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Volumn 20, Issue 2, 2015, Pages 2973-3000

Indole alkaloids from Catharanthus roseus: Bioproduction and their effect on human health

Author keywords

Bioactivity; Bioproduction; Catharanthus roseus; Indole alkaloids

Indexed keywords

ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; PLANT EXTRACT; RAUWOLFIA ALKALOID;

EID: 84928969120     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20022973     Document Type: Review
Times cited : (202)

References (132)
  • 2
    • 84903372823 scopus 로고    scopus 로고
    • The Vinca alkaloids
    • Kufe, D.W., Pollock, R.E., Weichselbaum, R.R., Bast, R.C., Gansler, T.S., Holland, J.F., Frei, E., Eds.; BC Decker Publisher: Hamilton, ON, Canada
    • Rowinsky, E. The Vinca alkaloids. In Cancer Medicine, 6th ed.; Kufe, D.W., Pollock, R.E., Weichselbaum, R.R., Bast, R.C., Gansler, T.S., Holland, J.F., Frei, E., Eds.; BC Decker Publisher: Hamilton, ON, Canada, 2003; Volume 2.
    • (2003) Cancer Medicine, 6th Ed. , vol.2
    • Rowinsky, E.1
  • 5
    • 0033041906 scopus 로고    scopus 로고
    • Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms: Blockage of cytokinesis without inhibition of the organelle duplication
    • Grellier, P.; Sinou, V.; Garrea de Loubresse, N.; Bylen, E.; Boulard, Y.; Schrevel, J. Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms: Blockage of cytokinesis without inhibition of the organelle duplication. Cell Motil. Cytoskeleton. 1999, 42, 36-47.
    • (1999) Cell Motil. Cytoskeleton. , vol.42 , pp. 36-47
    • Grellier, P.1    Sinou, V.2    Garrea De Loubresse, N.3    Bylen, E.4    Boulard, Y.5    Schrevel, J.6
  • 6
    • 84884642888 scopus 로고    scopus 로고
    • ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus
    • Yu, F.; de Luca, V. ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus. Proc. Natl. Acad. Sci. USA 2013 110, 15830-15835.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 15830-15835
    • Yu, F.1    De Luca, V.2
  • 8
    • 0006920208 scopus 로고
    • Growth related dimerization of vindoline and catharanthine in Catharanthus roseus and effect of wounding on the process
    • Naaranlahti, T.; Auriola, S.; Lapinjoki, S.P. Growth related dimerization of vindoline and catharanthine in Catharanthus roseus and effect of wounding on the process. Phytochemistry 1991, 30, 1451-1453.
    • (1991) Phytochemistry , vol.30 , pp. 1451-1453
    • Naaranlahti, T.1    Auriola, S.2    Lapinjoki, S.P.3
  • 9
    • 0005356746 scopus 로고
    • Distribution of catharanthine, vindoline and 3′,4′-anhydrovinblastine in the aerial parts of some Catharanthus roseus plants and the significance thereof in relation to alkaloid production in cultured cells
    • Kurz, W.G.W., Ed. Springer-Verlag: Berlin, Germany
    • Balsevich, J.; Bishop, G. Distribution of catharanthine, vindoline and 3′,4′-anhydrovinblastine in the aerial parts of some Catharanthus roseus plants and the significance thereof in relation to alkaloid production in cultured cells. In Primary and Secondary Metabolism of Plant Cell Cultures II, 1st ed.; Kurz, W.G.W., Ed.; Springer-Verlag: Berlin, Germany, 1989; pp. 149-153.
    • (1989) Primary and Secondary Metabolism of Plant Cell Cultures II, 1st Ed. , pp. 149-153
    • Balsevich, J.1    Bishop, G.2
  • 11
    • 0344972955 scopus 로고    scopus 로고
    • Purification and characterization of α-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G.Don
    • Sottomayor, M.; Lopéz-Serrano, M.; DiCosmo, F.; Ros Barceló, A. Purification and characterization of α-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don. FEBS Lett. 1998, 428, 299-303.
    • (1998) FEBS Lett , vol.428 , pp. 299-303
    • Sottomayor, M.1    Lopéz-Serrano, M.2    DiCosmo, F.3    Ros Barceló, A.4
  • 12
    • 84879729230 scopus 로고    scopus 로고
    • Vacuolar transport of the medicinal alkaloids from Catharanthus roseus is mediated by a proton-driven antiport
    • Carqueijeiro, I.; Noronha, H.; Duarte, P.; Geros, H.; Sottomayor, M. Vacuolar transport of the medicinal alkaloids from Catharanthus roseus is mediated by a proton-driven antiport. Plant Physiol. 2013, 162, 1486-1496.
    • (2013) Plant Physiol. , vol.162 , pp. 1486-1496
    • Carqueijeiro, I.1    Noronha, H.2    Duarte, P.3    Geros, H.4    Sottomayor, M.5
  • 13
    • 34249872436 scopus 로고    scopus 로고
    • Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: From biochemical processing to metabolic engineering
    • Zhao, J.; Verpoorte, R. Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: From biochemical processing to metabolic engineering. Phytochem. Rev. 2007, 6, 435-457.
    • (2007) Phytochem. Rev. , vol.6 , pp. 435-457
    • Zhao, J.1    Verpoorte, R.2
  • 14
    • 84889033726 scopus 로고    scopus 로고
    • Catharanthus roseus and prospects of its endophytes: A new avenue for production of bioactive metabolites
    • Koul, M.; Lakra, N.S.; Chandra, R.; Chandra, S. Catharanthus roseus and prospects of its endophytes: A new avenue for production of bioactive metabolites. Int. J. Pharm. Sci. Res. 2013, 4, 2705-2716.
    • (2013) Int. J. Pharm. Sci. Res. , vol.4 , pp. 2705-2716
    • Koul, M.1    Lakra, N.S.2    Chandra, R.3    Chandra, S.4
  • 15
    • 33846513478 scopus 로고    scopus 로고
    • Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats
    • Nayak, B.S.; Pereira, L.M.P. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats. BMC Complement. Altern. Med. 2006, 6, 41-46.
    • (2006) BMC Complement. Altern. Med. , vol.6 , pp. 41-46
    • Nayak, B.S.1    Pereira, L.M.P.2
  • 16
    • 79953102034 scopus 로고    scopus 로고
    • Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    • Özçelik, B.; Kartal, M.; Orhan, I. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm. Biol. 2011, 49, 396-402.
    • (2011) Pharm. Biol. , vol.49 , pp. 396-402
    • Özçelik, B.1    Kartal, M.2    Orhan, I.3
  • 19
    • 84862777630 scopus 로고    scopus 로고
    • Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus
    • Wang, L.; He, H.P.; Di, Y.T.; Zhang, Y.; Hao, X.J. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus. Tetrahedron Lett. 2012, 53, 1576-1578.
