메뉴 건너뛰기




Volumn 7, Issue 7, 2015, Pages 980-992

Immunotherapy for hepatocellular carcinoma: From basic research to clinical use

Author keywords

Adoptive immunotherapy; Checkpoint blockade; Chemokine; Chimeric antigen receptor; Interferon; Tumor vaccine

Indexed keywords


EID: 84928986303     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v7.i7.980     Document Type: Article
Times cited : (38)

References (143)
  • 1
    • 0033777169 scopus 로고    scopus 로고
    • Primary liver tumors
    • [PMID: 11126378]
    • Lau WY. Primary liver tumors. Semin Surg Oncol 2000; 19: 135-144 [PMID: 11126378]
    • (2000) Semin Surg Oncol , vol.19 , pp. 135-144
    • Lau, W.Y.1
  • 2
    • 84928983105 scopus 로고    scopus 로고
    • GLOBOCAN 2012: estimated cancer incidence, motality and prevalence worldwide in 2012
    • [Accessed in 26 August, 2014]. Available from: URL
    • Cancer IAfRo. GLOBOCAN 2012: estimated cancer incidence, motality and prevalence worldwide in 2012. [Accessed in 26 August, 2014]. Available from: URL: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
  • 3
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: an update
    • [PMID: 21374666]
    • Bruix J, Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53: 1020-1022 [PMID: 21374666 DOI: 10.1002/ hep.24199]
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 5
    • 84863983544 scopus 로고    scopus 로고
    • Immunobiology of hepatocellular carcinoma
    • [PMID: 21479622]
    • Flecken T, Spangenberg HC, Thimme R. Immunobiology of hepatocellular carcinoma. Langenbecks Arch Surg 2012; 397: 673-680 [PMID: 21479622 DOI: 10.1007/s00423-011-0783-x]
    • (2012) Langenbecks Arch Surg , vol.397 , pp. 673-680
    • Flecken, T.1    Spangenberg, H.C.2    Thimme, R.3
  • 6
    • 84902244229 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to hepatocellular carcinoma treatment
    • [PMID: 24159587]
    • Miamen AG, Dong H, Roberts LR. Immunotherapeutic approaches to hepatocellular carcinoma treatment. Liver Cancer 2012; 1: 226-237 [PMID: 24159587 DOI: 10.1159/000343837]
    • (2012) Liver Cancer , vol.1 , pp. 226-237
    • Miamen, A.G.1    Dong, H.2    Roberts, L.R.3
  • 7
    • 33845420396 scopus 로고    scopus 로고
    • The role of cytokines in hepatocellular carcinoma
    • [PMID: 16946019]
    • Budhu A, Wang XW. The role of cytokines in hepatocellular carcinoma. J Leukoc Biol 2006; 80: 1197-1213 [PMID: 16946019 DOI: 10.1189/jlb.0506297]
    • (2006) J Leukoc Biol , vol.80 , pp. 1197-1213
    • Budhu, A.1    Wang, X.W.2
  • 8
    • 79954657385 scopus 로고    scopus 로고
    • Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma
    • [PMID: 21145847]
    • Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, Yin XY, Zheng L. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol 2011; 54: 948-955 [PMID: 21145847 DOI: 10.1016/ j.jhep.2010.08.041]
    • (2011) J Hepatol , vol.54 , pp. 948-955
    • Kuang, D.M.1    Zhao, Q.2    Wu, Y.3    Peng, C.4    Wang, J.5    Xu, Z.6    Yin, X.Y.7    Zheng, L.8
  • 9
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • [PMID: 19329213]
    • Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 2009; 50: 980-989 [PMID: 19329213 DOI: 10.1016/j.jhep.2008.12.033]
    • (2009) J Hepatol , vol.50 , pp. 980-989
    • Zhang, J.P.1    Yan, J.2    Xu, J.3    Pang, X.H.4    Chen, M.S.5    Li, L.6    Wu, C.7    Li, S.P.8    Zheng, L.9
  • 11
    • 84858153171 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
    • [PMID: 22182446]
    • Li T, Yang Y, Hua X, Wang G, Liu W, Jia C, Tai Y, Zhang Q, Chen G. Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO. Cancer Lett 2012; 318: 154-161 [PMID: 22182446 DOI: 10.1016/j.canlet.2011.12.020]
    • (2012) Cancer Lett , vol.318 , pp. 154-161
    • Li, T.1    Yang, Y.2    Hua, X.3    Wang, G.4    Liu, W.5    Jia, C.6    Tai, Y.7    Zhang, Q.8    Chen, G.9
  • 12
    • 59149106939 scopus 로고    scopus 로고
    • IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53
    • [PMID: 19141642]
    • Herzer K, Hofmann TG, Teufel A, Schimanski CC, Moehler M, Kanzler S, Schulze-Bergkamen H, Galle PR. IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Cancer Res 2009; 69: 855-862 [PMID: 19141642 DOI: 10.1158/0008-5472. CAN-08-2831]
    • (2009) Cancer Res , vol.69 , pp. 855-862
    • Herzer, K.1    Hofmann, T.G.2    Teufel, A.3    Schimanski, C.C.4    Moehler, M.5    Kanzler, S.6    Schulze-bergkamen, H.7    Galle, P.R.8
  • 13
    • 84865508002 scopus 로고    scopus 로고
    • Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)
    • [PMID: 22056812]
    • Li P, Du Q, Cao Z, Guo Z, Evankovich J, Yan W, Chang Y, Shao L, Stolz DB, Tsung A, Geller DA. Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett 2012; 314: 213-222 [PMID: 22056812 DOI: 10.1016/j.canlet.2011.09.031]
    • (2012) Cancer Lett , vol.314 , pp. 213-222
    • Li, P.1    Du, Q.2    Cao, Z.3    Guo, Z.4    Evankovich, J.5    Yan, W.6    Chang, Y.7    Shao, L.8    Stolz, D.B.9    Tsung, A.10    Geller, D.A.11
  • 20
    • 84862558130 scopus 로고    scopus 로고
    • Therapeutic efficacy of combination therapy with intra-arterial 5-fluorouracil and systemic pegylated interferon α-2b for advanced hepatocellular carcinoma with portal venous invasion
    • [PMID: 22072099]
    • Kasai K, Ushio A, Kasai Y, Sawara K, Miyamoto Y, Oikawa K, Kuroda H, Takikawa Y, Suzuki K. Therapeutic efficacy of combination therapy with intra-arterial 5-fluorouracil and systemic pegylated interferon α-2b for advanced hepatocellular carcinoma with portal venous invasion. Cancer 2012; 118: 3302-3310 [PMID: 22072099 DOI: 10.1002/cncr.26648]
    • (2012) Cancer , vol.118 , pp. 3302-3310
    • Kasai, K.1    Ushio, A.2    Kasai, Y.3    Sawara, K.4    Miyamoto, Y.5    Oikawa, K.6    Kuroda, H.7    Takikawa, Y.8    Suzuki, K.9
  • 21
    • 84878590204 scopus 로고    scopus 로고
    • Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma
    • [PMID: 23564564]
    • Lee D, Chung YH, Kim JA, Park WH, Jin YJ, Shim JH, Ryu SH, Jang MK, Yu E, Lee YJ. Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma. Cancer 2013; 119: 2239-2246 [PMID: 23564564 DOI: 10.1002/cncr.28082]
    • (2013) Cancer , vol.119 , pp. 2239-2246
    • Lee, D.1    Chung, Y.H.2    Kim, J.A.3    Park, W.H.4    Jin, Y.J.5    Shim, J.H.6    Ryu, S.H.7    Jang, M.K.8    Yu, E.9    Lee, Y.J.10
