Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5667-5672

  Ortega, Janice ^a   Li, Jessie Y ^b,d   Lee, Sanghee ^a   Tong, Dan ^a,c   Gu, Liya ^a   Li, Guo Min ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Paul Laurence Dunbar High School   (United States)

^c Tsinghua University   (China)

^d YALE UNIVERSITY   (United States)

Author keywords

Cancer; EGFR; Genome instability; Mismatch repair; PCNA phosphorylation

Indexed keywords

ASPARTIC ACID; CYCLINE; ENDONUCLEASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMIC ACID; PHENYLALANINE; PROTEIN; PROTEIN MUTS; PROTEIN MUTS ALPHA; PROTEIN MUTS BETA; TYROSINE; UNCLASSIFIED DRUG; DNA; PROTEIN BINDING;

ARTICLE; CANCER CELL; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; FEMALE; HCT116 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MISMATCH REPAIR; MUTATION RATE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; UTERINE CERVIX CANCER; WESTERN BLOTTING; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; COLORECTAL TUMOR; DISEASE COURSE; DNA SEQUENCE; FLUORESCENCE MICROSCOPY; GENETICS; GENOME; HUMAN GENOME; METABOLISM; MUTATION; NEOPLASM; TUMOR CELL LINE;

EUKARYOTA;

CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DNA; DNA MISMATCH REPAIR; GENOME; GENOME, HUMAN; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE ANALYSIS, DNA; TYROSINE;

EID: 84928913838     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417711112     Document Type: Article

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