    • (2012) Tetrahedron Lett. , vol.53 , pp. 1576-1578
    • Wang, L.1    He, H.P.2    Di, Y.T.3    Zhang, Y.4    Hao, X.J.5
  • 20
    • 3242727890 scopus 로고    scopus 로고
    • Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats
    • Vats, V.; Yadav, S.P.; Biswas, N.R.; Grover, J.K. Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats. J. Ethnopharmacol. 2004, 93, 289-294.
    • (2004) J. Ethnopharmacol. , vol.93 , pp. 289-294
    • Vats, V.1    Yadav, S.P.2    Biswas, N.R.3    Grover, J.K.4
  • 21
    • 33845975658 scopus 로고    scopus 로고
    • Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice
    • Kumar, M.; Hunag, Y.; Glinka, Y.; Prud'Homme, G.J.; Wang, Q. Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Gene Ther. 2006, 14, 162-172.
    • (2006) Gene Ther. , vol.14 , pp. 162-172
    • Kumar, M.1    Hunag, Y.2    Glinka, Y.3    Prud'Homme, G.J.4    Wang, Q.5
  • 22
    • 0034908609 scopus 로고    scopus 로고
    • Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats
    • Ghosh, S.; Suryawanshi, S.A. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J. Exp. Biol. 2001, 39, 748-759.
    • (2001) Indian J. Exp. Biol. , vol.39 , pp. 748-759
    • Ghosh, S.1    Suryawanshi, S.A.2
  • 25
    • 0036624720 scopus 로고    scopus 로고
    • Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: A new oral therapy for erectile dysfunction
    • Lebret, T.; Hervé, J.M.; Gorny, P.; Worcel, M.; Botto, H. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: A new oral therapy for erectile dysfunction. Eur. Urol. 2002, 41, 608-613.
    • (2002) Eur. Urol. , vol.41 , pp. 608-613
    • Lebret, T.1    Hervé, J.M.2    Gorny, P.3    Worcel, M.4    Botto, H.5
  • 27
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka, M.T.; O'Banion, M.K. Inflammatory processes in Alzheimer's disease. J. Neuroimmunol. 2007, 184, 69-91.
    • (2007) J. Neuroimmunol. , vol.184 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 29
    • 84907209097 scopus 로고    scopus 로고
    • Molecular docking studies of Rhizophora mucronata alkaloids against neuroinflammatory marker cyclooxygenase 2
    • Manigandan, V.; Gurudeeban, S.; Satyavani, K.; Ramanathan, T. Molecular docking studies of Rhizophora mucronata alkaloids against neuroinflammatory marker cyclooxygenase 2. Int. J. Biol. Chem. 2014, 8, 91-99.
    • (2014) Int. J. Biol. Chem. , vol.8 , pp. 91-99
    • Manigandan, V.1    Gurudeeban, S.2    Satyavani, K.3    Ramanathan, T.4
  • 30
    • 0031788303 scopus 로고    scopus 로고
    • Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA, and other molecular targets
    • Wink, M.; Schmeller, T.; Latz-Brüning, B. Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA, and other molecular targets. J. Chem. Ecol. 1998, 24, 1881-1937.
    • (1998) J. Chem. Ecol. , vol.24 , pp. 1881-1937
    • Wink, M.1    Schmeller, T.2    Latz-Brüning, B.3
  • 31
    • 0003133882 scopus 로고
    • Rauwolfia serpentina in the treatment of high blood pressure. A review of the literature
    • Vakil, R.J. Rauwolfia serpentina in the treatment of high blood pressure. A review of the literature. Circulation 1955, 12, 220-229.
    • (1955) Circulation , vol.12 , pp. 220-229
    • Vakil, R.J.1
  • 33
  • 35
    • 84897489675 scopus 로고    scopus 로고
    • Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: Vincristine and vinblastine
    • Rai, V.; Tandon, P.K.; Khatoon, S. Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: Vincristine and vinblastine. BioMed Res. Int. 2014, 2014, doi:10.1155/2014/934182.
    • (2014) BioMed Res. Int. , vol.2014
    • Rai, V.1    Tandon, P.K.2    Khatoon, S.3
  • 36
    • 84928967297 scopus 로고    scopus 로고
    • Anhydrovinblastine for the Treatment of Cervical and Lung Cancer
    • EP
    • Kutney, J.; Mayer, L.; Schmidt, B. Anhydrovinblastine for the Treatment of Cervical and Lung Cancer. EP0969839 A1, 2000.
    • (2000)
    • Kutney, J.1    Mayer, L.2    Schmidt, B.3
  • 37
    • 84897949779 scopus 로고    scopus 로고
    • Validated HILIC-MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study
    • Zhu, R.H.; Li, H.D.; Cai, H.L.; Jiang, Z.P.; Xu, P.; Dai, L.B.; Peng, W.X. Validated HILIC-MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study. J. Pharm. Biomed. Anal. 2014, 96, 31-36.
    • (2014) J. Pharm. Biomed. Anal. , vol.96 , pp. 31-36
    • Zhu, R.H.1    Li, H.D.2    Cai, H.L.3    Jiang, Z.P.4    Xu, P.5    Dai, L.B.6    Peng, W.X.7
  • 38
    • 35349028892 scopus 로고    scopus 로고
    • Razoxane and vindesine in advanced soft tissue sarcomas: Impact on metastasis, survival and radiation response
    • Rhomberg, W.; Eiter, H.; Schmid, F.; Saely, C. Razoxane and vindesine in advanced soft tissue sarcomas: Impact on metastasis, survival and radiation response. Anticancer Res. 2007, 27, 3609-3614.
    • (2007) Anticancer Res. , vol.27 , pp. 3609-3614
    • Rhomberg, W.1    Eiter, H.2    Schmid, F.3    Saely, C.4
  • 39
    • 0034074996 scopus 로고    scopus 로고
    • Vinorelbine - A clinical review
    • Gregory, R.K.; Smith, I.E. Vinorelbine - A clinical review. Br. J. Cancer 2000, 82, 1907-1913.
    • (2000) Br. J. Cancer , vol.82 , pp. 1907-1913
    • Gregory, R.K.1    Smith, I.E.2
  • 40
    • 84856328530 scopus 로고    scopus 로고
    • Oral vinorelbine in metastatic breast cancer: A review of current clinical trial results
    • Aapro, M.; Finek, J. Oral vinorelbine in metastatic breast cancer: A review of current clinical trial results. Cancer Treat. Rev. 2012, 38, 120-126.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 120-126
    • Aapro, M.1    Finek, J.2
  • 41
    • 84878442860 scopus 로고    scopus 로고
    • Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy
    • Bellmunt, J.; Fougeray, R.; Rosenberg, J.E.; von der Maase, H.; Schutz, F.A.; Salhi, Y.; Culine, S.; Choueiri, T.K. Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy. Ann. Oncol. 2013, 24, 1466-1472.