  • 22
    • 69049092776 scopus 로고    scopus 로고
    • Combination therapy with transarterial chemoembolization and interferon-alpha compared with transarterial chemoembolization alone for hepatitis B virus related unresectable hepatocellular carcinoma
    • [PMID: 19486255]
    • Li M, Lu C, Cheng J, Zhang J, Cao C, Xu J, Xu J, Pan H, Zhong B, Tucker S, Wang D. Combination therapy with transarterial chemoembolization and interferon-alpha compared with transarterial chemoembolization alone for hepatitis B virus related unresectable hepatocellular carcinoma. J Gastroenterol Hepatol 2009; 24: 1437-1444 [PMID: 19486255 DOI: 10.1111/j.1440-1746.2009.05863. x]
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1437-1444
    • Li, M.1    Lu, C.2    Cheng, J.3    Zhang, J.4    Cao, C.5    Xu, J.6    Xu, J.7    Pan, H.8    Zhong, B.9    Tucker, S.10    Wang, D.11
  • 23
    • 77952422635 scopus 로고    scopus 로고
    • Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): a meta-regression approach
    • [PMID: 20395009]
    • Shen YC, Hsu C, Chen LT, Cheng CC, Hu FC, Cheng AL. Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): a meta-regression approach. J Hepatol 2010; 52: 889-894 [PMID: 20395009 DOI: 10.1016/j.jhep.2009.12.041]
    • (2010) J Hepatol , vol.52 , pp. 889-894
    • Shen, Y.C.1    Hsu, C.2    Chen, L.T.3    Cheng, C.C.4    Hu, F.C.5    Cheng, A.L.6
  • 24
    • 84879802731 scopus 로고    scopus 로고
    • A meta-analysis of adjuvant therapy after potentially curative treatment for hepatocellular carcinoma
    • [PMID: 23781519]
    • Wang J, He XD, Yao N, Liang WJ, Zhang YC. A meta-analysis of adjuvant therapy after potentially curative treatment for hepatocellular carcinoma. Can J Gastroenterol 2013; 27: 351-363 [PMID: 23781519]
    • (2013) Can J Gastroenterol , vol.27 , pp. 351-363
    • Wang, J.1    He, X.D.2    Yao, N.3    Liang, W.J.4    Zhang, Y.C.5
  • 25
    • 84862277821 scopus 로고    scopus 로고
    • Combined anti-tumor effects of IFN-α and sorafenib on hepatocellular carcinoma in vitro and in vivo
    • [PMID: 22634008]
    • Wang L, Jia D, Duan F, Sun Z, Liu X, Zhou L, Sun L, Ren S, Ruan Y, Gu J. Combined anti-tumor effects of IFN-α and sorafenib on hepatocellular carcinoma in vitro and in vivo. Biochem Biophys Res Commun 2012; 422: 687-692 [PMID: 22634008 DOI: 10.1016/j.bbrc.2012.05.056]
    • (2012) Biochem Biophys Res Commun , vol.422 , pp. 687-692
    • Wang, L.1    Jia, D.2    Duan, F.3    Sun, Z.4    Liu, X.5    Zhou, L.6    Sun, L.7    Ren, S.8    Ruan, Y.9    Gu, J.10
  • 26
    • 66149162007 scopus 로고    scopus 로고
    • Benefits and risks of interferon therapy for hepatitis B
    • [PMID: 19399806]
    • Perrillo R. Benefits and risks of interferon therapy for hepatitis B. Hepatology 2009; 49: S103-S111 [PMID: 19399806 DOI: 10.1002/hep.22956]
    • (2009) Hepatology , vol.49 , pp. S103-S111
    • Perrillo, R.1
  • 27
    • 84904265622 scopus 로고    scopus 로고
    • MiR-221 accentuates IFN's anti-HCV effect by downregulating SOCS1 and SOCS3
    • 343-350 [PMID: 25019494]
    • Xu G, Yang F, Ding CL, Wang J, Zhao P, Wang W, Ren H. MiR-221 accentuates IFN's anti-HCV effect by downregulating SOCS1 and SOCS3. Virology 2014; 462-463: 343-350 [PMID: 25019494 DOI: 10.1016/j.virol.2014.06.024]
    • (2014) Virology , pp. 462-463
    • Xu, G.1    Yang, F.2    Ding, C.L.3    Wang, J.4    Zhao, P.5    Wang, W.6    Ren, H.7
  • 28
    • 0028999561 scopus 로고
    • Combined transarterial targeting locoregional immunotherapychemotherapy for patients with unresectable hepatocellular carcinoma: a new alternative for an old problem
    • [PMID: 7544232]
    • Lygidakis NJ, Kosmidis P, Ziras N, Parissis J, Kyparidou E. Combined transarterial targeting locoregional immunotherapychemotherapy for patients with unresectable hepatocellular carcinoma: a new alternative for an old problem. J Interferon Cytokine Res 1995; 15: 467-472 [PMID: 7544232 DOI: 10.1089/ jir.1995.15.467]
    • (1995) J Interferon Cytokine Res , vol.15 , pp. 467-472
    • Lygidakis, N.J.1    Kosmidis, P.2    Ziras, N.3    Parissis, J.4    Kyparidou, E.5
  • 31
    • 84885430641 scopus 로고    scopus 로고
    • The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma
    • [PMID: 23907578]
    • Yuan L, Zhao H, Zhang L, Liu X. The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma. Tumour Biol 2013; 34: 3027-3034 [PMID: 23907578 DOI: 10.1007/ s13277-013-0867-z]
    • (2013) Tumour Biol , vol.34 , pp. 3027-3034
    • Yuan, L.1    Zhao, H.2    Zhang, L.3    Liu, X.4
  • 32
    • 84906535982 scopus 로고    scopus 로고
    • Roles for chemokines in liver disease
    • e1 [PMID: 25066692]
    • Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology 2014; 147: 577-594. e1 [PMID: 25066692 DOI: 10.1053/ j.gastro.2014.06.043]
    • (2014) Gastroenterology , vol.147 , pp. 577-594
    • Marra, F.1    Tacke, F.2
  • 33
  • 34
    • 84899141082 scopus 로고    scopus 로고
    • The effects of the CCR6/CCL20 biological axis on the invasion and metastasis of hepatocellular carcinoma
    • [PMID: 24743888]
    • Du D, Liu Y, Qian H, Zhang B, Tang X, Zhang T, Liu W. The effects of the CCR6/CCL20 biological axis on the invasion and metastasis of hepatocellular carcinoma. Int J Mol Sci 2014; 15: 6441-6452 [PMID: 24743888 DOI: 10.3390/ijms15046441]
    • (2014) Int J Mol Sci , vol.15 , pp. 6441-6452
    • Du, D.1    Liu, Y.2    Qian, H.3    Zhang, B.4    Tang, X.5    Zhang, T.6    Liu, W.7
  • 35
    • 11444252814 scopus 로고    scopus 로고
    • Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma
    • [PMID: 15639651]
    • Liu Y, Poon RT, Hughes J, Feng X, Yu WC, Fan ST. Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma. Clin Immunol 2005; 114: 174-182 [PMID: 15639651 DOI: 10.1016/j.clim.2004.10.006]
    • (2005) Clin Immunol , vol.114 , pp. 174-182
    • Liu, Y.1    Poon, R.T.2    Hughes, J.3    Feng, X.4    Yu, W.C.5    Fan, S.T.6
  • 37
    • 84922214829 scopus 로고    scopus 로고
    • Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions
    • [PMID: 24912948]
    • Hato T, Goyal L, Greten TF, Duda DG, Zhu AX. Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions. Hepatology 2014; 60: 1776-1782 [PMID: 24912948 DOI: 10.1002/hep.27246]
    • (2014) Hepatology , vol.60 , pp. 1776-1782
