930-938.
13. Sohal SS, Reid D, Soltani A, et al. Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease. Respir Res 2011; 12: 130.
14. Milara J, Peiro T, Serrano A, et al. Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax 2013; 68: 410-420.
15. Gohy S, Detry B, Bouzin C, et al. Increased vimentin expression in human primary bronchial epithelium reconstituted in vitro from patients with COPD. Eur Respir J 2013; 42: Suppl. 57, P3124.
16. Gohy S, Detry B, Polette M, et al. Epithelial to mesenchymal transition in the airway epithelium from COPD patients: Correlation to disease severity. ERS Lung Science Conference 2014. Available from http://www.ers-education.org/Media/Media.aspx?idMedia=255936 Date last updated: September 2014. Date last accessed: November 11, 2014.
17. Wilson JW, Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin Exp Allergy 1997; 27: 363-371.
18. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.
19. Gaide Chevronnay HP, Janssens V, Van Der Smissen P, et al. Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys. J Am Soc Nephrol 2014; 25: 1256-1269.
20. Chilosi M, Poletti V, Zamo A, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 2003; 162: 1495-1502.
21. Yao HW, Xie QM, Chen JQ, et al. TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci 2004; 76: 29-37.
22. Bartis D, Mise N, Mahida RY, et al. Epithelial-mesenchymal transition in lung development and disease: Does it exist and is it important? Thorax 2014; 69: p760-765.
23. Pain M, Bermudez O, Lacoste P, et al. Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype. Eur Respir Rev 2014; 23: 118-130.
24. Johnson JR, Roos A, Berg T, et al. Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. PLoS One 2011; 6: E16175.
25. Ward C, Forrest IA, Murphy DM, et al. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005; 60: 865-871.
26. Hupin C, Gohy S, Bouzin C, et al. Features of mesenchymal transition in the airway epithelium from chronic rhinosinusitis. Allergy 2014; 69: 1540-1549.
27. Heijink IH, Brandenburg SM, Postma DS, et al. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 2012; 39: 419-428.
28. Bourdin A, Neveu D, Vachier I, et al. Specificity of basement membrane thickening in severe asthma. J Allergy Clin Immunol 2007; 119: 1367-1374.
29. Benayoun L, Druilhe A, Dombret MC, et al. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167: 1360-1368.
30. Noe V, Fingleton B, Jacobs K, et al. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci 2001; 114: 111-118.
31. Coraux C, Kileztky C, Polette M, et al. Airway epithelial integrity is protected by a long-acting β2-adrenergic receptor agonist. Am J Respir Cell Mol Biol 2004; 30: 605-612.
32. Pierrou S, Broberg P, O'Donnell RA, et al. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175: 577-586.
33. Comer DM, Kidney JC, Ennis M, et al. Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers. Eur Respir J 2013; 41: 1058-1067.
34. Randell SH. Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3: 718-725.
35. Daly TJ, Weston WL. Retinoid effects on fibroblast proliferation and collagen synthesis in vitro and on fibrotic disease in vivo. J Am Acad Dermatol 1986; 15: 900-902.
36. Smolonska J, Wijmenga C, Postma DS, et al. Meta-analyses on suspected chronic obstructive pulmonary disease genes: A summary of 20 years' research. Am J Respir Crit Care Med 2009; 180: 618-631.
37. Soler Artigas M, Loth DW, Wain LV, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 2011; 43: 1082-1090.
38. Takizawa H, Tanaka M, Takami K, et al. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001; 163: 1476-1483.
39. Hackett TL, Warner SM, Stefanowicz D, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009; 180: 122-133.
40. Wang RD, Wright JL, Churg A. Transforming growth factor-beta1 drives airway remodeling in cigarette smoke-exposed tracheal explants. Am J Respir Cell Mol Biol 2005; 33: 387-393.
41. Kaelin WG Jr, McKnight SL. Influence of metabolism on epigenetics and disease. Cell 2013; 153: 56-69.
42. Podowski M, Calvi C, Metzger S, et al. Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest 2012; 122: 229-240.