    • (2013) Ann. Oncol. , vol.24 , pp. 1466-1472
    • Bellmunt, J.1    Fougeray, R.2    Rosenberg, J.E.3    Von Der Maase, H.4    Schutz, F.A.5    Salhi, Y.6    Culine, S.7    Choueiri, T.K.8
  • 42
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • Hadfield, J.A.; Lawrence, N.J.; McGown, A.T. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle. Med. Res. Rev. 1998, 18, 259-296.
    • (1998) Med. Res. Rev. , vol.18 , pp. 259-296
    • Hadfield, J.A.1    Lawrence, N.J.2    McGown, A.T.3
  • 44
    • 0038674316 scopus 로고    scopus 로고
    • The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics
    • Okouneva, T.; Hill, B.T.; Wilson, L.; Jordan, M.A. The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol. Cancer Ther. 2003, 2, 427-436.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 427-436
    • Okouneva, T.1    Hill, B.T.2    Wilson, L.3    Jordan, M.A.4
  • 46
    • 0025610485 scopus 로고
    • Instability of pleomorphic tubulin paracrystals artificially induced by Vinca alkaloids in tissue-cultured cells
    • Takanari, H.; Yosida, T.; Morita, J.; Izutsu, K.; Ito, T. Instability of pleomorphic tubulin paracrystals artificially induced by Vinca alkaloids in tissue-cultured cells. Biol. Cell 1990, 70, 83-90.
    • (1990) Biol. Cell , vol.70 , pp. 83-90
    • Takanari, H.1    Yosida, T.2    Morita, J.3    Izutsu, K.4    Ito, T.5
  • 47
    • 65549161484 scopus 로고    scopus 로고
    • Entropy and enthalpy in the activity of tubulin-based antimitotic agents
    • Daly, E.M.; Taylor, R.E. Entropy and enthalpy in the activity of tubulin-based antimitotic agents. Curr. Chem. Biol. 2009, 3, 47-59.
    • (2009) Curr. Chem. Biol. , vol.3 , pp. 47-59
    • Daly, E.M.1    Taylor, R.E.2
  • 49
    • 84857727692 scopus 로고    scopus 로고
    • Tubulin-based structure-affinity relationship for antimitotic Vinca alkaloid
    • Coderch, C.; Morreale, A.; Gago, F. Tubulin-based structure-affinity relationship for antimitotic Vinca alkaloid. Anticancer Agents Med. Chem. 2012, 12, 219-225.
    • (2012) Anticancer Agents Med. Chem. , vol.12 , pp. 219-225
    • Coderch, C.1    Morreale, A.2    Gago, F.3
  • 50
    • 37349081963 scopus 로고    scopus 로고
    • Vinflunine, a novel microtubule inhibitor, suppresses calmodulin interaction with the microtubule-associated protein STOP
    • Makarov, A.A.; Tsvetkov, P.O.; Villard, C.; Esquieu, D.; Pourroy, B.; Fahy, J.; Braguer, D.; Peyrot, V.; Lafitte, D. Vinflunine, a novel microtubule inhibitor, suppresses calmodulin interaction with the microtubule-associated protein STOP. Biochemistry 2007, 46, 14899-14906.
    • (2007) Biochemistry , vol.46 , pp. 14899-14906
    • Makarov, A.A.1    Tsvetkov, P.O.2    Villard, C.3    Esquieu, D.4    Pourroy, B.5    Fahy, J.6    Braguer, D.7    Peyrot, V.8    Lafitte, D.9
  • 51
  • 52
    • 84894612306 scopus 로고    scopus 로고
    • Deciphering the molecular mechanism of anti-tubulin plant derived drugs
    • Barbier, P.; Tsvetkov, P.O.; Breuzard, G.; Devred, F. Deciphering the molecular mechanism of anti-tubulin plant derived drugs. Phytochem. Rev. 2013, 13, 157-169.
    • (2013) Phytochem. Rev. , vol.13 , pp. 157-169
    • Barbier, P.1    Tsvetkov, P.O.2    Breuzard, G.3    Devred, F.4
  • 53
    • 0020177022 scopus 로고
    • Exploitation of plant cells for the production of natural compounds
    • Deus, B.; Zenk, MH. Exploitation of plant cells for the production of natural compounds. Biotechnol. Bioeng. 1982, 24, 1965-1974.
    • (1982) Biotechnol. Bioeng. , vol.24 , pp. 1965-1974
    • Deus, B.1    Zenk, M.H.2
  • 54
    • 0005763442 scopus 로고
    • Biosynthesis and accumulation of indole alkaloids in cell suspension cultures of Catharanthus roseus cultivars
    • Neumann, K.H., Barz, W., Reinhard, E., Eds.; Springer-Verlag: Berlin, Germany
    • Kurz, W.G.W.; Chatson, K.B.; Constabel. F. Biosynthesis and accumulation of indole alkaloids in cell suspension cultures of Catharanthus roseus cultivars. In Primary and Secondary Metabolism of Plant Cell Cultures, 1st ed.; Neumann, K.H., Barz, W., Reinhard, E., Eds.; Springer-Verlag: Berlin, Germany, 1985; Volume 5, pp. 143-153.
    • (1985) Primary and Secondary Metabolism of Plant Cell Cultures, 1st Ed. , vol.5 , pp. 143-153
    • Kurz, W.G.W.1    Chatson, K.B.2    Constabel, F.3
  • 55
    • 0000339735 scopus 로고
    • Recent Advances in Indole Alkaloid Production by Catharanthus roseus (Periwinkle)
    • Ganapathi, B.; Kargi, F. Recent Advances in Indole Alkaloid Production by Catharanthus roseus (Periwinkle). J. Exp. Bot. 1990, 41, 259-267.
    • (1990) J. Exp. Bot. , vol.41 , pp. 259-267
    • Ganapathi, B.1    Kargi, F.2
  • 56
    • 0011594246 scopus 로고
    • Effects of long term preservation on growth and productivity of Panax ginseng and Catharanthus roseus cell culture
    • Mannonen, L.; Toivonen, L.; Kauppinen, V.C. Effects of long term preservation on growth and productivity of Panax ginseng and Catharanthus roseus cell culture. Plant Cell Rep. 1990, 9, 173-177.
    • (1990) Plant Cell Rep. , vol.9 , pp. 173-177
    • Mannonen, L.1    Toivonen, L.2    Kauppinen, V.C.3
  • 58
    • 34249875679 scopus 로고    scopus 로고
    • Catharanthus terpenoid indole alkaloids: Biosynthesis and regulation
    • El-Sayed, M.; Verpoorte, R. Catharanthus terpenoid indole alkaloids: Biosynthesis and regulation. Phytochem. Rev. 2007, 6, 277-305.
    • (2007) Phytochem. Rev. , vol.6 , pp. 277-305
    • El-Sayed, M.1    Verpoorte, R.2
  • 59
    • 0023636507 scopus 로고
    • Alkaloid production in root and shoot cultures of Catharanthus roseus
    • Endo, T.; Goodbody, A.E.; Misawa, M. Alkaloid production in root and shoot cultures of Catharanthus roseus. Planta Med. 1987, 53, 479-482.
