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Volumn 16, Issue 6, 2015, Pages 484-491

New developments of clinical trial in immunotherapy for alzheimer's disease

Author keywords

Alzheimer s disease; Antibodies; Clinical trials; Immunotherapy; Vaccines

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BAPINEUZUMAB; CRENEZUMAB; GANTENERUMAB; IMMUNOGLOBULIN; PONEZUMAB; SOLANEZUMAB; TAU PROTEIN; VANUTIDE CRIDIFICAR; MONOCLONAL ANTIBODY;

EID: 84928957555     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920101606150407112319     Document Type: Article
Times cited : (9)

References (69)
  • 1
    • 84872119357 scopus 로고    scopus 로고
    • Alzheimer Disease International. The worldwide economic impact of dementia 2010
    • e3
    • Wimo, A.; Jönsson, L.; Bond, J.; Prince, M.; Winblad, B. Alzheimer Disease International. The worldwide economic impact of dementia 2010. Alzheimers. Dement., 2013, 9(1), 1-11.e3.
    • (2013) Alzheimers. Dement , vol.9 , Issue.1 , pp. 1-11
    • Wimo, A.1    Jönsson, L.2    Bond, J.3    Prince, M.4    Winblad, B.5
  • 2
    • 0026597063 scopus 로고
    • Alzheimer’s disease: The amyloid cascadehypothesis
    • Hardy, J.A.; Higgins, G.A. Alzheimer’s disease: The amyloid cascadehypothesis. Science, 1992, 256, 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 3
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • Tanzi, R. E.; Bertram, L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell, 2005, 120, 545-555.
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 7
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alzheimer's disease
    • Weiner, H.L.; Frenkel, D. Immunology and immunotherapy of Alzheimer's disease. Nat. Rev. Immunol., 2006, 6, 404-416.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 10
    • 77953872812 scopus 로고    scopus 로고
    • Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    • Boche, D.; Donald, J.; Love, S.; Harris, S.; Neal, J.W.; Holmes, C.; Nicoll, J.A. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta. Neuropathol., 2010, 120, 13-20.
    • (2010) Acta. Neuropathol. , vol.120 , pp. 13-20
    • Boche, D.1    Donald, J.2    Love, S.3    Harris, S.4    Neal, J.W.5    Holmes, C.6    Nicoll, J.A.7
  • 11
    • 84862315328 scopus 로고    scopus 로고
    • Active immunotherapy for Alzheimer's disease
    • Wisniewski, T. Active immunotherapy for Alzheimer's disease. Lancet. Neurol., 2012, 11, 571-572.
    • (2012) Lancet. Neurol. , vol.11 , pp. 571-572
    • Wisniewski, T.1
  • 13
    • 56349119351 scopus 로고    scopus 로고
    • Linking Abeta and tau in late-onset Alzheimer's disease: A dual pathway hypothesis
    • Small, S.A.; Duff, K. Linking Abeta and tau in late-onset Alzheimer's disease: A dual pathway hypothesis. Neuron, 2008, 60, 534-542.
    • (2008) Neuron , vol.60 , pp. 534-542
    • Small, S.A.1    Duff, K.2
  • 15
    • 18144415471 scopus 로고    scopus 로고
    • Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    • Fox, N.C.; Black, R.S.; Gilman, S.; Rossor, M.N.; Griffith, S.G.; Jenkins, L.; Koller, M. Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology, 2005, 64, 1563-1572.
    • (2005) Neurology , vol.64 , pp. 1563-1572
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6    Koller, M.7
  • 18
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792-associated meningoencephalitis
    • Pride, M.; Seubert, P.; Grundman, M.; Hagen, M.; Eldridge, J.; Black, R. S. Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792-associated meningoencephalitis. Neurodegener. Dis., 2008, 5, 194-196.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5    Black, R.S.6
