Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus

Protoplasma

Volumn 242, Issue 1, 2010, Pages 35-47

  Shukla, Ashutosh K ^a   Shasany, Ajit K ^a   Verma, Ram K ^a   Gupta, Madan M ^a   Mathur, Ajay K ^a   Khanuja, Suman P S ^a,b  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b C41 42 Double Storey ^*  (India)

Author keywords

Catharanthus roseus; DAT; Methyl jasmonate (MeJa); Pythium aphanidermatum; SGD; Terpenoid indole alkaloids (TIAs)

Indexed keywords

MESSENGER RNA; RAUWOLFIA ALKALOID; VEGETABLE PROTEIN;

ARTICLE; BIOSYNTHESIS; CATHARANTHUS; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PYTHIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE CULTURE TECHNIQUE;

BIOSYNTHETIC PATHWAYS; CATHARANTHUS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, PLANT; PLANT PROTEINS; PYTHIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SECOLOGANIN TRYPTAMINE ALKALOIDS; TISSUE CULTURE TECHNIQUES;

CATHARANTHUS ROSEUS; PYTHIUM; PYTHIUM APHANIDERMATUM;

EID: 77954031470     PISSN: 0033183X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00709-010-0120-1     Document Type: Article

References (55)

1. Aerts RJ, Gisi D, De Carolis E, De Luca V, Baumann TW (1994) Methyl jasmonate vapor increases the developmentally controlled synthesis of alkaloids in Catharanthus and Cinchona seedlings. Plant J 5: 635-643.
2. Aerts RJ, Schäfer A, Hesse M, Baumann TW, Slusarenko A (1996) Signalling molecules and the synthesis of alkaloids in Catharanthus roseus seedlings. Phytochemistry 42: 417-422.
3. Babcock PA, Carew DP (1962) Tissue culture of the Apocynaceae. I. Culture requirements and alkaloid analysis. Lloydia 25: 209-213.
4. Blasko G, Cordell GA (1990) Isolation, structure elucidation, and biosynthesis of the bisindole alkaloids of Catharanthus. In: Brossi A, Suffness M (eds) The Alkaloids, Vol. 37. Academic, San Diego, pp 1-76.
5. Campos-Tamayo F, Hernández-Domínguez E, Vázquez-Flota F (2008) Vindoline formation in shoot cultures of Catharanthus roseus is synchronously activated with morphogenesis through the last biosynthetic step. Ann Bot 102: 409-415.
6. Daddona PE, Wright JL, Hutchinson CR (1976) Alkaloid catabolism and mobilization in Catharanthus roseus. Phytochemistry 15: 941-945.
7. Datta A, Srivastava PS (1997) Variation in vinblastine production by Catharanthus roseus during in vivo and in vitro differentiation. Phytochemistry 46: 135-137.
8. De Luca V, Cutler AJ (1987) Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol 85: 1099-1102.
9. Dutta A, Batra J, Pandey-Rai S, Singh D, Kumar S, Sen J (2005) Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don. Planta 220: 376-383.
10. Eilert U, Constabel F, Kurz WGW (1986) Elicitor-stimulation of monoterpene indole alkaloid formation in suspension cultures of Catharanthus roseus. J Plant Physiol 126: 11-22.
11. El-Sayed M, Choi YH, Frédérich M, Roytrakul S, Verpoorte R (2004) Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine. Biotechnol Lett 26: 793-798.
12. Endo T, Goodbody A, Misawa M (1987) Alkaloid production in root and shoot cultures of Catharanthus roseus. Planta Med 53: 479-482.
13. Facchini PJ, De Luca V (2008) Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J 54: 763-784.
14. Geerlings A, Ibanez MM-L, Memelink J, van der Heijden R, Verpoorte R (2000) Molecular cloning and analysis of strictosidine β-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Biol Chem 275: 3051-3056.
15. Gundlach H, Müller MJ, Kutchan TM, Zenk MH (1992) Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures. Proc Natl Acad Sci USA 89: 2389-2393.
16. Gupta MM, Singh DV, Tripathi AK, Pandey R, Verma RK, Singh S, Shasany AK, Khanuja SPS (2005) Simultaneous determination of vincristine, vinblastine, catharanthine and vindoline in leaves of Catharanthus roseus by high performance liquid chromatography. J Chromatogr Sci 43: 450-453.
17. Harris AL, Nylund HB, Carew DP (1964) Tissue culture studies of certain members of the Apocynaceae. Lloydia 27: 322-327.
18. Hernandez-Dominguez E, Campos-Tamayo F, Vazquez-Flota F (2004) Vindoline synthesis in in vitro shoot cultures of Catharanthus roseus. Biotechnol Lett 26: 671-674.
19. Hirata K, Yamanaka A, Kurano N, Miyamoto K, Miura Y (1987) Production of indole alkaloids in multiple shoot cultures of Catharanthus roseus (L.) G. Don. Agric Biol Chem 51: 1311-1317.
20. Krueger RJ, Carew DP, Lui JHC, Staba EJ (1982) Initiation, maintenance and alkaloid content of Catharanthus roseus leaf organ cultures. Planta Med 45: 56-57.
21. Kuboyama T, Yokoshima S, Tokuyama H, Fukuyama T (2004) Stereocontrolled total synthesis of (+)-vincristine. Proc Natl Acad Sci USA 101: 11966-11970.
22. Kulkarni RN, Baskaran K, Chandrashekara RS, Khanuja SPS, Darokar MP, Shasany AK, Uniyal GC, Gupta MM, Kumar S (2003) 'Dhawal', a high alkaloid producing periwinkle plant. US Patent 6, 548, 746.
23. Leonard E, Runguphan W, O'Connor S, Prather KJ (2009) Opportunities in metabolic engineering to facilitate scalable alkaloid production. Nat Chem Biol 5: 292-300.
24. Memelink J, Verpoorte R, Kijne JW (2001) ORCAnisation of jasmonate-responsive gene expression in alkaloid metabolism. Trends Plant Sci 6: 212-219.