    • (1987) Planta Med. , vol.53 , pp. 479-482
    • Endo, T.1    Goodbody, A.E.2    Misawa, M.3
  • 60
    • 77954031470 scopus 로고    scopus 로고
    • Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus
    • Shukla, A.K.; Shasany, A.K.; Verma, R.K.; Gupta, M.M.; Mathur, A.K.; Khanuja, P.S.P. Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Protoplasma 2010, 24, 35-47.
    • (2010) Protoplasma , vol.24 , pp. 35-47
    • Shukla, A.K.1    Shasany, A.K.2    Verma, R.K.3    Gupta, M.M.4    Mathur, A.K.5    Khanuja, P.S.P.6
  • 61
    • 0027909097 scopus 로고
    • Production of indole alkaloids by selected hairy root lines of Catharanthus roseus
    • Bhadra, R.; Vani, S.; Shanks, J.V. Production of indole alkaloids by selected hairy root lines of Catharanthus roseus. Biotechnol. Bioeng. 1993, 41, 581-592.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 581-592
    • Bhadra, R.1    Vani, S.2    Shanks, J.V.3
  • 62
    • 0029188578 scopus 로고
    • An interchangeable system of hairy root and cell suspension cultures of Catharanthus roseus for indole alkaloid production
    • Jung, K.H.; Kwak, S.S.; Choi, C.Y.; Liu, J.R. An interchangeable system of hairy root and cell suspension cultures of Catharanthus roseus for indole alkaloid production. Plant Cell Rep. 1995, 15, 51-54.
    • (1995) Plant Cell Rep. , vol.15 , pp. 51-54
    • Jung, K.H.1    Kwak, S.S.2    Choi, C.Y.3    Liu, J.R.4
  • 63
    • 0032420445 scopus 로고    scopus 로고
    • Relation between the amount of rolC gene product and indole alkaloid accumulation in Catharanthus roseus transformed root cultures
    • Palazón, J.; Cusidó, R.M.; Gonzalo, J.; Bonfill, M.; Morales, C.; Pinol, T. Relation between the amount of rolC gene product and indole alkaloid accumulation in Catharanthus roseus transformed root cultures. J. Plant Physiol. 1998, 153, 712-718.
    • (1998) J. Plant Physiol. , vol.153 , pp. 712-718
    • Palazón, J.1    Cusidó, R.M.2    Gonzalo, J.3    Bonfill, M.4    Morales, C.5    Pinol, T.6
  • 65
    • 0034924544 scopus 로고    scopus 로고
    • Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus
    • Zhao, J.; Hu, Q.; Guo, Y.Q.; Zhu, W.H. Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus. Appl. Microbiol. Biotechnol. 2001, 55, 693-698.
    • (2001) Appl. Microbiol. Biotechnol. , vol.55 , pp. 693-698
    • Zhao, J.1    Hu, Q.2    Guo, Y.Q.3    Zhu, W.H.4
  • 66
    • 58149394663 scopus 로고    scopus 로고
    • Effects of NaCl on the growth and alkaloid content of Catharanthus roseus seedlings
    • Wang, J.Y.; Liu, Z.P.; Liu, L.; Liu, C. Effects of NaCl on the growth and alkaloid content of Catharanthus roseus seedlings. J. Appl. Ecol. 2008, 19, 2143-2148.
    • (2008) J. Appl. Ecol. , vol.19 , pp. 2143-2148
    • Wang, J.Y.1    Liu, Z.P.2    Liu, L.3    Liu, C.4
  • 68
    • 0035054408 scopus 로고    scopus 로고
    • Enhanced indole alkaloid production in suspension compact callus clusters of Catharanthus roseus: Impacts of plant growth regulators and sucrose
    • Zhao, J.; Zhu, W.H.; Hu, Q.; He, X.W. Enhanced indole alkaloid production in suspension compact callus clusters of Catharanthus roseus: Impacts of plant growth regulators and sucrose. Plant Growth Reg. 2001, 33, 33-41.
    • (2001) Plant Growth Reg. , vol.33 , pp. 33-41
    • Zhao, J.1    Zhu, W.H.2    Hu, Q.3    He, X.W.4
  • 69
    • 0026648778 scopus 로고
    • Improvement of the catharanthine productivity in hairy root cultures of Catharanthus roseus by using monosaccharides as a carbon source
    • Jung, K.H.; Kwak, S.S.; Kim, S.W.; Lee, H.; Choi, C.Y.; Liu, J.R. Improvement of the catharanthine productivity in hairy root cultures of Catharanthus roseus by using monosaccharides as a carbon source. Biotechnol. Lett. 1992, 14, 695-700.
    • (1992) Biotechnol. Lett. , vol.14 , pp. 695-700
    • Jung, K.H.1    Kwak, S.S.2    Kim, S.W.3    Lee, H.4    Choi, C.Y.5    Liu, J.R.6
  • 70
    • 78651417656 scopus 로고    scopus 로고
    • New method to enhance ajmalicine production in Catharanthus roseus cell cultures based on the use of cyclodextrins
    • Almagro, L.; López-Pérez, A.J.; Pedreño, M.A. New method to enhance ajmalicine production in Catharanthus roseus cell cultures based on the use of cyclodextrins. Biotechnol. Lett. 2010, 33, 381-385.
    • (2010) Biotechnol. Lett. , vol.33 , pp. 381-385
    • Almagro, L.1    López-Pérez, A.J.2    Pedreño, M.A.3
  • 71
    • 0034606713 scopus 로고    scopus 로고
    • The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells
    • Lee, C.W.T.; Shuler, M.L. The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells. Biotechnol. Bioeng. 2000, 67, 61-71.
    • (2000) Biotechnol. Bioeng. , vol.67 , pp. 61-71
    • Lee, C.W.T.1    Shuler, M.L.2
  • 72
    • 0000984708 scopus 로고
    • Stimulation of ajmalicine production and excretion from Catharanthus roseus: Effects of adsorption in situ, elicitors, and alginate immobilization
    • Asada, M.; Shuler, M.L. Stimulation of ajmalicine production and excretion from Catharanthus roseus: Effects of adsorption in situ, elicitors, and alginate immobilization. Appl. Microbiol. Biotechnol. 1989, 30, 475-481.
    • (1989) Appl. Microbiol. Biotechnol. , vol.30 , pp. 475-481
    • Asada, M.1    Shuler, M.L.2
  • 73
    • 84862784260 scopus 로고    scopus 로고
    • Effect of UV light on secondary metabolite biosynthesis in plant cell cultures elicited with cyclodextrins and methyljasmonate
    • Vasanthaiah, H.K.N., Kambiranda, D., Eds.; InTech Janeza Trdine: Rijeka, Croatia
    • Almagro, L.; Sabater-Jara, A.B.; Belchi-Navarro, S.; Fernandez-Perez, F.; Bru, R.; Pedreño, M.A. Effect of UV light on secondary metabolite biosynthesis in plant cell cultures elicited with cyclodextrins and methyljasmonate. In Plants and Environment, 1st ed.; Vasanthaiah, H.K.N., Kambiranda, D., Eds.; InTech Janeza Trdine: Rijeka, Croatia, 2011; Volume 1, pp. 115-136.