  • 19
    • 67849102202 scopus 로고    scopus 로고
    • Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing
    • Ryan, J. M.; Grundman, M. Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing. J. Alz-heimers. Dis., 2009, 17, 243.
    • (2009) J. Alz-Heimers. Dis. , vol.17 , pp. 243
    • Ryan, J.M.1    Grundman, M.2
  • 20
    • 85039889975 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov/ct2/results?term=ACC-001&Search= Search
  • 21
    • 84862331908 scopus 로고    scopus 로고
    • Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-in-human study
    • Winblad, B.; Andreasen, N.; Minthon, L.; Floesser, A.; Imbert, G.; Dumortier, T.; Maguire, R.P.; Blennow, K.; Lundmark, J.; Staufenbiel, M.; Orgogozo, J.M.; Graf, A. Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-in-human study. Lancet. Neurol., 2012, 11, 597-604.
    • (2012) Lancet. Neurol. , vol.11 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5    Dumortier, T.6    Maguire, R.P.7    Blennow, K.8    Lundmark, J.9    Staufenbiel, M.10    Orgogozo, J.M.11    Graf, A.12
  • 22
    • 84894033757 scopus 로고    scopus 로고
    • Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease
    • Panza, F.; Logroscino, G.; Imbimbo, B. P.; Solfrizzi, V. Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease? Curr. Opin. Psychiatr., 2014, 27, 128-137.
    • (2014) Curr. Opin. Psychiatr. , vol.27 , pp. 128-137
    • Panza, F.1    Logroscino, G.2    Imbimbo, B.P.3    Solfrizzi, V.4
  • 23
    • 63249137056 scopus 로고    scopus 로고
    • Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing
    • Schneeberger, A.; Mandler, M.; Otawa, O.; Zauner, W.; Mattner, F.; Schmidt, W. Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing. J. Nutr. Health Aging, 2009, 13, 264-267.
    • (2009) J. Nutr. Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3    Zauner, W.4    Mattner, F.5    Schmidt, W.6
  • 24
    • 77953872812 scopus 로고    scopus 로고
    • Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    • Boche, D.; Donald, J.; Love, S.; Harris, S.; Neal, J.W.; Holmes, C.; Nicoll, J.A. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta Neuropathol., 2010, 120(1), 13-20.
    • (2010) Acta Neuropathol. , vol.120 , Issue.1 , pp. 13-20
    • Boche, D.1    Donald, J.2    Love, S.3    Harris, S.4    Neal, J.W.5    Holmes, C.6    Nicoll, J.A.7
  • 25
    • 85039881090 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov/ct2/results?term=UB+311&Search=S earch
  • 26
    • 85039873239 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov/ct2/results?term=+V950+&Search= Search
  • 27
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Dodart, J.C.; Paul, S.M.; Holtzman, D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2001, 98, 8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 29
    • 0642370868 scopus 로고    scopus 로고
    • Immunological approach for the treatment of Alzheimer's disease
    • Solomon, B. Immunological approach for the treatment of Alzheimer's disease. J. Mol. Neurosci., 2003, 20, 283-286.
    • (2003) J. Mol. Neurosci. , vol.20 , pp. 283-286
    • Solomon, B.1
  • 30
    • 33744499734 scopus 로고    scopus 로고
    • Mechanisms of A beta plaque clearance following passive A beta immunization
    • Morgan, D. Mechanisms of A beta plaque clearance following passive A beta immunization. Neurodegener. Dis., 2005, 2, 261-266.
    • (2005) Neurodegener. Dis. , vol.2 , pp. 261-266
    • Morgan, D.1
  • 34
    • 84863750982 scopus 로고    scopus 로고
    • Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients-with mild to moderate Alzheimer disease
    • Blennow, K.; Zetterberg, H.; Rinne, J.O.; Salloway, S.; Wei, J.; Black, R.; Grundman, M.; Liu, E. Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients-with mild to moderate Alzheimer disease. Arch. Neurol., 2012, 69, 1002-1010.
    • (2012) Arch. Neurol. , vol.69 , pp. 1002-1010
    • Blennow, K.1    Zetterberg, H.2    Rinne, J.O.3    Salloway, S.4    Wei, J.5    Black, R.6    Grundman, M.7    Liu, E.8
  • 36
    • 84871660406 scopus 로고    scopus 로고
    • Pathogenesis and disease-modifying therapy in Alzheimer's disease: The flat line of progress
    • Castellani, R.J.; Perry, G. Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress. Arch. Med. Res., 2012, 43, 694-698.
    • (2012) Arch. Med. Res. , vol.43 , pp. 694-698
    • Castellani, R.J.1    Perry, G.2
  • 37
    • 84905490065 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β
    • Crespi, G.A.; Ascher, D.B.; Parker, M.W.; Miles, L.A. Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β. Acta Crystallogr. F Struct. Biol. Commun., 2014, 70(Pt 3), 374-377.
    • (2014) Acta Crystallogr. F Struct. Biol. Commun. , vol.70 , pp. 374-377
    • Crespi, G.A.1    Ascher, D.B.2    Parker, M.W.3    Miles, L.A.4
  • 38
    • 77951086901 scopus 로고    scopus 로고
    • Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease
    • Siemers, E.R.; Friedrich, S.; Dean, R.A.; Gonzales, C.R.; Farlow, M.R.; Paul, S.M.; Demattos, R.B. Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease. Clin. Neuropharmacol., 2010, 33, 67-73.
    • (2010) Clin. Neuropharmacol. , vol.33 , pp. 67-73
    • Siemers, E.R.1    Friedrich, S.2    Dean, R.A.3    Gonzales, C.R.4    Farlow, M.R.5    Paul, S.M.6    Demattos, R.B.7
  • 39
    • 84855854663 scopus 로고    scopus 로고
    • Comparison of phar-macokinetics, pharmacodynamics, safety, and tolerability of the amyloid beta monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease
    • Uenaka, K.; Nakano, M.; Willis, B.A.; Friedrich, S.; Ferguson-Sells, L.; Dean, R.A.; Ieiri, I.; Siemers, E.R. Comparison of phar-macokinetics, pharmacodynamics, safety, and tolerability of the amyloid beta monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease. Clin. Neu-ropharmacol., 2012, 35, 25-29.
    • (2012) Clin. Neu-Ropharmacol. , vol.35 , pp. 25-29
    • Uenaka, K.1    Nakano, M.2    Willis, B.A.3    Friedrich, S.4    Ferguson-Sells, L.5    Dean, R.A.6    Ieiri, I.7    Siemers, E.R.8
  • 40
  • 43
    • 84892710970 scopus 로고    scopus 로고
    • Antiamyloid therapy for Alzheimer's disease--are we on the right road
    • Karran, E.; Hardy, J. Antiamyloid therapy for Alzheimer's disease--are we on the right road?N. Engl. J. Med., 2014, 370, 377-378.
    • (2014) N. Engl. J. Med. , vol.370 , pp. 377-378
    • Karran, E.1    Hardy, J.2
  • 47
    • 84881025664 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Farlow, M.R.; Brosch, J.R. Immunotherapy for Alzheimer's disease. Neurol. Clin., 2013, 31, 869-878.
    • (2013) Neurol. Clin. , vol.31 , pp. 869-878
    • Farlow, M.R.1    Brosch, J.R.2
  • 49
    • 84863245510 scopus 로고    scopus 로고
    • 39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomol-gus monkeys with 12-week recovery period
    • Freeman, G.B.; Lin, J.C.; Pons, J.; Raha, N.M. 39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomol-gus monkeys with 12-week recovery period. J. Alzheimers. Dis., 2012, 28, 531-541.
    • (2012) J. Alzheimers. Dis. , vol.28 , pp. 531-541
    • Freeman, G.B.1    Lin, J.C.2    Pons, J.3    Raha, N.M.4