25. Menke FLH, Champion A, Kijne JW, Memelink J (1999a) A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J 18: 4455-4463.
26. Menke FLH, Parchmann S, Mueller MJ, Kijne JW, Memelink J (1999b) Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in Catharanthus roseus. Plant Physiol 119: 1289-1296.
27. Mersey BG, Cutler AJ (1986) Differential distribution of specific indole alkaloids in leaves of Catharanthus roseus. Can J Bot 64: 1039-1045.
28. Miura Y, Hirata K, Kurano N, Miyamoto K, Uchida K (1988) Formation of vinblastine in multiple shoot culture of Catharanthus roseus. Planta Med 54: 18-20.
29. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-497.
30. Murata J, Roepke J, Gordon H, De Luca V (2008) The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20: 524-542.
31. Neuss N (1980) The spectrum of biological activities of indole alkaloids. In: Phillipson JD, Zenk MH (eds) Indole and biogenetically related alkaloids. Academic, London, pp 293-313.
32. Pasquali G, Porto DD, Fett-Neto AG (2006) Metabolic engineering of cell cultures versus whole plant complexity in production of bioactive monoterpene indole alkaloids: recent progress related to old dilemma. J Biosci Bioeng 101: 287-296.
33. Patterson BD, Carew DP (1969) Growth and alkaloid formation in Catharanthus roseus tissue cultures. Lloydia 32: 131-140.
34. Peebles CA, Hughes EH, Shanks JV, San KY (2009) Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time. Met Eng 11: 76-86.
35. Potier P (1980) Is the modified Polonovski reaction biomimetic? In: Phillipson JD, Zenk MH (eds) Indole and biogenetically related alkaloids. Academic, London, pp 159-169.
36. Ramani S, Jayabaskaran C (2008) Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B light. J Mol Signal 3: 9.
37. Reda F (1978) Distribution and accumulation of alkaloids in Catharanthus roseus G. Don during development. Pharmazie 33: 233-234.
38. Rijhwani SK, Shanks JV (1998) Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures. Biotechnol Prog 14: 442-449.
39. Shukla AK (2005) Molecular studies on biosynthesis of shoot alkaloids in Catharanthus roseus (L.) G. Don. PhD thesis, Department of Biochemistry, University of Lucknow, India.
40. Shukla YN, Rani A, Kumar S (1997) Effect of temperature and pH on the extraction of total alkaloids from Catharanthus roseus leaves. J Med Aromat Plant Sci 19: 430-431.
41. + mRNA for downstream reactions from some medicinal and aromatic plants. Indian J Exp Biol 43: 197-201.
42. Shukla AK, Shasany AK, Gupta MM, Khanuja SPS (2006) Transcriptome analysis in Catharanthus roseus leaves and roots for comparative terpenoid indole alkaloid profiles. J Exp Bot 57: 3921-3932.
43. Skrypina NA, Timofeeva AV, Khaspekov GL, Savochkina LP, Beabealashvilli RS (2003) Total RNA suitable for molecular biology analysis. J Biotechnol 105: 1-9.
44. Svoboda GH, Blake DA (1975) The phytochemistry and pharmacology of Catharanthus roseus (L) G. Don. In: Taylor WI, Farnsworth NR (eds) The Catharanthus Alkaloids. Marcel Dekker, New York, pp 45-83.
45. van der Fits L, Memelink J (2000) ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science 289: 295-297.
46. van der Fits L, Memelink J (2001) The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. Plant J 25: 43-53.
47. van der Fits L, Zhang H, Menke FLH, Deneka M, Memelink J (2000) A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a jasmonate-independent signal transduction pathway. Plant Mol Biol 44: 675-685.
48. van der Heijden R, Verpoorte R, Ten Hoopen HJG (1989) Cell and tissue cultures of Catharanthus roseus (L) G Don: a literature survey. Plant Cell Tiss Organ Cult 18: 231-280.
49. van der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R (2004) The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem 11: 607-628.
50. Vazquez-Flota F, De Luca V, Carrillo-Pech M, Canto-Flick A, de Lourdes Miranda-Ham M (2002) Vindoline biosynthesis is transcriptionally blocked in Catharanthus roseus cell suspension cultures. Mol Biotechnol 22: 1-8.
51. Vazquez-Flota F, Carrillo-Pech M, Minero-Garcia Y, Miranda-Ham MDL (2004) Alkaloid metabolism in wounded Catharanthus roseus seedlings. Plant Physiol Biochem 42: 623-628.
52. Vázquez-Flota F, Hernández-Domínguez E, de Lourdes Miranda-Ham M, Monforte-González M (2009) A differential response to chemical elicitors in Catharanthus roseus in vitro cultures. Biotechnol Lett 31: 591-595.
53. Verpoorte R, van der Heijden R, Moreno PRH (1997) Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus cells. In: Cordell GA (ed) The Alkaloids, Vol. 49. Academic, San Diego, pp 221-299.
54. Vom Endt D, e Silva MS, Kijne JW, Pasquali G, Memelink J (2007) Identification of a bipartite jasmonate-responsive promoter element in the Catharanthus roseus ORCA3 transcription factor gene that interacts specifically with AT-hook DNA-binding proteins. Plant Physiol 144: 1680-1689.
55. Yokoshima S, Ueda T, Kobayashi S, Sato A, Kuboyama T, Tokuyama H, Fukuyama T (2002) Stereocontrolled total synthesis of (+)-vinblastine. J Am Chem Soc 124: 2137-2139.