    • Hato, T.1    Goyal, L.2    Greten, T.F.3    Duda, D.G.4    Zhu, A.X.5
  • 41
    • 0035923535 scopus 로고    scopus 로고
    • PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    • [PMID: 11698646]
    • Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA 2001; 98: 13866-13871 [PMID: 11698646 DOI: 10.1073/pnas.231486598]
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13866-13871
    • Okazaki, T.1    Maeda, A.2    Nishimura, H.3    Kurosaki, T.4    Honjo, T.5
  • 42
    • 33745402810 scopus 로고    scopus 로고
    • Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86
    • [PMID: 16708397]
    • Manzotti CN, Liu MK, Burke F, Dussably L, Zheng Y, Sansom DM. Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86. Eur J Immunol 2006; 36: 1413-1422 [PMID: 16708397 DOI: 10.1002/eji.200535170]
    • (2006) Eur J Immunol , vol.36 , pp. 1413-1422
    • Manzotti, C.N.1    Liu, M.K.2    Burke, F.3    Dussably, L.4    Zheng, Y.5    Sansom, D.M.6
  • 43
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • [PMID: 20008522]
    • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206: 3015-3029 [PMID: 20008522 DOI: 10.1084/ jem.20090847]
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3    Vanguri, V.K.4    Freeman, G.J.5    Kuchroo, V.K.6    Sharpe, A.H.7
  • 45
    • 61549087798 scopus 로고    scopus 로고
    • Cancer prevention by vaccination against hepatitis B
    • [PMID: 19213561]
    • Chang MH. Cancer prevention by vaccination against hepatitis B. Recent Results Cancer Res 2009; 181: 85-94 [PMID: 19213561]
    • (2009) Recent Results Cancer Res , vol.181 , pp. 85-94
    • Chang, M.H.1
  • 46
    • 84906705637 scopus 로고    scopus 로고
    • Tumor markers for hepatocellular carcinoma
    • [PMID: 24649215]
    • Zhao YJ, Ju Q, Li GC. Tumor markers for hepatocellular carcinoma. Mol Clin Oncol 2013; 1: 593-598 [PMID: 24649215 DOI: 10.3892/ mco.2013.119]
    • (2013) Mol Clin Oncol , vol.1 , pp. 593-598
    • Zhao, Y.J.1    Ju, Q.2    Li, G.C.3
  • 50
    • 84896493342 scopus 로고    scopus 로고
    • Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma
    • [PMID: 24122861]
    • Hong Y, Peng Y, Guo ZS, Guevara-Patino J, Pang J, Butterfield LH, Mivechi NF, Munn DH, Bartlett DL, He Y. Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma. Hepatology 2014; 59: 1448-1458 [PMID: 24122861 DOI: 10.1002/hep.26893]
    • (2014) Hepatology , vol.59 , pp. 1448-1458
    • Hong, Y.1    Peng, Y.2    Guo, Z.S.3    Guevara-patino, J.4    Pang, J.5    Butterfield, L.H.6    Mivechi, N.F.7    Munn, D.H.8    Bartlett, D.L.9    He, Y.10
  • 51
    • 84860274799 scopus 로고    scopus 로고
    • Development of a Listeria monocytogenes-based vaccine against hepatocellular carcinoma
    • [PMID: 21927025]
    • Chen Y, Yang D, Li S, Gao Y, Jiang R, Deng L, Frankel FR, Sun B. Development of a Listeria monocytogenes-based vaccine against hepatocellular carcinoma. Oncogene 2012; 31: 2140-2152 [PMID: 21927025 DOI: 10.1038/onc.2011.395]
    • (2012) Oncogene , vol.31 , pp. 2140-2152
    • Chen, Y.1    Yang, D.2    Li, S.3    Gao, Y.4    Jiang, R.5    Deng, L.6    Frankel, F.R.7    Sun, B.8
  • 52
    • 34548565788 scopus 로고    scopus 로고
    • Inhibition effects on liver tumors of BALB/c mice bearing H22 cells by immunization with a recombinant immunogen of GnRH linked to heat shock protein 65
    • [PMID: 17728021]
    • Zhang Y, Xu J, Zhao R, Liu J, Wu J. Inhibition effects on liver tumors of BALB/c mice bearing H22 cells by immunization with a recombinant immunogen of GnRH linked to heat shock protein 65. Vaccine 2007; 25: 6911-6921 [PMID: 17728021 DOI: 10.1016/ j.vaccine.2007.07.034]
    • (2007) Vaccine , vol.25 , pp. 6911-6921
    • Zhang, Y.1    Xu, J.2    Zhao, R.3    Liu, J.4    Wu, J.5
  • 53
    • 85047686311 scopus 로고    scopus 로고
    • Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status
    • [PMID: 19627485]
    • Saini N, Srinivasan R, Chawla Y, Sharma S, Chakraborti A, Rajwanshi A. Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status. Liver Int 2009; 29: 1162-1170 [PMID: 19627485 DOI: 10.1111/j.1478-3231.2009.02082. x]
    • (2009) Liver Int , vol.29 , pp. 1162-1170
    • Saini, N.1    Srinivasan, R.2    Chawla, Y.3    Sharma, S.4    Chakraborti, A.5    Rajwanshi, A.6
  • 55
    • 77953963578 scopus 로고    scopus 로고
    • A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • [PMID: 20478057]
    • Greten TF, Forner A, Korangy F, N'Kontchou G, Barget N, Ayuso C, Ormandy LA, Manns MP, Beaugrand M, Bruix J. A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer 2010; 10: 209 [PMID: 20478057 DOI: 10.1186/1471-2407-10-209]
    • (2010) BMC Cancer , vol.10 , pp. 209
    • Greten, T.F.1    Forner, A.2    Korangy, F.3    N'Kontchou, G.4    Barget, N.5    Ayuso, C.6    Ormandy, L.A.7    Manns, M.P.8    Beaugrand, M.9    Bruix, J.10
  • 57
    • 34247611546 scopus 로고    scopus 로고
    • A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma
    • [PMID: 17186291]
    • Lan YH, Li YG, Liang ZW, Chen M, Peng ML, Tang L, Hu HD, Ren H. A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma. Cancer Immunol Immunother 2007; 56: 1009-1016 [PMID: 17186291 DOI: 10.1007/s00262-006-0254-3]
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1009-1016
    • Lan, Y.H.1    Li, Y.G.2    Liang, Z.W.3    Chen, M.4    Peng, M.L.5    Tang, L.6    Hu, H.D.7    Ren, H.8
  • 58
    • 84902659421 scopus 로고    scopus 로고
    • GPC3 DNA vaccine elicits potent cellular antitumor immunity against HCC in mice
    • [PMID: 24901124]
    • Li SQ, Lin J, Qi CY, Fu SJ, Xiao WK, Peng BG, Liang LJ. GPC3 DNA vaccine elicits potent cellular antitumor immunity against HCC in mice. Hepatogastroenterology 2014; 61: 278-284 [PMID: 24901124]
    • (2014) Hepatogastroenterology , vol.61 , pp. 278-284
    • Li, S.Q.1    Lin, J.2    Qi, C.Y.3    Fu, S.J.4    Xiao, W.K.5    Peng, B.G.6    Liang, L.J.7
  • 59
    • 84865414055 scopus 로고    scopus 로고
    • DNA vaccine encoding alpha-fetoprotein with fused ornithine decarboxylase degradation signal significantly suppresses hepatocellular carcinoma growth in mice
    • [PMID: 22888633]
    • Morozov AV, Morozov VA, Astakhova TM, Timofeev AV, Karpov VL. [DNA vaccine encoding alpha-fetoprotein with fused ornithine decarboxylase degradation signal significantly suppresses hepatocellular carcinoma growth in mice]. Mol Biol (Mosk) 2012; 46: 434-451 [PMID: 22888633]
