Generation of cytokine-induced killer cells using exogenous interleukin- 2, -7 or-12

Cancer Immunology Immunotherapy

Volumn 47, Issue 4, 1998, Pages 221-226

  Zoll, Birgit ^a   Lefterova, Petja ^a   Csipai, Markus ^a   Finke, Sigrun ^a   Trojaneck, Beate ^a   Ebert, Oliver ^a   Micka, Bettina ^a   Roigk, Klaus ^a   Fehlinger, Matthias ^a   Schmidt Wolf, Gabriele D ^a   Huhn, Dieter ^a   Schmidt Wolf, Ingo G H ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cytokine induced killer cells; Interleukin 12; Interleukin 2; Interleukin 7

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CD28 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; LACTATE DEHYDROGENASE; MONOCLONAL ANTIBODY CD3;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KILLER CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; TARGET CELL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, SURFACE; APOPTOSIS; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-7; INTERLEUKINS; KILLER CELLS, LYMPHOKINE-ACTIVATED; LYMPHOCYTE ACTIVATION; MICE; MICE, SCID;

EID: 0032433319     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050524     Document Type: Article

References (16)

1. Armant M, Delespesse G, Sarfati M (1995) IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression. Immunology 85:331-337
2. + cells derived from T cells with potent in vivo antitumor activity in mice with SCID. J Immunol 153:1687-1696
3. + killer cells. Blood 86:3493-3499
4. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 65:55-63
5. Notter M, Ludwig W-D, Bremer S, Thiel E (1993) Selective targeting of human lymphokine-activated killer cells by CD3 monoclonal antibody against the interferon-inducible high-affinity Fe gamma RI receptor (CD64) on autologous acute-myeloid leukemic blast cells. Blood 82:3113-3124
6. Rakhmilevich AL, Turner J, Ford MJ, McCabe D, Sun WH, Sondel PM, Grota K, Yang N (1996) Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc Natl Acad Sci USA 93:6291-6296
7. Rodolfo M, Zilocchi C, Melani C, Cappetti B, Arioli I, Parmiani G, Colombo MP (1996) Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antignes. J Immunol 157:5536-5542
8. Scheffold C, Brandt K, Johnston V, Lefterova P, Huhn D, Neubauer A, Negrin RS, Schmidt-Wolf IGH (1995) Potential of autologous immunologic effector cells for bone marrow purging in patients with chronic myeloic leukemia. Bone Marrow Transplant 15:33-39
9. Schmidt-Wolf IGH, Negrin RS, Kiem HP, Blume KG, Weissman IL (1991) Use of a SCID mouse human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor activity. J Exp Med 174:139-149
10. Schmidt-Wolf IGH, Lefterova P, Mehta BA, Fernandez LP, Huhn D, Blume KG, Weissman IL, Negrin RS (1993) Phenotypic characterization and identification of effector cells involved in tumor recognition of cytokine-induced killer cells. Exp Hematol 21:1673-1679
11. Schmidt-Wolf IGH, Lefterova P, Johnston V, Neubauer A, Huhn D, Negrin R, Blume KG (1994) Propagation of T cells with NK cell marker. Br J Haematol 87:453-458
12. Schmidt-Wolf IGH, Neubauer A, Finke S, Csipai M, Wittig B, Huhn D (1994) Interleukin-7 gene therapy for patients with metastatic colon cancer, renal cell cancer, malignant melanoma or lymphoma. Hum Gene Ther 5:1161-1169
13. Schmidt-Wolf IGH, Grimm B, Brandt K, Lefterova P, Johnston V, Scheffold C, Huhn D, Serke S (1995) Propagation of large numbers of cells of a human mixed-lineage T-lymphoid/myeloid. Br J Haematol 90:512-517
14. Schmidt-Wolf IGH, Lefterova P, Johnston V, Scheffold C, Csipai M, Mehta B, Tsuruo T, Huhn D, Blume KG, Negrin RS (1996) Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells. Cell Immunol 169:85-90
15. Schmidt-Wolf GD, Negrin RS, Schmidt-Wolf IGH (1997) Activated T cells and cytokine-induced CD3+ CD56+ killer cells. Ann Hematol 74:51-56
16. Tahara H, Lotze MT (1995) Antitumor effects of interleukin-12 (IL-12): applications for the immunotherapy and gene therapy and gene therapy of cancer. Gene Ther 2:96-106