    • (2011) Plants and Environment, 1st Ed. , vol.1 , pp. 115-136
    • Almagro, L.1    Sabater-Jara, A.B.2    Belchi-Navarro, S.3    Fernandez-Perez, F.4    Bru, R.5    Pedreño, M.A.6
  • 74
    • 0037781988 scopus 로고    scopus 로고
    • Studies on Production of Ajmalicine in Shake Flasks by Multiple Shoot Cultures of Catharanthus roseus
    • Satdive, R.K.; Fulzele, D.P.; Eapen, S. Studies on Production of Ajmalicine in Shake Flasks by Multiple Shoot Cultures of Catharanthus roseus. Biotechnol. Prog. 2003, 19, 1071-1075.
    • (2003) Biotechnol. Prog. , vol.19 , pp. 1071-1075
    • Satdive, R.K.1    Fulzele, D.P.2    Eapen, S.3
  • 75
    • 22044456149 scopus 로고    scopus 로고
    • Sparge gas composition affects biomass and ajmalicine production from immobilized cell cultures of Catharanthus roseus
    • Lee-Parson, C.W.T.; Shuler, M.L. Sparge gas composition affects biomass and ajmalicine production from immobilized cell cultures of Catharanthus roseus. Enzym. Microb. Technol. 2005, 37, 424-434.
    • (2005) Enzym. Microb. Technol. , vol.37 , pp. 424-434
    • Lee-Parson, C.W.T.1    Shuler, M.L.2
  • 76
    • 0036174780 scopus 로고    scopus 로고
    • Effect of phytohormones on growth and alkaloid accumulation by a Catharanthus roseus cell suspension cultures fed with alkaloid precursors tryptamine and loganin
    • El-Sayed, M.; Verpoorte, R. Effect of phytohormones on growth and alkaloid accumulation by a Catharanthus roseus cell suspension cultures fed with alkaloid precursors tryptamine and loganin. Plant Cell Tissue Organ Cult. 2002, 68, 265-270.
    • (2002) Plant Cell Tissue Organ Cult. , vol.68 , pp. 265-270
    • El-Sayed, M.1    Verpoorte, R.2
  • 77
    • 0034725086 scopus 로고    scopus 로고
    • Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures
    • Morgan, J.A.; Shanks, J.V. Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures. J. Biotechnol. 2000, 79, 137-145.
    • (2000) J. Biotechnol. , vol.79 , pp. 137-145
    • Morgan, J.A.1    Shanks, J.V.2
  • 78
    • 79958258082 scopus 로고    scopus 로고
    • Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures
    • Li, M.; Peebles, C.A.; Shanks, J.V.; San, K.Y. Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures. Biotechnol. Prog. 2011, 27, 625-630.
    • (2011) Biotechnol. Prog. , vol.27 , pp. 625-630
    • Li, M.1    Peebles, C.A.2    Shanks, J.V.3    San, K.Y.4
  • 79
    • 84904811935 scopus 로고    scopus 로고
    • Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus
    • Goldhaber-Pasillas, G.D.; Mustafa, N.R.; Verpoorte, R. Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus. Molecules 2014, 19, 10242-10260.
    • (2014) Molecules , vol.19 , pp. 10242-10260
    • Goldhaber-Pasillas, G.D.1    Mustafa, N.R.2    Verpoorte, R.3
  • 80
    • 84911806316 scopus 로고    scopus 로고
    • Synergistic and additive influence of cyclodextrins and methyl jasmonate on the expression of the terpenoid indole alkaloid pathway genes and metabolites in Catharanthus roseus cell cultures
    • Almagro, L.; Gutierrez, J.; Pedreño, M.A.; Sottomayor, M. Synergistic and additive influence of cyclodextrins and methyl jasmonate on the expression of the terpenoid indole alkaloid pathway genes and metabolites in Catharanthus roseus cell cultures. Plant Cell Tissue Organ Cult. 2014, 119, 543-551.
    • (2014) Plant Cell Tissue Organ Cult. , vol.119 , pp. 543-551
    • Almagro, L.1    Gutierrez, J.2    Pedreño, M.A.3    Sottomayor, M.4
  • 81
    • 67949102172 scopus 로고    scopus 로고
    • Differential secretion and accumulation of terpene indole alkaloids in hairy roots of Catharanthus roseus treated with methyl jasmonate
    • Ruiz-May, E.; Galaz-Ávalos, R.M.; Loyola-Vargas, V.M. Differential secretion and accumulation of terpene indole alkaloids in hairy roots of Catharanthus roseus treated with methyl jasmonate. Mol. Biotechnol. 2009, 41, 278-285.
    • (2009) Mol. Biotechnol. , vol.41 , pp. 278-285
    • Ruiz-May, E.1    Galaz-Ávalos, R.M.2    Loyola-Vargas, V.M.3
  • 82
    • 0036008008 scopus 로고    scopus 로고
    • Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus
    • Namdeo, A.; Patil, S.; Fulzele, D.P. Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus. Biotechnol. Prog. 2002, 18, 159-162.
    • (2002) Biotechnol. Prog. , vol.18 , pp. 159-162
    • Namdeo, A.1    Patil, S.2    Fulzele, D.P.3
  • 83
    • 84881613841 scopus 로고    scopus 로고
    • Interaction between abscisic acid and nitric oxide in PB90 induced catharanthine biosynthesis of Catharanthus roseus cell suspension cultures
    • Chen, Q.; Chen, Z.; Lu, L.; Jin, H.; Sun, L.; Yu, Q.; Xu, H.; Yang, F.; Fu, M.; Li, S.; et al. Interaction between abscisic acid and nitric oxide in PB90 induced catharanthine biosynthesis of Catharanthus roseus cell suspension cultures. Biotechnol. Prog. 2013, 29, 994-1001.
    • (2013) Biotechnol. Prog. , vol.29 , pp. 994-1001
    • Chen, Q.1    Chen, Z.2    Lu, L.3    Jin, H.4    Sun, L.5    Yu, Q.6    Xu, H.7    Yang, F.8    Fu, M.9    Li, S.10
  • 84
    • 44049106946 scopus 로고    scopus 로고
    • Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B light
    • Ramani, S.; Jayabaskaran, C. Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B light. J. Mol. Signal. 2008, 3, 9-14.
    • (2008) J. Mol. Signal. , vol.3 , pp. 9-14
    • Ramani, S.1    Jayabaskaran, C.2
  • 85
    • 0035821039 scopus 로고    scopus 로고
    • Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors
    • Zhao, J.; Zhu, W.H.; Hu, Q. Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors. Enzym. Microb. Technol. 2001, 28, 673-681.