    • (2012) Mol Biol (Mosk) , vol.46 , pp. 434-451
    • Morozov, A.V.1    Morozov, V.A.2    Astakhova, T.M.3    Timofeev, A.V.4    Karpov, V.L.5
  • 60
    • 84899635997 scopus 로고    scopus 로고
    • Alpha fetoprotein DNA prime and adenovirus boost immunization of two hepatocellular cancer patients
    • [PMID: 24708667]
    • Butterfield LH, Economou JS, Gamblin TC, Geller DA. Alpha fetoprotein DNA prime and adenovirus boost immunization of two hepatocellular cancer patients. J Transl Med 2014; 12: 86 [PMID: 24708667 DOI: 10.1186/1479-5876-12-86]
    • (2014) J Transl Med , vol.12 , pp. 86
    • Butterfield, L.H.1    Economou, J.S.2    Gamblin, T.C.3    Geller, D.A.4
  • 61
    • 0034100047 scopus 로고    scopus 로고
    • Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection
    • [PMID: 10824889]
    • Kakumu S, Ito S, Ishikawa T, Mita Y, Tagaya T, Fukuzawa Y, Yoshioka K. Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J Gastroenterol Hepatol 2000; 15: 431-436 [PMID: 10824889 DOI: 10.1046/j.1440-1746.2000.02161.x]
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 431-436
    • Kakumu, S.1    Ito, S.2    Ishikawa, T.3    Mita, Y.4    Tagaya, T.5    Fukuzawa, Y.6    Yoshioka, K.7
  • 63
    • 0032807075 scopus 로고    scopus 로고
    • Dendritic cells with immature phenotype and defective function in the peripheral blood from patients with hepatocellular carcinoma
    • [PMID: 10453947]
    • Ninomiya T, Akbar SM, Masumoto T, Horiike N, Onji M. Dendritic cells with immature phenotype and defective function in the peripheral blood from patients with hepatocellular carcinoma. J Hepatol 1999; 31: 323-331 [PMID: 10453947 DOI: 10.1016/ S0168-8278(99)80231-1]
    • (1999) J Hepatol , vol.31 , pp. 323-331
    • Ninomiya, T.1    Akbar, S.M.2    Masumoto, T.3    Horiike, N.4    Onji, M.5
  • 64
    • 33644535813 scopus 로고    scopus 로고
    • Dendritic cell infiltration and prognosis of human hepatocellular carcinoma
    • [PMID: 16421755]
    • Cai XY, Gao Q, Qiu SJ, Ye SL, Wu ZQ, Fan J, Tang ZY. Dendritic cell infiltration and prognosis of human hepatocellular carcinoma. J Cancer Res Clin Oncol 2006; 132: 293-301 [PMID: 16421755 DOI: 10.1007/s00432-006-0075-y]
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 293-301
    • Cai, X.Y.1    Gao, Q.2    Qiu, S.J.3    Ye, S.L.4    Wu, Z.Q.5    Fan, J.6    Tang, Z.Y.7
  • 65
  • 66
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • [PMID: 15573129]
    • Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 2004; 4: 941-952 [PMID: 15573129 DOI: 10.1038/nri1498]
    • (2004) Nat Rev Immunol , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 68
    • 81555227862 scopus 로고    scopus 로고
    • Dendritic cell-based vaccines positively impact natural killer and regulatory T cells in hepatocellular carcinoma patients
    • [PMID: 21969837]
    • Bray SM, Vujanovic L, Butterfield LH. Dendritic cell-based vaccines positively impact natural killer and regulatory T cells in hepatocellular carcinoma patients. Clin Dev Immunol 2011; 2011: 249281 [PMID: 21969837 DOI: 10.1155/2011/249281]
    • (2011) Clin Dev Immunol , vol.2011 , pp. 249281
    • Bray, S.M.1    Vujanovic, L.2    Butterfield, L.H.3
  • 69
    • 68549104042 scopus 로고    scopus 로고
    • Comparative analysis of DC fused with allogeneic hepatocellular carcinoma cell line HepG2 and autologous tumor cells as potential cancer vaccines against hepatocellular carcinoma
    • [PMID: 19545862]
    • Cao DY, Yang JY, Yue SQ, Tao KS, Song ZS, Wang DS, Yang YL, Dou KF. Comparative analysis of DC fused with allogeneic hepatocellular carcinoma cell line HepG2 and autologous tumor cells as potential cancer vaccines against hepatocellular carcinoma. Cell Immunol 2009; 259: 13-20 [PMID: 19545862 DOI: 10.1016/ j.cellimm.2009.05.007]
    • (2009) Cell Immunol , vol.259 , pp. 13-20
    • Cao, D.Y.1    Yang, J.Y.2    Yue, S.Q.3    Tao, K.S.4    Song, Z.S.5    Wang, D.S.6    Yang, Y.L.7    Dou, K.F.8
  • 70
    • 33845337663 scopus 로고    scopus 로고
    • Comparative analysis of DC fused with tumor cells or transfected with tumor total RNA as potential cancer vaccines against hepatocellular carcinoma
    • [PMID: 17148035]
    • Zhang HM, Zhang LW, Liu WC, Cheng J, Si XM, Ren J. Comparative analysis of DC fused with tumor cells or transfected with tumor total RNA as potential cancer vaccines against hepatocellular carcinoma. Cytotherapy 2006; 8: 580-588 [PMID: 17148035 DOI: 10.1080/14653240600991353]
    • (2006) Cytotherapy , vol.8 , pp. 580-588
    • Zhang, H.M.1    Zhang, L.W.2    Liu, W.C.3    Cheng, J.4    Si, X.M.5    Ren, J.6
  • 71
    • 22744442701 scopus 로고    scopus 로고
    • Antitumour activity mediated by CD4+ cytotoxic T lymphocytes against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12
    • [PMID: 16011514]
    • Homma S, Komita H, Sagawa Y, Ohno T, Toda G. Antitumour activity mediated by CD4+ cytotoxic T lymphocytes against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12. Immunology 2005; 115: 451-461 [PMID: 16011514 DOI: 10.1111/j.1365-2567.2005.02179. x]
    • (2005) Immunology , vol.115 , pp. 451-461
    • Homma, S.1    Komita, H.2    Sagawa, Y.3    Ohno, T.4    Toda, G.5
  • 72
    • 0037384518 scopus 로고    scopus 로고
    • A phase I study of autologous dendritic cell-based immunotherapy for patients with unresectable primary liver cancer
    • [PMID: 12649744]
    • Iwashita Y, Tahara K, Goto S, Sasaki A, Kai S, Seike M, Chen CL, Kawano K, Kitano S. A phase I study of autologous dendritic cell-based immunotherapy for patients with unresectable primary liver cancer. Cancer Immunol Immunother 2003; 52: 155-161 [PMID: 12649744]
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 155-161
    • Iwashita, Y.1    Tahara, K.2    Goto, S.3    Sasaki, A.4    Kai, S.5    Seike, M.6    Chen, C.L.7    Kawano, K.8    Kitano, S.9
  • 74
    • 24144433435 scopus 로고    scopus 로고
    • Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial
    • [PMID: 16113606]
    • Lee WC, Wang HC, Hung CF, Huang PF, Lia CR, Chen MF. Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial. J Immunother 2005; 28: 496-504 [PMID: 16113606 DOI: 10.1097/01.cji.0000171291.72039. e2]
    • (2005) J Immunother , vol.28 , pp. 496-504