  • 50
    • 84872970450 scopus 로고    scopus 로고
    • Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease
    • Burstein, A.H.; Zhao, Q.; Ross, J.; Styren, S.; Landen, J.W.; Ma, W.W.; McCush, F.; Alvey, C.; Kupiec, J.W.; Bednar, M.M. Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease. Clin. Neuropharmacol., 2013, 36, 8-13.
    • (2013) Clin. Neuropharmacol. , vol.36 , pp. 8-13
    • Burstein, A.H.1    Zhao, Q.2    Ross, J.3    Styren, S.4    Landen, J.W.5    Ma, W.W.6    McCush, F.7    Alvey, C.8    Kupiec, J.W.9    Bednar, M.M.10
  • 51
    • 84872960603 scopus 로고    scopus 로고
    • Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: A phase I, randomized, placebo-controlled, double-blind, dose-escalation study
    • Landen, J.W.; Zhao, Q.; Cohen, S.; Borrie, M.; Woodward, M.; Billing, C.B., Jr.; Bales, K.; Alvey, C.; McCush, F.; Yang, J.; Kupiec, J.W.; Bednar, M.M. Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: A phase I, randomized, placebo-controlled, double-blind, dose-escalation study. Clin. Neuropharmacol., 2013, 36, 14-23.
    • (2013) Clin. Neuropharmacol. , vol.36 , pp. 14-23
    • Landen, J.W.1    Zhao, Q.2    Cohen, S.3    Borrie, M.4    Woodward, M.5    Billing, C.B.6    Bales, K.7    Alvey, C.8    McCush, F.9    Yang, J.10    Kupiec, J.W.11    Bednar, M.M.12
  • 53
    • 84873487586 scopus 로고    scopus 로고
    • Genentech's Alzheimer's antibody trial to study disease prevention
    • Garber, K. Genentech's Alzheimer's antibody trial to study disease prevention. Nat. Biotechnol., 2012, 30, 731-732.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 731-732
    • Garber, K.1
  • 58
    • 84876336245 scopus 로고    scopus 로고
    • Aβ immunotherapy for Alzheimer's disease
    • Sakai, K.; Yamada, M. Aβ immunotherapy for Alzheimer's disease. Brain Nerve, 2013, 65(4), 461-468.
    • (2013) Brain Nerve , vol.65 , Issue.4 , pp. 461-468
    • Sakai, K.1    Yamada, M.2
  • 60
    • 84903168717 scopus 로고    scopus 로고
    • Amyloid-beta concentration and structure influences the transport and immunomodulatory effects of IVIG
    • Wuest, D.M.; Lee, K.H. Amyloid-beta concentration and structure influences the transport and immunomodulatory effects of IVIG. J. Neurochem., 2014, 130(1), 136-44.
    • (2014) J. Neurochem. , vol.130 , Issue.1 , pp. 136-144
    • Wuest, D.M.1    Lee, K.H.2
  • 65
    • 84878427627 scopus 로고    scopus 로고
    • Intravenous immunoglobulin and Alzheimer's disease: What now
    • Loeffler, D.A. Intravenous immunoglobulin and Alzheimer's disease: what now? J. Neuroinflammation, 2013, 10, 70.
    • (2013) J. Neuroinflammation , vol.10 , pp. 70
    • Loeffler, D.A.1
  • 68
    • 84865676982 scopus 로고    scopus 로고
    • Engineered antibody approaches for Alzheimer's disease immunotherapy
    • Robert, R.; Wark, K.L. Engineered antibody approaches for Alzheimer's disease immunotherapy. Arch. Biochem. Biophys., 2012, 526, 132-138.
    • (2012) Arch. Biochem. Biophys. , vol.526 , pp. 132-138
    • Robert, R.1    Wark, K.L.2
  • 69
    • 84867370380 scopus 로고    scopus 로고
    • Beneficial effect of antibodies against beta- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice
    • Rabinovich-Nikitin, I.; Rakover, I.S.; Becker, M.; Solomon, B. Beneficial effect of antibodies against beta- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice. PloS One, 2012, 7, e46650.
    • (2012) Plos One , vol.7
    • Rabinovich-Nikitin, I.1    Rakover, I.S.2    Becker, M.3    Solomon, B.4


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