    • (2001) Enzym. Microb. Technol. , vol.28 , pp. 673-681
    • Zhao, J.1    Zhu, W.H.2    Hu, Q.3
  • 86
    • 0032127941 scopus 로고    scopus 로고
    • Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
    • Canel, C.; Lopes-Cardoso, M.I.; Whitmer, S.; van der Fits, L.; Pasquali, G.; van der Heijden, R.; Hoge, J.H.C.; Verpoorte, R. Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 1998, 205, 414-419.
    • (1998) Planta , vol.205 , pp. 414-419
    • Canel, C.1    Lopes-Cardoso, M.I.2    Whitmer, S.3    Van Der Fits, L.4    Pasquali, G.5    Van Der Heijden, R.6    Hoge, J.H.C.7    Verpoorte, R.8
  • 87
    • 0037178212 scopus 로고    scopus 로고
    • Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus
    • Whitmer, S.; van der Heijden, R.; Verpoorte, R. Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus. J. Biotechnol. 2002, 96, 193-203.
    • (2002) J. Biotechnol. , vol.96 , pp. 193-203
    • Whitmer, S.1    Van Der Heijden, R.2    Verpoorte, R.3
  • 88
    • 34447109108 scopus 로고    scopus 로고
    • Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots
    • Magnotta, M.; Murata, J.; Chen, J.; de Luca, V. Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots. Phytochemistry 2007, 68, 1922-1931.
    • (2007) Phytochemistry , vol.68 , pp. 1922-1931
    • Magnotta, M.1    Murata, J.2    Chen, J.3    De Luca, V.4
  • 89
    • 79954772238 scopus 로고    scopus 로고
    • Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus
    • Jaggi, M.; Kumar, S., Sinha, A.K. Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus. Appl. Microbiol. Biotechnol. 2011, 90, 1005-1016.
    • (2011) Appl. Microbiol. Biotechnol. , vol.90 , pp. 1005-1016
    • Jaggi, M.1    Kumar, S.2    Sinha, A.K.3
  • 90
    • 79952103915 scopus 로고    scopus 로고
    • The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots
    • Peebles, C.; Sander, G.W.; Hughes, E.H.; Peacock, R.; Shanks, J.V.; San, K.Y. The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab. Eng. 2011, 13, 234-240.
    • (2011) Metab. Eng. , vol.13 , pp. 234-240
    • Peebles, C.1    Sander, G.W.2    Hughes, E.H.3    Peacock, R.4    Shanks, J.V.5    San, K.Y.6
  • 91
    • 84885065762 scopus 로고    scopus 로고
    • Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis
    • Rai, A.; Smita, S.S.; Singh, A.K.; Shanker, K.; Nagegowda, D.A. Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis. Mol. Plant 2013, 6, 1531-1549.
    • (2013) Mol. Plant , vol.6 , pp. 1531-1549
    • Rai, A.1    Smita, S.S.2    Singh, A.K.3    Shanker, K.4    Nagegowda, D.A.5
  • 92
    • 0031416208 scopus 로고    scopus 로고
    • Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon feeding of secologanin
    • Hallard, D.; van der Heijden, R.; Verpoorte, R.; Lopez-Cardoso, I.; Pasquali, G.; Memelink, J.; Hoge, J.H.C. Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon feeding of secologanin. Plant Cell Rep. 1997, 17, 50-54.
    • (1997) Plant Cell Rep. , vol.17 , pp. 50-54
    • Hallard, D.1    Van Der Heijden, R.2    Verpoorte, R.3    Lopez-Cardoso, I.4    Pasquali, G.5    Memelink, J.6    Hoge, J.H.C.7
  • 94
    • 0037718115 scopus 로고    scopus 로고
    • Biotechnology for production of plant secondary metabolites
    • Verpoorte, R.; Contin, A.; Memelink, J. Biotechnology for production of plant secondary metabolites. Phytochem. Rev. 2002, 1, 13-25.
    • (2002) Phytochem. Rev. , vol.1 , pp. 13-25
    • Verpoorte, R.1    Contin, A.2    Memelink, J.3
  • 95
    • 82755176592 scopus 로고    scopus 로고
    • The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus
    • Suttipanta, N.; Pattanaik, S.; Kulshrestha, M.; Patra, B.; Singh, S.K.; Yuan, L. The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol. 2011, 157, 2081-2093.
    • (2011) Plant Physiol. , vol.157 , pp. 2081-2093
    • Suttipanta, N.1    Pattanaik, S.2    Kulshrestha, M.3    Patra, B.4    Singh, S.K.5    Yuan, L.6
  • 96
    • 84864741062 scopus 로고    scopus 로고
    • CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids
    • Raina, S.K.; Wankhede, D.P.; Jaggi, M.; Singh, P.; Jalmi, S.K.; Raghuram, B.; Sheikh, A.H.; Sinha, A.K. CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids. BMC Plant Biol. 2012, 12, 134, doi:10.1186/1471-2229-12-134.
    • (2012) BMC Plant Biol. , vol.12 , pp. 134
    • Raina, S.K.1    Wankhede, D.P.2    Jaggi, M.3    Singh, P.4    Jalmi, S.K.5    Raghuram, B.6    Sheikh, A.H.7    Sinha, A.K.8
  • 97
    • 79955778587 scopus 로고    scopus 로고
    • Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots
    • Tang, K.X.; Liu, D.H.; Wang, Y.L.; Cui, L.J.; Ren, W.W.; Sun, F. Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots. Russ. J. Plant Physiol. 2011, 58, 415-422.
    • (2011) Russ. J. Plant Physiol. , vol.58 , pp. 415-422
    • Tang, K.X.1    Liu, D.H.2    Wang, Y.L.3    Cui, L.J.4    Ren, W.W.5    Sun, F.6
  • 98
    • 79955587604 scopus 로고    scopus 로고
    • Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpresion of transcriptional factor ORCA2
    • Liu, D.H.; Ren, W.W.; Cui, L.J.; Zhang, L.D.; Sun, X.F.; Tang, K.X. Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpresion of transcriptional factor ORCA2. Afr. J. Biotechnol. 2011, 10, 3260-3268.
    • (2011) Afr. J. Biotechnol. , vol.10 , pp. 3260-3268
    • Liu, D.H.1    Ren, W.W.2    Cui, L.J.3    Zhang, L.D.4    Sun, X.F.5    Tang, K.X.6
  • 99
    • 84865167953 scopus 로고    scopus 로고
    • Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics
    • Pan, Q,; Wang, Q.; Yuan, F.; Xing, S.; Zhao, J.; Choi, Y.H.; Verpoorte, R.; Tian, Y.; Wang, G.; Tang, K. Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. PLoS One 2012, 7, e43038.