    • Lee, W.C.1    Wang, H.C.2    Hung, C.F.3    Huang, P.F.4    Lia, C.R.5    Chen, M.F.6
  • 76
    • 58949092553 scopus 로고    scopus 로고
    • A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma
    • [PMID: 18980227]
    • Palmer DH, Midgley RS, Mirza N, Torr EE, Ahmed F, Steele JC, Steven NM, Kerr DJ, Young LS, Adams DH. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology 2009; 49: 124-132 [PMID: 18980227 DOI: 10.1002/hep.22626]
    • (2009) Hepatology , vol.49 , pp. 124-132
    • Palmer, D.H.1    Midgley, R.S.2    Mirza, N.3    Torr, E.E.4    Ahmed, F.5    Steele, J.C.6    Steven, N.M.7    Kerr, D.J.8    Young, L.S.9    Adams, D.H.10
  • 77
    • 84867765852 scopus 로고    scopus 로고
    • Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma
    • [PMID: 22971679]
    • Tada F, Abe M, Hirooka M, Ikeda Y, Hiasa Y, Lee Y, Jung NC, Lee WB, Lee HS, Bae YS, Onji M. Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. Int J Oncol 2012; 41: 1601-1609 [PMID: 22971679 DOI: 10.3892/ijo.2012.1626]
    • (2012) Int J Oncol , vol.41 , pp. 1601-1609
    • Tada, F.1    Abe, M.2    Hirooka, M.3    Ikeda, Y.4    Hiasa, Y.5    Lee, Y.6    Jung, N.C.7    Lee, W.B.8    Lee, H.S.9    Bae, Y.S.10    Onji, M.11
  • 78
    • 14744275172 scopus 로고    scopus 로고
    • Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    • [PMID: 15725956]
    • Chi KH, Liu SJ, Li CP, Kuo HP, Wang YS, Chao Y, Hsieh SL. Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother 2005; 28: 129-135 [PMID: 15725956]
    • (2005) J Immunother , vol.28 , pp. 129-135
    • Chi, K.H.1    Liu, S.J.2    Li, C.P.3    Kuo, H.P.4    Wang, Y.S.5    Chao, Y.6    Hsieh, S.L.7
  • 79
  • 80
    • 77949907629 scopus 로고    scopus 로고
    • Enhancement of tumorspecific T-cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma
    • [PMID: 19739081]
    • Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, Kaneko S. Enhancement of tumorspecific T-cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma. Int J Cancer 2010; 126: 2164-2174 [PMID: 19739081 DOI: 10.1002/ijc.24882]
    • (2010) Int J Cancer , vol.126 , pp. 2164-2174
    • Mizukoshi, E.1    Nakamoto, Y.2    Arai, K.3    Yamashita, T.4    Mukaida, N.5    Matsushima, K.6    Matsui, O.7    Kaneko, S.8
  • 81
    • 0026228442 scopus 로고
    • Adopted immunochemotherapy using IL-2 and spleen LAK cell--randomized study
    • [PMID: 1658591]
    • Une Y, Kawata A, Uchino J. [Adopted immunochemotherapy using IL-2 and spleen LAK cell--randomized study]. Nihon Geka Gakkai Zasshi 1991; 92: 1330-1333 [PMID: 1658591]
    • (1991) Nihon Geka Gakkai Zasshi , vol.92 , pp. 1330-1333
    • Une, Y.1    Kawata, A.2    Uchino, J.3
  • 82
    • 0028997445 scopus 로고
    • Adjuvant chemoimmunotherapy for hepatocellular carcinoma patients. Adriamycin, interleukin-2, and lymphokineactivated killer cells versus adriamycin alone
    • [PMID: 7747715]
    • Kawata A, Une Y, Hosokawa M, Wakizaka Y, Namieno T, Uchino J, Kobayashi H. Adjuvant chemoimmunotherapy for hepatocellular carcinoma patients. Adriamycin, interleukin-2, and lymphokineactivated killer cells versus adriamycin alone. Am J Clin Oncol 1995; 18: 257-262 [PMID: 7747715]
    • (1995) Am J Clin Oncol , vol.18 , pp. 257-262
    • Kawata, A.1    Une, Y.2    Hosokawa, M.3    Wakizaka, Y.4    Namieno, T.5    Uchino, J.6    Kobayashi, H.7
  • 83
    • 0030039155 scopus 로고    scopus 로고
    • Analytical study of the clinical response to two distinct adoptive immunotherapies for advanced hepatocellular carcinoma: comparison between LAK cell and CTL therapy
    • [PMID: 8811496]
    • Haruta I, Yamauchi K, Aruga A, Komatsu T, Takasaki K, Hayashi N, Hanyu F. Analytical study of the clinical response to two distinct adoptive immunotherapies for advanced hepatocellular carcinoma: comparison between LAK cell and CTL therapy. J Immunother Emphasis Tumor Immunol 1996; 19: 218-223 [PMID: 8811496]
    • (1996) J Immunother Emphasis Tumor Immunol , vol.19 , pp. 218-223
    • Haruta, I.1    Yamauchi, K.2    Aruga, A.3    Komatsu, T.4    Takasaki, K.5    Hayashi, N.6    Hanyu, F.7
  • 84
    • 84887827193 scopus 로고    scopus 로고
    • Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms
    • [PMID: 24084446]
    • Introna M, Golay J, Rambaldi A. Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms. Immunol Lett 2013; 155: 27-30 [PMID: 24084446 DOI: 10.1016/j. imlet.2013.09.017]
    • (2013) Immunol Lett , vol.155 , pp. 27-30
    • Introna, M.1    Golay, J.2    Rambaldi, A.3
  • 85
    • 0038235904 scopus 로고    scopus 로고
    • Cytokine-induced killer cells: NK-like T cells with cytotolytic specificity against leukemia
    • [PMID: 14565644]
    • Linn YC, Hui KM. Cytokine-induced killer cells: NK-like T cells with cytotolytic specificity against leukemia. Leuk Lymphoma 2003; 44: 1457-1462 [PMID: 14565644 DOI: 10.3109/104281903 09178764]
    • (2003) Leuk Lymphoma , vol.44 , pp. 1457-1462
    • Linn, Y.C.1    Hui, K.M.2
  • 86
    • 0025856106 scopus 로고
    • Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity
    • [PMID: 1711560]
    • Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 1991; 174: 139-149 [PMID: 1711560]
    • (1991) J Exp Med , vol.174 , pp. 139-149
    • Schmidt-wolf, I.G.1    Negrin, R.S.2    Kiem, H.P.3    Blume, K.G.4    Weissman, I.L.5
  • 88
    • 0035031130 scopus 로고    scopus 로고
    • Expansion of cytotoxic CD3+ CD56+ cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation
    • [PMID: 11349808]
    • Alvarnas JC, Linn YC, Hope EG, Negrin RS. Expansion of cytotoxic CD3+ CD56+ cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation. Biol Blood Marrow Transplant 2001; 7: 216-222 [PMID: 11349808 DOI: 10.1053/bbmt.2001.v7.pm11349808]
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 216-222
    • Alvarnas, J.C.1    Linn, Y.C.2    Hope, E.G.3    Negrin, R.S.4
  • 89
    • 84875282081 scopus 로고    scopus 로고
    • Cytokine-induced killer cells promote antitumor immunity
    • [PMID: 23536996]
    • Jiang J, Wu C, Lu B. Cytokine-induced killer cells promote antitumor immunity. J Transl Med 2013; 11: 83 [PMID: 23536996 DOI: 10.1186/1479-5876-11-83]
    • (2013) J Transl Med , vol.11 , pp. 83
    • Jiang, J.1    Wu, C.2    Lu, B.3
  • 90
    • 55249095629 scopus 로고    scopus 로고
    • In vivo trafficking and survival of cytokineinduced killer cells resulting in minimal GVHD with retention of antitumor activity
