A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma

Cancer Immunology, Immunotherapy

Volumn 56, Issue 7, 2007, Pages 1009-1016

  Lan, Ying Hua ^a,b   Li, Yong Guo ^a,b   Liang, Zeng Wei ^a   Chen, Min ^a   Peng, Ming Li ^a   Tang, Li ^a   Hu, Huai Dong ^a   Ren, Hong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Alpha fetoprotein; DNA vaccine; Heat shock protein 70; Hepatocellular carcinoma

Indexed keywords

ALPHA FETOPROTEIN HEAT SHOCK PROTEIN 70 COMPLEX; DNA VACCINE; PLASMID VECTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CHIMERA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; ERADICATION THERAPY; LIFESPAN; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

ALPHA-FETOPROTEINS; ANIMALS; CANCER VACCINES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHIMERA; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HSP70 HEAT-SHOCK PROTEINS; IMMUNOTHERAPY; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; PLASMIDS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA;

EID: 34247611546     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-006-0254-3     Document Type: Article

References (25)

1. Miller AM, Ozenci V, Kiessling R, Pisa P (2005) Immune monitoring in a phase 1 trial of a PSA DNA vaccine in patients with hormone-refractory prostate cancer. J Immunother 28:389-395
2. Qin H, Zhou C, Wang D, Ma W, Liang X, Lin C, Zhang Y, Zhang S (2006) Enhancement of antitumour immunity by a novel chemotactic antigen DNA vaccine encoding chemokines and multiepitopes of prostate-tumour-associated antigens. Immunology 117:419-430
3. Vollmer CM Jr, Eilber FC, Butterfield LH, Ribas A, Dissette VB, Koh A, Montejo LD, Lee MC, Andrews KJ, McBride WH, Glaspy JA, Economou JS (1999) Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma. Cancer Res 59:3064-3067
4. Brasseur F, Marchand M, Vanwijck R, Herin M, Lethe B, Chomez P, Boon T (1992) Human gene MAGE-1, which codes for a tumor-rejection antigen, is expressed by some breast tumors. Int J Cancer 52:839-841
5. Kawakami Y, Eliyahu S, Jennings C, Sakaguchi K, Kang X, Southwood S, Robbins PF, Sette A, Appella E, Rosenberg SA (1995) Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. J Immunol 154:3961-3968
6. Hodge JW (1996) Carcinoembryonic antigen as a target for cancer vaccines. Cancer Immunol Immunother 43:127-134
7. Boon T, van der Bruggen P (1996) Human tumor antigens recognized by T lymphocytes. J Exp Med 183:725-729
8. Bei R, Budillon A, Reale MG, Capuano G, Pomponi D, Budillon G, Frati L, Muraro R (1999) Cryptic epitopes on alpha-fetoprotein induce spontaneous immune responses in hepatocellular carcinoma, liver cirrhosis, and chronic hepatitis patients. Cancer Res 59:5471-5474
9. Bei R, Masuelli L, Moriconi E, Visco V, Moretti A, Kraus MH, Muraro R (1999) Immune responses to all ErbB family receptors detectable in serum of cancer patients. Oncogene 18:1267-1275
10. Butterfield LH, Koh A, Meng W, Vollmer CM, Ribas A, Dissette V, Lee E, Glaspy JA, McBride WH, Economou JS (1999) Generation of human T-cell responses to an HLAA2.1-restricted peptide epitope derived from alpha-fetoprotein. Cancer Res 59:3134-3142
11. Hanke P, Serwe M, Dombrowski F, Sauerbruch T, Caselmann WH (2002) DNA vaccination with AFP-encoding plasmid DNA prevents growth of subcutaneous AFP-expressing tumors and does not interfere with liver regeneration in mice. Cancer Gene Ther 9:346-355
12. Srivastava PK, Udono H (1994) Heat shock protein-peptide complexes in cancer immunotherapy. Curr Opin Immunol 6:728-732
13. Todryk S, Melcher AA, Hardwick N, Linardakis E, Bateman A, Colombo MP, Stoppacciaro A, Vile RG (1999) Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J Immunol 163:1398-1408
14. Srivastava PK, Amato RJ (2001) Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents. Vaccine 19:2590-2597
15. Lewis JJ (2004) Therapeutic cancer vaccines: using unique antigens. Proc Natl Acad Sci U.S.A 101(Suppl 2):14653-14656
16. Hoos A, Levey DL (2003) Vaccination with heat shock protein-peptide complexes: from basic science to clinical applications. Expert Rev Vaccines 2:369-379
17. Wang Y, Kelly CG, Singh M, McGowan EG, Carrara AS, Bergmeier LA, Lehner T (2002) Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70. J Immunol 169:2422-2429
18. Wei YQ, Zhao X, Kariya Y, Teshigawara K, Uchida A (1995) Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells. Cancer Immunol Immunother 40:73-78
19. Massa C, Guiducci C, Arioli I, Parenza M, Colombo MP, Melani C (2004) Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70. Cancer Res 64:1502-1508
20. Wang MH, Grossmann ME, Young CY (2004) Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth. Br J Cancer 90:926-931
21. Suzue K, Young RA (1996) Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol 156:873-879
22. Chen CH, Wang TL, Hung CF, Yang Y, Young RA, Pardoll DM, Wu TC (2000) Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res 60:1035-1042
23. Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC (2004) Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther 11:1011-1018
24. Peng M, Chen M, Ling N, Xu H, Qing Y, Ren H (2006) Novel vaccines for the treatment of chronic HBV infection based on mycobacterial heat shock protein 70. Vaccine 24:887-896
25. Grimm CF, Ortmann D, Mohr L, Michalak S, Krohne TU, Meckel S, Eisele S, Encke J, Blum HE, Geissler M (2000) Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice. Gastroenterology 119:1104-1112