    • (2012) PLoS One , vol.7 , pp. e43038
    • Pan, Q.1    Wang, Q.2    Yuan, F.3    Xing, S.4    Zhao, J.5    Choi, Y.H.6    Verpoorte, R.7    Tian, Y.8    Wang, G.9    Tang, K.10
  • 100
    • 0031720190 scopus 로고    scopus 로고
    • Influence of auxins on alkaloid accumulation by a transgenic cell line of Catharanthus roseus
    • Whitmer, S.; Verpoorte, R.; Canel, C. Influence of auxins on alkaloid accumulation by a transgenic cell line of Catharanthus roseus. Plant Cell Tissue Organ Cult. 1998, 53, 135-141.
    • (1998) Plant Cell Tissue Organ Cult. , vol.53 , pp. 135-141
    • Whitmer, S.1    Verpoorte, R.2    Canel, C.3
  • 101
    • 0035060547 scopus 로고    scopus 로고
    • Effects of light and plant growth regulators on the biosynthesis of vindoline and other indole alkaloids in Catharanthus roseus callus cultures
    • Zhao, J.; Zhu, W.H.; Hu, Q. Effects of light and plant growth regulators on the biosynthesis of vindoline and other indole alkaloids in Catharanthus roseus callus cultures. Plant Growth Reg. 2001, 33, 43-49.
    • (2001) Plant Growth Reg. , vol.33 , pp. 43-49
    • Zhao, J.1    Zhu, W.H.2    Hu, Q.3
  • 102
    • 0001463098 scopus 로고
    • Different shake flask closures alter gas phase composition and ajmalicine production in Catharanthus roseus cell suspensions
    • Lee, C.W.T.; Shuler. M.L. Different shake flask closures alter gas phase composition and ajmalicine production in Catharanthus roseus cell suspensions. Biotechnol. Technol. 1991, 5, 173-178.
    • (1991) Biotechnol. Technol. , vol.5 , pp. 173-178
    • Lee, C.W.T.1    Shuler, M.L.2
  • 103
    • 3342941008 scopus 로고    scopus 로고
    • Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine
    • El-Sayed, M.; Choi, Y.H.; Fréderichrich, M.; Roytrakul, S.; Verpoorte, R. Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine. Biotechnol. Lett. 2004, 26, 793-798.
    • (2004) Biotechnol. Lett. , vol.26 , pp. 793-798
    • El-Sayed, M.1    Choi, Y.H.2    Fréderichrich, M.3    Roytrakul, S.4    Verpoorte, R.5
  • 104
    • 0036232568 scopus 로고    scopus 로고
    • Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus
    • Whitmer, S.; van der Heijden, R.; Verpoorte, R. Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus. Plant Cell Tissue Organ Cult. 2000, 69, 85-93.
    • (2000) Plant Cell Tissue Organ Cult. , vol.69 , pp. 85-93
    • Whitmer, S.1    Van Der Heijden, R.2    Verpoorte, R.3
  • 105
    • 0001173656 scopus 로고
    • Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus
    • Moreno, P.R.H.; van der Heijden, R.; Verpoorte, R. Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 1993, 12, 702-705.
    • (1993) Plant Cell Rep. , vol.12 , pp. 702-705
    • Moreno, P.R.H.1    Van Der Heijden, R.2    Verpoorte, R.3
  • 107
    • 0006021295 scopus 로고
    • Elicitor mediated induction of phenylalanine ammonia lyase and tryptophan decarboxylase; accumulation of phenols and indole alkaloids in cell suspension cultures of Catharanthus roseus
    • Seitz, H.U.; Eilert, U.; de Luca, V.; Kurz, W.G.W. Elicitor mediated induction of phenylalanine ammonia lyase and tryptophan decarboxylase; accumulation of phenols and indole alkaloids in cell suspension cultures of Catharanthus roseus. Plant Cell Tissue Organ Cult. 1989, 18, 71-78.
    • (1989) Plant Cell Tissue Organ Cult. , vol.18 , pp. 71-78
    • Seitz, H.U.1    Eilert, U.2    De Luca, V.3    Kurz, W.G.W.4
  • 108
    • 0026206131 scopus 로고
    • Effects of precursor stimulating agents on formation of indole formation by C. roseus in a biofilm reactor
    • Kargi, F.; Ganapathi, B. Effects of precursor stimulating agents on formation of indole formation by C. roseus in a biofilm reactor. Enzym. Microb. Technol. 1991, 13, 643-647.
    • (1991) Enzym. Microb. Technol. , vol.13 , pp. 643-647
    • Kargi, F.1    Ganapathi, B.2
  • 109
    • 0027069449 scopus 로고
    • Stimulation of dimeric alkaloid production by near ultraviolet light in multiple shoot cultures of Catharanthus roseus
    • Hirata, K.; Horiuchi, M.; Asada, M.; Ando, T.; Miyamota, K.; Miura, Y. Stimulation of dimeric alkaloid production by near ultraviolet light in multiple shoot cultures of Catharanthus roseus. Ferment Bioeng. 1992, 74, 222-225.
    • (1992) Ferment Bioeng. , vol.74 , pp. 222-225
    • Hirata, K.1    Horiuchi, M.2    Asada, M.3    Ando, T.4    Miyamota, K.5    Miura, Y.6
  • 110
    • 21644459656 scopus 로고    scopus 로고
    • Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation
    • Lee-Parsons, C.W.; Ertürk, S.; Tengtrakool, J. Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation. Biotechnol. Lett. 2004, 26, 1595-1599.
    • (2004) Biotechnol. Lett. , vol.26 , pp. 1595-1599
    • Lee-Parsons, C.W.1    Ertürk, S.2    Tengtrakool, J.3
  • 111
    • 17444362978 scopus 로고    scopus 로고
    • Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells
    • Xu, M.; Dong, J. Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells. Appl. Microbiol. Biotechnol. 2005, 67, 40-44.
    • (2005) Appl. Microbiol. Biotechnol. , vol.67 , pp. 40-44
    • Xu, M.1    Dong, J.2
  • 112
    • 34249908095 scopus 로고    scopus 로고
    • Transcription factors involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus
    • Memelink, J.; Gantet, P. Transcription factors involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Phytochem. Rev. 2007, 6, 353-362.
    • (2007) Phytochem. Rev. , vol.6 , pp. 353-362
    • Memelink, J.1    Gantet, P.2
  • 113
    • 1842373854 scopus 로고    scopus 로고
    • Effect of acetylsalicylic acid on secondary metabolism of Catharanthus roseus tumor suspension cultures
    • Godoy-Hernández, G.C.; Loyola-Vargas, V.M. Effect of acetylsalicylic acid on secondary metabolism of Catharanthus roseus tumor suspension cultures. Plant Cell Rep. 1997, 16, 287-290.
    • (1997) Plant Cell Rep. , vol.16 , pp. 287-290
    • Godoy-Hernández, G.C.1    Loyola-Vargas, V.M.2
  • 114
    • 67651097490 scopus 로고    scopus 로고
    • The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots
    • Binder, B.Y.; Peebles, C.A.; Shanks, J.V.; San, K.Y. The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots. Biotechnol. Prog. 2009, 25, 861-865.