    • [PMID: 18565854]
    • Nishimura R, Baker J, Beilhack A, Zeiser R, Olson JA, Sega EI, Karimi M, Negrin RS. In vivo trafficking and survival of cytokineinduced killer cells resulting in minimal GVHD with retention of antitumor activity. Blood 2008; 112: 2563-2574 [PMID: 18565854 DOI: 10.1182/blood-2007-06-092817]
    • (2008) Blood , vol.112 , pp. 2563-2574
    • Nishimura, R.1    Baker, J.2    Beilhack, A.3    Zeiser, R.4    Olson, J.A.5    Sega, E.I.6    Karimi, M.7    Negrin, R.S.8
  • 92
    • 84855520803 scopus 로고    scopus 로고
    • Cytokine induced killer cells as promising immunotherapy for solid tumors
    • [PMID: 21716717]
    • Sangiolo D. Cytokine induced killer cells as promising immunotherapy for solid tumors. J Cancer 2011; 2: 363-368 [PMID: 21716717 DOI: 10.7150/jca.2.363]
    • (2011) J Cancer , vol.2 , pp. 363-368
    • Sangiolo, D.1
  • 93
    • 67650359909 scopus 로고    scopus 로고
    • Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation
    • [PMID: 19463075]
    • Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M, Cignetti A. Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin Biol Ther 2009; 9: 831-840 [PMID: 19463075 DOI: 10.1517/14712590903005552]
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 831-840
    • Sangiolo, D.1    Mesiano, G.2    Carnevale-schianca, F.3    Piacibello, W.4    Aglietta, M.5    Cignetti, A.6
  • 94
    • 84863343628 scopus 로고    scopus 로고
    • Cytokine-induced killer cells in the treatment of patients with solid carcinomas: a systematic review and pooled analysis
    • [PMID: 22277010]
    • Ma Y, Zhang Z, Tang L, Xu YC, Xie ZM, Gu XF, Wang HX. Cytokine-induced killer cells in the treatment of patients with solid carcinomas: a systematic review and pooled analysis. Cytotherapy 2012; 14: 483-493 [PMID: 22277010 DOI: 10.3109/14653249.201 1.649185]
    • (2012) Cytotherapy , vol.14 , pp. 483-493
    • Ma, Y.1    Zhang, Z.2    Tang, L.3    Xu, Y.C.4    Xie, Z.M.5    Gu, X.F.6    Wang, H.X.7
  • 95
    • 40749152776 scopus 로고    scopus 로고
    • Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas
    • [PMID: 18157013]
    • Weng DS, Zhou J, Zhou QM, Zhao M, Wang QJ, Huang LX, Li YQ, Chen SP, Wu PH, Xia JC. Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas. J Immunother 2008; 31: 63-71 [PMID: 18157013 DOI: 10.1097/ CJI.0b013e31815a121b]
    • (2008) J Immunother , vol.31 , pp. 63-71
    • Weng, D.S.1    Zhou, J.2    Zhou, Q.M.3    Zhao, M.4    Wang, Q.J.5    Huang, L.X.6    Li, Y.Q.7    Chen, S.P.8    Wu, P.H.9    Xia, J.C.10
  • 96
    • 57449105089 scopus 로고    scopus 로고
    • A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma
    • Hui D, Qiang L, Jian W, Ti Z, Da-Lu K. A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma. Digestive and Liver Disease 2009; 41: 36-41 [DOI: 10.1016/j. dld.2008.04.007]
    • (2009) Digestive and Liver Disease , vol.41 , pp. 36-41
    • Hui, D.1    Qiang, L.2    Jian, W.3    Ti, Z.4    Da-lu, K.5
  • 97
    • 79955835802 scopus 로고    scopus 로고
    • Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study
    • [PMID: 20109346]
    • Hao MZ, Lin HL, Chen Q, Ye YB, Chen QZ, Chen MS. Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study. Chin J Cancer 2010; 29: 172-177 [PMID: 20109346]
    • (2010) Chin J Cancer , vol.29 , pp. 172-177
    • Hao, M.Z.1    Lin, H.L.2    Chen, Q.3    Ye, Y.B.4    Chen, Q.Z.5    Chen, M.S.6
  • 98
    • 79952337336 scopus 로고    scopus 로고
    • Phase I clinical study of combination therapy with microwave ablation and cellular immunotherapy in hepatocellular carcinoma
    • [PMID: 21258206]
    • Zhou P, Liang P, Dong B, Yu X, Han Z, Xu Y. Phase I clinical study of combination therapy with microwave ablation and cellular immunotherapy in hepatocellular carcinoma. Cancer Biol Ther 2011; 11: 450-456 [PMID: 21258206 DOI: 10.4161/ cbt.11.5.14669]
    • (2011) Cancer Biol Ther , vol.11 , pp. 450-456
    • Zhou, P.1    Liang, P.2    Dong, B.3    Yu, X.4    Han, Z.5    Xu, Y.6
  • 99
    • 84880207675 scopus 로고    scopus 로고
    • Cytokine-induced killer cells in combination with transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma patients
    • [PMID: 23719239]
    • Huang ZM, Li W, Li S, Gao F, Zhou QM, Wu FM, He N, Pan CC, Xia JC, Wu PH, Zhao M. Cytokine-induced killer cells in combination with transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma patients. J Immunother 2013; 36: 287-293 [PMID: 23719239 DOI: 10.1097/ CJI.0b013e3182948452]
    • (2013) J Immunother , vol.36 , pp. 287-293
    • Huang, Z.M.1    Li, W.2    Li, S.3    Gao, F.4    Zhou, Q.M.5    Wu, F.M.6    He, N.7    Pan, C.C.8    Xia, J.C.9    Wu, P.H.10    Zhao, M.11
  • 101
    • 0036285984 scopus 로고    scopus 로고
    • Antitumor activities of human autologous cytokineinduced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo
    • [PMID: 12046071]
    • Wang FS, Liu MX, Zhang B, Shi M, Lei ZY, Sun WB, Du QY, Chen JM. Antitumor activities of human autologous cytokineinduced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World J Gastroenterol 2002; 8: 464-468 [PMID: 12046071]
    • (2002) World J Gastroenterol , vol.8 , pp. 464-468
    • Wang, F.S.1    Liu, M.X.2    Zhang, B.3    Shi, M.4    Lei, Z.Y.5    Sun, W.B.6    Du, Q.Y.7    Chen, J.M.8
  • 102
    • 84878029051 scopus 로고    scopus 로고
    • Cytokineinduced killer (CIK) cell therapy for patients with hepatocellular carcinoma: efficacy and safety
    • [PMID: 23210562]
    • Ma Y, Xu YC, Tang L, Zhang Z, Wang J, Wang HX. Cytokineinduced killer (CIK) cell therapy for patients with hepatocellular carcinoma: efficacy and safety. Exp Hematol Oncol 2012; 1: 11 [PMID: 23210562]
    • (2012) Exp Hematol Oncol , vol.1 , pp. 11
    • Ma, Y.1    Xu, Y.C.2    Tang, L.3    Zhang, Z.4    Wang, J.5    Wang, H.X.6
  • 103
    • 84912530810 scopus 로고    scopus 로고
    • A meta-analysis of cytokine-induced killer cells therapy in combination with minimally invasive treatment for hepatocellular carcinoma
    • [PMID: 24924902]
    • Li X, Dai D, Song X, Liu J, Zhu L, Xu W. A meta-analysis of cytokine-induced killer cells therapy in combination with minimally invasive treatment for hepatocellular carcinoma. Clin Res Hepatol Gastroenterol 2014; 38: 583-591 [PMID: 24924902 DOI: 10.1016/j.clinre.2014.04.010]
