Targeting PI3K-p110α suppresses influenza virus infection in chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 191, Issue 9, 2015, Pages 1012-1023

  Hsu, Alan Chen Yu ^a   Starkey, Malcolm R ^a   Hanish, Irwan ^a,b   Parsons, Kristy ^a   Haw, Tatt Jhong ^a   Howland, Linda J ^a   Barr, Ian ^c   Mahony, James B ^d   Foster, Paul S ^a   Knight, Darryl A ^a,e   Wark, Peter A ^a,f   Hansbro, Philip M ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c WHO COLLABORATING CENTRE FOR REFERENCE AND RESEARCH ON INFLUENZA   (Australia)

^d MCMASTER UNIVERSITY   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Chronic obstructive pulmonary disease; Influenza; Innate immunity; PI3K

Indexed keywords

ANTIVIRUS AGENT; BETA INTERFERON; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; PROTEIN P110 ALPHA; RETINOIC ACID INDUCIBLE PROTEIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFECTION RISK; INFECTION SENSITIVITY; INFLUENZA; INNATE IMMUNITY; LUNG FUNCTION; LUNG LAVAGE; MALE; MIDDLE AGED; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN TARGETING; VIRUS ENTRY; VIRUS INACTIVATION; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; BRONCHUS; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; EPITHELIUM CELL; INFLUENZA, HUMAN; ORTHOMYXOVIRIDAE INFECTIONS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VIROLOGY;

ADULT; AGED; ANIMALS; ANTIVIRAL AGENTS; BRONCHI; CELLS, CULTURED; ENZYME INHIBITORS; EPITHELIAL CELLS; FEMALE; HUMANS; INFLUENZA, HUMAN; MALE; MICE; MIDDLE AGED; ORTHOMYXOVIRIDAE INFECTIONS; PHOSPHATIDYLINOSITOL 3-KINASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84928983152     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201501-0188OC     Document Type: Article

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