Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease

Journal of Molecular Biology

Volumn 421, Issue 4-5, 2012, Pages 525-536

  La Porte, Sherry L ^a   Bollini, Sangeetha Subbarao ^a   Lanz, Thomas A ^a   Abdiche, Yasmina N ^a   Rusnak, Alexander S ^a   Ho, Wei Hsien ^a   Kobayashi, Dione ^a   Harrabi, Ons ^a   Pappas, Danielle ^a   Mina, Erene W ^a   Milici, Anthony J ^a   Kawabe, Thomas T ^a   Bales, Kelly ^a   Lin, John C ^a   Pons, Jaume ^a  

^a PFIZER INC   (United States)

Author keywords

Alzheimer's disease; amyloid; antibody; A 40; immunotherapy

Indexed keywords

AMYLOID BETA PROTEIN; EPITOPE; PONEZUMAB;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DOSE COMPARISON; DRUG INDICATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; FEMALE; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

MUS MUSCULUS;

EID: 84864286560     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.11.047     Document Type: Article

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