    • (2014) Clin Res Hepatol Gastroenterol , vol.38 , pp. 583-591
    • Li, X.1    Dai, D.2    Song, X.3    Liu, J.4    Zhu, L.5    Xu, W.6
  • 104
    • 27744566433 scopus 로고    scopus 로고
    • Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas
    • [PMID: 16168521]
    • Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N. Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas. J Hepatol 2005; 43: 1013-1020 [PMID: 16168521 DOI: 10.1016/ j.jhep.2005.05.026]
    • (2005) J Hepatol , vol.43 , pp. 1013-1020
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Hiramatsu, N.4    Sakamori, R.5    Yamaguchi, S.6    Hayashi, N.7
  • 105
    • 0036831613 scopus 로고    scopus 로고
    • New aspects of natural-killer-cell surveillance and therapy of cancer
    • [PMID: 12415255]
    • Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002; 2: 850-861 [PMID: 12415255 DOI: 10.1038/nrc928]
    • (2002) Nat Rev Cancer , vol.2 , pp. 850-861
    • Smyth, M.J.1    Hayakawa, Y.2    Takeda, K.3    Yagita, H.4
  • 106
    • 33644517272 scopus 로고    scopus 로고
    • Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans
    • [PMID: 16440347]
    • Ishiyama K, Ohdan H, Ohira M, Mitsuta H, Arihiro K, Asahara T. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans. Hepatology 2006; 43: 362-372 [PMID: 16440347 DOI: 10.1002/ hep.21035]
    • (2006) Hepatology , vol.43 , pp. 362-372
    • Ishiyama, K.1    Ohdan, H.2    Ohira, M.3    Mitsuta, H.4    Arihiro, K.5    Asahara, T.6
  • 107
    • 55249097842 scopus 로고    scopus 로고
    • Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients
    • [PMID: 18824414]
    • Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Clin Immunol 2008; 129: 428-437 [PMID: 18824414 DOI: 10.1016/j.clim.2008.08.012]
    • (2008) Clin Immunol , vol.129 , pp. 428-437
    • Cai, L.1    Zhang, Z.2    Zhou, L.3    Wang, H.4    Fu, J.5    Zhang, S.6    Shi, M.7    Zhang, H.8    Yang, Y.9    Wu, H.10    Tien, P.11    Wang, F.S.12
  • 109
    • 33845332083 scopus 로고    scopus 로고
    • Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver
    • [PMID: 17108139]
    • Subleski JJ, Hall VL, Back TC, Ortaldo JR, Wiltrout RH. Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver. Cancer Res 2006; 66: 11005-11012 [PMID: 17108139 DOI: 10.1158/0008-5472. CAN-06-0811]
    • (2006) Cancer Res , vol.66 , pp. 11005-11012
    • Subleski, J.J.1    Hall, V.L.2    Back, T.C.3    Ortaldo, J.R.4    Wiltrout, R.H.5
  • 110
    • 33845929522 scopus 로고    scopus 로고
    • Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma
    • [PMID: 17182598]
    • Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, Kaneko S. Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma. J Immunol 2007; 178: 574-583 [PMID: 17182598]
    • (2007) J Immunol , vol.178 , pp. 574-583
    • Tsuchiyama, T.1    Nakamoto, Y.2    Sakai, Y.3    Marukawa, Y.4    Kitahara, M.5    Mukaida, N.6    Kaneko, S.7
  • 112
    • 34247842744 scopus 로고    scopus 로고
    • The biology of NKT cells
    • [PMID: 17150027]
    • Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007; 25: 297-336 [PMID: 17150027 DOI: 10.1146/annurev.immunol.25.022106.141711]
    • (2007) Annu Rev Immunol , vol.25 , pp. 297-336
    • Bendelac, A.1    Savage, P.B.2    Teyton, L.3
  • 113
    • 0042123683 scopus 로고    scopus 로고
    • NKT cells from normal and tumorbearing human livers are phenotypically and functionally distinct from murine NKT cells
    • [PMID: 12902477]
    • Kenna T, Golden-Mason L, Porcelli SA, Koezuka Y, Hegarty JE, O'Farrelly C, Doherty DG. NKT cells from normal and tumorbearing human livers are phenotypically and functionally distinct from murine NKT cells. J Immunol 2003; 171: 1775-1779 [PMID: 12902477 DOI: 10.4049/jimmunol.171.4.1775]
    • (2003) J Immunol , vol.171 , pp. 1775-1779
    • Kenna, T.1    Golden-mason, L.2    Porcelli, S.A.3    Koezuka, Y.4    Hegarty, J.E.5    O'Farrelly, C.6    Doherty, D.G.7
  • 114
    • 44849083151 scopus 로고    scopus 로고
    • NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis
    • [PMID: 18322166]
    • Berzofsky JA, Terabe M. NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis. J Immunol 2008; 180: 3627-3635 [PMID: 18322166 DOI: 10.4049/jimmunol.180.6.3627]
    • (2008) J Immunol , vol.180 , pp. 3627-3635
    • Berzofsky, J.A.1    Terabe, M.2
  • 117
    • 65249101637 scopus 로고    scopus 로고
    • The promise and potential pitfalls of chimeric antigen receptors
    • [PMID: 19327974]
    • Sadelain M, Brentjens R, Rivière I. The promise and potential pitfalls of chimeric antigen receptors. Curr Opin Immunol 2009; 21: 215-223 [PMID: 19327974 DOI: 10.1016/j.coi.2009.02.009]
    • (2009) Curr Opin Immunol , vol.21 , pp. 215-223
    • Sadelain, M.1    Brentjens, R.2    Rivière, I.3
  • 118
    • 84863085396 scopus 로고    scopus 로고
    • CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe
    • [PMID: 22613370]
    • Gilham DE, Debets R, Pule M, Hawkins RE, Abken H. CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. Trends Mol Med 2012; 18: 377-384 [PMID: 22613370 DOI: 10.1016/j.molmed.2012.04.009]
    • (2012) Trends Mol Med , vol.18 , pp. 377-384
    • Gilham, D.E.1    Debets, R.2    Pule, M.3    Hawkins, R.E.4    Abken, H.5
  • 119
    • 84862838257 scopus 로고    scopus 로고
    • Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
    • [PMID: 22262649]
    • Curran KJ, Pegram HJ, Brentjens RJ. Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions. J Gene Med 2012; 14: 405-415 [PMID: 22262649 DOI: 10.1002/jgm.2604]
    • (2012) J Gene Med , vol.14 , pp. 405-415
    • Curran, K.J.1    Pegram, H.J.2    Brentjens, R.J.3
  • 120
    • 84862775412 scopus 로고    scopus 로고
    • Targeted immunotherapy of cancer with CAR T cells: achievements and challenges
    • [PMID: 22527245]
    • Lipowska-Bhalla G, Gilham DE, Hawkins RE, Rothwell DG. Targeted immunotherapy of cancer with CAR T cells: achievements and challenges. Cancer Immunol Immunother 2012; 61: 953-962 [PMID: 22527245 DOI: 10.1007/s00262-012-1254-0]
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 953-962
    • Lipowska-bhalla, G.1    Gilham, D.E.2    Hawkins, R.E.3    Rothwell, D.G.4
  • 121
    • 70449123840 scopus 로고    scopus 로고
    • Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?"