    • (2009) Biotechnol. Prog. , vol.25 , pp. 861-865
    • Binder, B.Y.1    Peebles, C.A.2    Shanks, J.V.3    San, K.Y.4
  • 117
    • 38949166148 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus
    • Costa, M.M.R.; Hilliou, F.; Duarte, P.; Pereira, L.G.; Almeida, I.; Leech, M.; Memelink, J.; Barcelo, A.R.; Sottomayor, M. Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. Plant Physiol. 2008, 146, 403-417.
    • (2008) Plant Physiol. , vol.146 , pp. 403-417
    • Costa, M.M.R.1    Hilliou, F.2    Duarte, P.3    Pereira, L.G.4    Almeida, I.5    Leech, M.6    Memelink, J.7    Barcelo, A.R.8    Sottomayor, M.9
  • 118
    • 0035121285 scopus 로고    scopus 로고
    • The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element
    • Van Der Fits, L.; Memelink, J. The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. Plant J. 2001, 25, 43-53.
    • (2001) Plant J. , vol.25 , pp. 43-53
    • Van Der Fits, L.1    Memelink, J.2
  • 119
    • 77953480387 scopus 로고    scopus 로고
    • Methyl jasmonic acid induced expression pattern of terpenoid indole alkaloid pathway genes in Catharanthus roseus seedlings
    • Wei, S. Methyl jasmonic acid induced expression pattern of terpenoid indole alkaloid pathway genes in Catharanthus roseus seedlings. Plant Growth Regul. 2010, 61, 243-251.
    • (2010) Plant Growth Regul. , vol.61 , pp. 243-251
    • Wei, S.1
  • 120
    • 78149361676 scopus 로고    scopus 로고
    • Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture
    • Zhou, M.L.; Zhu, X.M.; Shao, J.R.; Wu, Y.M.; Tang, Y.X. Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture. Appl. Microbiol. Biotechnol. 2010, 88, 737-750.
    • (2010) Appl. Microbiol. Biotechnol. , vol.88 , pp. 737-750
    • Zhou, M.L.1    Zhu, X.M.2    Shao, J.R.3    Wu, Y.M.4    Tang, Y.X.5
  • 122
    • 0032811420 scopus 로고    scopus 로고
    • Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in Catharanthus roseus
    • Menke, F.L.; Parchmann, S.; Mueller, M.J.; Kijne, J.W.; Memelink, J. Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in Catharanthus roseus. Plant Physiol. 1999, 119, 1289-1296.
    • (1999) Plant Physiol. , vol.119 , pp. 1289-1296
    • Menke, F.L.1    Parchmann, S.2    Mueller, M.J.3    Kijne, J.W.4    Memelink, J.5
  • 123
    • 31044437014 scopus 로고    scopus 로고
    • Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures
    • Bru, R.; Sellés, S.; Casado-Vela, J.; Belchí-Navarro, S.; Pedreño, M.A. Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures. J. Agric. Food Chem. 2006, 54, 65-71.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 65-71
    • Bru, R.1    Sellés, S.2    Casado-Vela, J.3    Belchí-Navarro, S.4    Pedreño, M.A.5
  • 124
    • 1842714379 scopus 로고    scopus 로고
    • Progress in plant metabolic engineering
    • Capell, T.; Christou, P. Progress in plant metabolic engineering. Curr. Opin. Biotechnol. 2004, 15, 148-154.
    • (2004) Curr. Opin. Biotechnol. , vol.15 , pp. 148-154
    • Capell, T.1    Christou, P.2
  • 125
    • 84894135250 scopus 로고    scopus 로고
    • Metabolic engineering approaches for production of biochemicals in food and medicinal plants
    • Wilson, S.A.; Roberts, S.C. Metabolic engineering approaches for production of biochemicals in food and medicinal plants. Curr. Opin. Biotechnol. 2014, 26, 174-182.
    • (2014) Curr. Opin. Biotechnol. , vol.26 , pp. 174-182
    • Wilson, S.A.1    Roberts, S.C.2
  • 126
    • 34249868452 scopus 로고    scopus 로고
    • Strategies for the genetic modification of the medicinal plant Catharanthus roseus (L.) G
    • Zárate, R.; Verpoorte, R. Strategies for the genetic modification of the medicinal plant Catharanthus roseus (L.) G. Don. Phytochem. Rev. 2007, 6, 475-491.
    • (2007) Don. Phytochem. Rev. , vol.6 , pp. 475-491
    • Zárate, R.1    Verpoorte, R.2
  • 128
    • 0242628016 scopus 로고    scopus 로고
    • CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter
    • Chatel, G.; Montiel, G.; Pre, M.; Memelink, J.; Thiersault, M.; Saint-Pierre, B.; Doireau, P.; Gantet, P. CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter. J. Exp. Bot. 2003, 54, 2587-2588.
    • (2003) J. Exp. Bot. , vol.54 , pp. 2587-2588
    • Chatel, G.1    Montiel, G.2    Pre, M.3    Memelink, J.4    Thiersault, M.5    Saint-Pierre, B.6    Doireau, P.7    Gantet, P.8
  • 129
    • 79958829032 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
    • Zhang, H.; Hedhili, S.; Montiel, G.; Zhang, Y.; Chatel, G.; Pre, M.; Gantet, P.; Memelink, J. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. Plant J. 2011, 67, 61-71.
    • (2011) Plant J. , vol.67 , pp. 61-71
    • Zhang, H.1    Hedhili, S.2    Montiel, G.3    Zhang, Y.4    Chatel, G.5    Pre, M.6    Gantet, P.7    Memelink, J.8
  • 130
    • 0034647914 scopus 로고    scopus 로고
    • ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism
    • Van der Fits, L.; Memelink, J. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science 2000, 289, 295-297.
    • (2000) Science , vol.289 , pp. 295-297
    • Van Der Fits, L.1    Memelink, J.2
  • 131
    • 77954541593 scopus 로고    scopus 로고
    • Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production
    • Wang, C.T.; Liu, H.; Gao, X.S.; Zhang, H.X. Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production. Plant Cell Rep. 2010, 29, 887-894.
    • (2010) Plant Cell Rep. , vol.29 , pp. 887-894
    • Wang, C.T.1    Liu, H.2    Gao, X.S.3    Zhang, H.X.4
  • 132
    • 84884998560 scopus 로고    scopus 로고
    • The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway
    • Li, C.Y.; Leopold, A.L.; Sander, G.W.; Shanks, J.V.; Zhao, L.; Gibson, S.I. The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway. BMC Plant Biol. 2013, 13, 155, doi:10.1186/1471-2229-13-155.
    • (2013) BMC Plant Biol. , vol.13 , pp. 155
    • Li, C.Y.1    Leopold, A.L.2    Sander, G.W.3    Shanks, J.V.4    Zhao, L.5    Gibson, S.I.6


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