    • [PMID: 19702437]
    • Dotti G, Savoldo B, Brenner M. Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?". Hum Gene Ther 2009; 20: 1229-1239 [PMID: 19702437 DOI: 10.1089/hum.2009.142]
    • (2009) Hum Gene Ther , vol.20 , pp. 1229-1239
    • Dotti, G.1    Savoldo, B.2    Brenner, M.3
  • 123
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • [PMID: 20179677]
    • Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010; 18: 843-851 [PMID: 20179677 DOI: 10.1038/mt.2010.24]
    • (2010) Mol Ther , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3    Dudley, M.E.4    Laurencot, C.M.5    Rosenberg, S.A.6
  • 124
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
    • [PMID: 17108138]
    • Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, Smith DD, Forman SJ, Jensen MC, Cooper LJ. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res 2006; 66: 10995-11004 [PMID: 17108138 DOI: 10.1158/0008-5472.CAN-06-0160]
    • (2006) Cancer Res , vol.66 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3    Pfeiffer, T.4    Olivares, S.5    Gonzalez, N.6    Smith, D.D.7    Forman, S.J.8    Jensen, M.C.9    Cooper, L.J.10
  • 125
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • [PMID: 21830940]
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011; 365: 725-733 [PMID: 21830940 DOI: 10.1056/ NEJMoa1103849]
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 127
    • 84905714921 scopus 로고    scopus 로고
    • Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo
    • [PMID: 24504024]
    • Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, Biondi A, Biagi E, Bonnet D. Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo. Leukemia 2014; 28: 1596-1605 [PMID: 24504024 DOI: 10.1038/leu.2014.62]
    • (2014) Leukemia , vol.28 , pp. 1596-1605
    • Pizzitola, I.1    Anjos-afonso, F.2    Rouault-pierre, K.3    Lassailly, F.4    Tettamanti, S.5    Spinelli, O.6    Biondi, A.7    Biagi, E.8    Bonnet, D.9
  • 128
    • 84863669099 scopus 로고    scopus 로고
    • T-cell therapy at the threshold
    • [PMID: 22781680]
    • June C, Rosenberg SA, Sadelain M, Weber JS. T-cell therapy at the threshold. Nat Biotechnol 2012; 30: 611-614 [PMID: 22781680 DOI: 10.1038/nbt.2305]
    • (2012) Nat Biotechnol , vol.30 , pp. 611-614
    • June, C.1    Rosenberg, S.A.2    Sadelain, M.3    Weber, J.S.4
  • 129
    • 79958840661 scopus 로고    scopus 로고
    • Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines
    • [PMID: 21145860]
    • Gehring AJ, Xue SA, Ho ZZ, Teoh D, Ruedl C, Chia A, Koh S, Lim SG, Maini MK, Stauss H, Bertoletti A. Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines. J Hepatol 2011; 55: 103-110 [PMID: 21145860 DOI: 10.1016/j.jhep.2010.10.025]
    • (2011) J Hepatol , vol.55 , pp. 103-110
    • Gehring, A.J.1    Xue, S.A.2    Ho, Z.Z.3    Teoh, D.4    Ruedl, C.5    Chia, A.6    Koh, S.7    Lim, S.G.8    Maini, M.K.9    Stauss, H.10    Bertoletti, A.11
  • 131
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience
    • [PMID: 16648493]
    • Lamers CH, Sleijfer S, Vulto AG, Kruit WH, Kliffen M, Debets R, Gratama JW, Stoter G, Oosterwijk E. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 2006; 24: e20-e22 [PMID: 16648493 DOI: 10.1200/ JCO.2006.05.9964]
    • (2006) J Clin Oncol , vol.24 , pp. e20-e22
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3    Kruit, W.H.4    Kliffen, M.5    Debets, R.6    Gratama, J.W.7    Stoter, G.8    Oosterwijk, E.9
  • 132
    • 34848818523 scopus 로고    scopus 로고
    • Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo
    • [PMID: 17479266]
    • Lamers CH, Langeveld SC, Groot-van Ruijven CM, Debets R, Sleijfer S, Gratama JW. Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo. Cancer Immunol Immunother 2007; 56: 1875-1883 [PMID: 17479266 DOI: 10.1007/s00262-007-0330-3]
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1875-1883
    • Lamers, C.H.1    Langeveld, S.C.2    Groot-van Ruijven, C.M.3    Debets, R.4    Sleijfer, S.5    Gratama, J.W.6
  • 134
    • 77950480974 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial
    • [PMID: 20357779]
    • Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther 2010; 18: 666-668 [PMID: 20357779 DOI: 10.1038/mt.2010.31]
    • (2010) Mol Ther , vol.18 , pp. 666-668
    • Brentjens, R.1    Yeh, R.2    Bernal, Y.3    Riviere, I.4    Sadelain, M.5
  • 135
    • 78149432308 scopus 로고    scopus 로고
    • Immune regulation of cancer
    • Disis ML. Immune regulation of cancer. J Clin Oncol 2010; 28: 4531-4538.
    • (2010) J Clin Oncol , vol.28 , pp. 4531-4538
    • Disis, M.L.1
  • 136
    • 76749151403 scopus 로고    scopus 로고
    • Immune responses to malignancies
    • Whiteside TL. Immune responses to malignancies. J Allergy Clin Immun 2010; 125 (Supplement 2): S272-S283 [DOI: 10.1016/ j.jaci.2009.09.045]
    • (2010) J Allergy Clin Immun , vol.125 , pp. S272-S283
    • Whiteside, T.L.1
  • 137
    • 34547749066 scopus 로고    scopus 로고
    • Emerging challenges in regulatory T cell function and biology
    • [PMID: 17673654]
    • Sakaguchi S, Powrie F. Emerging challenges in regulatory T cell function and biology. Science 2007; 317: 627-629 [PMID: 17673654 DOI: 10.1126/science.1142331]
    • (2007) Science , vol.317 , pp. 627-629
    • Sakaguchi, S.1    Powrie, F.2
  • 138
    • 68549136586 scopus 로고    scopus 로고
    • Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
    • [PMID: 19569243]
    • Zhou J, Ding T, Pan W, Zhu LY, Li L, Zheng L. Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer 2009; 125: 1640-1648 [PMID: 19569243 DOI: 10.1002/ijc.24556]
    • (2009) Int J Cancer , vol.125 , pp. 1640-1648
    • Zhou, J.1    Ding, T.2    Pan, W.3    Zhu, L.Y.4    Li, L.5    Zheng, L.6
  • 139
    • 33847384529 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
    • [PMID: 17289884]
    • Kobayashi N, Hiraoka N, Yamagami W, Ojima H, Kanai Y, Kosuge T, Nakajima A, Hirohashi S. FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 2007; 13: 902-911 [PMID: 17289884 DOI: 10.1158/1078-0432.CCR-06-2363]
    • (2007) Clin Cancer Res , vol.13 , pp. 902-911
    • Kobayashi, N.1    Hiraoka, N.2    Yamagami, W.3    Ojima, H.4    Kanai, Y.5    Kosuge, T.6    Nakajima, A.7    Hirohashi, S.8
  • 140
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • [PMID: 17577038]
    • Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, Xiao YS, Xu Y, Li YW, Tang ZY. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 2007; 25: 2586-2593 [PMID: 17577038 DOI: 10.1200/JCO.2006.09.4565]
    • (2007) J Clin Oncol , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.J.2    Fan, J.3    Zhou, J.4    Wang, X.Y.5    Xiao, Y.S.6    Xu, Y.7    Li, Y.W.8    Tang, Z.Y.9
  • 141
    • 84870299577 scopus 로고    scopus 로고
    • Tumor-infiltrating FoxP3+ Tregs and CD8+ T cells affect the prognosis of hepatocellular carcinoma patients
    • [PMID: 23207161]
    • Huang Y, Wang FM, Wang T, Wang YJ, Zhu ZY, Gao YT, Du Z. Tumor-infiltrating FoxP3+ Tregs and CD8+ T cells affect the prognosis of hepatocellular carcinoma patients. Digestion 2012; 86: 329-337 [PMID: 23207161 DOI: 10.1159/000342801]
    • (2012) Digestion , vol.86 , pp. 329-337
    • Huang, Y.1    Wang, F.M.2    Wang, T.3    Wang, Y.J.4    Zhu, Z.Y.5    Gao, Y.T.6    Du, Z.7
  • 142
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity
    • [PMID: 10553041]
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999; 163: 5211-5218 [PMID: 10553041]
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 143
    • 79955615251 scopus 로고    scopus 로고
    • Immunotherapy of hepatocellular carcinoma: is there a place for regulatory T-lymphocyte depletion?
    • [PMID: 21524167]
    • Cany J, Tran L, Gauttier V, Judor JP, Vassaux G, Ferry N, Conchon S. Immunotherapy of hepatocellular carcinoma: is there a place for regulatory T-lymphocyte depletion? Immunotherapy 2011; 3: 32-34 [PMID: 21524167 DOI: 10.2217/imt.11.29]
    • (2011) Immunotherapy , vol.3 , pp. 32-34
    • Cany, J.1    Tran, L.2    Gauttier, V.3    Judor, J.P.4    Vassaux, G.5    Ferry, N.6    Conchon, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.